DEC1 binding to the proximal promoter of CYP3A4 ascribes to the downregulation of CYP3A4 expression by IL-6 in primary human hepatocytes

Biochemical Pharmacology

Volumn 84, Issue 5, 2012, Pages 701-711

  Mao, Zhao ^a,c   Luan, Xiaofei ^a   Cao, Gang ^c   Liu, Wei ^a   Xiong, Jing ^a   Hu, Gang ^a   Chen, Ruini ^a   Ning, Rui ^a   Shang, Wei ^a   Yang, Jian ^a   Yan, Bingfang ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c JINLING HOSPITAL   (China)

Author keywords

Cytochrome P450 3A4 (CYP3A4); Differentially expressed in chondrocytes 1 (DEC1); Interleukin 6 (IL 6); Transcription regulator

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYTOCHROME P450 3A4; DIFFERENTIALLY EXPRESSED IN CHONDROCYTES 1 PROTEIN; INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 6; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL STRAIN HEPG2; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; SITE DIRECTED MUTAGENESIS;

BASE SEQUENCE; BINDING SITES; CELL LINE; CYTOCHROME P-450 CYP3A; DNA PRIMERS; DOWN-REGULATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HEPATOCYTES; INTERLEUKIN-6; MUTAGENESIS, SITE-DIRECTED; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR PROTEINS;

EID: 84864398664     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.010     Document Type: Article

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