Cytochrome P450 mRNA expression in the rodent brain: Species-, sex-, and region-dependent differences

Drug Metabolism and Disposition

Volumn 42, Issue 2, 2014, Pages 239-244

  Stamou, Marianna ^a   Wu, Xianai ^b   Kania Korwel, Izabela ^b   Lehmler, Hans Joachim ^b   Lein, Pamela J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORN OIL; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B; CYTOCHROME P450 2S1; CYTOCHROME P450 3A; CYTOCHROME P450 4X1; DEXAMETHASONE; ISOPROTEIN; MESSENGER RNA; PHENOBARBITAL; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; BRAIN REGION; CEREBELLUM; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; LIVER; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; RODENT; SEX DIFFERENCE; SPECIES DIFFERENCE;

ANIMALS; BRAIN; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FEMALE; ISOENZYMES; LIVER; MALE; MICE; MICE, INBRED C57BL; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SEX FACTORS; SPECIES SPECIFICITY;

EID: 84891786002     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.113.054239     Document Type: Article

References (35)

1. Al-Anizy M, Horley NJ, Kuo CW, Gillett LC, Laughton CA, Kendall D, Barrett DA, Parker T, and Bell DR (2006) Cytochrome P450 Cyp4x1 is a major P450 protein in mouse brain. FEBS J 273:936-947.
2. Ariyoshi N, Oguri K, Koga N, Yoshimura H, and Funae Y (1995) Metabolism of highly persistent PCB congener, 2,4,5,29,49,59-hexachlorobiphenyl, by human CYP2B6. Biochem Biophys Res Commun 212:455-460.
3. Bhamre S, Anandatheerthavarada HK, Shankar SK, and Ravindranath V (1992) Microsomal cytochrome P450 in human brain regions. Biochem Pharmacol 44:1223-1225.
4. Bylund J, Zhang C, and Harder DR (2002) Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain. Biochem Biophys Res Commun 296:677-684.
5. Choudhary D, Jansson I, Schenkman JB, Sarfarazi M, and Stoilov I (2003) Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Arch Biochem Biophys 414:91-100. (Pubitemid 36555449)
6. Corcos L and Berthou F (2008) The CYP2B subfamily, RSC Publishing, Cambridge.
7. Crane AL, Klein K, and Olson JR (2012) Bioactivation of chlorpyrifos by CYP2B6 variants. Xenobiotica 42:1255-1262.
8. Curran CP, Nebert DW, Genter MB, Patel KV, Schaefer TL, Skelton MR, Williams MT, and Vorhees CV (2011) In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environ Health Perspect 119:1286-1293.
9. Ding X and Kaminsky LS (2003) Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts. Annu Rev Pharmacol Toxicol 43:149-173. (Pubitemid 37372638)
10. Dutheil F, Dauchy S, Diry M, Sazdovitch V, Cloarec O, Mellottée L, Bièche I, Ingelman- Sundberg M, Flinois JP, and de Waziers I, et al. (2009) Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function. Drug Metab Dispos 37:1528-1538.
11. Erratico CA, Szeitz A, and Bandiera SM (2013) Biotransformation of 2,29,4,49-tetrabromodiphenyl ether (BDE-47) by human liver microsomes: identification of cytochrome P450 2B6 as the major enzyme involved. Chem Res Toxicol 26:721-731.
12. Feo ML, Gross MS, McGarrigle BP, Eljarrat E, Barcelo D, Aga DS, and Olson JR (2013) Biotransformation of BDE-47 to potentially toxic metabolites is predominantly mediated by human CYP2B6. Environ Health Perspect 121:440-446, 446e441-447.
13. Ferguson CS and Tyndale RF (2011) Cytochrome P450 enzymes in the brain: emerging evidence of biological significance. Trends Pharmacol Sci 32:708-714.
14. Foxenberg RJ, McGarrigle BP, Knaak JB, Kostyniak PJ, and Olson JR (2007) Human hepatic cytochrome p450-specific metabolism of parathion and chlorpyrifos. Drug Metab Dispos 35: 189-193. (Pubitemid 46148729)
15. Greenblatt DJ, He P, von Moltke LL, and Court MH(2008) The CYP3 family, in Cytochromes P450: Role in the Metabolism and Toxicity of Drugs and Other Xenobiotics, pp 354-383, The Royal Society of Chemistry, London.
16. Guengerich FP, Tang Z, Salamanca-Pinzón SG, and Cheng Q (2010) Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm. Mol Interv 10:153-163.
17. Hedlund E, Gustafsson JA, and Warner M (2001) Cytochrome P450 in the brain; a review. Curr Drug Metab 2:245-263. (Pubitemid 32785272)
18. Kania-Korwel I, Barnhart CD, Stamou M, Truong KM, El-Komy MH, Lein PJ, Veng-Pedersen P, and Lehmler HJ (2012) 2,29,3,59,6-Pentachlorobiphenyl (PCB 95) and its hydroxylated metabolites are enantiomerically enriched in female mice. Environ Sci Technol 46: 11393-11401.
19. Kania-Korwel I, Hrycay EG, Bandiera SM, and Lehmler H-J (2008) 2,29,3,39,6,69-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem Res Toxicol 21:1295-1303. (Pubitemid 351967395)
20. Khokhar JY and Tyndale RF (2012) Rat brain CYP2B-enzymatic activation of chlorpyrifos to the oxon mediates cholinergic neurotoxicity. Toxicol Sci 126:325-335.
21. Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, and Pessah IN (2011) Para- and ortho-substitutions are key determinants of polybrominated diphenyl ether activity toward ryanodine receptors and neurotoxicity. Environ Health Perspect 119:519-526.
22. Meyer RP, Gehlhaus M, Knoth R, and Volk B (2007) Expression and function of cytochrome p450 in brain drug metabolism. Curr Drug Metab 8:297-306. (Pubitemid 46780059)
23. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45.
24. Ravindranath V and Strobel HW (2013) Cytochrome P450-mediated metabolism in brain: functional roles and their implications. Expert Opin Drug Metab Toxicol 9:551-558.
25. Renaud HJ, Cui JY, Khan M, and Klaassen CD (2011) Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice. Toxicol Sci 124:261-277.
26. Schilter B, Andersen MR, Acharya C, and Omiecinski CJ (2000) Activation of cytochrome P450 gene expression in the rat brain by phenobarbital-like inducers. J Pharmacol Exp Ther 294: 916-922. (Pubitemid 30666841)
27. Schilter B and Omiecinski CJ (1993) Regional distribution and expression modulation of cytochrome P-450 and epoxide hydrolase mRNAs in the rat brain. Mol Pharmacol 44:990-996. (Pubitemid 23344965)
28. Spencer PS and Lein PJ(2013) Neurotoxicity, in Encyclopedia of Toxicology (Wexler P ed), Elsevier, Oxford, UK.
29. Tang J, Cao Y, Rose RL, Brimfield AA, Dai D, Goldstein JA, and Hodgson E (2001) Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Drug Metab Dispos 29:1201-1204. (Pubitemid 32800231)
30. Upadhya SC, Chinta SJ, Pai HV, Boyd MR, and Ravindranath V (2002) Toxicological consequences of differential regulation of cytochrome p450 isoforms in rat brain regions by phenobarbital. Arch Biochem Biophys 399:56-65. (Pubitemid 34848310)
31. Volk B, Meyer RP, von Lintig F, Ibach B, and Knoth R (1995) Localization and characterization of cytochrome P450 in the brain. In vivo and in vitro investigations on phenytoin- and phenobarbital-inducible isoforms. Toxicol Lett 82-83:655-662. (Pubitemid 26054753)
32. Warner M, Köhler C, Hansson T, and Gustafsson J-Å (1988) Regional distribution of cytochrome P-450 in the rat brain: spectral quantitation and contribution of P-450b,e, and P-450c,d. J Neurochem 50:1057-1065.
33. Woodland C, Huang TT, Gryz E, Bendayan R, and Fawcett JP (2008) Expression, activity and regulation of CYP3A in human and rodent brain. Drug Metab Rev 40:149-168. (Pubitemid 351220645)
34. Yoo JSH, Hong JY, Ning SM, and Yang CS (1990) Roles of dietary corn oil in the regulation of cytochromes P450 and glutathione S-transferases in rat liver. J Nutr 120:1718-1726.
35. Zhou K, Khokhar JY, Zhao B, and Tyndale RF (2013) First demonstration that brain CYP2Dmediated opiate metabolic activation alters analgesia in vivo. Biochem Pharmacol 85:1848-1855.