Age-related inducibility of carboxylesterases by the antiepileptic agent phenobarbital and implications in drug metabolism and lipid accumulation

Biochemical Pharmacology

Volumn 84, Issue 2, 2012, Pages 232-239

  Xiao, Da ^a   Chen, Yi Tzai ^a   Yang, Dongfang ^a   Yan, Bingfang ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Aspirin; Carboxylesterases; Clopidogrel; Developmental regulation; Liver steatosis

Indexed keywords

ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; CARBOXYLESTERASE; CLOPIDOGREL; DRUG METABOLIZING ENZYME; MESSENGER RNA; PHENOBARBITAL;

ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG METABOLISM; ENZYME INDUCTION; HUMAN; HUMAN CELL; LIPID BLOOD LEVEL; LIPID METABOLISM; LIPID STORAGE; MALE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTICONVULSANTS; ASPIRIN; CARBOXYLIC ESTER HYDROLASES; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROLYSIS; LIPID METABOLISM; LIVER; MICE; MICE, INBRED C57BL; NAPHTHALENEACETIC ACIDS; PHENOBARBITAL; TICLOPIDINE;

EID: 84861230084     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.04.002     Document Type: Article

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