Inositol hexakisphosphate kinase-2 acts as an effector of the vertebrate Hedgehog pathway

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 46, 2010, Pages 19921-19926

  Sarmah, Bhaskarjyoti ^a,b   Wente, Susan R ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Diphosphoryl inositol tetrakisphosphate; Inositol hexakisphosphate; Inositol pentakisphosphate; Inositol polyphosphate multikinase; Ipk2

Indexed keywords

CYCLOPAMINE; DIPHOSPHORYL INOSITOL PHOSPHATE; INOSITOL HEXAKISPHOSPHATE KINASE 2; INOSITOL PHOSPHATE; MESSENGER RNA; PICRIC ACID; PROTEIN KINASE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR SMOM2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; CELL FUNCTION; CELL MIGRATION; CONFERENCE PAPER; CONTROLLED STUDY; CRANIOFACIAL MORPHOLOGY; EMBRYO; EMBRYO DEVELOPMENT; ENZYME ACTIVITY; GENE EXPRESSION; GENE OVEREXPRESSION; GENE TARGETING; GLI1 GENE; HEDGEHOG; MAMMAL CELL; MORPHOGENESIS; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SOMITE; VERTEBRATE; ZEBRA FISH;

DANIO RERIO; ERINACEIDAE; IPS; MAMMALIA; VERTEBRATA;

EID: 78650561718     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007256107     Document Type: Article

References (49)

1. Varjosalo M, Taipale J (2008) Hedgehog: Functions and mechanisms. Genes Dev 22: 2454-2472.
2. Jiang J, Hui CC (2008) Hedgehog signaling in development and cancer. Dev Cell 15:801-812.
3. Eaton S (2008) Multiple roles for lipids in the Hedgehog signalling pathway. Nat Rev Mol Cell Biol 9:437-445.
4. Hausmann G, von Mering C, Basler K (2009) The hedgehog signaling pathway: Where did it come from? PLoS Biol 7:e1000146.
5. Balla T, Szentpetery Z, Kim YJ (2009) Phosphoinositide signaling: New tools and insights. Physiology (Bethesda) 24:231-244.
6. Alcázar-Román AR, Wente SR (2008) Inositol polyphosphates: A new frontier for regulating gene expression. Chromosoma 117:1-13.
7. York JD (2006) Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta 1761:552-559.
8. Saiardi A, Caffrey JJ, Snyder SH, Shears SB (2000) The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis. J Biol Chem 275:24686-24692.
9. York SJ, Armbruster BN, Greenwell P, Petes TD, York JD (2005) Inositol diphosphate signaling regulates telomere length. J Biol Chem 280:4264-4269.
10. Saiardi A, Sciambi C, McCaffery JM, Wendland B, Snyder SH (2002) Inositol pyrophosphates regulate endocytic trafficking. Proc Natl Acad Sci USA 99:14206-14211.
11. Luo HR, et al. (2003) Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns (3,4,5) P3 interactions. Cell 114:559-572.
12. Illies C, et al. (2007) Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells. Science 318:1299-1302.
13. Nagata E, et al. (2005) Inositol hexakisphosphate kinase-2, a physiologic mediator of cell death. J Biol Chem 280:1634-1640.
14. Santagati F, Rijli FM (2003) Cranial neural crest and the building of the vertebrate head. Nat Rev Neurosci 4:806-818.
15. Wada N, et al. (2005) Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development 132:3977-3988.
16. Cordero D, et al. (2004) Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes. J Clin Invest 114:485-494.
17. Kucenas S, et al. (2008) CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nat Neurosci 11:143-151.
18. Lin H, et al. (2009) Structural analysis and detection of biological inositol pyrophosphates reveal that the family of VIP/diphosphoinositol pentakisphosphate kinases are 1/3-kinases. J Biol Chem 284:1863-1872.
19. Mulugu S, et al. (2007) A conserved family of enzymes that phosphorylate inositol hexakisphosphate. Science 316:106-109.
20. Sarmah B, Latimer AJ, Appel B, Wente SR (2005) Inositol polyphosphates regulate zebrafish left-right asymmetry. Dev Cell 9:133-145.
21. Dottori M, Gross MK, Labosky P, Goulding M (2001) The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate. Development 128:4127-4138.
22. Knight RD, et al. (2003) Lockjaw encodes a zebrafish tfap2a required for early neural crest development. Development 130:5755-5768.
23. Yan YL, et al. (2005) A pair of Sox: Distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Development 132:1069-1083.
24. Akimenko MA, Ekker M, Wegner J, Lin W, Westerfield M (1994) Combinatorial expression of three zebrafish genes related to distal-less: Part of a homeobox gene code for the head. J Neurosci 14:3475-3486.
25. Luo R, An M, Arduini BL, Henion PD (2001) Specific pan-neural crest expression of zebrafish Crestin throughout embryonic development. Dev Dyn 220:169-174.
26. Barresi MJ, Stickney HL, Devoto SH (2000) The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity. Development 127:2189-2199.
27. Blagden CS, Currie PD, Ingham PW, Hughes SM (1997) Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog. Genes Dev 11:2163-2175.
28. Eberhart JK, Swartz ME, Crump JG, Kimmel CB (2006) Early Hedgehog signaling from neural to oral epithelium organizes anterior craniofacial development. Development 133:1069-1077.
29. Chen W, Burgess S, Hopkins N (2001) Analysis of the zebrafish Smoothened mutant reveals conserved and divergent functions of hedgehog activity. Development 128:2385-2396.
30. van Eeden FJ, et al. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development 123:153-164.
31. Krauss S, Concordet JP, Ingham PW (1993) A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 75:1431-1444.
32. Concordet JP, et al. (1996) Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development 122:2835-2846.
33. Karlstrom RO, et al. (2003) Genetic analysis of zebrafish gli1 and gli2 reveals divergent requirements for gli genes in vertebrate development. Development 130:1549-1564.
34. Hatta K, Bremiller R, Westerfield M, Kimmel CB (1991) Diversity of expression of engrailed-like antigens in zebrafish. Development 112:821-832.
35. Honjo Y, Eisen JS (2005) Slow muscle regulates the pattern of trunk neural crest migration in zebrafish. Development 132:4461-4470.
36. Taipale J, et al. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406:1005-1009.
37. Cooper MK, et al. (2003) A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet 33:508-513.
38. Padmanabhan U, Dollins DE, Fridy PC, York JD, Downes CP (2009) Characterization of a selective inhibitor of inositol hexakisphosphate kinases: Use in defining biological roles and metabolic relationships of inositol pyrophosphates. J Biol Chem 284:10571-10582.
39. Chen JK, Taipale J, Young KE, Maiti T, Beachy PA (2002) Small molecule modulation of Smoothened activity. Proc Natl Acad Sci USA 99:14071-14076.
40. Alexandre C, Jacinto A, Ingham PW (1996) Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 10:2003-2013.
41. Cooper MK, Porter JA, Young KE, Beachy PA (1998) Teratogen-mediated inhibition of target tissue response to Shh signaling. Science 280:1603-1607.
42. Incardona JP, Gaffield W, Kapur RP, Roelink H (1998) The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 125:3553-3562.
43. Morrison BH, et al. (2009) Gene deletion of inositol hexakisphosphate kinase 2 predisposes to aerodigestive tract carcinoma. Oncogene 28:2383-2392.
44. Sarmah B, Wente SR (2010) Zebrafish inositol polyphosphate kinases: New effectors of cilia and developmental signaling. Adv Enzyme Regul 50:309-323.
45. Bhandari R, Juluri KR, Resnick AC, Snyder SH (2008) Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Proc Natl Acad Sci USA 105:2349-2353.
46. Gaidarov I, Krupnick JG, Falck JR, Benovic JL, Keen JH (1999) Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. EMBO J 18:871-881.
47. Milano SK, Kim YM, Stefano FP, Benovic JL, Brenner C (2006) Nonvisual arrestin oligomerization and cellular localization are regulated by inositol hexakisphosphate binding. J Biol Chem 281:9812-9823.
48. Kovacs JJ, et al. (2008) Beta-arrestin-mediated localization of smoothened to the primary cilium. Science 320:1777-1781.
49. Sarmah B, Winfrey VP, Olson GE, Appel B, Wente SR (2007) A role for the inositol kinase Ipk1 in ciliary beating and length maintenance. Proc Natl Acad Sci USA 104:19843-19848.