Synthetic Inositol phosphate analogs reveal that PPIP5K2 has a surface-mounted substrate capture site that is a target for drug discovery

Chemistry and Biology

Volumn 21, Issue 5, 2014, Pages 689-699

  Wang, Huanchen ^a   Godage, Himali Y ^b   Riley, Andrew M ^b   Weaver, Jeremy D ^a   Shears, Stephen B ^a   Potter, Barry V L ^b  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; DIPHOSPHOINOSITOL PENTAKISPHOSPHATE 1 KINASE; DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE 2; INOSITOL HEXAKISPHOSPHATE 5 KINASE; INOSITOL PENTAKISPHOSPHATE; INOSITOL PENTAKISPHOSPHATE 2 KINASE; INOSITOL PHOSPHATE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; LIGAND; PHOSPHOTRANSFERASE; PPIP5K2 PROTEIN, HUMAN;

ARTICLE; BINDING SITE; BIOSYNTHESIS; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; HUMAN; HYDROGENOLYSIS; HYDROLYSIS; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SITE DIRECTED MUTAGENESIS; ANTAGONISTS AND INHIBITORS; BIOCATALYSIS; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYME SPECIFICITY; METABOLISM; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

BINDING SITES; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; HUMANS; INOSITOL PHOSPHATES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SURFACE PROPERTIES;

EID: 84901467306     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.03.009     Document Type: Article

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