Proinflammatory signal suppresses proliferation and shifts macrophage metabolism from Myc-dependent to HIF1α-dependent

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 6, 2016, Pages 1564-1569

  Liu, Lingling ^a   Luc, Yun ^b   Martinez, Jennifer ^c   Bi, Yujing ^d   Lian, Gaojian ^a,e   Wang, Tingting ^a   Milasta, Sandra ^f   Wang, Jian ^b   Yang, Mao ^f   Liu, Guangwei ^b   Green, Douglas R ^f   Wang, Ruoning ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b FUDAN UNIVERSITY   (China)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^e UNIVERSITY OF SOUTH CHINA   (China)

^f ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cell cycle; HIF1 ; Macrophage; Metabolism; Myc

Indexed keywords

CARBON 14; COLONY STIMULATING FACTOR 1; CRE RECOMBINASE; CYCLIN D3; CYCLIN DEPENDENT KINASE 4; DEOXYGLUCOSE; FATTY ACID; GAMMA INTERFERON; GLUCOSE; GLUTAMINE; GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LIPOPOLYSACCHARIDE; MYC PROTEIN; PALMITIC ACID; PROTEIN TYROSINE PHOSPHATASE; TRICARBOXYLIC ACID; MESSENGER RNA; MITOGENIC AGENT; TRANSCRIPTOME;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOSYNTHESIS; BONE MARROW DERIVED MACROPHAGE; CELL CYCLE; CELL FUNCTION; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME INHIBITION; FATTY ACID OXIDATION; GENE DELETION; GLYCOLYSIS; IN VIVO STUDY; INFLAMMATION; METABOLIC CAPACITY; MYELOID LEUKEMIA; NONHUMAN; NUCLEAR REPROGRAMMING; ONCOGENE MYC; PRIORITY JOURNAL; PROTEIN METABOLISM; SEPSIS; SIGNAL TRANSDUCTION; UPREGULATION; VIRUS ONCOGENE; ANIMAL; C57BL MOUSE; CELL POLARITY; DISEASE MODEL; DRUG EFFECTS; GENETICS; MACROPHAGE; METABOLISM; PATHOLOGY;

ANIMALS; CELL CYCLE; CELL POLARITY; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; GENE DELETION; GLYCOLYSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; INTERFERON-GAMMA; LIPOPOLYSACCHARIDES; MACROPHAGE COLONY-STIMULATING FACTOR; MACROPHAGES; METABOLIC NETWORKS AND PATHWAYS; MICE, INBRED C57BL; MITOGENS; PROTO-ONCOGENE PROTEINS C-MYC; RNA, MESSENGER; SEPSIS; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84957800096     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1518000113     Document Type: Article

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