Evolutionary conserved gene co-expression drives generation of self-antigen diversity in medullary thymic epithelial cells

Journal of Autoimmunity

Volumn 67, Issue , 2016, Pages 65-75

  Rattay, Kristin ^a   Meyer, Hannah Verena ^a,d   Herrmann, Carl ^a,b   Brors, Benedikt ^a,c   Kyewski, Bruno ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c German Consortium for Translational Cancer Research (DKTK)   (Germany)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

Gene co expression; Medullary thymic epithelial cells; Promiscuous gene expression; Tissue restricted antigen; Tolerance

Indexed keywords

CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 1; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; GLYCOPROTEIN; GLYCOPROTEIN 2; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; INSULIN; INSULIN 2; INVOLUCRIN; PODOPLANIN; TETRASPANIN; TETRASPANIN 8; TISSUE ANTIGEN; TISSUE RESTRICTED ANTIGEN; UNCLASSIFIED DRUG; AUTOANTIGEN; PROTEIN BINDING; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BINDING SITE; CELL DIFFERENTIATION; CELL MATURATION; CELL SURFACE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DOWN REGULATION; ENZYME ISOLATION; EPITHELIUM CELL; EX VIVO STUDY; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION; GENE ONTOLOGY; GENE POOL; GENETIC CONSERVATION; GENETIC HETEROGENEITY; GENETIC IDENTIFICATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOME; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MEDULLARY THYMIC EPITHELIAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERLAPPING GENE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY MECHANISM; SPECIES CONSERVATION; THYMOCYTE; TRANSCRIPTOMICS; UPREGULATION; ANIMAL; ANTIBODY SPECIFICITY; CLUSTER ANALYSIS; CYTOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC VARIATION; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR EVOLUTION; NUCLEOTIDE MOTIF; THYMUS; TRANSCRIPTION INITIATION; TRANSGENIC MOUSE;

ANIMALS; AUTOANTIGENS; BINDING SITES; CELL DIFFERENTIATION; CLUSTER ANALYSIS; EPITHELIAL CELLS; EVOLUTION, MOLECULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC VARIATION; HUMANS; MICE; MICE, TRANSGENIC; NUCLEOTIDE MOTIFS; ORGAN SPECIFICITY; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; THYMUS GLAND; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84957592522     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2015.10.001     Document Type: Article

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