메뉴 건너뛰기




Volumn 67, Issue 8, 2007, Pages 3919-3926

Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: Implications for self-tolerance and tumor therapy

Author keywords

[No Author keywords available]

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; MONOCLONAL ANTIBODY; MUCIN 1; TUMOR ANTIGEN;

EID: 34248550936     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-2112     Document Type: Article
Times cited : (72)

References (51)
  • 1
    • 17144417748 scopus 로고    scopus 로고
    • Dendritic cells as therapeutic vaccines against cancer
    • Banchereau J, Palucka AK. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005;5: 296-306.
    • (2005) Nat Rev Immunol , vol.5 , pp. 296-306
    • Banchereau, J.1    Palucka, A.K.2
  • 2
    • 0038208181 scopus 로고    scopus 로고
    • Antigen loading of dendritic cells with whole tumor cell preparations
    • Thumann P, Moc I, Humrich J, et al. Antigen loading of dendritic cells with whole tumor cell preparations. J Immunol Methods 2003;277:1-16.
    • (2003) J Immunol Methods , vol.277 , pp. 1-16
    • Thumann, P.1    Moc, I.2    Humrich, J.3
  • 3
    • 0034331218 scopus 로고    scopus 로고
    • Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells
    • Brossart P, Wirths S, Stuhler G, Reichardt VL, Kanz L, Brugger W. Induction of cytotoxic T-lymphocyte responses in vivo after vaccinations with peptide-pulsed dendritic cells. Blood 2000;96:3102-8.
    • (2000) Blood , vol.96 , pp. 3102-3108
    • Brossart, P.1    Wirths, S.2    Stuhler, G.3    Reichardt, V.L.4    Kanz, L.5    Brugger, W.6
  • 4
    • 0028068621 scopus 로고
    • Recognition of the ALL-specific BCR-ABL junction in P190bcr-abl by monoclonal antibody ER-FP1
    • van Denderen J, ten Hacken P, Berendes P, et al. Recognition of the ALL-specific BCR-ABL junction in P190bcr-abl by monoclonal antibody ER-FP1. Leukemia 1994;8:1503-9.
    • (1994) Leukemia , vol.8 , pp. 1503-1509
    • van Denderen, J.1    ten Hacken, P.2    Berendes, P.3
  • 5
    • 27144514758 scopus 로고    scopus 로고
    • Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma
    • Kruit WH, van Ojik HH, Brichard VG, et al. Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma. Int J Cancer 2005;117: 596-604.
    • (2005) Int J Cancer , vol.117 , pp. 596-604
    • Kruit, W.H.1    van Ojik, H.H.2    Brichard, V.G.3
  • 6
    • 0942288397 scopus 로고    scopus 로고
    • Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters
    • Gotter J, Brors B, Hergenhahn M, Kyewski B. Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters. J Exp Med 2004;199:155-66.
    • (2004) J Exp Med , vol.199 , pp. 155-166
    • Gotter, J.1    Brors, B.2    Hergenhahn, M.3    Kyewski, B.4
  • 7
    • 0035171545 scopus 로고    scopus 로고
    • Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self
    • Derbinski J, Schulte A, Kyewski B, Klein L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol 2001;2:1032-9.
    • (2001) Nat Immunol , vol.2 , pp. 1032-1039
    • Derbinski, J.1    Schulte, A.2    Kyewski, B.3    Klein, L.4
  • 8
    • 22244447452 scopus 로고    scopus 로고
    • Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire
    • Bos R, van Duikeren S, van Hall T, et al. Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoire. Cancer Res 2005;65:6443-9.
    • (2005) Cancer Res , vol.65 , pp. 6443-6449
    • Bos, R.1    van Duikeren, S.2    van Hall, T.3
  • 9
    • 27144445820 scopus 로고    scopus 로고
    • Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells
    • Allen S, Read S, DiPaolo R, et al. Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells. J Immunol 2005; 175:5759-64.
    • (2005) J Immunol , vol.175 , pp. 5759-5764
    • Allen, S.1    Read, S.2    DiPaolo, R.3
  • 10
    • 23744515712 scopus 로고    scopus 로고
    • Posttranslational modifications of self-antigens
    • Doyle HA, Mamula MJ. Posttranslational modifications of self-antigens. Ann N Y Acad Sci 2005;1050:1-9.
    • (2005) Ann N Y Acad Sci , vol.1050 , pp. 1-9
    • Doyle, H.A.1    Mamula, M.J.2
  • 11
    • 7044235838 scopus 로고    scopus 로고
    • Post-translational modifications of self antigens: Implications for autoimmunity
    • Anderton SM. Post-translational modifications of self antigens: implications for autoimmunity. Curr Opin Immunol 2004;16:753-8.
    • (2004) Curr Opin Immunol , vol.16 , pp. 753-758
    • Anderton, S.M.1
  • 12
    • 0028950808 scopus 로고
    • Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components
    • Wesseling J, van der Valk SW, Vos HL, Sonnenberg A, Hilkens J. Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol 1995;129:255-65.
    • (1995) J Cell Biol , vol.129 , pp. 255-265
    • Wesseling, J.1    van der Valk, S.W.2    Vos, H.L.3    Sonnenberg, A.4    Hilkens, J.5
  • 13
    • 0021740104 scopus 로고
    • Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors
    • Kufe D, Inghirami G, Abe M, Hayes D, Justi-Wheeler H, Schlom J. Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. Hybridoma 1984;3:223-32.
    • (1984) Hybridoma , vol.3 , pp. 223-232
    • Kufe, D.1    Inghirami, G.2    Abe, M.3    Hayes, D.4    Justi-Wheeler, H.5    Schlom, J.6
  • 14
    • 0031455501 scopus 로고    scopus 로고
    • Epitope fingerprinting' using overlapping 20-mer peptides of the MUC1 tandem repeat sequence
    • Schol DJ, Meulenbroek MF, Snijdewint FG, et al. 'Epitope fingerprinting' using overlapping 20-mer peptides of the MUC1 tandem repeat sequence. Tumour Biol 1998;19 Suppl 1:35-45.
    • (1998) Tumour Biol , vol.19 , Issue.SUPPL. 1 , pp. 35-45
    • Schol, D.J.1    Meulenbroek, M.F.2    Snijdewint, F.G.3
  • 15
    • 0023617395 scopus 로고
    • Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin
    • Burchell J, Gendler S, Taylor-Papadimitriou J, et al. Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res 1987;47: 5476-82.
    • (1987) Cancer Res , vol.47 , pp. 5476-5482
    • Burchell, J.1    Gendler, S.2    Taylor-Papadimitriou, J.3
  • 16
    • 11144354528 scopus 로고    scopus 로고
    • Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by CHO-K1 cells in protein-free medium
    • Link T, Backstrom M, Graham R, et al. Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by CHO-K1 cells in protein-free medium. J Biotechnol 2004;110:51-62.
    • (2004) J Biotechnol , vol.110 , pp. 51-62
    • Link, T.1    Backstrom, M.2    Graham, R.3
  • 17
    • 33344473830 scopus 로고    scopus 로고
    • Expression of aberrantly glycosylated tumor Mucin-1 on human dendritic cells after transduction with a fiber-modified adenoviral vector
    • van Leeuwen EBM, Cloosen S, Senden-Gijsbers BLMG, et al. Expression of aberrantly glycosylated tumor Mucin-1 on human dendritic cells after transduction with a fiber-modified adenoviral vector. Cytotherapy 2005;8:24-35.
    • (2005) Cytotherapy , vol.8 , pp. 24-35
    • van Leeuwen, E.B.M.1    Cloosen, S.2    Senden-Gijsbers, B.L.M.G.3
  • 18
    • 0024353046 scopus 로고
    • A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas
    • Girling A, Bartkova J, Burchell J, Gendler S, Gillett C, Taylor-Papadimitriou J. A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int J Cancer 1989;43:1072-6.
    • (1989) Int J Cancer , vol.43 , pp. 1072-1076
    • Girling, A.1    Bartkova, J.2    Burchell, J.3    Gendler, S.4    Gillett, C.5    Taylor-Papadimitriou, J.6
  • 21
    • 8344258397 scopus 로고    scopus 로고
    • Mucin-1 is expressed on dendritic cells, both in vitro and in vivo
    • Cloosen S, Thio M, Vanclee A, et al. Mucin-1 is expressed on dendritic cells, both in vitro and in vivo. Int Immunol 2004;16:1561-71.
    • (2004) Int Immunol , vol.16 , pp. 1561-1571
    • Cloosen, S.1    Thio, M.2    Vanclee, A.3
  • 22
    • 0346103716 scopus 로고    scopus 로고
    • Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus
    • Hale LP, Markert ML. Corticosteroids regulate epithelial cell differentiation and Hassall body formation in the human thymus. J Immunol 2004;172:617-24.
    • (2004) J Immunol , vol.172 , pp. 617-624
    • Hale, L.P.1    Markert, M.L.2
  • 23
    • 4544258485 scopus 로고    scopus 로고
    • Self-representation in the thymus: An extended view
    • Kyewski B, Derbinski J. Self-representation in the thymus: an extended view. Nat Rev Immunol 2004;4: 688-98.
    • (2004) Nat Rev Immunol , vol.4 , pp. 688-698
    • Kyewski, B.1    Derbinski, J.2
  • 24
    • 0027464958 scopus 로고
    • Heterogeneity of mucin gene expression in normal and neoplastic tissues
    • Ho SB, Niehans GA, Lyftogt C, et al. Heterogeneity of mucin gene expression in normal and neoplastic tissues. Cancer Res 1993;53:641-51.
    • (1993) Cancer Res , vol.53 , pp. 641-651
    • Ho, S.B.1    Niehans, G.A.2    Lyftogt, C.3
  • 25
    • 0031875185 scopus 로고    scopus 로고
    • Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma
    • Reis CA, David L, Seixas M, Burchell J, Sobrinho-Simoes M. Expression of fully and under-glycosylated forms of MUC1 mucin in gastric carcinoma. Int J Cancer 1998;79:402-10.
    • (1998) Int J Cancer , vol.79 , pp. 402-410
    • Reis, C.A.1    David, L.2    Seixas, M.3    Burchell, J.4    Sobrinho-Simoes, M.5
  • 26
    • 22344449972 scopus 로고    scopus 로고
    • Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels
    • Derbinski J, Gabler J, Brors B, et al. Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med 2005;202:33-45.
    • (2005) J Exp Med , vol.202 , pp. 33-45
    • Derbinski, J.1    Gabler, J.2    Brors, B.3
  • 27
    • 27544506907 scopus 로고    scopus 로고
    • High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients
    • Schmitz-Winnenthal FH, Volk C, Zgraggen K, et al. High frequencies of functional tumor-reactive T cells in bone marrow and blood of pancreatic cancer patients. Cancer Res 2005;65:10079-87.
    • (2005) Cancer Res , vol.65 , pp. 10079-10087
    • Schmitz-Winnenthal, F.H.1    Volk, C.2    Zgraggen, K.3
  • 28
    • 33748052024 scopus 로고    scopus 로고
    • The shaping of a polyvalent and highly individual T-cell repertoire in the bone marrow of breast cancer patients
    • Sommerfeldt N, Schutz F, Sohn C, Forster J, Schirrmacher V, Beckhove P. The shaping of a polyvalent and highly individual T-cell repertoire in the bone marrow of breast cancer patients. Cancer Res 2006;66:8258-65.
    • (2006) Cancer Res , vol.66 , pp. 8258-8265
    • Sommerfeldt, N.1    Schutz, F.2    Sohn, C.3    Forster, J.4    Schirrmacher, V.5    Beckhove, P.6
  • 29
    • 33745247366 scopus 로고    scopus 로고
    • Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients
    • Wierecky J, Muller MR, Wirths S, et al. Immunologic and clinical responses after vaccinations with peptide-pulsed dendritic cells in metastatic renal cancer patients. Cancer Res 2006;66:5910-8.
    • (2006) Cancer Res , vol.66 , pp. 5910-5918
    • Wierecky, J.1    Muller, M.R.2    Wirths, S.3
  • 30
    • 33747092627 scopus 로고    scopus 로고
    • T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity
    • Zehn D, Bevan MJ. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 2006;25:261-70.
    • (2006) Immunity , vol.25 , pp. 261-270
    • Zehn, D.1    Bevan, M.J.2
  • 31
    • 11144355864 scopus 로고    scopus 로고
    • Generation of carcinoembryonic antigen (CEA)-specific T-cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides
    • Liu KJ. Generation of carcinoembryonic antigen (CEA)-specific T-cell responses in HLA-A*0201 and HLA-A*2402 late-stage colorectal cancer patients after vaccination with dendritic cells loaded with CEA peptides. Clin Cancer Res 2004;10:2645-51.
    • (2004) Clin Cancer Res , vol.10 , pp. 2645-2651
    • Liu, K.J.1
  • 32
    • 0030854842 scopus 로고    scopus 로고
    • T-cell recognition of tumor-associated carbohydrates: The nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity
    • Galli-Stampino L, Meinjohanns E, Frische K, et al. T-cell recognition of tumor-associated carbohydrates: the nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity. Cancer Res 1997;57:3214-22.
    • (1997) Cancer Res , vol.57 , pp. 3214-3222
    • Galli-Stampino, L.1    Meinjohanns, E.2    Frische, K.3
  • 33
    • 0348013088 scopus 로고    scopus 로고
    • O-linked glycans control glycoprotein processing by antigen-presenting cells: A biochemical approach to the molecular aspects of MUC1 processing by dendritic cells
    • Hanisch FG, Schwientek T, Bergwelt-Baildon MS, Schultze JL, Finn O. O-linked glycans control glycoprotein processing by antigen-presenting cells: a biochemical approach to the molecular aspects of MUC1 processing by dendritic cells. Eur J Immunol 2003;33: 3242-54.
    • (2003) Eur J Immunol , vol.33 , pp. 3242-3254
    • Hanisch, F.G.1    Schwientek, T.2    Bergwelt-Baildon, M.S.3    Schultze, J.L.4    Finn, O.5
  • 34
    • 0031569587 scopus 로고    scopus 로고
    • Carbohydrate and peptide specificity of MHC class II-restricted T cell hybridomas raised against an O-glycosylated self peptide
    • Jensen T, Hansen P, Galli-Stampino L, et al. Carbohydrate and peptide specificity of MHC class II-restricted T cell hybridomas raised against an O-glycosylated self peptide. J Immunol 1997;158:3769-78.
    • (1997) J Immunol , vol.158 , pp. 3769-3778
    • Jensen, T.1    Hansen, P.2    Galli-Stampino, L.3
  • 35
    • 0033563771 scopus 로고    scopus 로고
    • Presentation of MUC1 tumor antigen by class I MHC and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells
    • Hiltbold EM. Alter MD, Ciborowski P, Finn OJ. Presentation of MUC1 tumor antigen by class I MHC and CTL function correlate with the glycosylation state of the protein taken up by dendritic cells. Cell Immunol 1999;194:143-9.
    • (1999) Cell Immunol , vol.194 , pp. 143-149
    • Hiltbold, E.M.1    Alter, M.D.2    Ciborowski, P.3    Finn, O.J.4
  • 36
    • 10044265684 scopus 로고    scopus 로고
    • Glycoprotein tumor antigens for immunotherapy of breast cancer
    • Vlad AM, Finn OJ. Glycoprotein tumor antigens for immunotherapy of breast cancer. Breast Dis 2004;20: 73-9.
    • (2004) Breast Dis , vol.20 , pp. 73-79
    • Vlad, A.M.1    Finn, O.J.2
  • 37
    • 0030996555 scopus 로고    scopus 로고
    • Cytotoxic T lymphocytes derived from bone marrow mononuclear cells of multiple myeloma patients recognize an underglycosylated form of MUC1 mucin
    • Noto H, Takahashi T, Makiguchi Y, Hayashi T, Hinoda Y, Imai K. Cytotoxic T lymphocytes derived from bone marrow mononuclear cells of multiple myeloma patients recognize an underglycosylated form of MUC1 mucin. Int Immunol 1997;9:791-8.
    • (1997) Int Immunol , vol.9 , pp. 791-798
    • Noto, H.1    Takahashi, T.2    Makiguchi, Y.3    Hayashi, T.4    Hinoda, Y.5    Imai, K.6
  • 38
    • 1542283702 scopus 로고    scopus 로고
    • Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas
    • Xu Y, Gendler SJ, Franco A. Designer glycopeptides for cytotoxic T cell-based elimination of carcinomas. J Exp Med 2004;199:707-16.
    • (2004) J Exp Med , vol.199 , pp. 707-716
    • Xu, Y.1    Gendler, S.J.2    Franco, A.3
  • 39
    • 33644821094 scopus 로고    scopus 로고
    • O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma
    • Stepensky D, Tzehoval E, Vadai E, Eisenbach L. O-glycosylated versus non-glycosylated MUC1-derived peptides as potential targets for cytotoxic immunotherapy of carcinoma. Clin Exp Immunol 2006;143:139-49.
    • (2006) Clin Exp Immunol , vol.143 , pp. 139-149
    • Stepensky, D.1    Tzehoval, E.2    Vadai, E.3    Eisenbach, L.4
  • 40
    • 0037162490 scopus 로고    scopus 로고
    • Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis
    • Backlund J, Carlsen S, Hoger T, et al. Predominant selection of T cells specific for the glycosylated collagen type II epitope (263-270) in humanized transgenic mice and in rheumatoid arthritis. Proc Natl Acad Sci U S A 2002;99:9960-5.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 9960-9965
    • Backlund, J.1    Carlsen, S.2    Hoger, T.3
  • 41
    • 29144482654 scopus 로고    scopus 로고
    • Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint
    • Nissim A, Winyard PG, Corrigall V, et al. Generation of neoantigenic epitopes after posttranslational modification of type II collagen by factors present within the inflamed joint. Arthritis Rheum 2005;52:3829-38.
    • (2005) Arthritis Rheum , vol.52 , pp. 3829-3838
    • Nissim, A.1    Winyard, P.G.2    Corrigall, V.3
  • 43
    • 9644254186 scopus 로고    scopus 로고
    • Increased non-canonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes
    • Ng B, Yang F, Huston DP, et al. Increased non-canonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes. J Allergy Clin Immunol 2004;114:1463-70.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 1463-1470
    • Ng, B.1    Yang, F.2    Huston, D.P.3
  • 45
    • 0035181956 scopus 로고    scopus 로고
    • Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice
    • Tanaka Y, Koido S, Chen D, Gendler SJ, Kufe D, Gong J. Vaccination with allogeneic dendritic cells fused to carcinoma cells induces antitumor immunity in MUC1 transgenic mice. Clin Immunol 2001;101:192-200.
    • (2001) Clin Immunol , vol.101 , pp. 192-200
    • Tanaka, Y.1    Koido, S.2    Chen, D.3    Gendler, S.J.4    Kufe, D.5    Gong, J.6
  • 46
    • 0035339389 scopus 로고    scopus 로고
    • Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection
    • Soares MM, Mehta V, Finn OJ. Three different vaccines based on the 140-amino acid MUC1 peptide with seven tandemly repeated tumor-specific epitopes elicit distinct immune effector mechanisms in wild-type versus MUC1-transgenic mice with different potential for tumor rejection. J Immunol 2001;166:6555-63.
    • (2001) J Immunol , vol.166 , pp. 6555-6563
    • Soares, M.M.1    Mehta, V.2    Finn, O.J.3
  • 47
    • 3142713000 scopus 로고    scopus 로고
    • Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice
    • Saha A, Chatterjee SK, Foon KA, et al. Dendritic cells pulsed with an anti-idiotype antibody mimicking carcinoembryonic antigen (CEA) can reverse immunological tolerance to CEA and induce antitumor immunity in CEA transgenic mice. Cancer Res 2004; 64:4995-5003.
    • (2004) Cancer Res , vol.64 , pp. 4995-5003
    • Saha, A.1    Chatterjee, S.K.2    Foon, K.A.3
  • 48
    • 33646165128 scopus 로고    scopus 로고
    • A central role for central tolerance
    • Kyewski B, Klein L. A central role for central tolerance. Annu Rev Immunol 2006;24:571-606.
    • (2006) Annu Rev Immunol , vol.24 , pp. 571-606
    • Kyewski, B.1    Klein, L.2
  • 50
    • 0033873631 scopus 로고    scopus 로고
    • Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas
    • Scholzel S, Zimmermann W, Schwarzkopf G, Grunert F, Rogaczewski B, Thompson J. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. Am J Pathol 2000;156:595-605.
    • (2000) Am J Pathol , vol.156 , pp. 595-605
    • Scholzel, S.1    Zimmermann, W.2    Schwarzkopf, G.3    Grunert, F.4    Rogaczewski, B.5    Thompson, J.6
  • 51
    • 0035879753 scopus 로고    scopus 로고
    • Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel
    • Mitas M, Mikhitarian K, Walters C, et al. Quantitative real-time RT-PCR detection of breast cancer micrometastasis using a multigene marker panel. Int J Cancer 2001;93:162-71.
    • (2001) Int J Cancer , vol.93 , pp. 162-171
    • Mitas, M.1    Mikhitarian, K.2    Walters, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.