Pregnane X receptor is required for interleukin-6-mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

Toxicology Letters

Volumn 197, Issue 3, 2010, Pages 219-226

  Yang, Jian ^a,b   Hao, Chunshu ^a   Yang, Dongfang ^b   Shi, Deshi ^b   Song, Xiulong ^b   Luan, Xiaofei ^a   Hu, Gang ^a   Yan, Bingfang ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Cytochrome P450 3A4 (CYP3A4); Interleukin 6 (IL 6); Pregnane X receptor (PXR); Transcription regulator; Transcription repression

Indexed keywords

CYTOCHROME P450 3A4; INTERLEUKIN 6; MESSENGER RNA; PREGNANE X RECEPTOR;

ADULT; AGED; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER; LIVER CELL; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION REGULATION;

EID: 77954953005     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.06.003     Document Type: Article

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