Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol

Journal of Pharmacology and Experimental Therapeutics

Volumn 319, Issue 3, 2006, Pages 1467-1476

  Tang, Man ^a   Mukundan, Madhu ^a   Yang, Jian ^a   Charpentier, Nathan ^a   LeCluyse, Edward L ^b   Black, Chris ^b   Yang, Dongfang ^a   Shi, Deshi ^a   Yan, Bingfang ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b CellzDirect Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; CARBOXYLESTERASE; CLOPIDOGREL;

ARTICLE; CELL VIABILITY; DRUG ACTIVITY; DRUG HYDROLYSIS; INTESTINE; LIVER; MICROSOME; PRIORITY JOURNAL; TRANSESTERIFICATION;

ANIMALS; ASPIRIN; CARBOXYLIC ESTER HYDROLASES; CELL LINE, TUMOR; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESTERS; ETHANOL; HUMANS; HYDROLYSIS; INTESTINES; MICROSOMES; MICROSOMES, LIVER; MUTAGENESIS, SITE-DIRECTED; PLATELET AGGREGATION INHIBITORS; RATS; TICLOPIDINE; TRANSFECTION;

EID: 33751171573     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.106.110577     Document Type: Article

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