Selective inhibition of inositol hexakisphosphate kinases (IP6Ks) enhances mesenchymal stem cell engraftment and improves therapeutic efficacy for myocardial infarction

Basic Research in Cardiology

Volumn 109, Issue 4, 2014, Pages

  Zhang, Zheng ^a,b   Liang, Dong ^a   Gao, Xue ^c   Zhao, Chuanxu ^a   Qin, Xing ^a   Xu, Yong ^c   Su, Tao ^a   Sun, Dongdong ^a   Li, Weijie ^a   Wang, Haichang ^a   Liu, Bing ^a   Cao, Feng ^a,c  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b Second Artillery General Hospital   (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Apoptosis; Inositol phosphates; Mesenchymal stem cells; Myocardial infarction

Indexed keywords

5 DIPHOSPHOINOSITOL PENTAKISPHOSPHATE; FIBROBLAST GROWTH FACTOR 2; INOSITOL HEXAKISPHOSPHATE KINASE; INOSITOL PENTAKISPHOSPHATE; N6 (4 NITROBENZYL)PURINE; PROTEIN KINASE; PROTEIN KINASE B; PURINE DERIVATIVE; SCATTER FACTOR; SOMATOMEDIN C; UNCLASSIFIED DRUG; VASCULOTROPIN; ENHANCED GREEN FLUORESCENT PROTEIN; FIREFLY LUCIFERASE; GREEN FLUORESCENT PROTEIN; INOSITOL PHOSPHATE; PHOSPHOTRANSFERASE; PROTEIN KINASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; ENGRAFTMENT; HEART INFARCTION; HEART MUSCLE FIBROSIS; HEART PROTECTION; HYPOXIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PARACRINE SIGNALING; PROTEIN PHOSPHORYLATION; ANGIOGENESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CONVALESCENCE; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; ENZYME ACTIVATION; ENZYMOLOGY; FIBROSIS; GENETICS; GRAFT SURVIVAL; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; MESENCHYMAL STROMA CELL; METABOLISM; MYOCARDIAL INFARCTION; PATHOLOGY; PATHOPHYSIOLOGY; REPORTER GENE; SIGNAL TRANSDUCTION; TIME; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FIBROSIS; GENES, REPORTER; GRAFT SURVIVAL; GREEN FLUORESCENT PROTEINS; INOSITOL PHOSPHATES; LUCIFERASES, FIREFLY; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; MICE, TRANSGENIC; MYOCARDIAL INFARCTION; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PURINES; RECOVERY OF FUNCTION; SIGNAL TRANSDUCTION; TIME FACTORS; VENTRICULAR FUNCTION, LEFT;

EID: 84901314372     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-014-0417-x     Document Type: Article

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