Randomized controlled trial of docosahexaenoic acid supplementation in midwestern U.S. human milk donors

Breastfeeding Medicine

Volumn 8, Issue 1, 2013, Pages 86-91

  Valentine, Christina J ^a   Morrow, Georgia ^b   Pennell, Michael ^c   Morrow, Ardythe L ^a   Hodge, Amanda ^d   Haban Bartz, Annette ^d   Collins, Kristin ^d   Rogers, Lynette K ^d  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b GRANT MEDICAL CENTER   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CARBOHYDRATE; DOCOSAHEXAENOIC ACID; FAT; ICOSAPENTAENOIC ACID; LINOLENIC ACID; PLACEBO; PROTEIN; SOYBEAN OIL;

ADULT; ARTICLE; BREAST MILK; CALORIE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIETITIAN; DONOR; FEMALE; FOOD COMPOSITION; FOOD INTAKE; GAS CHROMATOGRAPHY; HUMAN; INFANT NUTRITION; LACTATION; MATERNAL AGE; MILK DONOR; MOTHER; PREMATURITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; BREAST FEEDING; DIET; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; FEASIBILITY STUDIES; FEMALE; FETAL DEVELOPMENT; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; MIDWESTERN UNITED STATES; MILK, HUMAN; PILOT PROJECTS; PREGNANCY; TISSUE DONORS;

EID: 84873344264     PISSN: 15568253     EISSN: 15568342     Source Type: Journal    
DOI: 10.1089/bfm.2011.0126     Document Type: Article

References (25)

1. Hay WW Jr. Nutritional requirements of extremely low birthweight infants. Acta Paediatr Suppl 1994;402:94-99. (Pubitemid 24335811)
2. Neu J, Valentine C, Meetze W. Scientifically-based strategies for nutrition of the high-risk low birth weight infant. Eur J Pediatr 1990;150:2-13.
3. Atkinson SA. Special nutritional needs of infants for prevention of and recovery from bronchopulmonary dysplasia. J Nutr 2001;131:942SY946S. (Pubitemid 32199175)
4. Poindexter BB, Langer JC, Dusick AM, et al. Early provision of parenteral amino acids in extremely low birth weight infants: Relation to growth and neurodevelopmental outcome. J Pediatr 2006;148:300-305.
5. Innis SM. Essential fatty acid transfer and fetal development. Placenta 2005;26(Suppl A):S70-S75.
6. Clandinin MT, Chappell JE, Leong S, et al. Intrauterine fatty acid accretion rates in human brain: Implications for fatty acid requirements. Early Hum Dev 1980;4:121-129. (Pubitemid 10064580)
7. Henriksen C, Haugholt K, Lindgren M, et al. Improved cognitive development among preterm infants attributable to early supplementation of human milk with docosahexaenoic acid and arachidonic acid. Pediatrics 2008;121:1137-1145.
8. Clandinin MT, Chappell JE, Heim T, et al. Fatty acid utilization in perinatal de novo synthesis of tissues. Early Hum Dev 1981;5:355-366. (Pubitemid 11014498)
9. Mayes C, Burdge GC, Bingham A, et al. Variation in [U-13C] alpha linolenic acid absorption, beta-oxidation and conversion to docosahexaenoic acid in the pre-term infant fed a DHA-enriched formula. Pediatr Res 2006;59:271-275. (Pubitemid 43841001)
10. Lapillonne A, Jensen CL. Reevaluation of the DHA requirement for the premature infant. Prostaglandins Leukot Essent Fatty Acids 2009;81:143-150.
11. Brenna JT, Varamini B, Jensen RG, et al. Docosahexaenoic and arachidonic acid concentrations in human breast milk worldwide. Am J Clin Nutr 2007;85:1457-1464. (Pubitemid 46890412)
12. Valentine CJ, Morrow G, Fernandez S, et al. Docosahexaenoic acid and amino acid contents in pasteurized donor milk are low for preterm infants. J Pediatr 2010;157:906-910.
13. American Academy of Pediatrics. Pediatric Nutrition Handbook, 6th ed. American Academy of Pediatrics, Elk Grove Village, IL, 2009.
14. Makrides M, Neumann MA, Gibson RA. Effect of maternal docosahexaenoic acid (DHA) supplementation on breast milk composition. Eur J Clin Nutr 1996;50:352-357. (Pubitemid 26185978)
15. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959;37:911-917.
16. Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957;226:497-509.
17. Box G, Hunter JS, Hunter W. Statistics for Experiments: An Introduction to Design, Data Analysis and Model Building, 2nd ed. John Wiley & Sons, New York, 2005.
18. Jensen CL, Maude M, Anderson RE, et al. Effect of docosahexaenoic acid supplementation of lactating women on the fatty acid composition of breast milk lipids and maternal and infant plasma phospholipids. Am J Clin Nutr 2000;71(1 Suppl):292SY299S. (Pubitemid 30046130)
19. Cunnane SC, Francescutti V, Brenna JT, et al. Breast-fed infants achieve a higher rate of brain and whole body docosahexaenoate accumulation than formula-fed infants not consuming dietary docosahexaenoate. Lipids 2000;35:105-111. (Pubitemid 30084637)
20. Francois CA, Connor SL, Bolewicz LC, et al. Supplementing lactating women with flaxseed oil does not increase docosahexaenoic acid in their milk. Am J Clin Nutr 2003;77:226-233. (Pubitemid 36015396)
21. Su HM, Bernardo L, Mirmiran M, et al. Dietary 18:3n-3 and 22:6n-3 as sources of 22:6n-3 accretion in neonatal baboon brain and associated organs. Lipids 1999;34(Suppl):S347-S350.
22. Helland IB, Smith L, Saarem K, et al. Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics 2003;111:e39-e44.
23. Makrides M, Gibson RA, McPhee AJ, et al. Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: A randomized controlled trial. JAMA 2010;304:1675-1683.
24. Martin CR, Dasilva DA, Cluette-Brown JE, et al. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. J Pediatr 2011;159:743-749.e1-e2.
25. Holm S. A simple sequentially rejective multiple test procedure. Scand J Stat 1979;6:65-70.