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Volumn 15, Issue 8, 2014, Pages 808-817

CYP3A4-mediated pharmacokinetic interactions in cancer therapy

Author keywords

Anticancer drugs; Cytochromes P450 (CYP) enzymes; Drug drug interactions; Pharmacokinetics

Indexed keywords

CYTOCHROME P450 ISOENZYME; ECHINACEA EXTRACT; GARLIC EXTRACT; GINKGO BILOBA EXTRACT; GINSENG EXTRACT; HERBACEOUS AGENT; HYPERICUM PERFORATUM EXTRACT; KAVA; PRESCRIPTION DRUG; SILYBUM MARIANUM EXTRACT; ANTINEOPLASTIC AGENT; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; CYTOCHROME P450 3A;

EID: 84928395247     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200216666150223152627     Document Type: Article
Times cited : (31)

References (77)
  • 2
    • 22144434701 scopus 로고    scopus 로고
    • Drug-drug interactions in oncology: Why are they important and can they be minimized
    • Blower, P.; de Wit, R.; Goodin, S.; Aapro, M. Drug-drug interactions in oncology: why are they important and can they be minimized? Crit. Rev. Oncol. Hematol., 2005, 55(2), 117-42.
    • (2005) Crit. Rev. Oncol. Hematol. , vol.55 , Issue.2 , pp. 117-142
    • Blower, P.1    De Wit, R.2    Goodin, S.3    Aapro, M.4
  • 3
    • 33745574979 scopus 로고    scopus 로고
    • Drug interactions in cancer therapy
    • Scripture, C.D.; Figg, W.D. Drug interactions in cancer therapy. Nat. Rev. Cancer, 2006, 6(7), 546-58.
    • (2006) Nat. Rev. Cancer , vol.6 , Issue.7 , pp. 546-558
    • Scripture, C.D.1    Figg, W.D.2
  • 4
    • 0034004083 scopus 로고    scopus 로고
    • Effects of the antifungal agents on oxidative drug metabolism: Clinical relevance
    • Venkatakrishnan, K.; von Moltke, L.L.; Greenblatt, D.J. Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin. Pharmacokinet., 2000, 38(2), 111-80.
    • (2000) Clin. Pharmacokinet. , vol.38 , Issue.2 , pp. 111-180
    • Venkatakrishnan, K.1    Von Moltke, L.L.2    Greenblatt, D.J.3
  • 5
    • 0032956839 scopus 로고    scopus 로고
    • Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: Comparison of Ki values and impact of CYP3A5 expression
    • Gibbs, M.A.; Thummel, K.E.; Shen, D.D.; Kunze, K.L. Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression. Drug Metab. Dispos., 1999, 27(2), 180-7.
    • (1999) Drug Metab. Dispos. , vol.27 , Issue.2 , pp. 180-187
    • Gibbs, M.A.1    Thummel, K.E.2    Shen, D.D.3    Kunze, K.L.4
  • 6
    • 33745281869 scopus 로고    scopus 로고
    • Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole
    • Chien, J.Y.; Lucksiri, A.; Ernest, C.S. 2nd; Gorski, J.C.; Wrighton, S.A.; Hall, S.D. Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole. Drug Metab. Dispos., 2006, 34(7), 1208-19.
    • (2006) Drug Metab. Dispos. , vol.34 , Issue.7 , pp. 1208-1219
    • Chien, J.Y.1    Lucksiri, A.2    Ernest, C.S.3    Gorski, J.C.4    Wrighton, S.A.5    Hall, S.D.6
  • 7
    • 33751540392 scopus 로고    scopus 로고
    • Drug-metabolizing enzyme inhibition by ketoconazole does not reduce interindividual variability of CYP3A activity as measured by oral midazolam
    • Chen, M.; Nafziger, A.N.; Bertino J.S. Jr. Drug-metabolizing enzyme inhibition by ketoconazole does not reduce interindividual variability of CYP3A activity as measured by oral midazolam. Drug Metab. Dispos., 2006, 34(12), 2079-82.
    • (2006) Drug Metab. Dispos. , vol.34 , Issue.12 , pp. 2079-2082
    • Chen, M.1    Nafziger, A.N.2    Bertino, J.S.3
  • 9
    • 47349102505 scopus 로고    scopus 로고
    • Clinical drugs that interact with St. John's wort and implication in drug development
    • Di, Y.M.; Li, C.G.; Xue, C.C.; Zhou, S.F. Clinical drugs that interact with St. John's wort and implication in drug development.Curr. Pharm. Des., 2008, 14(17), 1723-42.
    • (2008) Curr. Pharm. Des. , vol.14 , Issue.17 , pp. 1723-1742
    • Di, Y.M.1    Li, C.G.2    Xue, C.C.3    Zhou, S.F.4
  • 10
    • 74549173179 scopus 로고    scopus 로고
    • Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: A prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study
    • Venkatakrishnan, K.; Rader, M.; Ramanathan, R.K.; Ramalingam, S.; Chen, E.; Riordan, W.; Trepicchio, W.; Cooper, M.; Karol, M.; von Moltke, L.; Neuwirth, R.; Egorin, M.; Chatta, G. Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: A prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study. Clin. Ther., 2009, 31 Pt 2, 2444-58.
    • (2009) Clin. Ther. , vol.31 , pp. 2444-2458
    • Venkatakrishnan, K.1    Rader, M.2    Ramanathan, R.K.3    Ramalingam, S.4    Chen, E.5    Riordan, W.6    Trepicchio, W.7    Cooper, M.8    Karol, M.9    Von Moltke, L.10    Neuwirth, R.11    Egorin, M.12    Chatta, G.13
  • 11
    • 82955187886 scopus 로고    scopus 로고
    • Effect of ketoconazole on the pharmacokinetics of oral bosutinib in healthy subjects
    • Abbas, R.; Hug, B.A.; Leister, C.; Burns, J.; Sonnichsen, D. Effect of ketoconazole on the pharmacokinetics of oral bosutinib in healthy subjects. J. Clin. Pharmacol., 2011, 51(12), 1721-7.
    • (2011) J. Clin. Pharmacol. , vol.51 , Issue.12 , pp. 1721-1727
    • Abbas, R.1    Hug, B.A.2    Leister, C.3    Burns, J.4    Sonnichsen, D.5
  • 14
    • 0033951849 scopus 로고    scopus 로고
    • Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide
    • Huang, Z.; Roy, P.; Waxman, D.J. Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide. Biochem. Pharmacol., 2000, 59(8), 961-72.
    • (2000) Biochem. Pharmacol. , vol.59 , Issue.8 , pp. 961-972
    • Huang, Z.1    Roy, P.2    Waxman, D.J.3
  • 17
    • 37249048453 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): A potent oral multi-targeted kinase inhibitor against SRC and BCRABL
    • Kamath, A.V.; Wang, J.; Lee, F.Y.; Marathe, P.H. Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): A potent oral multi-targeted kinase inhibitor against SRC and BCRABL. Cancer Chemother. Pharmacol.,2008, 61(3), 365-76.
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , Issue.3 , pp. 365-376
    • Kamath, A.V.1    Wang, J.2    Lee, F.Y.3    Marathe, P.H.4
  • 19
    • 0031716724 scopus 로고    scopus 로고
    • Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: Enzyme specificity, interindividual distribution and metabolic contribution in human liver
    • Shou, M.; Martinet, M.; Korzekwa, K.R.; Krausz, K.W.; Gonzalez, F.J.; Gelboin, H.V. Role of human cytochrome P450 3A4 and 3A5 in the metabolism of taxotere and its derivatives: enzyme specificity, interindividual distribution and metabolic contribution in human liver. Pharmacogenetics, 1998, 8(5), 391-401.
    • (1998) Pharmacogenetics , vol.8 , Issue.5 , pp. 391-401
    • Shou, M.1    Martinet, M.2    Korzekwa, K.R.3    Krausz, K.W.4    Gonzalez, F.J.5    Gelboin, H.V.6
  • 21
    • 0142212226 scopus 로고    scopus 로고
    • Docetaxel and ketoconazole in advanced hormone-refractory prostate carcinoma: A phase i and pharmacokinetic study
    • Van Veldhuizen, P.J.; Reed, G.; Aggarwal, A.; Baranda, J.; Zulfiqar, M.; Williamson, S. Docetaxel and ketoconazole in advanced hormone-refractory prostate carcinoma: A phase I and pharmacokinetic study. Cancer, 2003, 98(9), 1855-62.
    • (2003) Cancer , vol.98 , Issue.9 , pp. 1855-1862
    • Van Veldhuizen, P.J.1    Reed, G.2    Aggarwal, A.3    Baranda, J.4    Zulfiqar, M.5    Williamson, S.6
  • 23
    • 38049054403 scopus 로고    scopus 로고
    • The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: Computer-based simulation (Sim-CYP) predicts in vivo metabolic inhibition
    • Rakhit, A.; Pantze, M.P.; Fettner, S.; Jones, H.M.; Charoin, J.E.; Riek, M.; Lum, B.L.; Hamilton, M. The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (Sim-CYP) predicts in vivo metabolic inhibition. Eur. J. Clin. Pharmacol., 2008, 64(1), 31-41.
    • (2008) Eur. J. Clin. Pharmacol. , vol.64 , Issue.1 , pp. 31-41
    • Rakhit, A.1    Pantze, M.P.2    Fettner, S.3    Jones, H.M.4    Charoin, J.E.5    Riek, M.6    Lum, B.L.7    Hamilton, M.8
  • 24
    • 84930883270 scopus 로고    scopus 로고
    • TARCEVA® (erlotinib) tablets, for oral use. Initial U.S Approval: 2004 (Accessed August 15, 2014)
    • TARCEVA® (erlotinib) tablets, for oral use. Initial U.S. Approval: 2004; (http://www.gene.com/download/pdf/tarceva-prescribing.pdf) (Accessed August 15, 2014).
  • 25
    • 0035821590 scopus 로고    scopus 로고
    • Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: Insights from docking, molecular dynamics, and quantum chemical calculations
    • Kuhn, B.; Jacobsen, W.; Christians, U.; Benet, L.Z.; Kollman, P.A. Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations. J. Med. Chem., 2001, 44(12), 2027-34.
    • (2001) J. Med. Chem. , vol.44 , Issue.12 , pp. 2027-2034
    • Kuhn, B.1    Jacobsen, W.2    Christians, U.3    Benet, L.Z.4    Kollman, P.A.5
  • 29
    • 84879955560 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of bexarotene in combination with gefitinib in the third-line treatment of non-smallcell lung cancer: Brief report
    • Padda, S.K.; Chhatwani, L.; Zhou, L.; Jacobs, C.D.; Lopez-Anaya, A.; Wakelee, H.A. Phase I and pharmacokinetic study of bexarotene in combination with gefitinib in the third-line treatment of non-smallcell lung cancer: brief report. Anticancer Drugs, 2013, 24(7), 731-5.
    • (2013) Anticancer Drugs , vol.24 , Issue.7 , pp. 731-735
    • Padda, S.K.1    Chhatwani, L.2    Zhou, L.3    Jacobs, C.D.4    Lopez-Anaya, A.5    Wakelee, H.A.6
  • 30
    • 4644287353 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects.Cancer Chemother
    • Dutreix, C.; Peng, B.; Mehring, G.; Hayes, M.; Capdeville, R.; Pokorny, R.; Seiberling, M. Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects.Cancer Chemother. Pharmacol., 2004, 54(4), 290-4.
    • (2004) Pharmacol. , vol.54 , Issue.4 , pp. 290-294
    • Dutreix, C.1    Peng, B.2    Mehring, G.3    Hayes, M.4    Capdeville, R.5    Pokorny, R.6    Seiberling, M.7
  • 35
    • 7044245637 scopus 로고    scopus 로고
    • The influence of St. John's wort on the pharmacokinetics and protein binding of imatinib mesylate
    • Smith, P.; Bullock, J.M.; Booker, B.M.; Haas, C.E.; Berenson, C.S.; Jusko, W.J. The influence of St. John's wort on the pharmacokinetics and protein binding of imatinib mesylate. Pharmacotherapy, 2004, 24(11), 1508-14.
    • (2004) Pharmacotherapy , vol.24 , Issue.11 , pp. 1508-1514
    • Smith, P.1    Bullock, J.M.2    Booker, B.M.3    Haas, C.E.4    Berenson, C.S.5    Jusko, W.J.6
  • 40
    • 63849243041 scopus 로고    scopus 로고
    • Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects
    • Smith, D.A.; Koch, K.M.; Arya, N.; Bowen, C.J.; Herendeen, J.M.; Beelen, A. Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects. Br. J. Clin. Pharmacol., 2009, 67(4), 421-6.
    • (2009) Br. J. Clin. Pharmacol. , vol.67 , Issue.4 , pp. 421-426
    • Smith, D.A.1    Koch, K.M.2    Arya, N.3    Bowen, C.J.4    Herendeen, J.M.5    Beelen, A.6
  • 41
    • 84890361087 scopus 로고    scopus 로고
    • Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers
    • Dutreix, C.; Munarini, F.; Lorenzo, S.; Roesel, J.; Wang, Y. Investigation into CYP3A4-mediated drug-drug interactions on midostaurin in healthy volunteers. Cancer Chemother. Pharmacol., 2013, 72(6), 1223-34.
    • (2013) Cancer Chemother. Pharmacol. , vol.72 , Issue.6 , pp. 1223-1234
    • Dutreix, C.1    Munarini, F.2    Lorenzo, S.3    Roesel, J.4    Wang, Y.5
  • 42
    • 50249158488 scopus 로고    scopus 로고
    • Effect of coadministration of ketoconazole, a strong CYP3A4 inhibitor, on pharmacokinetics and tolerability of motesanib diphosphate (AMG 706) in patients with advanced solid tumors
    • Lorusso, P.; Heath, E.I.; McGreivy, J.; Sun, Y.N.; Melara, R.; Yan, L.; Malburg, L.; Ingram, M.; Wiezorek, J.; Chen, L.; Pilat, M.J. Effect of coadministration of ketoconazole, a strong CYP3A4 inhibitor, on pharmacokinetics and tolerability of motesanib diphosphate (AMG 706) in patients with advanced solid tumors. Invest. New Drugs, 2008, 26(5), 455-62.
    • (2008) Invest. New Drugs , vol.26 , Issue.5 , pp. 455-462
    • Lorusso, P.1    Heath, E.I.2    McGreivy, J.3    Sun, Y.N.4    Melara, R.5    Yan, L.6    Malburg, L.7    Ingram, M.8    Wiezorek, J.9    Chen, L.10    Pilat, M.J.11
  • 43
    • 79952596398 scopus 로고    scopus 로고
    • Pharmacokinetics of oral neratinib during co- Administration of ketoconazole in healthy subjects
    • Abbas, R.; Hug, B.A.; Leister, C.; Burns, J.; Sonnichsen, D. Pharmacokinetics of oral neratinib during co- Administration of ketoconazole in healthy subjects. Br. J. Clin. Pharmacol., 2011, 71(4), 522-7.
    • (2011) Br. J. Clin. Pharmacol. , vol.71 , Issue.4 , pp. 522-527
    • Abbas, R.1    Hug, B.A.2    Leister, C.3    Burns, J.4    Sonnichsen, D.5
  • 45
    • 69249224593 scopus 로고    scopus 로고
    • Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice
    • Mounier, N.; Katlama, C.; Costagliola, D.; Chichmanian, R.M.; Spano, J.P. Drug interactions between antineoplastic and antiretroviral therapies: Implications and management for clinical practice. Crit. Rev. Oncol. Hematol., 2009, 72(1), 10-20.
    • (2009) Crit. Rev. Oncol. Hematol. , vol.72 , Issue.1 , pp. 10-20
    • Mounier, N.1    Katlama, C.2    Costagliola, D.3    Chichmanian, R.M.4    Spano, J.P.5
  • 46
    • 0029928409 scopus 로고    scopus 로고
    • Delavirdine mesylate, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor
    • Freimuth, W.W. Delavirdine mesylate, a potent non-nucleoside HIV-1 reverse transcriptase inhibitor. Adv. Exp. Med. Biol., 1996, 394, 279-89.
    • (1996) Adv. Exp. Med. Biol. , vol.394 , pp. 279-289
    • Freimuth, W.W.1
  • 47
    • 84866943631 scopus 로고    scopus 로고
    • A phase i trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer
    • Secord, A.A.; Teoh, D.K.; Barry, W.T.; Yu, M.; Broadwater, G.; Havrilesky, L.J.; Lee, P.S.; Berchuck, A.; Lancaster, J.; Wenham, R.M. A phase I trial of dasatinib, an SRC-family kinase inhibitor, in combination with paclitaxel and carboplatin in patients with advanced or recurrent ovarian cancer. Clin. Cancer Res., 2012, 18(19), 5489-98.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.19 , pp. 5489-5498
    • Secord, A.A.1    Teoh, D.K.2    Barry, W.T.3    Yu, M.4    Broadwater, G.5    Havrilesky, L.J.6    Lee, P.S.7    Berchuck, A.8    Lancaster, J.9    Wenham, R.M.10
  • 48
    • 84861806284 scopus 로고    scopus 로고
    • The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers
    • Shi, J.G.; Chen, X.; Emm, T.; Scherle, P.A.; McGee, R.F.; Lo, Y.; Landman, R.R.; G., M.E.,Jr; Punwani, N.G.; Williams, W.V.; Yeleswaram, S. The effect of CYP3A4 inhibition or induction on the pharmacokinetics and pharmacodynamics of orally administered ruxolitinib (INCB018424 phosphate) in healthy volunteers. J. Clin. Pharmacol., 2012, 52(6), 809-18.
    • (2012) J. Clin. Pharmacol. , vol.52 , Issue.6 , pp. 809-818
    • Shi, J.G.1    Chen, X.2    Emm, T.3    Scherle, P.A.4    McGee, R.F.5    Lo, Y.6    Landman, R.R.7    Jr., G.M.E.8    Punwani, N.G.9    Williams, W.V.10    Yeleswaram, S.11
  • 49
    • 60549098640 scopus 로고    scopus 로고
    • Sorafenib: A review of its use in advanced hepatocellular carcinoma
    • Keating, G.M.; Santoro, A. Sorafenib: A review of its use in advanced hepatocellular carcinoma. Drugs, 2009, 69(2), 223-40.
    • (2009) Drugs , vol.69 , Issue.2 , pp. 223-240
    • Keating, G.M.1    Santoro, A.2
  • 53
    • 65249087328 scopus 로고    scopus 로고
    • A population pharmacokinetic meta- Analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients
    • Houk, B.E.; Bello, C.L.; Kang, D.; Amantea, M. A population pharmacokinetic meta- Analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients. Clin. Cancer Res., 2009, 15(7), 2497-506.
    • (2009) Clin. Cancer Res. , vol.15 , Issue.7 , pp. 2497-2506
    • Houk, B.E.1    Bello, C.L.2    Kang, D.3    Amantea, M.4
  • 54
    • 33646437882 scopus 로고    scopus 로고
    • The effect of ketoconazole (KETO), a potent CYP3A4 inhibitor, on SU011248 pharmacokinetics (PK) in Caucasian and Asian healthy subjects
    • abstract 553
    • Washington, C.; Eli, M.; Bello, C.; Schaaf, L.; Polasek, E.; Tan, L.H., Scigalla, P.; Sarapa, N. The effect of ketoconazole (KETO), a potent CYP3A4 inhibitor, on SU011248 pharmacokinetics (PK) in Caucasian and Asian healthy subjects. Proc. Am. Soc. Clin. Oncol., 2003, 22(138), abstract 553.
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , Issue.138
    • Washington, C.1    Eli, M.2    Bello, C.3    Schaaf, L.4    Polasek, E.5    Tan, L.H.6    Scigalla, P.7    Sarapa, N.8
  • 55
  • 56
    • 0033398416 scopus 로고    scopus 로고
    • Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors
    • Villikka, K.; Kivisto, K.T.; Maenpaa, H.; Joensuu, H.; Neuvonen, P.J. Cytochrome P450-inducing antiepileptics increase the clearance of vincristine in patients with brain tumors. Clin. Pharmacol. Ther., 1999, 66(6), 589-93.
    • (1999) Clin. Pharmacol. Ther. , vol.66 , Issue.6 , pp. 589-593
    • Villikka, K.1    Kivisto, K.T.2    Maenpaa, H.3    Joensuu, H.4    Neuvonen, P.J.5
  • 58
    • 84872736842 scopus 로고    scopus 로고
    • Prediction of crizotinib-midazolam interaction using the Simcyp population-based simulator: Comparison of CYP3A time-dependent inhibition between human liver microsomes versus hepatocytes
    • Mao, J.; Johnson, T.R.; Shen, Z.; Yamazaki, S. Prediction of crizotinib-midazolam interaction using the Simcyp population-based simulator: comparison of CYP3A time-dependent inhibition between human liver microsomes versus hepatocytes. Drug Metab. Dispos., 2013, 41(2), 343-52.
    • (2013) Drug Metab. Dispos. , vol.41 , Issue.2 , pp. 343-352
    • Mao, J.1    Johnson, T.R.2    Shen, Z.3    Yamazaki, S.4
  • 59
    • 82455192303 scopus 로고    scopus 로고
    • Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: A phase I/II pharmacokinetic interaction study
    • Flaherty, K.T.; Lathia, C.; Frye, R.F.; Schuchter, L.; Redlinger, M.; Rosen, M.; O'Dwyer, P.J. Interaction of sorafenib and cytochrome P450 isoenzymes in patients with advanced melanoma: A phase I/II pharmacokinetic interaction study. Cancer Chemother. Pharmacol., 2011, 68(5), 1111-8.
    • (2011) Cancer Chemother. Pharmacol. , vol.68 , Issue.5 , pp. 1111-1118
    • Flaherty, K.T.1    Lathia, C.2    Frye, R.F.3    Schuchter, L.4    Redlinger, M.5    Rosen, M.6    O'Dwyer, P.J.7
  • 61
    • 10744231436 scopus 로고    scopus 로고
    • Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.Br
    • O'Brien, S.G.; Meinhardt, P.; Bond, E.; Beck, J.; Peng, B.; Dutreix, C.; Mehring, G.; Milosavljev, S.; Huber, C.; Capdeville, R.; Fischer, T. Effects of imatinib mesylate (STI571, Glivec) on the pharmacokinetics of simvastatin, a cytochrome p450 3A4 substrate, in patients with chronic myeloid leukaemia.Br. J. Cancer, 2003, 89(10), 1855-9.
    • (2003) J. Cancer , vol.89 , Issue.10 , pp. 1855-1859
    • O'Brien, S.G.1    Meinhardt, P.2    Bond, E.3    Beck, J.4    Peng, B.5    Dutreix, C.6    Mehring, G.7    Milosavljev, S.8    Huber, C.9    Capdeville, R.10    Fischer, T.11
  • 62
    • 84859047420 scopus 로고    scopus 로고
    • Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates
    • Filppula, A.M.; Laitila, J.; Neuvonen, P.J.; Backman, J.T. Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br. J. Pharmacol.,2012, 165(8), 2787-98.
    • (2012) Br. J. Pharmacol. , vol.165 , Issue.8 , pp. 2787-2798
    • Filppula, A.M.1    Laitila, J.2    Neuvonen, P.J.3    Backman, J.T.4
  • 63
    • 77958498524 scopus 로고    scopus 로고
    • An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors
    • Goh, B.C.; Reddy, N.J.; Dandamudi, U.B.; Laubscher, K.H.; Peckham, T.; Hodge, J.P.; Suttle, A.B.; Arumugham, T.; Xu, Y.; Xu, C.F.; Lager, J.; Dar, M.M.; Lewis, L.D. An evaluation of the drug interaction potential of pazopanib, an oral vascular endothelial growth factor receptor tyrosine kinase inhibitor, using a modified Cooperstown 5+1 cocktail in patients with advanced solid tumors. Clin. Pharmacol. Ther., 2010, 88(5), 652-9.
    • (2010) Clin. Pharmacol. Ther. , vol.88 , Issue.5 , pp. 652-659
    • Goh, B.C.1    Reddy, N.J.2    Dandamudi, U.B.3    Laubscher, K.H.4    Peckham, T.5    Hodge, J.P.6    Suttle, A.B.7    Arumugham, T.8    Xu, Y.9    Xu, C.F.10    Lager, J.11    Dar, M.M.12    Lewis, L.D.13
  • 65
    • 78650346448 scopus 로고    scopus 로고
    • Tamoxifen metabolite isomer separation and quantification by liquid chromatography-tandem mass spectrometry
    • Jaremko, M.; Kasai, Y.; Barginear, M.F.; Raptis, G.; Desnick, R.J.; Yu, C. Tamoxifen metabolite isomer separation and quantification by liquid chromatography-tandem mass spectrometry. Anal. Chem., 2010, 82(24), 10186-93.
    • (2010) Anal. Chem. , vol.82 , Issue.24 , pp. 10186-10193
    • Jaremko, M.1    Kasai, Y.2    Barginear, M.F.3    Raptis, G.4    Desnick, R.J.5    Yu, C.6
  • 66
    • 0032836573 scopus 로고    scopus 로고
    • Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer
    • Dowsett, M.; Pfister, C.; Johnston, S.R.; Miles, D.W.; Houston, S.J.; Verbeek, J.A.; Gundacker, H.; Sioufi, A.; Smith, I.E. Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer. Clin. Cancer Res., 1999, 5(9), 2338-43.
    • (1999) Clin. Cancer Res. , vol.5 , Issue.9 , pp. 2338-2343
    • Dowsett, M.1    Pfister, C.2    Johnston, S.R.3    Miles, D.W.4    Houston, S.J.5    Verbeek, J.A.6    Gundacker, H.7    Sioufi, A.8    Smith, I.E.9
  • 68
    • 0030908183 scopus 로고    scopus 로고
    • Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase
    • Grimm, S.W.; Dyroff, M.C. Inhibition of human drug metabolizing cytochromes P450 by anastrozole, a potent and selective inhibitor of aromatase. Drug Metab. Dispos., 1997, 25(5), 598-602.
    • (1997) Drug Metab. Dispos. , vol.25 , Issue.5 , pp. 598-602
    • Grimm, S.W.1    Dyroff, M.C.2
  • 69
    • 0032943956 scopus 로고    scopus 로고
    • The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer
    • Dowsett, M.; Tobias, J.S.; Howell, A.; Blackman, G.M.; Welch, H.; King, N.; Ponzone, R.; von Euler, M.; Baum, M. The effect of anastrozole on the pharmacokinetics of tamoxifen in post-menopausal women with early breast cancer. Br. J. cancer, 1999, 79(2), 311-5.
    • (1999) Br. J. Cancer , vol.79 , Issue.2 , pp. 311-315
    • Dowsett, M.1    Tobias, J.S.2    Howell, A.3    Blackman, G.M.4    Welch, H.5    King, N.6    Ponzone, R.7    Von Euler, M.8    Baum, M.9
  • 70
    • 0035800525 scopus 로고    scopus 로고
    • Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: A sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial
    • Dowsett, M.; Cuzick, J.; Howell, A.; Jackson, I.; Group, A.T. Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: A sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial. Br. J. Cancer, 2001, 85(3), 317-24.
    • (2001) Br. J. Cancer , vol.85 , Issue.3 , pp. 317-324
    • Dowsett, M.1    Cuzick, J.2    Howell, A.3    Jackson, I.4    Group, A.T.5
  • 77
    • 80052878600 scopus 로고    scopus 로고
    • Drug interaction potential of toremifene and Ndesmethyltoremifene with multiple cytochrome P450 isoforms
    • Kim, J.; Peraire, C.; Sola, J.; Johanning, K.M.; Dalton, J.T.; Veverka, K.A. Drug interaction potential of toremifene and Ndesmethyltoremifene with multiple cytochrome P450 isoforms. Xenobiotica, 2011, 41(10), 851-62.
    • (2011) Xenobiotica , vol.41 , Issue.10 , pp. 851-862
    • Kim, J.1    Peraire, C.2    Sola, J.3    Johanning, K.M.4    Dalton, J.T.5    Veverka, K.A.6


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