메뉴 건너뛰기




Volumn 96, Issue 3, 2014, Pages 340-348

Functional gene variants of CYP3A4

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CLOPIDOGREL; CYCLOSPORIN A; CYTOCHROME P450 3A4; ENDOXIFEN; EVEROLIMUS; FENTANYL; FLUTICASONE; FLUTICASONE PROPIONATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; MEVINOLIN; MIDAZOLAM; NIFEDIPINE; PACLITAXEL; PROGESTERONE; QUETIAPINE; RAPAMYCIN; SIMVASTATIN; SUNITINIB; TACROLIMUS; TAMOXIFEN; TESTOSTERONE;

EID: 84907876975     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2014.129     Document Type: Review
Times cited : (217)

References (76)
  • 1
    • 84875211310 scopus 로고    scopus 로고
    • Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
    • Zanger, U.M. & Schwab, M. Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation. Pharmacol. Ther. 138, 103-141 (2013).
    • (2013) Pharmacol. Ther. , vol.138 , pp. 103-141
    • Zanger, U.M.1    Schwab, M.2
  • 2
    • 84455194082 scopus 로고    scopus 로고
    • Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities
    • Ohtsuki, S. et al. Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities. Drug Metab. Dispos. 40, 83-92 (2012).
    • (2012) Drug Metab. Dispos. , vol.40 , pp. 83-92
    • Ohtsuki, S.1
  • 3
    • 84876720172 scopus 로고    scopus 로고
    • Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for druginduced osteomalacia
    • Wang, Z. et al. Enhancement of hepatic 4-hydroxylation of 25-hydroxyvitamin D3 through CYP3A4 induction in vitro and in vivo: Implications for druginduced osteomalacia. J. Bone Miner. Res. 28, 1101-1116 (2013).
    • (2013) J. Bone Miner. Res. , vol.28 , pp. 1101-1116
    • Wang, Z.1
  • 4
    • 84897023548 scopus 로고    scopus 로고
    • Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance
    • Werk, A.N. et al. Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance. Clin. Pharmacol. Ther. 95, 416-422 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.95 , pp. 416-422
    • Werk, A.N.1
  • 5
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl, P. et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat. Genet. 27, 383-391 (2001).
    • (2001) Nat. Genet. , vol.27 , pp. 383-391
    • Kuehl, P.1
  • 6
    • 0032547341 scopus 로고    scopus 로고
    • Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4
    • Rebbeck, T.R., Jaffe, J.M., Walker, A.H., Wein, A.J. & Malkowicz, S.B. Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4. J. Natl. Cancer Inst. 90, 1225-1229 (1998).
    • (1998) J. Natl. Cancer Inst. , vol.90 , pp. 1225-1229
    • Rebbeck, T.R.1    Jaffe, J.M.2    Walker, A.H.3    Wein, A.J.4    Malkowicz, S.B.5
  • 7
    • 0345643389 scopus 로고    scopus 로고
    • Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5'-upstream regulatory region
    • Westlind, A., Löfberg, L., Tindberg, N., Andersson, T.B. & Ingelman-Sundberg, M. Interindividual differences in hepatic expression of CYP3A4: Relationship to genetic polymorphism in the 5'-upstream regulatory region. Biochem. Biophys. Res. Commun. 259, 201-205 (1999).
    • (1999) Biochem. Biophys. Res. Commun. , vol.259 , pp. 201-205
    • Westlind, A.1    Löfberg, L.2    Tindberg, N.3    Andersson, T.B.4    Ingelman-Sundberg, M.5
  • 8
    • 0037139169 scopus 로고    scopus 로고
    • Mutation analysis of the human CYP3A4 gene 5' regulatory region: Population screening using non-radioactive SSCP
    • Hamzeiy, H., Vahdati-Mashhadian, N., Edwards, H.J. & Goldfarb, P.S. Mutation analysis of the human CYP3A4 gene 5' regulatory region: Population screening using non-radioactive SSCP. Mutat. Res. 500, 103-110 (2002).
    • (2002) Mutat. Res. , vol.500 , pp. 103-110
    • Hamzeiy, H.1    Vahdati-Mashhadian, N.2    Edwards, H.J.3    Goldfarb, P.S.4
  • 9
    • 1542573393 scopus 로고    scopus 로고
    • Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population
    • Fukushima-Uesaka, H. et al. Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population. Hum. Mutat. 23, 100 (2004).
    • (2004) Hum. Mutat. , vol.23 , pp. 100
    • Fukushima-Uesaka, H.1
  • 10
    • 84880917962 scopus 로고    scopus 로고
    • A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-Transplanted patients
    • T avira, B., Coto, E., Diaz-Corte, C., Alvarez, V., López-Larrea, C. & Ortega, F. A search for new CYP3A4 variants as determinants of tacrolimus dose requirements in renal-Transplanted patients. Pharmacogenet. Genomics 23, 445-448 (2013).
    • (2013) Pharmacogenet. Genomics , vol.23 , pp. 445-448
    • Tavira, B.1    Coto, E.2    Diaz-Corte, C.3    Alvarez, V.4    López-Larrea, C.5    Ortega, F.6
  • 11
    • 79960633918 scopus 로고    scopus 로고
    • Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs
    • Wang, D., Guo, Y., Wrighton, S.A., Cooke, G.E. & Sadee, W. Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs. Pharmacogenomics J. 11, 274-286 (2011).
    • (2011) Pharmacogenomics J. , vol.11 , pp. 274-286
    • Wang, D.1    Guo, Y.2    Wrighton, S.A.3    Cooke, G.E.4    Sadee, W.5
  • 12
    • 80054963743 scopus 로고    scopus 로고
    • Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients
    • Elens, L. et al. Effect of a new functional CYP3A4 polymorphism on calcineurin inhibitors' dose requirements and trough blood levels in stable renal transplant patients. Pharmacogenomics 12, 1383-1396 (2011).
    • (2011) Pharmacogenomics , vol.12 , pp. 1383-1396
    • Elens, L.1
  • 13
    • 80054924410 scopus 로고    scopus 로고
    • A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients
    • Elens, L. et al. A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients. Clin. Chem. 57, 1574-1583 (2011).
    • (2011) Clin. Chem. , vol.57 , pp. 1574-1583
    • Elens, L.1
  • 14
    • 84885021006 scopus 로고    scopus 로고
    • Impact of CYP3A4 22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: Toward updated genotype-based dosage guidelines
    • Elens, L. et al. Impact of CYP3A4 22 allele on tacrolimus pharmacokinetics in early period after renal transplantation: Toward updated genotype-based dosage guidelines. Ther. Drug Monit. 35, 608-616 (2013).
    • (2013) Ther. Drug Monit. , vol.35 , pp. 608-616
    • Elens, L.1
  • 15
    • 84896792376 scopus 로고    scopus 로고
    • Effect of CYP3A4 22, CYP3A5 3, and CYP3A combined genotypes on cyclosporine, everolimus, and tacrolimus pharmacokinetics in renal transplantation
    • Moes, D.J. et al. Effect of CYP3A4 22, CYP3A5 3, and CYP3A combined genotypes on cyclosporine, everolimus, and tacrolimus pharmacokinetics in renal transplantation. CPT Pharmacometrics Syst. Pharmacol. 3, e100 (2014).
    • (2014) CPT Pharmacometrics Syst. Pharmacol. , vol.3
    • Moes, D.J.1
  • 16
    • 84880461075 scopus 로고    scopus 로고
    • CYP3A4 22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients
    • Gijsen, V.M. et al. CYP3A4 22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients. Pharmacogenomics 14, 1027-1036 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 1027-1036
    • Gijsen, V.M.1
  • 17
    • 84901657706 scopus 로고    scopus 로고
    • The influence of CYP3A PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients
    • Lunde, I. et al. The influence of CYP3A, PPARA, and POR genetic variants on the pharmacokinetics of tacrolimus and cyclosporine in renal transplant recipients. Eur. J. Clin. Pharmacol. 70, 685-693 (2014).
    • (2014) Eur. J. Clin. Pharmacol. , vol.70 , pp. 685-693
    • Lunde, I.1
  • 18
    • 84889832224 scopus 로고    scopus 로고
    • Effect of CYP3A4 22, POR 28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients
    • Woillard, J.B., Kamar, N., Coste, S., Rostaing, L., Marquet, P. & Picard, N. Effect of CYP3A4 22, POR 28, and PPARA rs4253728 on sirolimus in vitro metabolism and trough concentrations in kidney transplant recipients. Clin. Chem. 59, 1761-1769 (2013).
    • (2013) Clin. Chem. , vol.59 , pp. 1761-1769
    • Woillard, J.B.1    Kamar, N.2    Coste, S.3    Rostaing, L.4    Marquet, P.5    Picard, N.6
  • 19
    • 84901690794 scopus 로고    scopus 로고
    • Tamoxifen-Associated hot flash severity is inversely correlated with endoxifen concentration and CYP3A4 22
    • Baxter, S.D., Teft, W.A., Choi, Y.H., Winquist, E. & Kim, R.B. Tamoxifen-Associated hot flash severity is inversely correlated with endoxifen concentration and CYP3A4 22. Breast Cancer Res. Treat. 145, 419-428 (2014).
    • (2014) Breast Cancer Res. Treat. , vol.145 , pp. 419-428
    • Baxter, S.D.1    Teft, W.A.2    Choi, Y.H.3    Winquist, E.4    Kim, R.B.5
  • 20
    • 84877575399 scopus 로고    scopus 로고
    • CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy
    • T eft, W.A. et al. CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy. Breast Cancer Res. Treat. 139, 95-105 (2013).
    • (2013) Breast Cancer Res. Treat. , vol.139 , pp. 95-105
    • Teft, W.A.1
  • 21
    • 84902834410 scopus 로고    scopus 로고
    • Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662
    • Diekstra, M.H. et al. Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662. Clin. Pharmacol. Ther. 96, 81-89 (2014).
    • (2014) Clin. Pharmacol. Ther. , vol.96 , pp. 81-89
    • Diekstra, M.H.1
  • 22
    • 84890362511 scopus 로고    scopus 로고
    • Cytochrome P450 3A4 22, PPAR-Alpha, and ARNT polymorphisms and clopidogrel response
    • Kreutz, R. et al. Cytochrome P450 3A4 22, PPAR-Alpha, and ARNT polymorphisms and clopidogrel response. Clin. Pharmacol. 5, 185-192 (2013).
    • (2013) Clin. Pharmacol. , vol.5 , pp. 185-192
    • Kreutz, R.1
  • 23
    • 84870347313 scopus 로고    scopus 로고
    • Influence of CYP3A4 CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients
    • Shi, Y. et al. Influence of CYP3A4, CYP3A5 and MDR-1 polymorphisms on tacrolimus pharmacokinetics and early renal dysfunction in liver transplant recipients. Gene 512, 226-231 (2013).
    • (2013) Gene , vol.512 , pp. 226-231
    • Shi, Y.1
  • 24
    • 84880570593 scopus 로고    scopus 로고
    • Fluticasone propionate pharmacogenetics: CYP3A4 22 polymorphism and pediatric asthma control
    • 1227.e1
    • Stockmann, C. et al. Fluticasone propionate pharmacogenetics: CYP3A4 22 polymorphism and pediatric asthma control. J. Pediatr. 162, 1222-7, 1227.e1 (2013).
    • (2013) J. Pediatr. , vol.162 , pp. 1222-1227
    • Stockmann, C.1
  • 25
    • 84876551991 scopus 로고    scopus 로고
    • CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control
    • Kitzmiller, J.P., Sullivan, D.M., Phelps, M.A., Wang, D. & Sadee, W. CYP3A4/5 combined genotype analysis for predicting statin dose requirement for optimal lipid control. Drug Metabol. Drug Interact. 28, 59-63 (2013).
    • (2013) Drug Metabol. Drug Interact. , vol.28 , pp. 59-63
    • Kitzmiller, J.P.1    Sullivan, D.M.2    Phelps, M.A.3    Wang, D.4    Sadee, W.5
  • 26
    • 81055140354 scopus 로고    scopus 로고
    • Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study
    • Elens, L. et al. Novel CYP3A4 intron 6 single nucleotide polymorphism is associated with simvastatin-mediated cholesterol reduction in the Rotterdam Study. Pharmacogenet. Genomics 21, 861-866 (2011).
    • (2011) Pharmacogenet. Genomics , vol.21 , pp. 861-866
    • Elens, L.1
  • 27
    • 84871453438 scopus 로고    scopus 로고
    • Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia
    • Hu, M., Mak, V.W., Xiao, Y. & Tomlinson, B. Associations between the genotypes and phenotype of CYP3A and the lipid response to simvastatin in Chinese patients with hypercholesterolemia. Pharmacogenomics 14, 25-34 (2013).
    • (2013) Pharmacogenomics , vol.14 , pp. 25-34
    • Hu, M.1    Mak, V.W.2    Xiao, Y.3    Tomlinson, B.4
  • 28
    • 0036221255 scopus 로고    scopus 로고
    • CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity
    • García-Martín, E. et al. CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity. Clin. Pharmacol. Ther. 71, 196-204 (2002).
    • (2002) Clin. Pharmacol. Ther. , vol.71 , pp. 196-204
    • García-Martín, E.1
  • 29
    • 0036020978 scopus 로고    scopus 로고
    • The CYP3A4 1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer
    • Spurdle, A.B. et al. The CYP3A4 1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer. Pharmacogenetics 12, 355-366 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 355-366
    • Spurdle, A.B.1
  • 30
    • 8544221912 scopus 로고    scopus 로고
    • CYP3A4 CYP3A5 and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer
    • Zeigler-Johnson, C. et al. CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. Cancer Res. 64, 8461-8467 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 8461-8467
    • Zeigler-Johnson, C.1
  • 31
    • 70349664493 scopus 로고    scopus 로고
    • Association of genotypes of the CYP3A cluster with midazolam disposition in vivo
    • Miao, J. et al. Association of genotypes of the CYP3A cluster with midazolam disposition in vivo. Pharmacogenomics J. 9, 319-326 (2009).
    • (2009) Pharmacogenomics J. , vol.9 , pp. 319-326
    • Miao, J.1
  • 32
    • 84858438174 scopus 로고    scopus 로고
    • Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation
    • Gervasini, G., Garcia, M., Macias, R.M., Cubero, J.J., Caravaca, F. & Benitez, J. Impact of genetic polymorphisms on tacrolimus pharmacokinetics and the clinical outcome of renal transplantation. Transpl. Int. 25, 471-480 (2012).
    • (2012) Transpl. Int. , vol.25 , pp. 471-480
    • Gervasini, G.1    Garcia, M.2    Macias, R.M.3    Cubero, J.J.4    Caravaca, F.5    Benitez, J.6
  • 33
    • 84868701343 scopus 로고    scopus 로고
    • Impact of CYP3A4 1B and CYP3A5 3 polymorphisms on the pharmacokinetics of cyclosporine and sirolimus in renal transplant recipients
    • Zochowska, D., Wyzgal, J. & Paczek, L. Impact of CYP3A4 1B and CYP3A5 3 polymorphisms on the pharmacokinetics of cyclosporine and sirolimus in renal transplant recipients. Ann. Transplant. 17, 36-44 (2012).
    • (2012) Ann. Transplant. , vol.17 , pp. 36-44
    • Zochowska, D.1    Wyzgal, J.2    Paczek, L.3
  • 34
    • 9144262579 scopus 로고    scopus 로고
    • CYP3A4 gene polymorphisms influence testosterone 6beta-hydroxylation
    • Murayama, N. et al. CYP3A4 gene polymorphisms influence testosterone 6beta-hydroxylation. Drug Metab. Pharmacokinet. 17, 150-156 (2002).
    • (2002) Drug Metab. Pharmacokinet. , vol.17 , pp. 150-156
    • Murayama, N.1
  • 35
    • 84888595114 scopus 로고    scopus 로고
    • Influence of cytochrome P450 (CYP) 3A4 1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients
    • Uesugi, M. et al. Influence of cytochrome P450 (CYP) 3A4 1G polymorphism on the pharmacokinetics of tacrolimus, probability of acute cellular rejection, and mRNA expression level of CYP3A5 rather than CYP3A4 in living-donor liver transplant patients. Biol. Pharm. Bull. 36, 1814-1821 (2013).
    • (2013) Biol. Pharm. Bull. , vol.36 , pp. 1814-1821
    • Uesugi, M.1
  • 36
    • 0033632228 scopus 로고    scopus 로고
    • CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity
    • Sata, F. et al. CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: Evidence for an allelic variant with altered catalytic activity. Clin. Pharmacol. Ther. 67, 48-56 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.67 , pp. 48-56
    • Sata, F.1
  • 37
    • 54349104898 scopus 로고    scopus 로고
    • Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone
    • Miyazaki, M., Nakamura, K., Fujita, Y., Guengerich, F.P., Horiuchi, R. & Yamamoto, K. Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosterone. Drug Metab. Dispos. 36, 2287-2291 (2008).
    • (2008) Drug Metab. Dispos. , vol.36 , pp. 2287-2291
    • Miyazaki, M.1    Nakamura, K.2    Fujita, Y.3    Guengerich, F.P.4    Horiuchi, R.5    Yamamoto, K.6
  • 38
    • 26444591592 scopus 로고    scopus 로고
    • CYP3A4 and CYP3A5 genotyping by pyrosequencing
    • Garsa, A.A., McLeod, H.L. & Marsh, S. CYP3A4 and CYP3A5 genotyping by pyrosequencing. BMC Med. Genet. 6, 19 (2005).
    • (2005) BMC Med. Genet. , vol.6 , pp. 19
    • Garsa, A.A.1    McLeod, H.L.2    Marsh, S.3
  • 39
    • 0035197548 scopus 로고    scopus 로고
    • Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos
    • Dai, D. et al. Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos. J. Pharmacol. Exp. Ther. 299, 825-831 (2001).
    • (2001) J. Pharmacol. Exp. Ther. , vol.299 , pp. 825-831
    • Dai, D.1
  • 40
    • 0346433752 scopus 로고    scopus 로고
    • CYP3A4 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin in primary hypercholesterolemia
    • Kajinami, K., Brousseau, M.E., Ordovas, J.M. & Schaefer, E.J. CYP3A4 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin in primary hypercholesterolemia. Am. J. Cardiol. 93, 104-107 (2004).
    • (2004) Am. J. Cardiol. , vol.93 , pp. 104-107
    • Kajinami, K.1    Brousseau, M.E.2    Ordovas, J.M.3    Schaefer, E.J.4
  • 41
    • 0035118585 scopus 로고    scopus 로고
    • Novel mutations of CYP3A4 in Chinese
    • Hsieh, K.P. et al. Novel mutations of CYP3A4 in Chinese. Drug Metab. Dispos. 29, 268-273 (2001).
    • (2001) Drug Metab. Dispos. , vol.29 , pp. 268-273
    • Hsieh, K.P.1
  • 42
    • 78049399957 scopus 로고    scopus 로고
    • Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide
    • Pratt-Hyatt, M., Zhang, H., Snider, N.T. & Hollenberg, P.F. Effects of a commonly occurring genetic polymorphism of human CYP3A4 (I118V) on the metabolism of anandamide. Drug Metab. Dispos. 38, 2075-2082 (2010).
    • (2010) Drug Metab. Dispos. , vol.38 , pp. 2075-2082
    • Pratt-Hyatt, M.1    Zhang, H.2    Snider, N.T.3    Hollenberg, P.F.4
  • 43
    • 20144378997 scopus 로고    scopus 로고
    • Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients
    • Wang, A. et al. Ile118Val genetic polymorphism of CYP3A4 and its effects on lipid-lowering efficacy of simvastatin in Chinese hyperlipidemic patients. Eur. J. Clin. Pharmacol. 60, 843-848 (2005).
    • (2005) Eur. J. Clin. Pharmacol. , vol.60 , pp. 843-848
    • Wang, A.1
  • 44
    • 0034959461 scopus 로고    scopus 로고
    • Identification and functional characterization of eight CYP3A4 protein variants
    • Eiselt, R. et al. Identification and functional characterization of eight CYP3A4 protein variants. Pharmacogenetics 11, 447-458 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 447-458
    • Eiselt, R.1
  • 45
    • 3142741726 scopus 로고    scopus 로고
    • Pharmacokinetics of midazolam in CYP3A4-And CYP3A5-genotyped subjects
    • Eap, C.B. et al. Pharmacokinetics of midazolam in CYP3A4-And CYP3A5-genotyped subjects. Eur. J. Clin. Pharmacol. 60, 231-236 (2004).
    • (2004) Eur. J. Clin. Pharmacol. , vol.60 , pp. 231-236
    • Eap, C.B.1
  • 46
    • 0036219998 scopus 로고    scopus 로고
    • Common allelic variants of cytochrome P4503A4 and their prevalence in different populations
    • Lamba, J.K. et al. Common allelic variants of cytochrome P4503A4 and their prevalence in different populations. Pharmacogenetics 12, 121-132 (2002).
    • (2002) Pharmacogenetics , vol.12 , pp. 121-132
    • Lamba, J.K.1
  • 47
    • 33746677973 scopus 로고    scopus 로고
    • Impact of the haplotype CYP3A4 16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer
    • Nakajima, Y. et al. Impact of the haplotype CYP3A4 16B harboring the Thr185Ser substitution on paclitaxel metabolism in Japanese patients with cancer. Clin. Pharmacol. Ther. 80, 179-191 (2006).
    • (2006) Clin. Pharmacol. Ther. , vol.80 , pp. 179-191
    • Nakajima, Y.1
  • 48
    • 80052851361 scopus 로고    scopus 로고
    • Association of ABCB1 CYP3A4 18B and CYP3A5 3 genotypes with the pharmacokinetics of tacrolimus in healthy Chinese subjects: A population pharmacokinetic analysis
    • Shi, X.J., Geng, F., Jiao, Z., Cui, X.Y., Qiu, X.Y. & Zhong, M.K. Association of ABCB1, CYP3A4 18B and CYP3A5 3 genotypes with the pharmacokinetics of tacrolimus in healthy Chinese subjects: A population pharmacokinetic analysis. J. Clin. Pharm. Ther. 36, 614-624 (2011).
    • (2011) J. Clin. Pharm. Ther. , vol.36 , pp. 614-624
    • Shi, X.J.1    Geng, F.2    Jiao, Z.3    Cui, X.Y.4    Qiu, X.Y.5    Zhong, M.K.6
  • 49
    • 55349128503 scopus 로고    scopus 로고
    • Association of MDR1 CYP3A4 18B, and CYP3A5 3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients
    • Qiu, X.Y. et al. Association of MDR1, CYP3A4 18B, and CYP3A5 3 polymorphisms with cyclosporine pharmacokinetics in Chinese renal transplant recipients. Eur. J. Clin. Pharmacol. 64, 1069-1084 (2008).
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , pp. 1069-1084
    • Qiu, X.Y.1
  • 50
    • 60349106806 scopus 로고    scopus 로고
    • The CYP3A4 18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density
    • Kang, Y.S. et al. The CYP3A4 18 genotype in the cytochrome P450 3A4 gene, a rapid metabolizer of sex steroids, is associated with low bone mineral density. Clin. Pharmacol. Ther. 85, 312-318 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.85 , pp. 312-318
    • Kang, Y.S.1
  • 51
    • 79959684375 scopus 로고    scopus 로고
    • Analysis of CYP3A4 genetic polymorphisms in Han Chinese
    • Zhou, Q. et al. Analysis of CYP3A4 genetic polymorphisms in Han Chinese. J. Hum. Genet. 56, 415-422 (2011).
    • (2011) J. Hum. Genet. , vol.56 , pp. 415-422
    • Zhou, Q.1
  • 52
    • 84876173508 scopus 로고    scopus 로고
    • Characterization of the genetic variation present in CYP3A4 in three South African populations
    • Drögemöller, B. et al. Characterization of the genetic variation present in CYP3A4 in three South African populations. Front. Genet. 4, 17 (2013).
    • (2013) Front. Genet. , vol.4 , Issue.17
    • Drögemöller, B.1
  • 53
    • 33645839857 scopus 로고    scopus 로고
    • Identification and characterization of CYP3A4 20, a novel rare CYP3A4 allele without functional activity
    • Westlind-Johnsson, A. et al. Identification and characterization of CYP3A4 20, a novel rare CYP3A4 allele without functional activity. Clin. Pharmacol. Ther. 79, 339-349 (2006).
    • (2006) Clin. Pharmacol. Ther. , vol.79 , pp. 339-349
    • Westlind-Johnsson, A.1
  • 54
    • 0036320872 scopus 로고    scopus 로고
    • Comparative metabolic capabilities of CYP3A4 CYP3A5, and CYP3A7
    • Williams, J.A. et al. Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab. Dispos. 30, 883-891 (2002).
    • (2002) Drug Metab. Dispos. , vol.30 , pp. 883-891
    • Williams, J.A.1
  • 55
    • 84903176068 scopus 로고    scopus 로고
    • Relative contributions of CYP3A4 versus CYP3A5 for CYP3Acleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide)
    • T seng, E. et al. Relative contributions of CYP3A4 versus CYP3A5 for CYP3Acleared drugs assessed in vitro using a CYP3A4-selective inactivator (CYP3cide). Drug Metabol. Disp. 42, 1163-1173 (2014).
    • (2014) Drug Metabol. Disp. , vol.42 , pp. 1163-1173
    • Tseng, E.1
  • 56
    • 22344450724 scopus 로고    scopus 로고
    • CYP3A5 genetic polymorphisms in different ethnic populations
    • Roy, J.N. et al. CYP3A5 genetic polymorphisms in different ethnic populations. Drug Metab. Dispos. 33, 884-887 (2005).
    • (2005) Drug Metab. Dispos. , vol.33 , pp. 884-887
    • Roy, J.N.1
  • 57
    • 0035217180 scopus 로고    scopus 로고
    • The genetic determinants of the CYP3A5 polymorphism
    • Hustert, E. et al. The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics 11, 773-779 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 773-779
    • Hustert, E.1
  • 58
    • 84870249940 scopus 로고    scopus 로고
    • NR1I2 polymorphisms are related to tacrolimus dose-Adjusted exposure and BK viremia in adult kidney transplantation
    • Barraclough, K.A. et al. NR1I2 polymorphisms are related to tacrolimus dose-Adjusted exposure and BK viremia in adult kidney transplantation. Transplantation 94, 1025-1032 (2012).
    • (2012) Transplantation , vol.94 , pp. 1025-1032
    • Barraclough, K.A.1
  • 59
    • 84861342919 scopus 로고    scopus 로고
    • PPARA: A novel genetic determinant of CYP3A4 in vitro and in vivo
    • Klein, K. et al. PPARA: A novel genetic determinant of CYP3A4 in vitro and in vivo. Clin. Pharmacol. Ther. 91, 1044-1052 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.91 , pp. 1044-1052
    • Klein, K.1
  • 60
    • 84876737381 scopus 로고    scopus 로고
    • Effect of the P450 oxidoreductase 28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers
    • Zhang, J.J., Zhang, H., Ding, X.L., Ma, S. & Miao, L.Y. Effect of the P450 oxidoreductase 28 polymorphism on the pharmacokinetics of tacrolimus in Chinese healthy male volunteers. Eur. J. Clin. Pharmacol. 69, 807-812 (2013).
    • (2013) Eur. J. Clin. Pharmacol. , vol.69 , pp. 807-812
    • Zhang, J.J.1    Zhang, H.2    Ding, X.L.3    Ma, S.4    Miao, L.Y.5
  • 61
    • 84892934437 scopus 로고    scopus 로고
    • Impact of POR 28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients
    • Elens, L. et al. Impact of POR 28 on the pharmacokinetics of tacrolimus and cyclosporine A in renal transplant patients. Ther. Drug Monit. 36, 71-79 (2014).
    • (2014) Ther. Drug Monit. , vol.36 , pp. 71-79
    • Elens, L.1
  • 62
    • 84864398664 scopus 로고    scopus 로고
    • DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes
    • Mao, Z. et al. DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes. Biochem. Pharmacol. 84, 701-711 (2012).
    • (2012) Biochem. Pharmacol. , vol.84 , pp. 701-711
    • Mao, Z.1
  • 63
    • 84865770458 scopus 로고    scopus 로고
    • Effects of interleukin 1β (IL-1β) and IL-1β/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture
    • Dickmann, L.J., Patel, S.K., Wienkers, L.C. & Slatter, J.G. Effects of interleukin 1β (IL-1β) and IL-1β/interleukin 6 (IL-6) combinations on drug metabolizing enzymes in human hepatocyte culture. Curr. Drug Metab. 13, 930-937 (2012).
    • (2012) Curr. Drug Metab. , vol.13 , pp. 930-937
    • Dickmann, L.J.1    Patel, S.K.2    Wienkers, L.C.3    Slatter, J.G.4
  • 64
    • 0033736153 scopus 로고    scopus 로고
    • In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone
    • McCune, J.S. et al. In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. Clin. Pharmacol. Ther. 68, 356-366 (2000).
    • (2000) Clin. Pharmacol. Ther. , vol.68 , pp. 356-366
    • McCune, J.S.1
  • 65
    • 70349268327 scopus 로고    scopus 로고
    • MicroRNAs regulate CYP3A4 expression via direct and indirect targeting
    • Pan, Y.Z., Gao, W. & Yu, A.M. MicroRNAs regulate CYP3A4 expression via direct and indirect targeting. Drug Metab. Dispos. 37, 2112-2117 (2009).
    • (2009) Drug Metab. Dispos. , vol.37 , pp. 2112-2117
    • Pan, Y.Z.1    Gao, W.2    Yu, A.M.3
  • 66
    • 84896092716 scopus 로고    scopus 로고
    • MicroRNA-34a is associated with expression of key hepatic transcription factors and cytochromes P450
    • Lamba, V., Ghodke, Y., Guan, W. & Tracy, T.S. microRNA-34a is associated with expression of key hepatic transcription factors and cytochromes P450. Biochem. Biophys. Res. Commun. 445, 404-411 (2014).
    • (2014) Biochem. Biophys. Res. Commun. , vol.445 , pp. 404-411
    • Lamba, V.1    Ghodke, Y.2    Guan, W.3    Tracy, T.S.4
  • 67
    • 0023858226 scopus 로고
    • Human P450PCN1: Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase
    • Gonzalez, F.J. et al. Human P450PCN1: Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 7, 79-86 (1988).
    • (1988) DNA , vol.7 , pp. 79-86
    • Gonzalez, F.J.1
  • 68
    • 84896401779 scopus 로고    scopus 로고
    • Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study
    • Barratt, D.T. et al. Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study. Pharmacogenet. Genomics 24, 185-194 (2014).
    • (2014) Pharmacogenet. Genomics , vol.24 , pp. 185-194
    • Barratt, D.T.1
  • 71
    • 84881039079 scopus 로고    scopus 로고
    • Influence of CYP3A4 genotypes in the outcome of serous ovarian cancer patients treated with first-line chemotherapy: Implication of a CYP3A4 activity profile
    • Assis, J. et al. Influence of CYP3A4 genotypes in the outcome of serous ovarian cancer patients treated with first-line chemotherapy: Implication of a CYP3A4 activity profile. Int. J. Clin. Exp. Med. 6, 552-561 (2013).
    • (2013) Int. J. Clin. Exp. Med. , vol.6 , pp. 552-561
    • Assis, J.1
  • 72
    • 84879474820 scopus 로고    scopus 로고
    • CYP3A4 22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity
    • de Graan, A.J. et al. CYP3A4 22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity. Clin. Cancer Res. 19, 3316-3324 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 3316-3324
    • De Graan, A.J.1
  • 73
    • 84896394539 scopus 로고    scopus 로고
    • The influence of the CYP3A4 22 polymorphism on serum concentration of quetiapine in psychiatric patients
    • van der Weide, K. & van der Weide, J. The influence of the CYP3A4 22 polymorphism on serum concentration of quetiapine in psychiatric patients. J. Clin. Psychopharmacol. 34, 256-260 (2014).
    • (2014) J. Clin. Psychopharmacol. , vol.34 , pp. 256-260
    • Van Der Weide, K.1    Van Der Weide, J.2
  • 74
    • 84893062040 scopus 로고    scopus 로고
    • CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-Adjusted trough concentrations in kidney transplant recipients
    • Kurzawski, M., Dabrowska, J., Dziewanowski, K., Domanski, L., Peruzynska, M. & Drozdzik, M. CYP3A5 and CYP3A4, but not ABCB1 polymorphisms affect tacrolimus dose-Adjusted trough concentrations in kidney transplant recipients. Pharmacogenomics 15, 179-188 (2014).
    • (2014) Pharmacogenomics , vol.15 , pp. 179-188
    • Kurzawski, M.1    Dabrowska, J.2    Dziewanowski, K.3    Domanski, L.4    Peruzynska, M.5    Drozdzik, M.6
  • 75
    • 84880681749 scopus 로고    scopus 로고
    • Effect of CYP3A5 expression on the inhibition of CYP3Acatalyzed drug metabolism: Impact on modeling CYP3A-mediated drug-drug interactions
    • Shirasaka, Y. et al. Effect of CYP3A5 expression on the inhibition of CYP3Acatalyzed drug metabolism: Impact on modeling CYP3A-mediated drug-drug interactions. Drug Metab. Dispos. 41, 1566-1574 (2013).
    • (2013) Drug Metab. Dispos. , vol.41 , pp. 1566-1574
    • Shirasaka, Y.1
  • 76
    • 84876331758 scopus 로고    scopus 로고
    • Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients
    • Willrich, M.A. et al. Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients. Clin. Chim. Acta 421, 157-163 (2013).
    • (2013) Clin. Chim. Acta , vol.421 , pp. 157-163
    • Willrich, M.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.