Inositol hexakisphosphate kinase 1 regulates neutrophil function in innate immunity by inhibiting phosphatidylinositol-(3,4,5)-trisphosphate signaling

Nature Immunology

Volumn 12, Issue 8, 2011, Pages 752-760

  Prasad, Amit ^a   Jia, Yonghui ^a   Chakraborty, Anutosh ^b   Li, Yitang ^a   Jain, Supriya K ^a   Zhong, Jia ^a   Roy, Saurabh Ghosh ^a   Loison, Fabien ^a   Mondal, Subhanjan ^a   Sakai, Jiro ^a   Blanchard, Catlyn ^a   Snyder, Solomon H ^b   Luo, Hongbo R ^a,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOATTRACTANT; INOSITOL HEXAKISPHOSPHATE KINASE 1; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOTRANSFERASE; PHYTIC ACID; PLECKSTRIN; PROTEIN KINASE B; PYROPHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENERGY TRANSFER; ENZYME REGULATION; INNATE IMMUNITY; MEMBRANE TRANSPORT; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DIMETHYL SULFOXIDE; HL-60 CELLS; HUMANS; IMMUNITY, INNATE; INOSITOL PHOSPHATES; ISOENZYMES; MICE; MICE, KNOCKOUT; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHAGOCYTOSIS; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); PROTO-ONCOGENE PROTEINS C-AKT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SIGNAL TRANSDUCTION;

EID: 80052026626     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2052     Document Type: Article

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