Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells

Clinical Cancer Research

Volumn 8, Issue 8, 2002, Pages 2696-2700

  Wu, Michael H ^a   Yan, Bingfang ^b   Humerickhouse, Rod ^a,c   Dolan, M Eileen ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 ETHYL 10 HYDROXYCAMPTOTHECIN; ANTINEOPLASTIC AGENT; CARBOXYLESTERASE; CARBOXYLESTERASE 2; IRINOTECAN; ISOPROTEIN; UNCLASSIFIED DRUG; 7-ETHYL-10-HYDROXYCAMPTOTHECIN; CAMPTOTHECIN; COMPLEMENTARY DNA; DRUG DERIVATIVE; ENZYME INHIBITOR;

ADENOCARCINOMA; ARTICLE; BINDING AFFINITY; COLORECTAL CARCINOMA; CONCENTRATION RESPONSE; DNA DETERMINATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG HYDROLYSIS; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME BINDING; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; MOLECULAR CLONING; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; CELL CULTURE; CHEMISTRY; COLORECTAL TUMOR; GENE LIBRARY; GENETICS; ISOELECTRIC FOCUSING; KINETICS; METABOLISM; POLYACRYLAMIDE GEL ELECTROPHORESIS; TIME; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; BLOTTING, WESTERN; CAMPTOTHECIN; CARBOXYLIC ESTER HYDROLASES; CLONING, MOLECULAR; COLORECTAL NEOPLASMS; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; GENE LIBRARY; HUMAN; HYDROLYSIS; ISOELECTRIC FOCUSING; KINETICS; PROTEIN ISOFORMS; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANSFECTION; TUMOR CELLS, CULTURED; HUMANS;

EID: 0036023452     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

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