Inositol hexakisphosphate kinases promote autophagy

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 12, 2010, Pages 2065-2071

  Nagata, Eiichiro ^a   Saiardi, Adolfo ^b   Tsukamoto, Hideo ^a   Satoh, Tadayuki ^a   Itoh, Yoshiko ^a   Itoh, Johbu ^a   Shibata, Mamoru ^c   Takizawa, Shunya ^a   Takagi, Shigeharu ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autophagy; Caspase independent cell death; Inositol hexakisphosphate kinases; Inositol pyrophosphate; MTOR PIP3

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; INOSITOL HEXAKISPHOSPHATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOTRANSFERASE; PHYTIC ACID; PROPIDIUM IODIDE; PYROPHOSPHATE; STAUROSPORINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL DEATH; CONTROLLED STUDY; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOCYTOCHEMISTRY; IMMUNOELECTRON MICROSCOPY; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RNA INTERFERENCE;

AUTOPHAGY; CELL DEATH; CELL SURVIVAL; HEK293 CELLS; HELA CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INOSITOL PHOSPHATES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); TRANSFECTION;

MAMMALIA;

EID: 78149283473     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.09.013     Document Type: Article

References (39)

1. Bennett M., Onnebo S.M., Azevedo C., Saiardi A. Inositol pyrophosphates: metabolism and signaling. Cell Mol Life Sci 2006, 63:552-564.
2. Burton A., Hu X., Saiardi A. Are inositol pyrophosphates signaling molecules?. J Cell Physiol 2009, 220:8-15.
3. Christensen S.T., Chemnitz J., Straarup E.M., Kristiansen K., Wheatley D.N., Rasmussen L. Staurosporine-induced cell death in Tetrahymena thermophila has mixed characteristics of both apoptotic and autophagic degeneration. Cell Biol Int 1998, 22:591-598.
4. Grewal S.S. Insulin/TOR signaling in growth and homeostasis: a view from the fly world. Int J Biochem Cell Biol 2009, 41:1006-1010.
5. Ikenoue T., Hong S., Inoki K. Monitoring mammalian target of rapamycin (mTOR) activity. Method Enzymol 2009, 452:165-180.
6. Irvine R.F., Schell M.J. Back in the water: the return of the inositol phosphates. Nat Rev Mol Cell Biol 2001, 2:327-338.
7. Itoh Y., Tanaka S., Takekoshi S., Itoh J., Osamura R.Y. Prohormone convertases (PC1/3 and PC2) in rat and human pancreas and islet cell tumors: subcellular immunohistochemical analysis. Pathol Int 1996, 46:726-737.
8. Klionsky D.J., Abeliovich H., Agostinis P., Agrawal D.K., Aliev G., Askew D.S., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008, 4:151-157.
9. Kroemer G., Levine B. Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol 2008, 9:1004-1010.
10. Luo H.R., Huang Y.E., Chen J.C., Saiardi A., Iijima M., Ye K., et al. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. Cell 2003, 114:559-572.
11. Mikoshiba K., Furuichi T., Miyawaki A. Structure and function of IP3 receptors. Semin Cell Biol 1994, 5:273-281.
12. 2+ channel: from discovery to new signaling concepts. J Neurochem 2007, 102:1426-1446.
13. Mizushima N., Ohsumi Y., Yoshimori T. Autophagosome formation in mammalian cells. Cell Struct Funct 2002, 27:421-429.
14. Mizushima N., Yoshimori T., Levine B. Methods in mammalian autophagy research. Cell 2010, 140:313-326.
15. Morrison B.H., Bauer J.A., Kalvakolanu D.V., Lindner D.J. Inositol hexakisphosphate kinase 2 mediates growth suppressive and apoptotic effects of interferon-beta in ovarian carcinoma cells. J Biol Chem 2001, 276:24965-24970.
16. Morrison B.H., Haney R., Lamarre E., Drazba J., Prestwich G.D., Lindner D.J. Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene 2009, 28:2383-2392.
17. Nagata E., Sawa A., Ross C.A., Snyder S.H. Autophagosome-like vacuole formation in Huntington's disease lymphoblasts. Neuroreport 2004, 15:1325-1328.
18. Nagata E., Luo R.H., Saiardi A., Bae B.I., Suzuki N., Snyder S.H. Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem 2005, 280:1634-1640.
19. Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol 2001, 2:211-216.
20. Oldham S., Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 2003, 13:79-85.
21. Periyasamy-Thandavan S., Jiang M., Schoenlein P., Dong A. Autophagy: molecular machinery, regulation and implications for renal patho-physiology. Am J Physiol 2009, 297:244-256.
22. Qiao L., Zhang J. Inhibition of lysosomal functions reduces proteasomal activity. Neurosci Lett 2009, 456:15-19.
23. Ravikumar B., Duden R., Rubinsztein D.C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum Mol Genet 2002, 11:1107-1117.
24. Resnick A.C., Saiardi A. Advanced article: inositol phosphates. Wiley encyclopedia of chemical biology 2008, 1-12. John Wiley & Sons Inc. T.P. Begley, N.J. Hoboken (Eds.).
25. Saiardi A., Erdjument-Bromage H., Snowman A.M., Tempst P., Snyder S.H. Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases. Curr Biol 1999, 9:1323-1326.
26. Saiardi A., Sciambi C., McCaffery J.M., Wendland B., Snyder S.H. Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci USA 2002, 99:14206-14211.
27. Saiardi A., Bhandari R., Resnick A.C., Snowman A.M., Snyder S.H. Phosphorylation of proteins by inositol pyrophosphates. Science 2004, 306:2101-2105.
28. Sarkar S., Floto R.A., Berger Z., Imarisio S., Cordenier A., Pasco M., et al. Lithium induces autophagy by inhibiting inositol monophosphatase. J Cell Biol 2005, 170:1101-1111.
29. Sarkar S., Rubinsztein D.C. Inositol and IP3 levels regulate autophagy. Autophagy 2006, 2:132-134.
30. Sarkar S., Peristein E.O., Imarisio S., Pineau S., Cordenier A., Maglathlin R.L., et al. Small molecules enhance autophagy and reduce toxicity in Huntington's disease models. Nat Chem Biol 2007, 3:331-338.
31. Sarkar S., Rubinsztein D.C. Huntington's disease: degradation of mutant huntingtin by autophagy. FEBS J 2008, 275:4263-4270.
32. Sarkar S., Krishna G., Imarisio S., Saiki S., O'Kane C.J., Rubinsztein D.C. A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin. Hum Mol Genet 2008, 17:170-178.
33. Scott R.C., Schuldiner O., Neufeld T.P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev Cell 2004, 7:167-178.
34. Schmelzie T., Hall M.N. TOR, a central controller of cell growth. Cell 2000, 103:253-262.
35. Shears S.B. Understanding the biological significance of diphosphoinositol polyphosphates ('inositol pyrophosphates'). Biochem Soc Symp 2007, 74:211-221.
36. Tsujimoto Y., Shimizu S. Another way to die: autophagic programmed cell death. Cell Death Differ 2005, 12:1528-1534.
37. Williams A., Sarkar S., Cuddon P., Ttofi E.K., Saiki S., Siddiqi F.H., et al. Novel targets for Huntington's disease in an mTOR-independent autophagy pathway. Nat Chem Biol 2008, 4:295-302.
38. Winslow A.R., Rubinsztein D.C. Autophagy in neurodegeneration and development. Biochem Biophys Acta 2008, 1782:723-729.
39. Yu L., Alva A., Su H., Dutt P., Freundt E., Welsh S., et al. Regulation of an ATG7-Beclin 1 program of autophagic cell death by caspase-8. Science 2004, 304:1500-1502.