-
1
-
-
0035171545
-
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
-
Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol (2001) 2(11):1032-9. doi: 10.1038/ni723
-
(2001)
Nat Immunol
, vol.2
, Issue.11
, pp. 1032-1039
-
-
Derbinski, J.1
Schulte, A.2
Kyewski, B.3
Klein, L.4
-
2
-
-
4544258485
-
Self-representation in the thymus: an extended view
-
Kyewski B, Derbinski J. Self-representation in the thymus: an extended view. Nat Rev Immunol (2004) 4(9):688-98. doi:10.1038/nri1436
-
(2004)
Nat Rev Immunol
, vol.4
, Issue.9
, pp. 688-698
-
-
Kyewski, B.1
Derbinski, J.2
-
3
-
-
33751513054
-
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
-
DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, et al. Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med (2006) 203(12):2727-35. doi:10.1084/jem.20061864
-
(2006)
J Exp Med
, vol.203
, Issue.12
, pp. 2727-2735
-
-
DeVoss, J.1
Hou, Y.2
Johannes, K.3
Lu, W.4
Liou, G.I.5
Rinn, J.6
-
4
-
-
0036315824
-
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes
-
Chentoufi AA, Polychronakos C. Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetes. Diabetes (2002) 51(5):1383-90. doi:10.2337/diabetes.51.5.1383
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1383-1390
-
-
Chentoufi, A.A.1
Polychronakos, C.2
-
5
-
-
70349194383
-
Thymus-specific deletion of insulin induces autoimmune diabetes
-
Fan Y, Rudert WA, Grupillo M, He J, Sisino G, Trucco M. Thymus-specific deletion of insulin induces autoimmune diabetes. EMBO J (2009) 28(18):2812-24. doi:10.1038/emboj.2009.212
-
(2009)
EMBO J
, vol.28
, Issue.18
, pp. 2812-2824
-
-
Fan, Y.1
Rudert, W.A.2
Grupillo, M.3
He, J.4
Sisino, G.5
Trucco, M.6
-
6
-
-
67549118180
-
Aire
-
Mathis D, Benoist C. Aire. Annu Rev Immunol (2009) 27:287-312. doi:10.1146/annurev.immunol.25.022106.141532
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 287-312
-
-
Mathis, D.1
Benoist, C.2
-
7
-
-
35748941369
-
Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire
-
Gray D, Abramson J, Benoist C, Mathis D. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med (2007) 204(11):2521-8. doi:10.1084/jem.20070795
-
(2007)
J Exp Med
, vol.204
, Issue.11
, pp. 2521-2528
-
-
Gray, D.1
Abramson, J.2
Benoist, C.3
Mathis, D.4
-
8
-
-
19244371723
-
APECED: a monogenic autoimmune disease providing new clues to self-tolerance
-
Peterson P, Nagamine K, Scott H, Heino M, Kudoh J, Shimizu N, et al. APECED: a monogenic autoimmune disease providing new clues to self-tolerance. Immunol Today (1998) 19(9):384-6. doi:10.1016/S0167-5699(98)01293-6
-
(1998)
Immunol Today
, vol.19
, Issue.9
, pp. 384-386
-
-
Peterson, P.1
Nagamine, K.2
Scott, H.3
Heino, M.4
Kudoh, J.5
Shimizu, N.6
-
9
-
-
0031685004
-
Gene defect behind APECED: a new clue to autoimmunity
-
Bjorses P, Aaltonen J, Horelli-Kuitunen N, Yaspo ML, Peltonen L. Gene defect behind APECED: a new clue to autoimmunity. Hum Mol Genet (1998) 7(10):1547-53. doi:10.1093/hmg/7.10.1547
-
(1998)
Hum Mol Genet
, vol.7
, Issue.10
, pp. 1547-1553
-
-
Bjorses, P.1
Aaltonen, J.2
Horelli-Kuitunen, N.3
Yaspo, M.L.4
Peltonen, L.5
-
10
-
-
0037112047
-
Projection of an immunological self shadow within the thymus by the Aire protein
-
Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, et al. Projection of an immunological self shadow within the thymus by the Aire protein. Science (2002) 298(5597):1395-401. doi:10.1126/science.1075958
-
(2002)
Science
, vol.298
, Issue.5597
, pp. 1395-1401
-
-
Anderson, M.S.1
Venanzi, E.S.2
Klein, L.3
Chen, Z.4
Berzins, S.P.5
Turley, S.J.6
-
11
-
-
84870300242
-
Models of Aire-dependent gene regulation for thymic negative selection
-
Danso-Abeam D, Humblet-Baron S, Dooley J, Liston A. Models of Aire-dependent gene regulation for thymic negative selection. Front Immunol (2011) 2:14. doi:10.3389/fimmu.2011.00014
-
(2011)
Front Immunol
, vol.2
, pp. 14
-
-
Danso-Abeam, D.1
Humblet-Baron, S.2
Dooley, J.3
Liston, A.4
-
12
-
-
52949125608
-
Transcriptional impact of Aire varies with cell type
-
Guerau-de-Arellano M, Mathis D, Benoist C. Transcriptional impact of Aire varies with cell type. Proc Natl Acad Sci U S A (2008) 105(37):14011-6. doi:10.1073/pnas.0806616105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.37
, pp. 14011-14016
-
-
Guerau-de-Arellano, M.1
Mathis, D.2
Benoist, C.3
-
13
-
-
56749184864
-
Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
-
Villasenor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci U S A (2008) 105(41):15854-9. doi:10.1073/pnas.0808069105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.41
, pp. 15854-15859
-
-
Villasenor, J.1
Besse, W.2
Benoist, C.3
Mathis, D.4
-
14
-
-
78650594600
-
Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells
-
Tykocinski LO, Sinemus A, Rezavandy E, Weiland Y, Baddeley D, Cremer C, et al. Epigenetic regulation of promiscuous gene expression in thymic medullary epithelial cells. Proc Natl Acad Sci U S A (2010) 107(45):19426-31. doi:10.1073/pnas.1009265107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.45
, pp. 19426-19431
-
-
Tykocinski, L.O.1
Sinemus, A.2
Rezavandy, E.3
Weiland, Y.4
Baddeley, D.5
Cremer, C.6
-
15
-
-
78650716158
-
Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions
-
Liu Z, Farley A, Chen L, Kirby BJ, Kovacs CS, Blackburn CC, et al. Thymus-associated parathyroid hormone has two cellular origins with distinct endocrine and immunological functions. PLoS Genet (2010) 6(12):e1001251. doi:10.1371/journal.pgen.1001251
-
(2010)
PLoS Genet
, vol.6
, Issue.12
-
-
Liu, Z.1
Farley, A.2
Chen, L.3
Kirby, B.J.4
Kovacs, C.S.5
Blackburn, C.C.6
-
16
-
-
84872494068
-
Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
-
Danso-Abeam D, Staats KA, Franckaert D, Van Den Bosch L, Liston A, Gray DH, et al. Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism. Eur J Immunol (2013) 43(1):75-84. doi:10.1002/eji.201242761
-
(2013)
Eur J Immunol
, vol.43
, Issue.1
, pp. 75-84
-
-
Danso-Abeam, D.1
Staats, K.A.2
Franckaert, D.3
Van Den Bosch, L.4
Liston, A.5
Gray, D.H.6
-
17
-
-
70450192681
-
AIRE activated tissue specific genes have histone modifications associated with inactive chromatin
-
Org T, Rebane A, Kisand K, Laan M, Haljasorg U, Andreson R, et al. AIRE activated tissue specific genes have histone modifications associated with inactive chromatin. Hum Mol Genet (2009) 18(24):4699-710. doi:10.1093/hmg/ddp433
-
(2009)
Hum Mol Genet
, vol.18
, Issue.24
, pp. 4699-4710
-
-
Org, T.1
Rebane, A.2
Kisand, K.3
Laan, M.4
Haljasorg, U.5
Andreson, R.6
-
18
-
-
84880009815
-
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression
-
Ucar O, Tykocinski LO, Dooley J, Liston A, Kyewski B. An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expression. Eur J Immunol (2013) 43(7):1769-78. doi:10.1002/eji.201343343
-
(2013)
Eur J Immunol
, vol.43
, Issue.7
, pp. 1769-1778
-
-
Ucar, O.1
Tykocinski, L.O.2
Dooley, J.3
Liston, A.4
Kyewski, B.5
-
19
-
-
84921446420
-
Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells
-
Rattay K, Claude J, Rezavandy E, Matt S, Hofmann TG, Kyewski B, et al. Homeodomain-interacting protein kinase 2, a novel autoimmune regulator interaction partner, modulates promiscuous gene expression in medullary thymic epithelial cells. J Immunol (2015) 194(3):921-8. doi:10.4049/jimmunol.1402694
-
(2015)
J Immunol
, vol.194
, Issue.3
, pp. 921-928
-
-
Rattay, K.1
Claude, J.2
Rezavandy, E.3
Matt, S.4
Hofmann, T.G.5
Kyewski, B.6
-
20
-
-
25144432460
-
Modifier loci condition autoimmunity provoked by Aire deficiency
-
Jiang W, Anderson MS, Bronson R, Mathis D, Benoist C. Modifier loci condition autoimmunity provoked by Aire deficiency. J Exp Med (2005) 202(6):805-15. doi:10.1084/jem.20050693
-
(2005)
J Exp Med
, vol.202
, Issue.6
, pp. 805-815
-
-
Jiang, W.1
Anderson, M.S.2
Bronson, R.3
Mathis, D.4
Benoist, C.5
-
21
-
-
84904541089
-
Interpreting the language of histone and DNA modifications
-
Rothbart SB, Strahl BD. Interpreting the language of histone and DNA modifications. Biochim Biophys Acta (2014) 1839(8):627-43. doi:10.1016/j.bbagrm.2014.03.001
-
(2014)
Biochim Biophys Acta
, vol.1839
, Issue.8
, pp. 627-643
-
-
Rothbart, S.B.1
Strahl, B.D.2
-
22
-
-
84874194072
-
DNA methylation: roles in mammalian development
-
Smith ZD, Meissner A. DNA methylation: roles in mammalian development. Nat Rev Genet (2013) 14(3):204-20. doi:10.1038/nrg3354
-
(2013)
Nat Rev Genet
, vol.14
, Issue.3
, pp. 204-220
-
-
Smith, Z.D.1
Meissner, A.2
-
23
-
-
22844457491
-
DNA methylation and human disease
-
Robertson KD. DNA methylation and human disease. Nat Rev Genet (2005) 6(8):597-610. doi:10.1038/nrg1655
-
(2005)
Nat Rev Genet
, vol.6
, Issue.8
, pp. 597-610
-
-
Robertson, K.D.1
-
24
-
-
79956330964
-
CpG islands and the regulation of transcription
-
Deaton AM, Bird A. CpG islands and the regulation of transcription. Genes Dev (2011) 25(10):1010-22. doi:10.1101/gad.2037511
-
(2011)
Genes Dev
, vol.25
, Issue.10
, pp. 1010-1022
-
-
Deaton, A.M.1
Bird, A.2
-
25
-
-
84865369147
-
DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
-
Bock C, Beerman I, Lien WH, Smith ZD, Gu H, Boyle P, et al. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells. Mol Cell (2012) 47(4):633-47. doi:10.1016/j.molcel.2012.06.019
-
(2012)
Mol Cell
, vol.47
, Issue.4
, pp. 633-647
-
-
Bock, C.1
Beerman, I.2
Lien, W.H.3
Smith, Z.D.4
Gu, H.5
Boyle, P.6
-
26
-
-
68049097008
-
Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal
-
Hemberger M, Dean W, Reik W. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal. Nat Rev Mol Cell Biol (2009) 10(8):526-37. doi:10.1038/nrm2727
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, Issue.8
, pp. 526-537
-
-
Hemberger, M.1
Dean, W.2
Reik, W.3
-
27
-
-
84878248139
-
DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus
-
Kaaij LT, van de Wetering M, Fang F, Decato B, Molaro A, van de Werken HJ, et al. DNA methylation dynamics during intestinal stem cell differentiation reveals enhancers driving gene expression in the villus. Genome Biol (2013) 14(5):R50. doi:10.1186/gb-2013-14-5-r50
-
(2013)
Genome Biol
, vol.14
, Issue.5
, pp. R50
-
-
Kaaij, L.T.1
van de Wetering, M.2
Fang, F.3
Decato, B.4
Molaro, A.5
van de Werken, H.J.6
-
28
-
-
84868261972
-
DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells
-
Wu G, Hirabayashi K, Sato S, Akiyama N, Akiyama T, Shiota K, et al. DNA methylation profile of Aire-deficient mouse medullary thymic epithelial cells. BMC Immunol (2012) 13:58. doi:10.1186/1471-2172-13-58
-
(2012)
BMC Immunol
, vol.13
, pp. 58
-
-
Wu, G.1
Hirabayashi, K.2
Sato, S.3
Akiyama, N.4
Akiyama, T.5
Shiota, K.6
-
29
-
-
17544385823
-
Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter
-
Murumagi A, Vahamurto P, Peterson P. Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. J Biol Chem (2003) 278(22):19784-90. doi:10.1074/jbc.M210437200
-
(2003)
J Biol Chem
, vol.278
, Issue.22
, pp. 19784-19790
-
-
Murumagi, A.1
Vahamurto, P.2
Peterson, P.3
-
30
-
-
81955167444
-
DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues
-
Kont V, Murumagi A, Tykocinski LO, Kinkel SA, Webster KE, Kisand K, et al. DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Mol Immunol (2011) 49(3):518-26. doi:10.1016/j.molimm.2011.09.022
-
(2011)
Mol Immunol
, vol.49
, Issue.3
, pp. 518-526
-
-
Kont, V.1
Murumagi, A.2
Tykocinski, L.O.3
Kinkel, S.A.4
Webster, K.E.5
Kisand, K.6
-
31
-
-
84870792079
-
Perceiving the epigenetic landscape through histone readers
-
Musselman CA, Lalonde ME, Cote J, Kutateladze TG. Perceiving the epigenetic landscape through histone readers. Nat Struct Mol Biol (2012) 19(12):1218-27. doi:10.1038/nsmb.2436
-
(2012)
Nat Struct Mol Biol
, vol.19
, Issue.12
, pp. 1218-1227
-
-
Musselman, C.A.1
Lalonde, M.E.2
Cote, J.3
Kutateladze, T.G.4
-
32
-
-
79953163378
-
Chromatin higher-order structures and gene regulation
-
Li G, Reinberg D. Chromatin higher-order structures and gene regulation. Curr Opin Genet Dev (2011) 21(2):175-86. doi:10.1016/j.gde.2011.01.022
-
(2011)
Curr Opin Genet Dev
, vol.21
, Issue.2
, pp. 175-186
-
-
Li, G.1
Reinberg, D.2
-
33
-
-
34848911602
-
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4
-
Vermeulen M, Mulder KW, Denissov S, Pijnappel WWMP, van Schaik FMA, Varier RA, et al. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell (2007) 131(1):58-69. doi:10.1016/j.cell.2007.08.016
-
(2007)
Cell
, vol.131
, Issue.1
, pp. 58-69
-
-
Vermeulen, M.1
Mulder, K.W.2
Denissov, S.3
Pijnappel, W.W.M.P.4
van Schaik, F.M.A.5
Varier, R.A.6
-
34
-
-
70349669271
-
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain
-
Moriniere J, Rousseaux S, Steuerwald U, Soler-Lopez M, Curtet S, Vitte AL, et al. Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature (2009) 461(7264):664-8. doi:10.1038/nature08397
-
(2009)
Nature
, vol.461
, Issue.7264
, pp. 664-668
-
-
Moriniere, J.1
Rousseaux, S.2
Steuerwald, U.3
Soler-Lopez, M.4
Curtet, S.5
Vitte, A.L.6
-
35
-
-
84879260661
-
A double take on bivalent promoters
-
Voigt P, Tee WW, Reinberg D. A double take on bivalent promoters. Genes Dev (2013) 27(12):1318-38. doi:10.1101/gad.219626.113
-
(2013)
Genes Dev
, vol.27
, Issue.12
, pp. 1318-1338
-
-
Voigt, P.1
Tee, W.W.2
Reinberg, D.3
-
36
-
-
33947619418
-
Functional plasticity in memory T helper cell responses
-
Krawczyk CM, Shen H, Pearce EJ. Functional plasticity in memory T helper cell responses. J Immunol (2007) 178(7):4080-8. doi:10.4049/jimmunol.178.7.4080
-
(2007)
J Immunol
, vol.178
, Issue.7
, pp. 4080-4088
-
-
Krawczyk, C.M.1
Shen, H.2
Pearce, E.J.3
-
37
-
-
65549115862
-
Plasticity of CD4+ T cell lineage differentiation
-
Zhou L, Chong MM, Littman DR. Plasticity of CD4+ T cell lineage differentiation. Immunity (2009) 30(5):646-55. doi:10.1016/j.immuni.2009.05.001
-
(2009)
Immunity
, vol.30
, Issue.5
, pp. 646-655
-
-
Zhou, L.1
Chong, M.M.2
Littman, D.R.3
-
38
-
-
84913594338
-
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia
-
Sansom SN, Shikama-Dorn N, Zhanybekova S, Nusspaumer G, Macaulay IC, Deadman ME, et al. Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res (2014) 24:1918-31. doi:10.1101/gr.171645.113
-
(2014)
Genome Res
, vol.24
, pp. 1918-1931
-
-
Sansom, S.N.1
Shikama-Dorn, N.2
Zhanybekova, S.3
Nusspaumer, G.4
Macaulay, I.C.5
Deadman, M.E.6
-
39
-
-
37549060329
-
AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells
-
Oven I, Brdickova N, Kohoutek J, Vaupotic T, Narat M, Peterlin BM. AIRE recruits P-TEFb for transcriptional elongation of target genes in medullary thymic epithelial cells. Mol Cell Biol (2007) 27(24):8815-23. doi:10.1128/MCB.01085-07
-
(2007)
Mol Cell Biol
, vol.27
, Issue.24
, pp. 8815-8823
-
-
Oven, I.1
Brdickova, N.2
Kohoutek, J.3
Vaupotic, T.4
Narat, M.5
Peterlin, B.M.6
-
40
-
-
84855995571
-
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells
-
Giraud M, Yoshida H, Abramson J, Rahl PB, Young RA, Mathis D, et al. Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cells. Proc Natl Acad Sci U S A (2012) 109(2):535-40. doi:10.1073/pnas.1119351109
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.2
, pp. 535-540
-
-
Giraud, M.1
Yoshida, H.2
Abramson, J.3
Rahl, P.B.4
Young, R.A.5
Mathis, D.6
-
41
-
-
84889651853
-
Dynamic changes of the epigenetic landscape during cellular differentiation
-
Dambacher S, de Almeida GP, Schotta G. Dynamic changes of the epigenetic landscape during cellular differentiation. Epigenomics (2013) 5(6):701-13. doi:10.2217/epi.13.67
-
(2013)
Epigenomics
, vol.5
, Issue.6
, pp. 701-713
-
-
Dambacher, S.1
de Almeida, G.P.2
Schotta, G.3
-
42
-
-
77958481159
-
Nucleosome-interacting proteins regulated by DNA and histone methylation
-
Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, Kouzarides T. Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell (2010) 143(3):470-84. doi:10.1016/j.cell.2010.10.012
-
(2010)
Cell
, vol.143
, Issue.3
, pp. 470-484
-
-
Bartke, T.1
Vermeulen, M.2
Xhemalce, B.3
Robson, S.C.4
Mann, M.5
Kouzarides, T.6
-
43
-
-
77649246145
-
Histone modification levels are predictive for gene expression
-
Karlic R, Chung HR, Lasserre J, Vlahovicek K, Vingron M. Histone modification levels are predictive for gene expression. Proc Natl Acad Sci U S A (2010) 107(7):2926-31. doi:10.1073/pnas.0909344107
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.7
, pp. 2926-2931
-
-
Karlic, R.1
Chung, H.R.2
Lasserre, J.3
Vlahovicek, K.4
Vingron, M.5
-
44
-
-
38649131259
-
Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism
-
Derbinski J, Pinto S, Rosch S, Hexel K, Kyewski B. Promiscuous gene expression patterns in single medullary thymic epithelial cells argue for a stochastic mechanism. Proc Natl Acad Sci U S A (2008) 105(2):657-62. doi:10.1073/pnas.0707486105
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.2
, pp. 657-662
-
-
Derbinski, J.1
Pinto, S.2
Rosch, S.3
Hexel, K.4
Kyewski, B.5
-
45
-
-
84883798955
-
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity
-
Pinto S, Michel C, Schmidt-Glenewinkel H, Harder N, Rohr K, Wild S, et al. Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversity. Proc Natl Acad Sci U S A (2013) 110(37):E3497-505. doi:10.1073/pnas.1308311110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.37
, pp. E3497-E3505
-
-
Pinto, S.1
Michel, C.2
Schmidt-Glenewinkel, H.3
Harder, N.4
Rohr, K.5
Wild, S.6
-
46
-
-
73349090560
-
Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells
-
Schoenfelder S, Sexton T, Chakalova L, Cope NF, Horton A, Andrews S, et al. Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells. Nat Genet (2010) 42(1):53-61. doi:10.1038/ng.496
-
(2010)
Nat Genet
, vol.42
, Issue.1
, pp. 53-61
-
-
Schoenfelder, S.1
Sexton, T.2
Chakalova, L.3
Cope, N.F.4
Horton, A.5
Andrews, S.6
-
47
-
-
84886777912
-
Chromosomal contact permits transcription between coregulated genes
-
Fanucchi S, Shibayama Y, Burd S, Weinberg MS, Mhlanga MM. Chromosomal contact permits transcription between coregulated genes. Cell (2013) 155(3):606-20. doi:10.1016/j.cell.2013.09.051
-
(2013)
Cell
, vol.155
, Issue.3
, pp. 606-620
-
-
Fanucchi, S.1
Shibayama, Y.2
Burd, S.3
Weinberg, M.S.4
Mhlanga, M.M.5
-
48
-
-
84899618724
-
Are genes switched on when they kiss?
-
Fanucchi S, Shibayama Y, Mhlanga MM. Are genes switched on when they kiss? Nucleus (2014) 5(2):103-12. doi:10.4161/nucl.28352
-
(2014)
Nucleus
, vol.5
, Issue.2
, pp. 103-112
-
-
Fanucchi, S.1
Shibayama, Y.2
Mhlanga, M.M.3
-
49
-
-
79960980390
-
Variegated gene expression caused by cell-specific long-range DNA interactions
-
Noordermeer D, de Wit E, Klous P, van de Werken H, Simonis M, Lopez-Jones M, et al. Variegated gene expression caused by cell-specific long-range DNA interactions. Nat Cell Biol (2011) 13(8):944-51. doi:10.1038/ncb2278
-
(2011)
Nat Cell Biol
, vol.13
, Issue.8
, pp. 944-951
-
-
Noordermeer, D.1
de Wit, E.2
Klous, P.3
van de Werken, H.4
Simonis, M.5
Lopez-Jones, M.6
-
50
-
-
80052266532
-
MicroRNAs can generate thresholds in target gene expression
-
Mukherji S, Ebert MS, Zheng GX, Tsang JS, Sharp PA, van Oudenaarden A. MicroRNAs can generate thresholds in target gene expression. Nat Genet (2011) 43(9):854-9. doi:10.1038/ng.905
-
(2011)
Nat Genet
, vol.43
, Issue.9
, pp. 854-859
-
-
Mukherji, S.1
Ebert, M.S.2
Zheng, G.X.3
Tsang, J.S.4
Sharp, P.A.5
van Oudenaarden, A.6
-
51
-
-
84904985459
-
Regulation of microRNA biogenesis
-
Ha M, Kim VN. Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol (2014) 15(8):509-24. doi:10.1038/nrm3838
-
(2014)
Nat Rev Mol Cell Biol
, vol.15
, Issue.8
, pp. 509-524
-
-
Ha, M.1
Kim, V.N.2
-
52
-
-
77955644289
-
Mammalian microRNAs predominantly act to decrease target mRNA levels
-
Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature (2010) 466(7308):835-40. doi:10.1038/nature09267
-
(2010)
Nature
, vol.466
, Issue.7308
, pp. 835-840
-
-
Guo, H.1
Ingolia, N.T.2
Weissman, J.S.3
Bartel, D.P.4
-
53
-
-
84880770383
-
Diversifying microRNA sequence and function
-
Ameres SL, Zamore PD. Diversifying microRNA sequence and function. Nat Rev Mol Cell Biol (2013) 14(8):475-88. doi:10.1038/nrm3611
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, Issue.8
, pp. 475-488
-
-
Ameres, S.L.1
Zamore, P.D.2
-
54
-
-
58249088751
-
MicroRNAs: target recognition and regulatory functions
-
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell (2009) 136(2):215-33. doi:10.1016/j.cell.2009.01.002
-
(2009)
Cell
, vol.136
, Issue.2
, pp. 215-233
-
-
Bartel, D.P.1
-
55
-
-
84883805211
-
The role of miRNAs in regulating gene expression networks
-
Gurtan AM, Sharp PA. The role of miRNAs in regulating gene expression networks. J Mol Biol (2013) 425(19):3582-600. doi:10.1016/j.jmb.2013.03.007
-
(2013)
J Mol Biol
, vol.425
, Issue.19
, pp. 3582-3600
-
-
Gurtan, A.M.1
Sharp, P.A.2
-
56
-
-
84875279378
-
Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells
-
Macedo C, Evangelista AF, Marques MM, Octacilio-Silva S, Donadi EA, Sakamoto-Hojo ET, et al. Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cells. Immunobiology (2013) 218(4):554-60. doi:10.1016/j.imbio.2012.06.013
-
(2013)
Immunobiology
, vol.218
, Issue.4
, pp. 554-560
-
-
Macedo, C.1
Evangelista, A.F.2
Marques, M.M.3
Octacilio-Silva, S.4
Donadi, E.A.5
Sakamoto-Hojo, E.T.6
-
57
-
-
56549129538
-
Chromatin structure analyses identify miRNA promoters
-
Ozsolak F, Poling LL, Wang Z, Liu H, Liu XS, Roeder RG, et al. Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 22(22):3172-83. doi:10.1101/gad.1706508
-
(2008)
Genes Dev
, vol.22
, Issue.22
, pp. 3172-3183
-
-
Ozsolak, F.1
Poling, L.L.2
Wang, Z.3
Liu, H.4
Liu, X.S.5
Roeder, R.G.6
-
58
-
-
77149153066
-
Structure and activity of putative intronic miRNA promoters
-
Monteys AM, Spengler RM, Wan J, Tecedor L, Lennox KA, Xing Y, et al. Structure and activity of putative intronic miRNA promoters. RNA (2010) 16(3):495-505. doi:10.1261/rna.1731910
-
(2010)
RNA
, vol.16
, Issue.3
, pp. 495-505
-
-
Monteys, A.M.1
Spengler, R.M.2
Wan, J.3
Tecedor, L.4
Lennox, K.A.5
Xing, Y.6
-
59
-
-
84870430950
-
Aire promotes the self-renewal of embryonic stem cells through Lin28
-
Bin G, Jiarong Z, Shihao W, Xiuli S, Cheng X, Liangbiao C, et al. Aire promotes the self-renewal of embryonic stem cells through Lin28. Stem Cells Dev (2012) 21(15):2878-90. doi:10.1089/scd.2012.0097
-
(2012)
Stem Cells Dev
, vol.21
, Issue.15
, pp. 2878-2890
-
-
Bin, G.1
Jiarong, Z.2
Shihao, W.3
Xiuli, S.4
Cheng, X.5
Liangbiao, C.6
-
60
-
-
84884206775
-
Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b
-
Matsuo T, Noguchi Y, Shindo M, Morita Y, Oda Y, Yoshida E, et al. Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b. Gene (2013) 530(1):19-25. doi:10.1016/j.gene.2013.08.015
-
(2013)
Gene
, vol.530
, Issue.1
, pp. 19-25
-
-
Matsuo, T.1
Noguchi, Y.2
Shindo, M.3
Morita, Y.4
Oda, Y.5
Yoshida, E.6
-
61
-
-
84855931651
-
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-alpha receptor
-
Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, et al. The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-alpha receptor. Nat Immunol (2012) 13(2):181-7. doi:10.1038/ni.2193
-
(2012)
Nat Immunol
, vol.13
, Issue.2
, pp. 181-187
-
-
Papadopoulou, A.S.1
Dooley, J.2
Linterman, M.A.3
Pierson, W.4
Ucar, O.5
Kyewski, B.6
-
62
-
-
84867287351
-
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection
-
Zuklys S, Mayer CE, Zhanybekova S, Stefanski HE, Nusspaumer G, Gill J, et al. MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selection. J Immunol (2012) 189(8):3894-904. doi:10.4049/jimmunol.1200783
-
(2012)
J Immunol
, vol.189
, Issue.8
, pp. 3894-3904
-
-
Zuklys, S.1
Mayer, C.E.2
Zhanybekova, S.3
Stefanski, H.E.4
Nusspaumer, G.5
Gill, J.6
-
63
-
-
84899547547
-
Canonical microRNAs in thymic epithelial cells promote central tolerance
-
Khan IS, Taniguchi RT, Fasano KJ, Anderson MS, Jeker LT. Canonical microRNAs in thymic epithelial cells promote central tolerance. Eur J Immunol (2014) 44(5):1313-9. doi:10.1002/eji.201344079
-
(2014)
Eur J Immunol
, vol.44
, Issue.5
, pp. 1313-1319
-
-
Khan, I.S.1
Taniguchi, R.T.2
Fasano, K.J.3
Anderson, M.S.4
Jeker, L.T.5
-
64
-
-
43449090367
-
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation
-
Orom UA, Nielsen FC, Lund AH. MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation. Mol Cell (2008) 30(4):460-71. doi:10.1016/j.molcel.2008.05.001
-
(2008)
Mol Cell
, vol.30
, Issue.4
, pp. 460-471
-
-
Orom, U.A.1
Nielsen, F.C.2
Lund, A.H.3
-
65
-
-
79955964537
-
Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay
-
Bruno IG, Karam R, Huang L, Bhardwaj A, Lou CH, Shum EY, et al. Identification of a microRNA that activates gene expression by repressing nonsense-mediated RNA decay. Mol Cell (2011) 42(4):500-10. doi:10.1016/j.molcel.2011.04.018
-
(2011)
Mol Cell
, vol.42
, Issue.4
, pp. 500-510
-
-
Bruno, I.G.1
Karam, R.2
Huang, L.3
Bhardwaj, A.4
Lou, C.H.5
Shum, E.Y.6
-
67
-
-
84911464247
-
Developing stratified epithelia: lessons from the epidermis and thymus
-
Roberts N, Horsley V. Developing stratified epithelia: lessons from the epidermis and thymus. Wiley Interdiscip Rev Dev Biol (2014) 3(6):389-402. doi:10.1002/wdev.146
-
(2014)
Wiley Interdiscip Rev Dev Biol
, vol.3
, Issue.6
, pp. 389-402
-
-
Roberts, N.1
Horsley, V.2
-
68
-
-
84907982768
-
Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus
-
Perry JS, Lio CW, Kau AL, Nutsch K, Yang Z, Gordon JI, et al. Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity (2014) 41(3):414-26. doi:10.1016/j.immuni.2014.08.007
-
(2014)
Immunity
, vol.41
, Issue.3
, pp. 414-426
-
-
Perry, J.S.1
Lio, C.W.2
Kau, A.L.3
Nutsch, K.4
Yang, Z.5
Gordon, J.I.6
-
69
-
-
84908008007
-
Love is in the Aire: mTECs share their assets
-
Kyewski B, Feuerer M. Love is in the Aire: mTECs share their assets. Immunity (2014) 41(3):343-5. doi:10.1016/j.immuni.2014.08.013
-
(2014)
Immunity
, vol.41
, Issue.3
, pp. 343-345
-
-
Kyewski, B.1
Feuerer, M.2
-
70
-
-
84879747232
-
Characterization of human thymic exosomes
-
Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, et al. Characterization of human thymic exosomes. PLoS One (2013) 8(7):e67554. doi:10.1371/journal.pone.0067554
-
(2013)
PLoS One
, vol.8
, Issue.7
-
-
Skogberg, G.1
Gudmundsdottir, J.2
van der Post, S.3
Sandstrom, K.4
Bruhn, S.5
Benson, M.6
-
71
-
-
79955070767
-
Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells
-
Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, Gonzalez S, Sanchez-Cabo F, Gonzalez MA, et al. Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun (2011) 2:282. doi:10.1038/ncomms1285
-
(2011)
Nat Commun
, vol.2
, pp. 282
-
-
Mittelbrunn, M.1
Gutierrez-Vazquez, C.2
Villarroya-Beltri, C.3
Gonzalez, S.4
Sanchez-Cabo, F.5
Gonzalez, M.A.6
-
72
-
-
84904396495
-
MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells
-
Okoye IS, Coomes SM, Pelly VS, Czieso S, Papayannopoulos V, Tolmachova T, et al. MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Immunity (2014) 41(1):89-103. doi:10.1016/j.immuni.2014.05.019
-
(2014)
Immunity
, vol.41
, Issue.1
, pp. 89-103
-
-
Okoye, I.S.1
Coomes, S.M.2
Pelly, V.S.3
Czieso, S.4
Papayannopoulos, V.5
Tolmachova, T.6
|