Structure of a human inositol 1,4,5-trisphosphate 3-kinase: Substrate binding reveals why it is not a phosphoinositide 3-kinase

Molecular Cell

Volumn 15, Issue 5, 2004, Pages 689-701

  González, Beatriz ^a   Schell, Michael J ^c   Letcher, Andrew J ^c   Veprintsev, Dmitry B ^b   Irvine, Robin F ^c   Williams, Roger L ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b Centre for Protein Engineering   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; INOSITOL TRISPHOSPHATE 3 KINASE; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; NONHUMAN; PROTEIN DOMAIN; PROTEIN FAMILY; X RAY ANALYSIS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; ISOENZYMES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PHOSPHATIDYLINOSITOLS; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

INSERTION SEQUENCES; MAMMALIA;

EID: 4444223742     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2004.08.004     Document Type: Article

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