Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development

Cochrane Database of Systematic Reviews

Volumn 2015, Issue 7, 2015, Pages

  Delgado Noguera, Mario F ^a   Calvache, Jose Andres ^a,d,e   Bonfill Cosp, Xavier ^b   Kotanidou, Eleni P ^c   Galli Tsinopoulou, Assimina ^c  

^a UNIVERSIDAD DEL CAUCA   (Colombia)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c ARISTOTLE UNIVERSITY MEDICAL SCHOOL   (Greece)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e Erasmus University Medical Centre Rotterdam ^*  (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

LONG CHAIN FATTY ACID; LONG CHAIN POLYUNSATURATED FATTY ACID; POLYUNSATURATED FATTY ACID; UNCLASSIFIED DRUG; UNSATURATED FATTY ACID;

AGE; ALLERGY; ATTENTION; BODY FAT DISTRIBUTION; BODY HEIGHT; BODY WEIGHT; BREAST FEEDING; CHILD DEVELOPMENT; CHILD GROWTH; COGNITIVE DEVELOPMENT; DRUG EFFICACY; EVIDENCE BASED PRACTICE; FAT MASS; FOLLOW UP; HEAD CIRCUMFERENCE; HIGH INCOME COUNTRY; HUMAN; INTELLIGENCE; LANGUAGE DEVELOPMENT; MENTAL PERFORMANCE; MOTOR DEVELOPMENT; OUTCOME ASSESSMENT; POSTNATAL DEPRESSION; PREGNANCY; PRIORITY JOURNAL; PROBLEM SOLVING; PSYCHOMOTOR ACTIVITY; REVIEW; SAFETY; SUPPLEMENTATION; SYSTEMATIC REVIEW; VISUAL ACUITY; WORKING MEMORY; FEMALE; GROWTH; INFANT; META ANALYSIS; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

ATTENTION; BREAST FEEDING; CHILD DEVELOPMENT; FATTY ACIDS, UNSATURATED; FEMALE; GROWTH; HUMANS; INFANT; INTELLIGENCE; LANGUAGE DEVELOPMENT; PROBLEM SOLVING; PSYCHOMOTOR PERFORMANCE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; VISUAL ACUITY;

EID: 84957413072     PISSN: 14651858     EISSN: None     Source Type: Journal    
DOI: 10.1002/14651858.CD007901.pub3     Document Type: Review

References (126)

1. Furuhjelm C, Jenmalm MC, Falth-Magnusson K, DuchIn K. Th1 and Th2 chemokines, vaccine-induced immunity, and allergic disease in infants after maternal -3 fatty acid supplementation during pregnancy and lactation. Pediatric Research 2011;69(3):259-64.
2. Furuhjelm C, Warstedt K, Fagerås M, Fälth-Magnusson K, Larsson J, Fredriksson M, et al. Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation. Pediatric Allergy & Immunology 2011;22(5):502-4.
3. Furuhjelm C, Warstedt K, Larsson J, Fredriksson M, Bottcher MF, Falth-Magnusson K, et al. Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy. Acta Paediatrica 2009;98(9):1461-7.
4. Gibson RA, Neumann MA, Makrides M. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. European Journal of Clinical Nutrition 1997;51(9):578-84. [PUBMED: 9306083]
5. Hauner H, Much D, Vollhardt C, Brunner S, Schmid D, Sedlmeier EM, et al. Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized controlled trial. American Journal of Clinical Nutrition 2012;95(2):383-94.
6. Hauner H, Vollhardt C, Schneider KT, Zimmermann A, Schuster T, Amann-Gassner U. The impact of nutritional fatty acids during pregnancy and lactation on early human adipose tissue development. Rationale and design of the INFAT study. Annals of Nutrition & Metabolism 2009;54(2):97-103.
7. Much D, Brunner S, Vollhardt C, Schmid D, Sedlmeier EM, Brüderl M, et al. Breast milk fatty acid profile in relation to infant growth and body composition: Results from the INFAT study. Pediatric Research 2013;74(2):230-7.
8. Much D, Brunner S, Vollhardt C, Schmid D, Sedlmeier EM, Brüderl M, et al. Effect of dietary intervention to reduce the n-6/n-3 fatty acid ratio on maternal and fetal fatty acid profile and its relation to offspring growth and body composition at 1 year of age. European Journal of Clinical Nutrition 2013;67(3):282-8.
9. Helland IB, Saugstad OD, Smith L, Saarem K, Solvoll K, Ganes T, et al. Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics 2001;108(5):E82. [PUBMED: 11694666]
10. Helland IB, Smith L, Blomen B, Saarem K, Saugstad OD, Drevon CA. Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics 2008;122(2):e472-9. [PUBMED: 18676533]
11. Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 2003;111(1):e39-44. [PUBMED: 12509593]
12. Jensen CL, Llorente AM, Voigt RG, Prager TC, Fraley JK, Zou YL, et al. Effects of maternal docosahexaenoic acid (dha) supplementation on visual and neurodevelopmental function of maternal depression and cognitive interference. Pediatric Research 1999;45:284A.
13. Jensen CL, Maude M, Anderson RE, Heird WC. Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. American Journal of Clinical Nutrition 2000;71(1 Suppl):292S-299S. [PUBMED: 10617985]
14. Jensen CL, Prager TC, Zou Y, Fraley JK, Maude M, Anderson RE, et al. Effects of maternal docosahexaenoic acid supplementation on visual function and growth of breast-fed term infants. Lipids 1999;34 Suppl:S225. [PUBMED: 10419159]
15. Jensen CL, Voigt RG, Llorente AM, Peters SU, Prager TC, Zou Y, et al. Effect of maternal docosahexaenoic acid (DHA) supplementation on neuropsychological and visual status of former breast-fed infants at five years of age. Journal of Pediatric Gastroenterology and Nutrition 2004;39(Suppl 1):S10.
16. Jensen CL, Voigt RG, Llorente AM, Peters SU, Prager TC, Zou YL, et al. Effects of early maternal docosahexaenoic acid intake on neuropsychological status and visual acuity at five years of age of breast-fed term infants. Journal of Pediatrics 2010;157(6):900-5.
17. Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Rozelle JC, et al. Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. American Journal of Clinical Nutrition 2005;82(1):125-32. [PUBMED: 16002810]
18. Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Turcich M, et al. Effect of maternal docosahexaenoic acid (DHA) supplementation on neuropsychological and visual status of former breast-fed infants at five years of age. Pediatric Research 2001;48:448A.
19. Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. American Journal of Obstetrics and Gynecology 2003;188(5):1348-53.
20. Voigt RG, Jensen CL, Fraley JK, Brown FR, Heird WC. Maternal docosahexaenoic acid (dha) does not affect neurodevelopmental outcome of breast-fed term infants at one year of age. Pediatric Research 1998;43(4 Suppl 2):270.
21. Voigt RG, Jensen CL, Fraley JK, Rozelle J, Turcich M, Heird WC. Effects of maternal docosahexaenoic acid supplementation on neurodevelopmental function of breast-fed infants at 12 and 30 months of age. Journal of Developmental and Behavioral Pediatrics 2000;21:384-5.
22. Asserhoj M, Nehammer S, Matthiessen J, Michaelsen KF, Lauritzen L. Maternal fish oil supplementation during lactation may adversely affect long-term blood pressure, energy intake, and physical activity of 7-year-old boys. Journal of Nutrition 2009;139(2):298-304. [PUBMED: 19091800]
23. Cheatham CL, Nerhammer AS, Asserhoj M, Michaelsen KF, Lauritzen L. Fish oil supplementation during lactation: effects on cognition and behavior at 7 years of age. Lipids 2011;46(7):637-45.
24. Cheatham CL, Nerhammer S, Asserhoj M, Michaelsen KF, Lauritzen L. Fish oil supplementation during lactation: Effects on cognition and behavior at 7 years of age. FASEB Journal 2011;25 Suppl:766.9.
25. Jorgensen MH, Michaelsen KF, Lauritzen L. Long chain polyunsaturated fatty acids and liver biochemistry in breast-fed infants. Journal of Pediatric Gastroenterology and Nutrition 2005;40(5):631-2.
26. Larnkjaer A, Christensen JH, Michaelsen KF, Lauritzen L. Maternal fish oil supplementation during lactation does not affect blood pressure, pulse wave velocity, or heart rate variability in 2.5-y-old children. Journal of Nutrition 2006;136(6):1539-44. [PUBMED: 16702318]
27. Lauritzen L, Halkjaer LB, Mikkelsen TB, Olsen SF, Michaelsen KF, Loland L, et al. Fatty acid composition of human milk in atopic Danish mothers. American Journal of Clinical Nutrition 2006;84(1):190-6. [PUBMED: 16825695]
28. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatric Research 2005;58(2):235-42. [PUBMED: 16006428]
29. Lauritzen L, Jorgensen MH, Mikkelsen TB, Skovgaard M, Straarup EM, Olsen SF, et al. Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes. Lipids 2004;39(3):195-206. [PUBMED: 15233397]
30. Lauritzen L, Jorgensen MH, Olsen SF, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reproduction, Nutrition, Development 2005;45(5):535-47. [PUBMED: 16188206]
31. Lauritzen L, Kjaer TM, Fruekilde MB, Michaelsen KF, Frokiaer H. Fish oil supplementation of lactating mothers affects cytokine production in 2 1/2-year-old children. Lipids 2005;40(7):669-76. [PUBMED: 16196417]
32. Ulbak J, Lauritzen L, Hansen HS, Michaelsen KF. Diet and blood pressure in 2.5-y-old Danish children. American Journal of Clinical Nutrition 2004;79(6):1095-102. [PUBMED: 15159241]
33. Bergmann RL, Bergmann KE, Richter R, Haschke-Becher E, Henrich W, Dudenhausen JW. Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements. Journal of Perinatal Medicine 2012;40:677-84.
34. Bergmann RL, Richter R, Bergmann KE, Dudenhausen JW, Haschke F. 21 months old infants are leaner if their mothers received low dose DHA supplements during pregnancy and lactation. European Journal of Pediatrics 2006;165 Suppl 1:114.
35. Bergmann RL, Richter R, Bergmann KE, Dudenhausen JW, Haschke F. 21 months old infants are leaner if their mothers received low dose DHA supplements during pregnancy and lactation. European Journal of Pediatrics 2006; Vol. 165, issue 1:114.
36. Lucia Bergmann R, Bergmann KE, Haschke-Becher E, Richter R, Dudenhausen JW, Barclay D, et al. Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy?. Journal of Perinatal Medicine 2007;35(4):295-300. [PUBMED: 17547539]
37. Doornbos B, van Goor SA, Dijck-Brouwer DA, Schaafsma A, Korf J, Muskiet FA. Supplementation of a low dose of DHA or DHA+AA does not prevent peripartum depressive symptoms in a small population based sample. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2009;33(1):49-52.
38. van Goor SA, Dijck-Brouwer DA, Doornbos B, Erwich JJ, Schaafsma A, Muskiet FA, et al. Supplementation of DHA but not DHA with arachidonic acid during pregnancy and lactation influences general movement quality in 12-week-old term infants. British Journal of Nutrition 2010;103(2):235-42.
39. van Goor SA, Dijck-Brouwer DA, Hadders-Algra M, Doornbos B, Erwich JJ, Schaafsma A, et al. Human milk arachidonic acid and docosahexaenoic acid contents increase following supplementation during pregnancy and lactation. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2009;80(1):65-9.
40. van Goor SA, Dijck-Brouwer DAJ, Erwich JJHM, Schaafsma A, Mijna Hadders-Algra M. The influence of supplemental docosahexaenoic and arachidonic acids during pregnancy and lactation on neurodevelopment at eighteen months. Prostaglandins Leukotrienes and Essential Fatty Acids 2011;84(5-6):139-46.
41. van Goor SA, Muskiet FAJ. The effect of a high DHA-fish oil and arachidonic acid (AA) supplementation during pregnancy and lactation on LCP status of mother and child and on the neurological development of the baby. Netherlands Trial Register (http://www.trialregister.nl) [accessed 1 November 2005] 2005.
42. van Goor SA, Schaafsma A, Erwich JJ, Dijck-Brouwer DA, Muskiet FA. Mildly abnormal general movement quality in infants is associated with higher Mead acid and lower arachidonic acid and shows a U-shaped relation with the DHA/AA ratio. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2010;82(1):15-20.
43. Anderson NK, Beerman KA, McGuire MA, Dasgupta N, Griinari JM, Williams J, et al. Dietary fat type influences total milk fat content in lean women. Journal of Nutrition 2005;135(3):416-21.
44. Bergmann RL, Haschke-Becher E, Klassen-Wigger P, Bergmann KE, Richter R, Dudenhausen JW, et al. Supplementation with 200 mg/day docosahexaenoic acid from mid-pregnancy through lactation improves the docosahexaenoic acid status of mothers with a habitually low fish intake and of their infants. Annals of Nutrition & Metabolism 2008;52(2):157-66. [PUBMED: 18446020]
45. Bertschi I, Collomb M, Rist L, Eberhard P, Sieber R, Butikofer U, et al. Maternal dietary Alpine butter intake affects human milk: fatty acids and conjugated linoleic acid isomers. Lipids 2005;40(6):581-7.
46. Boris J, Jensen B, Salvig JD, Secher NJ, Olsen SF. A randomized controlled trial of the effect of fish oil supplementation in late pregnancy and early lactation on the n-3 fatty acid content in human breast milk. Lipids 2004;39(12):1191-6. [PUBMED: 15736915]
47. Cant A, Shay J, Horrobin DF. The effect of maternal supplementation with linoleic and gamma-linolenic acids on the fat composition and content of human milk: a placebo-controlled trial. Journal of Nutritional Science and Vitaminology 1991;37(6):573-9. [PUBMED: 1668100]
48. Craig-Schmidt MC, Weete JD, Faircloth SA, Wickwire MA, Livant EJ. The effect of hydrogenated fat in the diet of nursing mothers on lipid composition and prostaglandin content of human milk. American Journal of Clinical Nutrition 1984;39(5):778-86.
49. Dunstan JA, Mitoulas LR, Dixon G, Doherty DA, Hartmann PE, Simmer K, et al. The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial. Pediatric Research 2007;62(6):689-94. [PUBMED: 17957152]
50. Fidler N, Sauerwald T, Demmelmair H, Pohl A, Koletzko B. Oxidation of an oil rich in docosahexaenoic acid compared to linoleic acid in lactating women. Annals of Nutrition & Metabolism 1999;43:339-45.
51. Fidler N, Sauerwald T, Pohl A, Demmelmair H, Koletzko B. Docosahexaenoic acid transfer into human milk after dietary supplementation: a randomized clinical trial. Journal of Lipid Research 2000;41(9):1376-83. [PUBMED: 10974044]
52. Fung EB, Ritchie LD, Walker BH, Gildengorin G, Crawford PB. Randomized, controlled trial to examine the impact of providing yogurt to women enrolled in WIC. Journal of Nutrition Education and Behavior 2010;42(3 Suppl):S22-S29.
53. Granot E, Jakobovich E, Rabinowitz R, Levy P, Schlesinger M. DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response. Mediators of Inflammation 2011;2011:493925.
54. Hasin A, Griinari JM, Williams JE, Shahin AM, McGuire MA, McGuire MK. Consumption of c9, t11-18:2 or t10, c12-18:2 enriched dietary supplements does not influence milk macronutrients in healthy, lactating women. Lipids 2007;42(9):835-43.
55. Hawkes JS, Bryan DL, Makrides M, Neumann MA, Gibson RA. A randomized trial of supplementation with docosahexaenoic acid-rich tuna oil and its effects on the human milk cytokines interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. American Journal of Clinical Nutrition 2002;75(4):754-60. [PUBMED: 11916764]
56. Helland IB, Saarem K, Saugstad OD, Drevon CA. Fatty acid composition in maternal milk and plasma during supplementation with cod liver oil. European Journal of Clinical Nutrition 1998;52(11):839-45. [PUBMED: 9846598]
57. Helland IB, Saugstad OD, Saarem K, Van Houwelingen AC, Nylander G, Drevon CA. Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. Journal of Maternal-Fetal and Neonatal Medicine 2006;19(7):397-406. [PUBMED: 16923694]
58. Henriksen C, Haugholt K, Lindgren M, Aurvag AK, Ronnestad A, Gronn M, et al. Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid. Pediatrics 2008;121(6):1137-45. [PUBMED: 18519483]
59. Kaapa P, Uhari M, Nikkari T, Viinikka L, Ylikorkala O. Dietary fatty acids and platelet thromboxane production in puerperal women and their offspring. American Journal of Obstetrics and Gynecology 1986;155:146-9.
60. Kitz R, Rose MA, Schonborn H, Zielen S, Bohles HJ. Impact of early dietary gamma-linolenic acid supplementation on atopic eczema in infancy. Pediatric Allergy and Immunology 2006;17(2):112-7.
61. Makrides M, Neumann MA, Gibson RA. Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. European Journal of Clinical Nutrition 1996;50(6):352-7. [PUBMED: 8793415]
62. Makrides M, Neumann MA, Gibson RA. Effect of maternal DHA supplementation on breast milk composition and infant fatty acid profiles. Journal of Paediatrics and Child Health 1997;33(Suppl 1):S55.
63. Makrides M, Hawkes JS, Neumann MA, Gibson RA. Nutritional effect of including egg yolk in the weaning diet of breast-fed and formula-fed infants: a randomized controlled trial. American Journal of Clinical Nutrition 2002;75(6):1084-92. [PUBMED: 12036817]
64. Makrides M, Gibson RA, McPhee AJ, Collins CT, Davis PG, Doyle LW, et al. Neurodevelopmental outcomes of preterm infants fed high-dose docosahexaenoic acid: a randomized controlled trial. JAMA 2009;301(2):175-82. [PUBMED: 19141765]
65. Martin-Alvarez E, Guerrero-Montenegro B, Romero-Paniagua MT, Lara-Villoslada F, Hurtado-Suazo JA. Maternal docosahexaenoic acid supplementation during pregnancy and lactation can modulate oxidative stress in the term newborn. Journal of Maternal-Fetal and Neonatal Medicine 2012;25(S2):40.
66. Masters N, McGuire MA, Beerman KA, Dasgupta N, McGuire MK. Maternal supplementation with CLA decreases milk fat in humans. Lipids 2002;37(2):133-8.
67. Mellies MJ, Ishikawa TT, Gartside P, Burton K, MacGee J, Allen K, et al. Effects of varying maternal dietary cholesterol and phytosterol in lactating women and their infants. American Journal of Clinical Nutrition 1978;31(8):1347-54.
68. Mellies MJ, Ishikawa TT, Gartside PS, Burton K, MacGee J, Allen K, et al. Effects of varying maternal dietary fatty acids in lactating women and their infants. American Journal of Clinical Nutrition 1979;32(2):299-303. [PUBMED: 420127]
69. Mosley SA, Shahin AM, Williams J, McGuire MA, McGuire MK. Supplemental conjugated linoleic acid consumption does not influence milk macronutrient contents in all healthy lactating women. Lipids 2007;42(8):723-9.
70. Palmer DJ, Gold MS, Makrides M. Effect of cooked and raw egg consumption on ovalbumin content of human milk: a randomized, double-blind, cross-over trial. Clinical and Experimental Allergy 2005;35(2):173-8.
71. Park Y, McGuire MK, Behr R, McGuire MA, Evans MA, Shultz TD. High-fat dairy product consumption increases Delta9c, 11t-18:2 (rumenic acid) and total lipid concentrations of human milk. Lipids 1999;34:543-9.
72. Potter JM, Nestel PJ. The effects of dietary fatty acids and cholesterol on the milk lipids of lactating women and the plasma cholesterol of breast-fed infants. The American Journal of Clinical Nutrition 1976;29(1):54-60. [PUBMED: 1246976]
73. Ritzenthaler KL, McGuire MK, McGuire MA, Shultz TD, Koepp AE, Luedecke LO, et al. Consumption of conjugated linoleic acid (CLA) from CLA-enriched cheese does not alter milk fat or immunity in lactating women. Journal of Nutrition 2005;135(3):422-30.
74. Scopesi F, Traggiai C, Levreri I, Gianotti D, Zucchi C, Calevo MG, et al. Lactating mothers on DHA enriched diet and breast milk composition. Journal of Maternal-Fetal and Neonatal Medicine 2008;21(Suppl 1):27.
75. Scopesi F, Calevo MG, Risso FM, Sannia A, Traverso F, Bruschettini M, et al. The impact of a DHA enriched diet on breast milk composition. Early Human Development 2011;87(Suppl):S96.
76. Shahin AM, McGuire MK, Anderson N, Williams J, McGuire MA. Effects of margarine and butter consumption on distribution of trans-18:1 fatty acid isomers and conjugated linoleic acid in major serum lipid classes in lactating women. Lipids 2006;41(2):141-7.
77. Smithers LG, Gibson RA, McPhee A, Makrides M. Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: results from the DINO trial. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2008;79(3-5):141-6. [PUBMED: 18951004]
78. Smithers LG, Gibson RA, McPhee A, Makrides M. Higher dose of docosahexaenoic acid in the neonatal period improves visual acuity of preterm infants: results of a randomized controlled trial. American Journal of Clinical Nutrition 2008;88(4):1049-56.
79. Smithers LG, Markrides M, Gibson RA. Human milk fatty acids from lactating mothers of preterm infants: a study revealing wide intra- and inter-individual variation. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2010;83(1):9-13.
80. Smithers LG, Gibson RA, Makrides M. Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial. American Journal of Clinical Nutrition 2011;93(6):1293-9. [DOI: 10.3945/ajcn.110.009647]
81. Tanaka K, Kon N, Ohkawa N, Yoshikawa N, Shimizu T. Does breastfeeding in the neonatal period influence the cognitive function of very-low-birth-weight infants at 5 years of age?. Brain & Development 2009;31(4):288-93. [PUBMED: 18640798]
82. Valentine CJ, Morrow G, Pennell M, Morrow AL, Hodge A, Haban-Bartz A, et al. Randomized controlled trial of docosahexaenoic Acid supplementation in midwestern US. Human milk donors. Breastfeeding Medicine 2013;8(1):86-91.
83. Warstedt K, Furuhjelm C, Duchen K, Falth-Magnusson K, Fageras M. The effects of omega-3 fatty acid supplementation in pregnancy on maternal eicosanoid, cytokine, and chemokine secretion. Pediatric Research 2009;66(2):212-7.
84. Weseler AR, Dirix CE, Bruins MJ, Hornstra G. Dietary arachidonic acid dose-dependently increases the arachidonic acid concentration in human milk. Journal of Nutrition 2008;138(11):2190-7.
85. Nahidi F, Taghizade S, Sadr S, Majd HA. Effects of omega-3 Fatty acids on postpartum depression [Chinese Source]. Iranian Journal of Obstetrics, Gynecology and Infertility 2011;14(6):46-53.
86. Campos-Martinez A, Serrano L, Medina M, Ochoa- J, Pena-Caballero M. Levels of docosahexaenoic acid in pregnant women and their children after taking a fish oil enriched diet. Journal of Maternal-Fetal and Neonatal Medicine 2012;25(S2):92.
87. Harris M, Stacy M, Baker S, McGirr K, Davalos D. The omega smart baby project: Effect of maternal DHA on infant development. FASEB Journal 2014;28(1 Suppl):[abstract no: 269.1].
88. Karlsson T, Birberg-Thornberg U, Duchen K, Gustafsson PA. LC-PUFA supplemented to mothers during pregnancy and breast-feeding improves cognitive performance in their children four years later - an rct study. 9th Congress of the ISSFAL; 29 May-2 June 2010; Maastricht, The Netherlands. 2010:113.
89. Agostoni C, Brunetti I, Di Marco A. Polyunsaturated fatty acids in human milk and neurological development in breastfed infants. Current Pediatric Reviews 2005;1:25-30.
90. Belfort MB, Rifas-Shiman SL, Kleinman KP, Guthrie LB, Bellinger DC, Taveras EM, et al. Infant feeding and childhood cognition at ages 3 and 7 years: Effects of breastfeeding duration and exclusivity. JAMA Pediatrics 2013;167(9):836-44.
91. Brenna JT, Varamini B, Jensen RG, Diersen-Schade DA, Boettcher JA, Arterburn LM. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. American Journal of Clinical Nutrition 2007;85(6):1457-64.
92. Campoy C, Escolano-Margarit MV, Anjos T, Szajewska H, Uauy R. Omega 3 fatty acids on child growth, visual acuity and neurodevelopment. British Journal of Nutrition 2012;107:S85-S106.
93. Cheatham CL, Colombo J, Carlson SE. N-3 fatty acids and cognitive and visual acuity development: methodologic and conceptual considerations. American Journal of Clinical Nutrition 2006;83(6 Suppl):1458S-1466S.
94. Cohen, J. Statistical Power Analysis for the Behavioral Sciences. 2nd Edition. Hillsdale, NJ: Lawrence Earlbaum Associates, 1988.
95. Fleith M, Clandinin MT. Dietary PUFA for preterm and term infants: review of clinical studies. Critical Reviews in Food Science and Nutrition 2005;45(3):205-29.
96. Gibson RA, Neumann MA, Makrides M. Effect of dietary docosahexaenoic acid on brain composition and neural function in term infants. Lipids 1996;31:S177-S181.
97. Gould JF, Smithers LG, Makrides M. The effect of maternal omega-3 (n-3) LCPUFA supplementation during pregnancy on early childhood cognitive and visual development: a systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition 2013;97:351-44.
98. McMaster University. GRADEpro. [Computer program on www.gradepro.org]. 2014. McMaster University, 2014.
99. Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B. Developmental potential in the first 5 years for children in developing countries. Lancet 2007;369(9555):60-70.
100. Hadders-Algra M. Variation and variability: key words in human motor development. Physical Therapy 2010;90(12):1823-37. [PUBMED: 20966209]
101. Helgi Library. Fish consumption per capita. http://www.helgilibrary.com/indicators/index/fish-consumption-per-capita accessed at 01.12.2014. [http://www.helgilibrary.com/indicators/index/fish-consumption-per-capita]
102. Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
103. Hoddinott P, Tappin D, Wright C. Breast feeding. BMJ 2008;336(7649):881-7.
104. Horta BL, Bahl R, Martines JC, Victora JC. Evidence on the Long-term Effects of Breastfeeding: Systematic Reviews and Meta-analyses. Geneva: World Health Organization, 2007.
105. Innis SM. Fatty acids and early human development. Early Human Development 2007;83(12):761-6.
106. Innis SM. Impact of maternal diet on human milk composition and neurological development of infants. American Journal of Clinical Nutrition 2014;99(3):734S-41S. [DOI: 10.3945/ajcn.113.072595]
107. Jensen CL, Voigt RG, Prager TC, Zou YL, Fraley JK, Rozelle JC, et al. Effects of maternal docosahexaenoic acid intake on visual function and neurodevelopment in breastfed term infants. American Journal of Clinical Nutrition 2005;82(1):125-32.
108. Jensen CL. Effects of n-3 fatty acids during pregnancy and lactation. American Journal of Clinical Nutrition 2006;83(6):1452S-1457S.
109. Jensen CL, Lapillonne A. Docosahexaenoic acid and lactation. Prostaglandins, Leukotrienes, and Essential Fatty Acids 2009;81(2-3):175-8.
110. Koletzko B, Lien E, Agostoni C, Böhles H, Campoy C, Cetin I, et al. The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. Journal of Perinatal Medicine 2008;36(1):5-14.
111. Koletzko B, Cetin I, Brenna T. Dietary fat intakes for pregnant and lactating women. British Journal of Nutrition 2007;98:873-7. [PUBMED: 17688705]
112. Larqué E, Gil-Sánchez A, Prieto-Sánchez MT, Koletzko B. Omega 3 fatty acids, gestation and pregnancy outcomes. British Journal of Nutrition 2012;107(Suppl 2):S77-84. [PUBMED: 22591905]
113. Lauritzen L, Jørgensen MH, Olsen SF, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation: effect on developmental outcome in breast-fed infants. Reproduction, Nutrition, Development 2005;45(5):535-47.
114. Llorente AM, Jensen CL, Voigt RG, Fraley JK, Berretta MC, Heird WC. Effect of maternal docosahexaenoic acid supplementation on postpartum depression and information processing. American Journal of Obstetrics and Gynecology 2003;188(5):1348-53.
115. McCann JC, Ames BN. Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals. American Journal of Clinical Nutrition 2005;82(2):281-95.
116. Olsen J, Melbye M, Olsen SF, Sørensen TI, Aaby P, Andersen AM, et al. The Danish National Birth Cohort--its background, structure and aim. Scandinavian Journal of Public Health 2001;29(4):300-7.
117. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
118. Schulzke SM, Patole SK, Simmer K. Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database of Systematic Reviews 2011, Issue 2. [DOI: 10.1002/14651858.CD000375.pub4]
119. Schunemann HJ. GRADE: from grading the evidence to developing recommendations. A description of the system and a proposal regarding the transferability of the results of clinical research to clinical practice [GRADE: Von der Evidenz zur Empfehlung. Beschreibung des Systems und Losungsbeitrag zur Ubertragbarkeit von Studienergebnissen]. Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen 2009;103(6):391-400. [PUBMED: 19839216]
120. Simmer K, Patole SK, Rao SC. Longchain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database of Systematic Reviews 2011, Issue 12. [DOI: 10.1002/14651858.CD000376.pub3]
121. Tinoco SM, Sichieri R, Moura AS, Santos Fda S, Carmo MG. The importance of essential fatty acids and the effect of trans fatty acids in human milk on fetal and neonatal development [Importancia dos acidos graxos essenciais e os efeitos dos acidos graxos trans do leite materno para o desenvolvimento fetal e neonatal]. Cadernos de Saude Publica 2007;23(3):525-34.
122. Torres AG, Trugo NM. Evidence of inadequate docosahexaenoic acid status in Brazilian pregnant and lactating women. Revista de Saude Publica 2009;43(2):359-68.
123. Uauy R, Hoffman DR, Mena P, Llanos A, Birch EE. Term infant studies of DHA and ARA supplementation on neurodevelopment: results of randomized controlled trials. Journal of Pediatrics 2003;4:S17-S25.
124. Walker SP, Wachs TD, Gardner JM, LozoffB, Wasserman GA, Pollitt E, et al. Child development: risk factors for adverse outcomes in developing countries. Lancet 2007;369(9556):145-57.
125. Welch AA, Lund E, Amiano P, Dorronsoro M, Brustad M, Kumle M, et al. Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutrition 2002;6B(5):1273-85.
126. Delgado-Noguera MF, Calvache JA, Bonfill Cosp X. Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database of Systematic Reviews 2010, Issue 12. [DOI: 10.1002/14651858.CD007901.pub2]