Does docosahexaenoic acid (DHA) status in pregnancy have any impact on postnatal growth? Six-year follow-up of a prospective randomized double-blind monocenter study on low-dose DHA supplements

Journal of Perinatal Medicine

Volumn 40, Issue 6, 2012, Pages 677-684

  Bergmann, Renate L ^a   Bergmann, Karl E ^a   Richter, Rolf ^a   Haschke Becher, Elisabeth ^b,c   Henrich, Wolfgang ^a   Dudenhausen, Joachim W ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b ELISABETHINEN HOSPITAL   (Austria)

^c PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

6 Year growth; Child follow up; Docosahexaenoic acid (DHA); Lactation; Pregnancy

Indexed keywords

DOCOSAHEXAENOIC ACID;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FOLLOW UP; GESTATIONAL AGE; HEAD CIRCUMFERENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTNATAL GROWTH; PRIORITY JOURNAL; PROSPECTIVE STUDY; SKINFOLD THICKNESS; SUPPLEMENTATION; BLOOD; DIETARY SUPPLEMENT; DOUBLE BLIND PROCEDURE; INFANT; PREGNANCY; RANDOMIZED CONTROLLED TRIAL;

DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; PREGNANCY; PROSPECTIVE STUDIES;

EID: 84869474591     PISSN: 03005577     EISSN: 16193997     Source Type: Journal    
DOI: 10.1515/jpm-2012-0080     Document Type: Article

References (50)

1. Agostoni C, Galli C, Riva E, Colombo C, Giovannini M, Marangoni F. Reduced docosahexaenoic acid synthesis may contribute to growth restriction in infants born to mothers who smoke. J Pediatr. 2005;147: 854-6. (Pubitemid 41774848)
2. Ailhaud G, Guesnet P. Fatty acid composition of fats is an early determinant of childhood obesity: a short review and opinion. Obes Rev. 2004;5: 21-6. (Pubitemid 38173591)
3. Andersen AD, Michaelsen KF, Hellgren LI, Trolle E, Lauritzen L. A randomized controlled intervention with fish oil versus sunflower oil from 9 to 18 months of age-exploring growth and skin fold thickness. Pediatr Res. 2011;70: 368-74.
4. Asserhøj M, Nehammer S, Matthiessen J, Michaelsen KF, Lauritzen L. Maternal fish oil supplementation during lactation may adversely effect long-term blood pressure, energy intake and physical activity of 7 year old boys. J Nutr. 2009;139: 298-304.
5. Bergmann KE, Thefeld W, Kurth BM. Der Kinder- und Jugendgesundheitssurvey soll die gesundheitliche Situation der Kinder- und Jugendlichen in Deutschland beschreiben. Mschr. Kinderheilkd. 2002;150: 1543-5.
6. Bergmann RL, Bergmann KE, Dudenhausen JW. Undernutrition and growth restriction in pregnancy. In: Barker DJP, Bergmann RL, Ogra PL, editors. The window of opportunity: pre-pregnancy to 24 months of age. NestléNutr Workshop Ser Pediatr Program. 2008;61: 103-21.
7. Bergmann RL, Bergmann KE, Haschke-Becher E, Richter R, Dudenhausen JW, Barclay D, et al. Does maternal docosahexaenoic acid supplementation during pregnancy and lactation lower BMI in late infancy? J Perinat Med. 2007;35: 295-300. (Pubitemid 47036978)
8. Bergmann RL, Bergmann KE, Kollmann F, Maaser R. Wachstum atlas. Papillon Wiesbaden, 1988.
9. Bergmann RL, Haschke-Becher L, Klassen-Wigger P, Bergmann KE, Richter R, Dudenhausen JW, et al. Supplementation with 200 mg/day docosahexaenoic acid from mid-pregnancy through lactation improves the docosahexaenoic acid status of mothers with a habitually low fish intake and of their infants. Nutr Metab. 2008;52: 157-66. (Pubitemid 351723137)
10. Caspi A, Williams B, Kim-Cohen J, Craig IW, Milne BJ, Poulton R, et al. Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. Proc Natl Acad Sci USA. 2007;104: 18860-5. (Pubitemid 350210787)
11. Cole TJ. Children grow and horses race: is the adiposity rebound a critical period for later obesity? BMC Pediatr. 2004; 4:6.
12. Courville AB, Harel O, Lammi-Keefe CJ. Consumption of DHA containing functional food during pregnancy is associated with lower infant ponderal index and cord plasma insulin concentration. Br J Nutr. 2011;106: 208-12.
13. Crawford MA, Hassan AG, Williams G. Essential fatty acids and fetal brain growth. Lancet. 1976;1: 452-3.
14. DeFina LF, Marcoux LG, Devers SM, Cleaver JP, Willis BL. Effects of omega-3 supplementation in combination with diet and exercise on weight loss and body composition. Am J Clin Nutr. 2011;93: 455-62.
15. Donahue SMA, Rifas-Shiman SL, Gold DR, Jouni ZE, Gillman MW, Oken E. Prenatal fatty acid status and child adiposity at age 3 y: results from a US pregnancy cohort. Am J Clin Nutr. 2011;93: 780-8.
16. Fickova M, Hubert P, Cremel G, Leray C. Dietary (n-3) and (n-6) polyunsaturated fatty acids rapidly modify fatty acid composition and insulin effects in rat adipocytes. J Nutr. 128: 512-19, 1998. (Pubitemid 28188346)
17. Gibson RA, Muhlhausler B, Makrides M. Conversion of linoleic acid and alpha-linolenic acid to long-chain polyunsaturated fatty acids (LCPUFAs), with a focus on pregnancy, lactation and the first 2 years of life. Matern Child Nutr. 2011;7(Suppl 2): 17-26.
18. Gibson RA, Neumann MA, Makrides M. Effect of increasing breast milk docosahexaenoic acid on plasma erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. Eur J Clin Nutr. 1997;51: 578-84. (Pubitemid 27424970)
19. Grandjean P, Weihe P. Arachidonic acid status during pregnancy is associated with polychlorinated biphenyl exposure. Am J Clin Nutr. 2003;77: 715-9. (Pubitemid 36258585)
20. Haggarty P. Effect of placental function on fatty acid requirements during pregnancy. Eur J Clin Nutr. 2004;58: 1559-70. (Pubitemid 40028517)
21. Hauner H, Much D, Vollhardt C, Brunner S, Schmidt D, Sedlmayer EM, et al. Effect of reducing the n-6:n-3 long-chain PUFA ratio during pregnancy and lactation on infant adipose tissue growth within the first year of life: an open-label randomized trial. Am J Clin Nutr. 2012;95: 383-94.
22. Helland IB, Saugstad OD, Smith L, Saarem K, Solvoll K, Ganes T, et al. Similar effects on infants of n-3 and n-6 fatty acids supplementation to pregnant and lactating women. Pediatrics. 2001;108:E82.
23. Helland IB, Smith L, Blomén B, Saarem K, Saugstad OD, Drevon CA. Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics. 2008;122:e472-9.
24. Horvath A, Koletzko B, Szajewska H. Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Br J Nutr. 2007;98: 253-9. (Pubitemid 47091365)
25. Innis SM. Metabolic programming of long-term outcomes due to fatty acid nutrition in early life. Matern Child Nutr. 2011;7(Suppl 2) 111-23.
26. Kim HK, Della-Fera MA, Baile CA. Docosahexaenoic acid inhibits adipocyte differentation and induces apoptosis in 3T3-L1 preadipocytes. J Nutr. 2006;136: 2965-9. (Pubitemid 44878557)
27. Koletzko B, Lattka E, Zeilinger S, Illig Th, Steer C. Genetic variants of the fatty acid desaturase gene cluster predicts amounts of red blood docosahexaenoic acid and other polyunsaturated fatty acids in pregnant women: findings from the Avon longitudinal study on parents and children. Am J Clin Nutr. 2011;93: 211-9.
28. Kulkarni A, Dangat K, Kale A, Sable P, Chavan-Gautam P, Joshi S. Effects of altered maternal folic acid, Vitamin B12 and docosahexaenoic acid on placental global DNA methylation patterns in Wistar rats. PLOs One. 2011;6:e17706.
29. Lapillonne A, Carlson SE. Polyunsaturated fatty acids and infant growth. Lipids. 2001;36: 901-11. (Pubitemid 33065191)
30. Lauritzen L, Hoppe C, Straarup EM, Michaelsen KF. Maternal fish oil supplementation in lactation and growth during the first 2.5 years of life. Pediatr Res. 2005;58: 235-42. (Pubitemid 41099867)
31. Makrides M, Collins CT, Gibson RA. Impact of fatty acid status on growth and neuro-behavioural development in humans. Matern Child Nutr. 2011;7(Suppl 2): 80-8.
32. Makrides M, Duley L, Olsen SF. Marine oil, and other prostaglandin precursor, supplementation for pregnancy uncomplicated by pre-eclampsia or intrauterine growth restriction. Cochrane Database Syst Rev. 2006;(3):CD003402.
33. Marquard A, Stöhr H, White K, Weber BHF. cDNA cloning, genomic structure, and chromosomal localization of three members of the human fatty acid desaturase family. Genomics. 2000;66: 175-83. (Pubitemid 30429752)
34. McCance RA, Widdowson EM. Review lecture: the determinants of growth and form. Proc R Soc Lond. 1974;185: 1-17.
35. Molto-Puigmarti C, Plat J, Mensink RP, Müller A, Zeegers MP. FADS1 FADS2 gene variants modify the association between fish intake and the docosahexaenoic acid proportions in human milk. Am J Clin Nutr. 2010;91: 1368-76.
36. Mulhausler BS, Gibson RA, Makrides M. Effect of long-chain polyunsaturated fatty acid supplementation during pregnancy or lactation on infant and child body composition: a systematic review. Am J Clin Nutr. 2010;92: 857-63.
37. Noreen EE, Sass MJ, Crow ML, Pabon VA, Brandauer J, Averill LK. Effect of supplemental fish oil on resting metabolic rate, body composition, and salivary cortisol in healthy adults. J Int Soc Sports Nutr. 2010;7: 31-7.
38. Oken E, Kleinman KP, Olsen SF, Rich-Edwards JW, Gillman MW. Association of seafood and elongated n-3 fatty acids with fetal growth and length of gestation: results from a US pregnancy cohort. Am J Epidemiol. 2004;160: 774-83. (Pubitemid 39362215)
39. Okuno M, Kajiwara K, Imai S, Kobayashi T, Honma N, Maki T, et al. Perilla oil prevents the excessive growth of visceral adipose tissue in rats by down-regulating adipocyte differentiation. J Nutr. 1997;127: 1752-57. (Pubitemid 27386399)
40. Plagemann A.'Fetal programming'and'functional teratogenesis': on epigenetic mechanisms and prevention of perinatally acquired lasting health risks. J Perinat Med. 2004;32: 297-305. (Pubitemid 39013841)
41. Plagemann A, Harder T, Dudenhausen JW. The diabetic pregnancy, macrosomia, and perinatal nutritional programming. In: Barker DJP, Bergmann RL, Ogra PL, editors. The window of opportunity: pre-pregnancy to 24 months of age. NestléNutr Workshop Ser Pediatr Program. 2008;61: 91-102.
42. Prader A, Tanner JM, Harnack CA. Catch-up growth following illness or starvation. J Pediatr. 1963;62: 646-59.
43. Ramakrishnan U, Stein AD, Parra-Cabrera S, Wang M, Imhoff- Kunsch B, Juárez-Márquez S, et al. Effect of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico. Food Nutr Bull. 2010;(Suppl):S108-16.
44. Rolland-Cachera MF, Deheeger M, Maillot M, Bellisle F. Early adiposity rebound: causes and consequences for obesity in children and adults. Int J Obes. 2006;30:S11-7. (Pubitemid 44837544)
45. Sovio U, Mook-Kanamori DO, Warrington MW, Lawrence R, Briollais L, et al. Early Growth Genetic Consortium. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLOS Genet. 2011;7:e1001317.
46. Stein AD, Wang M, Martorell R, Neufeld LM, Flores-Ayala R, Rivera JA, et al. Growth to age 18 months following prenatal supplementation with docosahexaenoic acid differs by maternal gravity in Mexico. J Nutr. 2011;141: 316-20.
47. Szajewska H, Horvath A, Koletzko B. Effect of n-3 long-chain polyunsaturated fatty acid supplementation of women with lowrisk pregnancies on pregnancy outcomes and growth measures at birth: a metaanalysis of randomized controlled trials. Am J Clin Nutr. 2006;83: 1337-44. (Pubitemid 44713064)
48. Tanner JM. Normal growth and techniques of growth assessment. Clin Endocrinol Metab. 1986;15: 411-51. (Pubitemid 17198038)
49. Watkins BA, Li Y, Lippman HE, Le Bouteiller L, Li Y, Seifert MF. Bioactive fatty acids: role in bone biology and bone cell function. Prog Lipid Res. 2001;40: 125-48. (Pubitemid 32008652)
50. WHO Multicentre Growth Reference Study Group, de Onis M. WHO child growth standards. Acta Paediatr Suppl 206;450: 16-26.