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Volumn 44, Issue , 2016, Pages 191-196

Towards pharmacological intervention in inositol pyrophosphate signalling

Author keywords

Cell signalling; Drug; Inositol phosphate; Pharmacology; Structure

Indexed keywords

1 KINASE DIPHOSPHOINOSITOL PENTAKISPHOPHATE KINASE; CYCLIN DEPENDENT KINASE; CYCLOHEXANE; INOSITOL PENTAKISPHOSPHATE KINASE; INOSITOL PYROPHOSPHATE; INSULIN; PHOSPHATE; PROTEIN KINASE; PYROPHOSPHATE; UNCLASSIFIED DRUG; [INOSITOL HEXAKISPHOSPHATE KINASES; INOSITOL HEXAKISPHOSPHATE KINASE; INOSITOL PHOSPHATE; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR; PYROPHOSPHORIC ACID DERIVATIVE;

EID: 84958042064     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20150184     Document Type: Article
Times cited : (12)

References (77)
  • 1
    • 84920848910 scopus 로고    scopus 로고
    • Inositol pyrophosphates: Why so many phosphates?
    • CrossRef PubMed
    • Shears, S.B. (2015) Inositol pyrophosphates: why so many phosphates? Adv. Biol. Regul. 57, 203-216 CrossRef PubMed
    • (2015) Adv. Biol. Regul , vol.57 , pp. 203-216
    • Shears, S.B.1
  • 2
    • 84878393302 scopus 로고    scopus 로고
    • Inositol pyrophosphates: Between signalling and metabolism
    • CrossRef PubMed
    • Wilson, M.S., Livermore, T.M. and Saiardi, A. (2013) Inositol pyrophosphates: between signalling and metabolism. Biochem. J. 452, 369-379 CrossRef PubMed
    • (2013) Biochem. J , vol.452 , pp. 369-379
    • Wilson, M.S.1    Livermore, T.M.2    Saiardi, A.3
  • 3
    • 14244268904 scopus 로고    scopus 로고
    • Inositol diphosphate signaling regulates telomere length
    • CrossRef PubMed
    • York, S.J., Armbruster, B.N., Greenwell, P., Petes, T.D. and York, J.D. (2005) Inositol diphosphate signaling regulates telomere length. J. Biol. Chem. 280, 4264-4269 CrossRef PubMed
    • (2005) J. Biol. Chem , vol.280 , pp. 4264-4269
    • York, S.J.1    Armbruster, B.N.2    Greenwell, P.3    Petes, T.D.4    York, J.D.5
  • 4
    • 13844311012 scopus 로고    scopus 로고
    • Inositol pyrophosphates regulate cell death and telomere length via pi3k-related protein kinases
    • CrossRef PubMed
    • Saiardi, A., Resnick, A.C., Snowman, A.M., Wendland, B. and Snyder, S.H. (2005) Inositol pyrophosphates regulate cell death and telomere length via PI3K-related protein kinases. Proc. Natl. Acad. Sci. U.S.A. 102, 1911-1914 CrossRef PubMed
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 1911-1914
    • Saiardi, A.1    Resnick, A.C.2    Snowman, A.M.3    Wendland, B.4    Snyder, S.H.5
  • 5
    • 0034637548 scopus 로고    scopus 로고
    • The inositol hexakisphosphate kinase family: Catalytic flexibility, and function in yeast vacuole biogenesis
    • CrossRef PubMed
    • Saiardi, A., Caffrey, J.J., Snyder, S.H. and Shears, S.B. (2000) The inositol hexakisphosphate kinase family: catalytic flexibility, and function in yeast vacuole biogenesis. J. Biol. Chem. 275, 24686-24692 CrossRef PubMed
    • (2000) J. Biol. Chem , vol.275 , pp. 24686-24692
    • Saiardi, A.1    Caffrey, J.J.2    Snyder, S.H.3    Shears, S.B.4
  • 7
    • 12544255427 scopus 로고    scopus 로고
    • Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death
    • CrossRef PubMed
    • Nagata, E., Luo, H.R., Saiardi, A., Bae, B.I., Suzuki, N. and Snyder, S.H. (2005) Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J. Biol. Chem. 280, 1634-1640 CrossRef PubMed
    • (2005) J. Biol. Chem , vol.280 , pp. 1634-1640
    • Nagata, E.1    Luo, H.R.2    Saiardi, A.3    Bae, B.I.4    Suzuki, N.5    Snyder, S.H.6
  • 8
    • 0035816638 scopus 로고    scopus 로고
    • Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-b in ovarian carcinoma cells
    • CrossRef PubMed
    • Morrison, B.H., Bauer, J.A., Kalvakolanu, D.V. and Lindner, D.J. (2001) Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-b in ovarian carcinoma cells. J. Biol. Chem. 276, 24965-24970 CrossRef PubMed
    • (2001) J. Biol. Chem , vol.276 , pp. 24965-24970
    • Morrison, B.H.1    Bauer, J.A.2    Kalvakolanu, D.V.3    Lindner, D.J.4
  • 10
    • 84873307807 scopus 로고    scopus 로고
    • Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair
    • CrossRef PubMed
    • Jadav, R.S., Chanduri, M.V., Sengupta, S. and Bhandari, R. (2013) Inositol pyrophosphate synthesis by inositol hexakisphosphate kinase 1 is required for homologous recombination repair. J. Biol. Chem. 288, 3312-3321 CrossRef PubMed
    • (2013) J. Biol. Chem , vol.288 , pp. 3312-3321
    • Jadav, R.S.1    Chanduri, M.V.2    Sengupta, S.3    Bhandari, R.4
  • 11
    • 0037176835 scopus 로고    scopus 로고
    • Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase c1 mutant yeast
    • CrossRef PubMed
    • Luo, H.R., Saiardi, A., Yu, H., Nagata, E., Ye, K. and Snyder, S.H. (2002) Inositol pyrophosphates are required for DNA hyperrecombination in protein kinase C1 mutant yeast. Biochemistry 41, 2509-2515 CrossRef PubMed
    • (2002) Biochemistry , vol.41 , pp. 2509-2515
    • Luo, H.R.1    Saiardi, A.2    Yu, H.3    Nagata, E.4    Ye, K.5    Snyder, S.H.6
  • 12
    • 81055137383 scopus 로고    scopus 로고
    • Influence of inositol pyrophosphates on cellular energy dynamics
    • CrossRef PubMed
    • Szijgyarto, Z., Garedew, A., Azevedo, C. and Saiardi, A. (2011) Influence of inositol pyrophosphates on cellular energy dynamics. Science 334, 802-805 CrossRef PubMed
    • (2011) Science , vol.334 , pp. 802-805
    • Szijgyarto, Z.1    Garedew, A.2    Azevedo, C.3    Saiardi, A.4
  • 13
    • 84886805114 scopus 로고    scopus 로고
    • Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels
    • CrossRef PubMed
    • Ghosh, S., Shukla, D., Suman, K., Lakshmi, B.J., Manorama, R., Kumar, S. and Bhandari, R. (2013) Inositol hexakisphosphate kinase 1 maintains hemostasis in mice by regulating platelet polyphosphate levels. Blood 122, 1478-1486 CrossRef PubMed
    • (2013) Blood , vol.122 , pp. 1478-1486
    • Ghosh, S.1    Shukla, D.2    Suman, K.3    Lakshmi, B.J.4    Manorama, R.5    Kumar, S.6    Bhandari, R.7
  • 14
    • 80052026626 scopus 로고    scopus 로고
    • Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-3,4,5)-trisphosphate signaling
    • CrossRef PubMed
    • Prasad, A., Jia, Y., Chakraborty, A., Li, Y., Jain, S.K., Zhong, J., Roy, S.G., Loison, F., Mondal, S., Sakai, J. et al. (2011) Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling. Nat. Immunol. 12, 752-760 CrossRef PubMed
    • (2011) Nat. Immunol , vol.12 , pp. 752-760
    • Prasad, A.1    Jia, Y.2    Chakraborty, A.3    Li, Y.4    Jain, S.K.5    Zhong, J.6    Roy, S.G.7    Loison, F.8    Mondal, S.9    Sakai, J.10
  • 15
    • 78650561718 scopus 로고    scopus 로고
    • Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate hedgehog pathway
    • CrossRef PubMed
    • Sarmah, B. and Wente, S.R. (2010) Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway. Proc. Natl. Acad. Sci. U.S.A. 107, 19921-19926 CrossRef PubMed
    • (2010) Proc. Natl. Acad. Sci. U.S.A , vol.107 , pp. 19921-19926
    • Sarmah, B.1    Wente, S.R.2
  • 16
    • 84888102525 scopus 로고    scopus 로고
    • Inositol pyrophosphates regulate jmjd2c-dependent histone demethylation
    • CrossRef PubMed
    • Burton, A., Azevedo, C., Andreassi, C., Riccio, A. and Saiardi, A. (2013) Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation. Proc. Natl. Acad. Sci. U.S.A. 110, 18970-18975 CrossRef PubMed
    • (2013) Proc. Natl. Acad. Sci. U.S.A , vol.110 , pp. 18970-18975
    • Burton, A.1    Azevedo, C.2    Andreassi, C.3    Riccio, A.4    Saiardi, A.5
  • 18
    • 34147092063 scopus 로고    scopus 로고
    • Regulation of a cyclin-cdk-cdk inhibitor complex by inositol pyrophosphates
    • CrossRef PubMed
    • Lee, Y.S., Mulugu, S., York, J.D. and O'Shea, E.K. (2007) Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. Science 316, 109-112 CrossRef PubMed
    • (2007) Science , vol.316 , pp. 109-112
    • Lee, Y.S.1    Mulugu, S.2    York, J.D.3    O'Shea, E.K.4
  • 19
    • 84907588726 scopus 로고    scopus 로고
    • The vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi
    • CrossRef PubMed
    • Pohlmann, J., Risse, C., Seidel, C., Pohlmann, T., Jakopec, V., Walla, E., Ramrath, P., Takeshita, N., Baumann, S., Feldbrugge, M. et al. (2014) The vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. PLoS. Genet. 10, e1004586 CrossRef PubMed
    • (2014) PLoS. Genet , vol.10 , pp. e1004586
    • Pohlmann, J.1    Risse, C.2    Seidel, C.3    Pohlmann, T.4    Jakopec, V.5    Walla, E.6    Ramrath, P.7    Takeshita, N.8    Baumann, S.9    Feldbrugge, M.10
  • 20
  • 21
    • 37249052435 scopus 로고    scopus 로고
    • Molecular basis of cyclin-cdk-cki regulation by reversible binding of an inositol pyrophosphate
    • CrossRef PubMed
    • Lee, Y.S., Huang, K., Quiocho, F.A. and O'Shea, E.K. (2008) Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate. Nat. Chem. Biol. 4, 25-32 CrossRef PubMed
    • (2009) Nat. Chem. Biol , vol.4 , pp. 25-32
    • Lee, Y.S.1    Huang, K.2    Quiocho, F.A.3    O'Shea, E.K.4
  • 23
    • 0141540848 scopus 로고    scopus 로고
    • Inositol pyrophosphates mediate chemotaxis in dictyostelium via pleckstrin homology domain-ptdins 3,4,5)p3 interactions
    • CrossRef PubMed
    • Luo, H.R., Huang, Y.E., Chen, J.C., Saiardi, A., Iijima, M., Ye, K., Huang, Y., Nagata, E., Devreotes, P. and Snyder, S.H. (2003) Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell 114, 559-572 CrossRef PubMed
    • (2003) Cell , vol.114 , pp. 559-572
    • Luo, H.R.1    Huang, Y.E.2    Chen, J.C.3    Saiardi, A.4    Iijima, M.5    Ye, K.6    Huang, Y.7    Nagata, E.8    Devreotes, P.9    Snyder, S.H.10
  • 24
    • 84880062887 scopus 로고    scopus 로고
    • Ppip5k1 modulates ligand competition between diphosphoinositol polyphosphates and ptdins 3,4,5)p3 for polyphosphoinositide-binding domains
    • CrossRef PubMed
    • Gokhale, N.A., Zaremba, A., Janoshazi, A.K., Weaver, J.D. and Shears, S.B. (2013) PPIP5K1 modulates ligand competition between diphosphoinositol polyphosphates and PtdIns(3,4,5)P3 for polyphosphoinositide-binding domains. Biochem. J. 453, 413-426 CrossRef PubMed
    • (2013) Biochem. J , vol.453 , pp. 413-426
    • Gokhale, N.A.1    Zaremba, A.2    Janoshazi, A.K.3    Weaver, J.D.4    Shears, S.B.5
  • 26
    • 10844275607 scopus 로고    scopus 로고
    • Inositol pyrophosphate: Physiologic phosphorylation of proteins
    • CrossRef PubMed
    • Saiardi, A., Bhandari, A., Resnick, R., Cain, A., Snowman, A.M. and Snyder, S.H. (2004) Inositol pyrophosphate: physiologic phosphorylation of proteins. Science 306, 2101-2105 CrossRef PubMed
    • (2004) Science , vol.306 , pp. 2101-2105
    • Saiardi, A.1    Bhandari, A.2    Resnick, R.3    Cain, A.4    Snowman, A.M.5    Snyder, S.H.6
  • 27
    • 84892164231 scopus 로고    scopus 로고
    • Chemical pyrophosphorylation of functionally diverse peptides
    • CrossRef PubMed
    • Marmelstein, A.M., Yates, L.M., Conway, J.H. and Fiedler, D. (2014) Chemical pyrophosphorylation of functionally diverse peptides. J. Am. Chem. Soc. 136, 108-111 CrossRef PubMed
    • (2014) J. Am. Chem. Soc , vol.136 , pp. 108-111
    • Marmelstein, A.M.1    Yates, L.M.2    Conway, J.H.3    Fiedler, D.4
  • 28
    • 75849158417 scopus 로고    scopus 로고
    • Inositol pyrophosphate mediated pyrophosphorylation of ap3b1 regulates HIV-1 gag release
    • CrossRef PubMed
    • Azevedo, C., Burton, A., Ruiz-Mateos, E., Marsh, M. and Saiardi, A. (2009) Inositol pyrophosphate mediated pyrophosphorylation of AP3B1 regulates HIV-1 Gag release. Proc. Natl. Acad. Sci. U.S.A. 106, 21161-21166 CrossRef PubMed
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.106 , pp. 21161-21166
    • Azevedo, C.1    Burton, A.2    Ruiz-Mateos, E.3    Marsh, M.4    Saiardi, A.5
  • 29
    • 79954464059 scopus 로고    scopus 로고
    • Diphosphoinositol polyphosphates: What are the mechanisms? Adv
    • CrossRef PubMed
    • Shears, S.B., Gokhale, N.A., Wang, H. and Zaremba, A. (2011) Diphosphoinositol polyphosphates: what are the mechanisms? Adv. Enzyme Regul 51, 13-25 CrossRef PubMed
    • (2011) Enzyme Regul , vol.51 , pp. 13-25
    • Shears, S.B.1    Gokhale, N.A.2    Wang, H.3    Zaremba, A.4
  • 30
    • 77957158189 scopus 로고    scopus 로고
    • Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: Structure, synthesis, and development of probes for studying biological activity
    • CrossRef PubMed
    • Best, M.D., Zhang, H. and Prestwich, G.D. (2010) Inositol polyphosphates, diphosphoinositol polyphosphates and phosphatidylinositol polyphosphate lipids: structure, synthesis, and development of probes for studying biological activity. Nat. Prod. Rep. 27, 1403-1430 CrossRef PubMed
    • (2010) Nat. Prod. Rep , vol.27 , pp. 1403-1430
    • Best, M.D.1    Zhang, H.2    Prestwich, G.D.3
  • 31
    • 84938151836 scopus 로고    scopus 로고
    • Synthetic tools for studying the chemical biology of insp8
    • CrossRef
    • Riley, A.M., Wang, H., Shears, S.B. and BV, L.P. (2015) Synthetic tools for studying the chemical biology of InsP8. Chem. Commun. 51, 12605-12608 CrossRef
    • (2015) Chem. Commun , vol.51 , pp. 12605-12608
    • Riley, A.M.1    Wang, H.2    Shears, S.B.3
  • 32
    • 84867934187 scopus 로고    scopus 로고
    • First synthetic analogues of diphosphoinositol polyphosphates: Interaction with ppip5 kinase
    • CrossRef
    • Riley, A.M., Wang, H., Weaver, J.D., Shears, S.B. and Potter, B.V.L. (2012) First synthetic analogues of diphosphoinositol polyphosphates: interaction with PPIP5 kinase. Chem. Commun. 48, 11292-11294 CrossRef
    • (2012) Chem. Commun , vol.48 , pp. 11292-11294
    • Riley, A.M.1    Wang, H.2    Weaver, J.D.3    Shears, S.B.4    Potter, B.V.L.5
  • 33
    • 84903791217 scopus 로고    scopus 로고
    • Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues
    • CrossRef PubMed
    • Wu, M., Chong, L.S., Capolicchio, S., Jessen, H.J., Resnick, A.C. and Fiedler, D. (2014) Elucidating diphosphoinositol polyphosphate function with nonhydrolyzable analogues. Angew. Chem. Int. Ed. Engl. 53, 9508-9511 CrossRef PubMed
    • (2014) Angew. Chem. Int. Ed. Engl , vol.53 , pp. 9508-9511
    • Wu, M.1    Chong, L.S.2    Capolicchio, S.3    Jessen, H.J.4    Resnick, A.C.5    Fiedler, D.6
  • 34
    • 84874408677 scopus 로고    scopus 로고
    • Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers
    • CrossRef PubMed
    • Wu, M., Dul, B.E., Trevisan, A.J. and Fiedler, D. (2013) Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate second messengers. Chem. Sci. 4, 405-410 CrossRef PubMed
    • (2013) Chem. Sci , vol.4 , pp. 405-410
    • Wu, M.1    Dul, B.E.2    Trevisan, A.J.3    Fiedler, D.4
  • 35
    • 84898022580 scopus 로고    scopus 로고
    • Inositol pyrophosphates mediate the DNA-pk/atm-p53 cell death pathway by regulating ck2 phosphorylation of tti1/tel2
    • CrossRef PubMed
    • Rao, F., Cha, J., Xu, J., Xu, R., Vandiver, M.S., Tyagi, R., Tokhunts, R., Koldobskiy, M.A., Fu, C., Barrow, R. et al. (2014) Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol. Cell 54, 119-132 CrossRef PubMed
    • (2014) Mol. Cell , vol.54 , pp. 119-132
    • Rao, F.1    Cha, J.2    Xu, J.3    Xu, R.4    Vandiver, M.S.5    Tyagi, R.6    Tokhunts, R.7    Koldobskiy, M.A.8    Fu, C.9    Barrow, R.10
  • 36
    • 84863684049 scopus 로고    scopus 로고
    • The use of phosphate bioisosteres in medicinal chemistry and chemical biology
    • CrossRef
    • Elliott, T.S., Slowey, A., Ye, Y. and Conway, S.J. (2012) The use of phosphate bioisosteres in medicinal chemistry and chemical biology. Med. Chem. Commun. 3, 735-751 CrossRef
    • (2012) Med. Chem. Commun , vol.3 , pp. 735-751
    • Elliott, T.S.1    Slowey, A.2    Ye, Y.3    Conway, S.J.4
  • 37
    • 84901467306 scopus 로고    scopus 로고
    • Synthetic inositol phosphate analogs reveal that ppip5k2 has a surface-mounted substrate capture site that is a target for drug discovery
    • CrossRef PubMed
    • Wang, H., Godage, H.Y., Riley, A.M., Weaver, J.D., Shears, S.B. and Potter, B.V.L. (2014) Synthetic inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery. Chem. Biol. 21, 689-699 CrossRef PubMed
    • (2014) Chem. Biol , vol.21 , pp. 689-699
    • Wang, H.1    Godage, H.Y.2    Riley, A.M.3    Weaver, J.D.4    Shears, S.B.5    Potter, B.V.L.6
  • 38
    • 77249142404 scopus 로고    scopus 로고
    • The art of the chemical probe
    • CrossRef PubMed
    • Frye, S.V. (2010) The art of the chemical probe. Nat. Chem. Biol. 6, 159-161 CrossRef PubMed
    • (2010) Nat. Chem. Biol , vol.6 , pp. 159-161
    • Frye, S.V.1
  • 39
    • 84878527256 scopus 로고    scopus 로고
    • Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the hdac rpd3l
    • CrossRef PubMed
    • Worley, J., Luo, X. and Capaldi, A.P. (2013) Inositol pyrophosphates regulate cell growth and the environmental stress response by activating the HDAC Rpd3L. Cell Rep. 3, 1476-1482 CrossRef PubMed
    • (2013) Cell Rep , vol.3 , pp. 1476-1482
    • Worley, J.1    Luo, X.2    Capaldi, A.P.3
  • 40
    • 84876081360 scopus 로고    scopus 로고
    • A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA
    • CrossRef PubMed
    • Brehm, M.A., Wundenberg, T., Williams, J., Mayr, G.W. and Shears, S.B. (2013) A non-catalytic role for inositol 1,3,4,5,6-pentakisphosphate 2-kinase in the synthesis of ribosomal RNA. J. Cell Sci. 126, 437-444 CrossRef PubMed
    • (2013) J. Cell Sci , vol.126 , pp. 437-444
    • Brehm, M.A.1    Wundenberg, T.2    Williams, J.3    Mayr, G.W.4    Shears, S.B.5
  • 42
    • 0027456498 scopus 로고
    • Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells
    • PubMed
    • Menniti, F.S., Miller, R.N., Putney, Jr., J.W. and Shears, S.B. (1993) Turnover of inositol polyphosphate pyrophosphates in pancreatoma cells. J. Biol. Chem. 268, 3850-3856 PubMed
    • (1993) J. Biol. Chem , vol.268 , pp. 3850-3856
    • Menniti, F.S.1    Miller, R.N.2    Putney, J.W.3    Shears, S.B.4
  • 43
    • 0032538976 scopus 로고    scopus 로고
    • A novel context for the "mutt" module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase
    • CrossRef PubMed
    • Safrany, S.T., Caffrey, J.J., Yang, X., Bembenek, M.E., Moyer, M.B., Burkhart, W.A. and Shears, S.B. (1998) A novel context for the "MutT" module, a guardian of cell integrity, in a diphosphoinositol polyphosphate phosphohydrolase. EMBO J. 17, 6599-6607 CrossRef PubMed
    • (1998) EMBO J , vol.17 , pp. 6599-6607
    • Safrany, S.T.1    Caffrey, J.J.2    Yang, X.3    Bembenek, M.E.4    Moyer, M.B.5    Burkhart, W.A.6    Shears, S.B.7
  • 44
    • 67449093365 scopus 로고    scopus 로고
    • Characterization of a selective inhibitor of inositol hexakisphosphate kinases: Use in defining biological roles and metabolic relationships of inositol pyrophosphates
    • CrossRef PubMed
    • Padmanabhan, U., Dollins, D.E., Fridy, P.C., York, J.D. and Downes, C.P. (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. J. Biol. Chem. 284, 10571-10582 CrossRef PubMed
    • (2009) J. Biol. Chem , vol.284 , pp. 10571-10582
    • Padmanabhan, U.1    Dollins, D.E.2    Fridy, P.C.3    York, J.D.4    Downes, C.P.5
  • 45
    • 84904651228 scopus 로고    scopus 로고
    • Discovery of insp6-kinases as insp6-dephosphorylating enzymes provides a new mechanism of cytosolic insp6 degradation driven by the cellular atp/adp ratio
    • CrossRef PubMed
    • Wundenberg, T., Grabinski, N., Lin, H. and Mayr, G.W. (2014) Discovery of InsP6-kinases as InsP6-dephosphorylating enzymes provides a new mechanism of cytosolic InsP6 degradation driven by the cellular ATP/ADP ratio. Biochem. J. 462, 173-184 CrossRef PubMed
    • (2014) Biochem. J , vol.462 , pp. 173-184
    • Wundenberg, T.1    Grabinski, N.2    Lin, H.3    Mayr, G.W.4
  • 46
    • 84909606322 scopus 로고    scopus 로고
    • Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the crl4-signalosome complex to regulate DNA repair and cell death
    • CrossRef PubMed
    • Rao, F., Xu, J., Khan, A.B., Gadalla, M.M., Cha, J.Y., Xu, R., Tyagi, R., Dang, Y., Chakraborty, A. and Snyder, S.H. (2014) Inositol hexakisphosphate kinase-1 mediates assembly/disassembly of the CRL4-signalosome complex to regulate DNA repair and cell death. Proc. Natl. Acad. Sci. U.S.A. 111, 16005-16010 CrossRef PubMed
    • (2014) Proc. Natl. Acad. Sci. U.S.A , vol.111 , pp. 16005-16010
    • Rao, F.1    Xu, J.2    Khan, A.B.3    Gadalla, M.M.4    Cha, J.Y.5    Xu, R.6    Tyagi, R.7    Dang, Y.8    Chakraborty, A.9    Snyder, S.H.10
  • 47
    • 84877350576 scopus 로고    scopus 로고
    • Cigarette smoke (cs) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate
    • CrossRef PubMed
    • Xu, Y., Li, H., Bajrami, B., Kwak, H., Cao, S., Liu, P., Zhou, J., Zhou, Y., Zhu, H., Ye, K. and Luo, H.R. (2013) Cigarette smoke (CS) and nicotine delay neutrophil spontaneous death via suppressing production of diphosphoinositol pentakisphosphate. Proc. Natl. Acad. Sci. U.S.A. 110, 7726-7731 CrossRef PubMed
    • (2013) Proc. Natl. Acad. Sci. U.S.A , vol.110 , pp. 7726-7731
    • Xu, Y.1    Li, H.2    Bajrami, B.3    Kwak, H.4    Cao, S.5    Liu, P.6    Zhou, J.7    Zhou, Y.8    Zhu, H.9    Ye, K.10    Luo, H.R.11
  • 48
    • 84901314372 scopus 로고    scopus 로고
    • Selective inhibition of inositol hexakisphosphate kinases (ip6ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction
    • CrossRef PubMed
    • Zhang, Z., Liang, D., Gao, X., Zhao, C., Qin, X., Xu, Y., Su, T., Sun, D., Li, W., Wang, H. et al. (2014) Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction. Basic Res. Cardiol. 109, 417 CrossRef PubMed
    • (2014) Basic Res. Cardiol , vol.109 , pp. 417
    • Zhang, Z.1    Liang, D.2    Gao, X.3    Zhao, C.4    Qin, X.5    Xu, Y.6    Su, T.7    Sun, D.8    Li, W.9    Wang, H.10
  • 49
    • 84929966581 scopus 로고    scopus 로고
    • Oncostatin m (osm) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity
    • CrossRef PubMed
    • Sun, D., Li, S., Wu, H., Zhang, M., Zhang, X., Wei, L., Qin, X. and Gao, E. (2015) Oncostatin M (OSM) protects against cardiac ischaemia/reperfusion injury in diabetic mice by regulating apoptosis, mitochondrial biogenesis and insulin sensitivity. J. Cell Mol. Med. 19, 1296-1307 CrossRef PubMed
    • (2015) J. Cell Mol. Med , vol.19 , pp. 1296-1307
    • Sun, D.1    Li, S.2    Wu, H.3    Zhang, M.4    Zhang, X.5    Wei, L.6    Qin, X.7    Gao, E.8
  • 50
    • 84903467558 scopus 로고    scopus 로고
    • Ip6k structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family
    • PubMed
    • Wang, H., DeRose, E.F., London, R.E. and Shears, S.B. (2014) IP6K structure and the molecular determinants of catalytic specificity in an inositol phosphate kinase family. Nat. Commun. 5, 4178 PubMed
    • (2014) Nat. Commun , vol.5 , pp. 4178
    • Wang, H.1    DeRose, E.F.2    London, R.E.3    Shears, S.B.4
  • 52
    • 84934959220 scopus 로고    scopus 로고
    • Examining a new role for zinc in regulating calcium release in cardiac muscle
    • CrossRef PubMed
    • Pitt, S.J. and Stewart, A.J. (2015) Examining a new role for zinc in regulating calcium release in cardiac muscle. Biochem. Soc. Trans. 43, 359-363 CrossRef PubMed
    • (2015) Biochem. Soc. Trans , vol.43 , pp. 359-363
    • Pitt, S.J.1    Stewart, A.J.2
  • 53
    • 77952626956 scopus 로고    scopus 로고
    • Zinc release from thapsigargin/ip3-sensitive stores in cultured cortical neurons
    • CrossRef PubMed
    • Stork, C.J. and Li, Y.V. (2010) Zinc release from thapsigargin/IP3-sensitive stores in cultured cortical neurons. J. Mol. Signal. 5, 5 CrossRef PubMed
    • (2010) J. Mol. Signal , vol.5 , pp. 5
    • Stork, C.J.1    Li, Y.V.2
  • 55
    • 84958046831 scopus 로고    scopus 로고
    • Modulation of epidermal growth factor stimulated erk phosphorylation and cell motility by inositol trisphosphate kinase
    • CrossRef PubMed
    • Sekar, M.C., Shahiwala, K., Leloup, L. and Wells, A. (2014) Modulation of epidermal growth factor stimulated ERK phosphorylation and cell motility by inositol trisphosphate kinase. J. Pharm. Sci. Pharmacol. 1, 160-164 CrossRef PubMed
    • (2014) J. Pharm. Sci. Pharmacol , vol.1 , pp. 160-164
    • Sekar, M.C.1    Shahiwala, K.2    Leloup, L.3    Wells, A.4
  • 56
    • 40649083560 scopus 로고    scopus 로고
    • Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis
    • CrossRef PubMed
    • Bhandari, R., Juluri, K.R., Resnick, A.C. and Snyder, S.H. (2008) Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc. Natl. Acad. Sci. U.S.A. 105, 2439-2353 CrossRef PubMed
    • (2009) Proc. Natl. Acad. Sci. U.S.A , vol.105 , pp. 2439-2353
    • Bhandari, R.1    Juluri, K.R.2    Resnick, A.C.3    Snyder, S.H.4
  • 57
    • 67650001655 scopus 로고    scopus 로고
    • Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma
    • CrossRef PubMed
    • Morrison, B.H., Haney, R., Lamarre, E., Drazba, J., Prestwich, G.D. and Lindner, D.J. (2009) Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene 28, 2383-2392 CrossRef PubMed
    • (2009) Oncogene , vol.28 , pp. 2383-2392
    • Morrison, B.H.1    Haney, R.2    Lamarre, E.3    Drazba, J.4    Prestwich, G.D.5    Lindner, D.J.6
  • 58
    • 4444223742 scopus 로고    scopus 로고
    • Structure of a human inositol 1,4,5-trisphosphate 3-kinase; Substrate binding reveals why it is not a phosphoinositide 3-kinase
    • CrossRef PubMed
    • Gonzalez, B., Schell, M.J., Letcher, A.J., Veprintsev, D.B., Irvine, R.F. and Williams, R.L. (2004) Structure of a human inositol 1,4,5-trisphosphate 3-kinase; substrate binding reveals why it is not a phosphoinositide 3-kinase. Mol. Cell 15, 689-701 CrossRef PubMed
    • (2004) Mol. Cell , vol.15 , pp. 689-701
    • Gonzalez, B.1    Schell, M.J.2    Letcher, A.J.3    Veprintsev, D.B.4    Irvine, R.F.5    Williams, R.L.6
  • 59
    • 0842274205 scopus 로고    scopus 로고
    • Rediscovering the sweet spot in drug discovery
    • CrossRef PubMed
    • Brown, D. and Superti-Furga, G. (2003) Rediscovering the sweet spot in drug discovery. Drug Discov. Today 8, 1067-1077 CrossRef PubMed
    • (2003) Drug Discov. Today , vol.8 , pp. 1067-1077
    • Brown, D.1    Superti-Furga, G.2
  • 62
    • 84897978560 scopus 로고    scopus 로고
    • Microfluidics fabrication of monodisperse biocompatible phospholipid vesicles for encapsulation and delivery of hydrophilic drug or active compound
    • CrossRef PubMed
    • Kong, F., Zhang, X. and Hai, M. (2014) Microfluidics fabrication of monodisperse biocompatible phospholipid vesicles for encapsulation and delivery of hydrophilic drug or active compound. Langmuir 30, 3905-3912 CrossRef PubMed
    • (2014) Langmuir , vol.30 , pp. 3905-3912
    • Kong, F.1    Zhang, X.2    Hai, M.3
  • 63
    • 77952583878 scopus 로고    scopus 로고
    • Enhancements of screening collections to address areas of unmet medical need: An industry perspective
    • CrossRef PubMed
    • Drewry, D.H. and Macarron, R. (2010) Enhancements of screening collections to address areas of unmet medical need: an industry perspective. Curr. Opin. Chem. Biol. 14, 289-298 CrossRef PubMed
    • (2010) Curr. Opin. Chem. Biol , vol.14 , pp. 289-298
    • Drewry, D.H.1    Macarron, R.2
  • 64
    • 84909595941 scopus 로고    scopus 로고
    • Screening technologies for small molecule discovery: The state of the art
    • CrossRef PubMed
    • Janzen, W.P. (2014) Screening technologies for small molecule discovery: the state of the art. Chem. Biol. 21, 1162-1170 CrossRef PubMed
    • (2014) Chem. Biol , vol.21 , pp. 1162-1170
    • Janzen, W.P.1
  • 65
  • 66
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • CrossRef PubMed
    • Lipinski, C.A., Lombardo, F., Dominy, B.W. and Feeney, P.J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46, 3-26 CrossRef PubMed
    • (2001) Adv. Drug Deliv. Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 68
    • 84877764863 scopus 로고    scopus 로고
    • The kinetic properties of a human ppip5k reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment
    • CrossRef
    • Weaver, J.D., Wang, H. and Shears, S.B. (2013) The kinetic properties of a human PPIP5K reveal that its kinase activities are protected against the consequences of a deteriorating cellular bioenergetic environment. Biosci. Rep. 33, 228-241 CrossRef
    • (2013) Biosci. Rep , vol.33 , pp. 228-241
    • Weaver, J.D.1    Wang, H.2    Shears, S.B.3
  • 69
    • 35649018626 scopus 로고    scopus 로고
    • Cloning and characterization of two human vip1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases
    • CrossRef PubMed
    • Fridy, P.C., Otto, J.C., Dollins, D.E. and York, J.D. (2007) Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. J. Biol. Chem. 282, 30754-30762 CrossRef PubMed
    • (2007) J. Biol. Chem , vol.282 , pp. 30754-30762
    • Fridy, P.C.1    Otto, J.C.2    Dollins, D.E.3    York, J.D.4
  • 71
    • 35648948848 scopus 로고    scopus 로고
    • Purification, sequencing, and molecular identification of a mammalian pp-insp5 kinase that is activated when cells are exposed to hyperosmotic stress
    • CrossRef PubMed
    • Choi, J.H., Williams, J., Cho, J., Falck, J.R. and Shears, S.B. (2007) Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress. J. Biol. Chem. 282, 30763-30775 CrossRef PubMed
    • (2007) J. Biol. Chem , vol.282 , pp. 30763-30775
    • Choi, J.H.1    Williams, J.2    Cho, J.3    Falck, J.R.4    Shears, S.B.5
  • 72
    • 79953703975 scopus 로고    scopus 로고
    • Fragment screening to predict druggability (ligandability) and lead discovery success
    • CrossRef PubMed
    • Edfeldt, F.N., Folmer, R.H. and Breeze, A.L. (2011) Fragment screening to predict druggability (ligandability) and lead discovery success. Drug Discov. Today 16, 284-287 CrossRef PubMed
    • (2011) Drug Discov. Today , vol.16 , pp. 284-287
    • Edfeldt, F.N.1    Folmer, R.H.2    Breeze, A.L.3
  • 73
    • 83655198346 scopus 로고    scopus 로고
    • Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding
    • CrossRef
    • Wang, H., Falck, J.R., Hall, T.M. and Shears, S.B. (2012) Structural basis for an inositol pyrophosphate kinase surmounting phosphate crowding. Nat. Chem. Biol. 8, 111-116 CrossRef
    • (2012) Nat. Chem. Biol , vol.8 , pp. 111-116
    • Wang, H.1    Falck, J.R.2    Hall, T.M.3    Shears, S.B.4
  • 74
    • 84911401229 scopus 로고    scopus 로고
    • Structure-based virtual screening for drug discovery: Principles, applications and recent advances
    • CrossRef PubMed
    • Lionta, E., Spyrou, G., Vassilatis, D. and Cournia, Z. (2014) Structure-based virtual screening for drug discovery: principles, applications and recent advances. Curr. Top. Med. Chem. 14, 1923-1938 CrossRef PubMed
    • (2014) Curr. Top. Med. Chem , vol.14 , pp. 1923-1938
    • Lionta, E.1    Spyrou, G.2    Vassilatis, D.3    Cournia, Z.4
  • 75
    • 84878177204 scopus 로고    scopus 로고
    • Hit expansion approaches using multiple similarity methods and virtualized query structures
    • CrossRef PubMed
    • Bergner, A. and Parel, S.P. (2013) Hit expansion approaches using multiple similarity methods and virtualized query structures. J. Chem. Inf. Model. 53, 1057-1066 CrossRef PubMed
    • (2013) J. Chem. Inf. Model , vol.53 , pp. 1057-1066
    • Bergner, A.1    Parel, S.P.2
  • 76
    • 84932631687 scopus 로고    scopus 로고
    • Drugging pi3k in cancer: Refining targets and therapeutic strategies
    • CrossRef PubMed
    • Yap, T.A., Bjerke, L., Clarke, P.A. and Workman, P. (2015) Drugging PI3K in cancer: refining targets and therapeutic strategies. Curr. Opin. Pharmacol. 23, 98-107 CrossRef PubMed
    • (2015) Curr. Opin. Pharmacol , vol.23 , pp. 98-107
    • Yap, T.A.1    Bjerke, L.2    Clarke, P.A.3    Workman, P.4
  • 77
    • 84922671892 scopus 로고    scopus 로고
    • Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase b1
    • CrossRef PubMed
    • Rao, F., Xu, J., Fu, C., Cha, J.Y., Gadalla, M.M., Xu, R., Barrow, J.C. and Snyder, S.H. (2015) Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase B1. Proc. Natl. Acad. Sci. U.S.A. 112, 1773-1778 CrossRef PubMed.
    • (2015) Proc. Natl. Acad. Sci. U.S.A , vol.112 , pp. 1773-1778
    • Rao, F.1    Xu, J.2    Fu, C.3    Cha, J.Y.4    Gadalla, M.M.5    Xu, R.6    Barrow, J.C.7    Snyder, S.H.8


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