Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation

Molecular Systems Biology

Volumn 8, Issue , 2012, Pages

  Bordbar, Aarash ^a   Mo, Monica L ^a   Nakayasu, Ernesto S ^b   Schrimpe Rutledge, Alexandra C ^b   Kim, Young Mo ^b   Metz, Thomas O ^b   Jones, Marcus B ^c   Frank, Bryan C ^b   Smith, Richard D ^b   Peterson, Scott N ^c   Hyduke, Daniel R ^a   Adkins, Joshua N ^b   Palsson, Bernhard O ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^c J CRAIG VENTER INSTITUTE   (United States)

Author keywords

constraint based modeling; immunometabolism; metabolic network reconstruction; RAW 264.7

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; ARGININE; ASPARTIC ACID; COLECALCIFEROL; GLUCOSE; GLUTAMINE; IMMUNOMODULATING AGENT; NITRIC OXIDE; PROLINE; PUTRESCINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRYPTOPHAN; IMMUNOLOGIC FACTOR; TRANSCRIPTOME;

ANIMAL CELL; ARTICLE; CELL LINE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENOME; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOSTIMULATION; MACROPHAGE ACTIVATION; MACROPHAGE FUNCTION; METABOLIC REGULATION; METABOLITE; METABOLOMICS; MONTE CARLO METHOD; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEOMICS; T LYMPHOCYTE; TRANSCRIPTOMICS; UREA CYCLE; ANIMAL; BIOLOGICAL MODEL; GENETICS; IMMUNOLOGY; LEUKEMIA; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE, TUMOR; GLUTAMINE; IMMUNOLOGIC FACTORS; LEUKEMIA; MACROPHAGE ACTIVATION; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MICE; MODELS, BIOLOGICAL; NITRIC OXIDE; PROTEOMICS; TRANSCRIPTOME;

MURINAE;

EID: 84863331725     PISSN: None     EISSN: 17444292     Source Type: Journal    
DOI: 10.1038/msb.2012.21     Document Type: Article

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