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Volumn 8, Issue 1, 2016, Pages

Epigenetic impact of infection on carcinogenesis: Mechanisms and applications

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; BIM PROTEIN; DEATH ASSOCIATED PROTEIN KINASE; DECITABINE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GLUTATHIONE TRANSFERASE P1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERLEUKIN 1BETA; JANUS KINASE; LATENT MEMBRANE PROTEIN 2; LATENT MEMBRANE PROTEIN 2A; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MICRORNA 124; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P15; PROTEIN P16; PROTEIN P21; PROTEIN P73; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SECRETED FRIZZLED RELATED PROTEIN 1; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR EMX1; TRANSCRIPTION FACTOR NKX6.1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84956728788     PISSN: None     EISSN: 1756994X     Source Type: Journal    
DOI: 10.1186/s13073-016-0267-2     Document Type: Review
Times cited : (108)

References (161)
  • 1
    • 78649489748 scopus 로고    scopus 로고
    • Why do viruses cause cancer? Highlights of the first century of human tumour virology
    • Moore PS, Chang Y. Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer. 2010;10:878-89.
    • (2010) Nat Rev Cancer , vol.10 , pp. 878-889
    • Moore, P.S.1    Chang, Y.2
  • 2
    • 84861648384 scopus 로고    scopus 로고
    • Global burden of cancers attributable to infections in 2008: a review and synthetic analysis
    • de Martel C, Ferlay J, Franceschi S, Vignat J, Bray F, Forman D, et al. Global burden of cancers attributable to infections in 2008: a review and synthetic analysis. Lancet Oncol. 2012;13:607-15.
    • (2012) Lancet Oncol , vol.13 , pp. 607-615
    • Martel, C.1    Ferlay, J.2    Franceschi, S.3    Vignat, J.4    Bray, F.5    Forman, D.6
  • 3
    • 34249303417 scopus 로고    scopus 로고
    • Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
    • Feitelson MA, Lee J. Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett. 2007;252:157-70.
    • (2007) Cancer Lett , vol.252 , pp. 157-170
    • Feitelson, M.A.1    Lee, J.2
  • 4
    • 33745517203 scopus 로고    scopus 로고
    • Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis
    • Kremsdorf D, Soussan P, Paterlini-Brechot P, Brechot C. Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis. Oncogene. 2006;25:3823-33.
    • (2006) Oncogene , vol.25 , pp. 3823-3833
    • Kremsdorf, D.1    Soussan, P.2    Paterlini-Brechot, P.3    Brechot, C.4
  • 5
    • 33745527481 scopus 로고    scopus 로고
    • Viral hepatitis and liver cancer: the case of hepatitis C
    • Levrero M. Viral hepatitis and liver cancer: the case of hepatitis C. Oncogene. 2006;25:3834-47.
    • (2006) Oncogene , vol.25 , pp. 3834-3847
    • Levrero, M.1
  • 6
    • 79955982548 scopus 로고    scopus 로고
    • Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes
    • Saha A, Robertson ES. Epstein-Barr virus-associated B-cell lymphomas: pathogenesis and clinical outcomes. Clin Cancer Res. 2011;17:3056-63.
    • (2011) Clin Cancer Res , vol.17 , pp. 3056-3063
    • Saha, A.1    Robertson, E.S.2
  • 8
    • 56449129788 scopus 로고    scopus 로고
    • Human papillomavirus and molecular considerations for cancer risk
    • Whiteside MA, Siegel EM, Unger ER. Human papillomavirus and molecular considerations for cancer risk. Cancer. 2008;113(10 Suppl):2981-94.
    • (2008) Cancer , vol.113 , Issue.10 , pp. 2981-2994
    • Whiteside, M.A.1    Siegel, E.M.2    Unger, E.R.3
  • 9
    • 72949087815 scopus 로고    scopus 로고
    • Human tumor-associated viruses and new insights into the molecular mechanisms of cancer
    • Martin D, Gutkind JS. Human tumor-associated viruses and new insights into the molecular mechanisms of cancer. Oncogene. 2008;27 Suppl 2:S31-42.
    • (2008) Oncogene , vol.27 , pp. S31-42
    • Martin, D.1    Gutkind, J.S.2
  • 10
    • 84865150120 scopus 로고    scopus 로고
    • MCV and Merkel cell carcinoma: a molecular success story
    • Arora R, Chang Y, Moore PS. MCV and Merkel cell carcinoma: a molecular success story. Curr Opin Virol. 2012;2:489-98.
    • (2012) Curr Opin Virol , vol.2 , pp. 489-498
    • Arora, R.1    Chang, Y.2    Moore, P.S.3
  • 11
    • 39749113080 scopus 로고    scopus 로고
    • Clonal integration of a polyomavirus in human Merkel cell carcinoma
    • Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319:1096-100.
    • (2008) Science , vol.319 , pp. 1096-1100
    • Feng, H.1    Shuda, M.2    Chang, Y.3    Moore, P.S.4
  • 13
    • 0039410919 scopus 로고
    • DNA methylation in adenovirus, adenovirus-transformed cells, and host cells
    • Gunthert U, Schweiger M, Stupp M, Doerfler W. DNA methylation in adenovirus, adenovirus-transformed cells, and host cells. Proc Natl Acad Sci U S A. 1976;73:3923-7.
    • (1976) Proc Natl Acad Sci U S A , vol.73 , pp. 3923-3927
    • Gunthert, U.1    Schweiger, M.2    Stupp, M.3    Doerfler, W.4
  • 14
    • 0015852676 scopus 로고
    • DNA methylation in normal and tumour virus-transformed cells in tissue culture. I. The level of DNA methylation in BHK21 cells and in BHK21 cells transformed by polyoma virus (PyY cells)
    • Rubery ED, Newton AA. DNA methylation in normal and tumour virus-transformed cells in tissue culture. I. The level of DNA methylation in BHK21 cells and in BHK21 cells transformed by polyoma virus (PyY cells). Biochim Biophys Acta. 1973;324:24-36.
    • (1973) Biochim Biophys Acta , vol.324 , pp. 24-36
    • Rubery, E.D.1    Newton, A.A.2
  • 15
    • 0036121312 scopus 로고    scopus 로고
    • Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma
    • Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol. 2002;160:787-94.
    • (2002) Am J Pathol , vol.160 , pp. 787-794
    • Kang, G.H.1    Lee, S.2    Kim, W.H.3    Lee, H.W.4    Kim, J.C.5    Rhyu, M.G.6
  • 16
    • 0141537154 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    • Kang GH, Lee HJ, Hwang KS, Lee S, Kim JH, Kim JS. Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol. 2003;163:1551-6.
    • (2003) Am J Pathol , vol.163 , pp. 1551-1556
    • Kang, G.H.1    Lee, H.J.2    Hwang, K.S.3    Lee, S.4    Kim, J.H.5    Kim, J.S.6
  • 17
    • 32944459562 scopus 로고    scopus 로고
    • High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk
    • Maekita T, Nakazawa K, Mihara M, Nakajima T, Yanaoka K, Iguchi M, et al. High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin Cancer Res. 2006;12:989-95.
    • (2006) Clin Cancer Res , vol.12 , pp. 989-995
    • Maekita, T.1    Nakazawa, K.2    Mihara, M.3    Nakajima, T.4    Yanaoka, K.5    Iguchi, M.6
  • 18
    • 79957485296 scopus 로고    scopus 로고
    • Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome
    • Herceg Z, Paliwal A. Epigenetic mechanisms in hepatocellular carcinoma: how environmental factors influence the epigenome. Mutat Res. 2011;727:55-61.
    • (2011) Mutat Res , vol.727 , pp. 55-61
    • Herceg, Z.1    Paliwal, A.2
  • 19
    • 84863954527 scopus 로고    scopus 로고
    • Epstein-Barr virus infection as an epigenetic driver of tumorigenesis
    • Kaneda A, Matsusaka K, Aburatani H, Fukayama M. Epstein-Barr virus infection as an epigenetic driver of tumorigenesis. Cancer Res. 2012;72:3445-50.
    • (2012) Cancer Res , vol.72 , pp. 3445-3450
    • Kaneda, A.1    Matsusaka, K.2    Aburatani, H.3    Fukayama, M.4
  • 20
    • 84857068434 scopus 로고    scopus 로고
    • Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers
    • Ushijima T, Hattori N. Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers. Clin Cancer Res. 2012;18:923-9.
    • (2012) Clin Cancer Res , vol.18 , pp. 923-929
    • Ushijima, T.1    Hattori, N.2
  • 21
    • 34047190317 scopus 로고    scopus 로고
    • Epigenetic field for cancerization
    • Ushijima T. Epigenetic field for cancerization. J Biochem Mol Biol. 2007;40:142-50.
    • (2007) J Biochem Mol Biol , vol.40 , pp. 142-150
    • Ushijima, T.1
  • 22
    • 84922365908 scopus 로고    scopus 로고
    • Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study
    • Asada K, Nakajima T, Shimazu T, Yamamichi N, Maekita T, Yokoi C, et al. Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study. Gut. 2015;64:388-96.
    • (2015) Gut , vol.64 , pp. 388-396
    • Asada, K.1    Nakajima, T.2    Shimazu, T.3    Yamamichi, N.4    Maekita, T.5    Yokoi, C.6
  • 23
    • 84906969231 scopus 로고    scopus 로고
    • Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes
    • Birdwell CE, Queen KJ, Kilgore PC, Rollyson P, Trutschl M, Cvek U, et al. Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes. J Virol. 2014;88:11442-58.
    • (2014) J Virol , vol.88 , pp. 11442-11458
    • Birdwell, C.E.1    Queen, K.J.2    Kilgore, P.C.3    Rollyson, P.4    Trutschl, M.5    Cvek, U.6
  • 24
    • 84941703212 scopus 로고    scopus 로고
    • Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection
    • Saha A, Jha HC, Upadhyay SK, Robertson ES. Epigenetic silencing of tumor suppressor genes during in vitro Epstein-Barr virus infection. Proc Natl Acad Sci U S A. 2015;112:E5199-207.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , pp. E5199-E5207
    • Saha, A.1    Jha, H.C.2    Upadhyay, S.K.3    Robertson, E.S.4
  • 25
    • 76649145629 scopus 로고    scopus 로고
    • Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells
    • Niwa T, Tsukamoto T, Toyoda T, Mori A, Tanaka H, Maekita T, et al. Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res. 2010;70:1430-40.
    • (2010) Cancer Res , vol.70 , pp. 1430-1440
    • Niwa, T.1    Tsukamoto, T.2    Toyoda, T.3    Mori, A.4    Tanaka, H.5    Maekita, T.6
  • 26
    • 84892759791 scopus 로고    scopus 로고
    • Hepatitis virus infection affects DNA methylation in mice with humanized livers
    • Okamoto Y, Shinjo K, Shimizu Y, Sano T, Yamao K, Gao W, et al. Hepatitis virus infection affects DNA methylation in mice with humanized livers. Gastroenterology. 2014;146:562-72.
    • (2014) Gastroenterology , vol.146 , pp. 562-572
    • Okamoto, Y.1    Shinjo, K.2    Shimizu, Y.3    Sano, T.4    Yamao, K.5    Gao, W.6
  • 27
    • 84870310377 scopus 로고    scopus 로고
    • Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells
    • Takeshima H, Ikegami D, Wakabayashi M, Niwa T, Kim YJ, Ushijima T. Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells. Carcinogenesis. 2012;33:2384-90.
    • (2012) Carcinogenesis , vol.33 , pp. 2384-2390
    • Takeshima, H.1    Ikegami, D.2    Wakabayashi, M.3    Niwa, T.4    Kim, Y.J.5    Ushijima, T.6
  • 28
    • 79952119029 scopus 로고    scopus 로고
    • Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation
    • Hur K, Niwa T, Toyoda T, Tsukamoto T, Tatematsu M, Yang HK, et al. Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation. Carcinogenesis. 2011;32:35-41.
    • (2011) Carcinogenesis , vol.32 , pp. 35-41
    • Hur, K.1    Niwa, T.2    Toyoda, T.3    Tsukamoto, T.4    Tatematsu, M.5    Yang, H.K.6
  • 29
    • 84916218648 scopus 로고    scopus 로고
    • Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer
    • Yoda Y, Takeshima H, Niwa T, Kim JG, Ando T, Kushima R, et al. Integrated analysis of cancer-related pathways affected by genetic and epigenetic alterations in gastric cancer. Gastric Cancer. 2015;18:65-76.
    • (2015) Gastric Cancer , vol.18 , pp. 65-76
    • Yoda, Y.1    Takeshima, H.2    Niwa, T.3    Kim, J.G.4    Ando, T.5    Kushima, R.6
  • 31
    • 78049354889 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric cancer: factors that modulate disease risk
    • Wroblewski LE, Peek Jr RM, Wilson KT. Helicobacter pylori and gastric cancer: factors that modulate disease risk. Clin Microbiol Rev. 2010;23:713-39.
    • (2010) Clin Microbiol Rev , vol.23 , pp. 713-739
    • Wroblewski, L.E.1    Peek, R.M.2    Wilson, K.T.3
  • 32
    • 0027972480 scopus 로고
    • H pylori and gastric cancer
    • Forman D, Webb P, Parsonnet J. H pylori and gastric cancer. Lancet. 1994;343:243-4.
    • (1994) Lancet , vol.343 , pp. 243-244
    • Forman, D.1    Webb, P.2    Parsonnet, J.3
  • 33
    • 0034793043 scopus 로고    scopus 로고
    • Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection
    • Ekstrom AM, Held M, Hansson LE, Engstrand L, Nyren O. Helicobacter pylori in gastric cancer established by CagA immunoblot as a marker of past infection. Gastroenterology. 2001;121:784-91.
    • (2001) Gastroenterology , vol.121 , pp. 784-791
    • Ekstrom, A.M.1    Held, M.2    Hansson, L.E.3    Engstrand, L.4    Nyren, O.5
  • 34
    • 74349106695 scopus 로고    scopus 로고
    • Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition
    • Asaka M, Kato M, Takahashi S, Fukuda Y, Sugiyama T, Ota H, et al. Guidelines for the management of Helicobacter pylori infection in Japan: 2009 revised edition. Helicobacter. 2010;15:1-20.
    • (2010) Helicobacter , vol.15 , pp. 1-20
    • Asaka, M.1    Kato, M.2    Takahashi, S.3    Fukuda, Y.4    Sugiyama, T.5    Ota, H.6
  • 35
    • 84878013732 scopus 로고    scopus 로고
    • Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori
    • Salama NR, Hartung ML, Muller A. Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori. Nat Rev Microbiol. 2013;11:385-99.
    • (2013) Nat Rev Microbiol , vol.11 , pp. 385-399
    • Salama, N.R.1    Hartung, M.L.2    Muller, A.3
  • 37
    • 0037057683 scopus 로고    scopus 로고
    • Helicobacter pylori infection
    • Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med. 2002;347:1175-86.
    • (2002) N Engl J Med , vol.347 , pp. 1175-1186
    • Suerbaum, S.1    Michetti, P.2
  • 38
    • 84955636803 scopus 로고    scopus 로고
    • Prediction of the 10-year probability of gastric cancer occurrence in the Japanese population: the JPHC study cohort II
    • Charvat H, Sasazuki S, Inoue M, Iwasaki M, Sawada N, Shimazu T, et al. Prediction of the 10-year probability of gastric cancer occurrence in the Japanese population: the JPHC study cohort II. Int J Cancer. 2015. doi: 10.1002/ijc.29705.
    • (2015) Int J Cancer
    • Charvat, H.1    Sasazuki, S.2    Inoue, M.3    Iwasaki, M.4    Sawada, N.5    Shimazu, T.6
  • 39
    • 1442310498 scopus 로고    scopus 로고
    • Focus on gastric cancer
    • Ushijima T, Sasako M. Focus on gastric cancer. Cancer Cell. 2004;5:121-5.
    • (2004) Cancer Cell , vol.5 , pp. 121-125
    • Ushijima, T.1    Sasako, M.2
  • 40
    • 84872849322 scopus 로고    scopus 로고
    • Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers
    • Kim JG, Takeshima H, Niwa T, Rehnberg E, Shigematsu Y, Yoda Y, et al. Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett. 2013;330:33-40.
    • (2013) Cancer Lett , vol.330 , pp. 33-40
    • Kim, J.G.1    Takeshima, H.2    Niwa, T.3    Rehnberg, E.4    Shigematsu, Y.5    Yoda, Y.6
  • 41
    • 84901680089 scopus 로고    scopus 로고
    • Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer
    • Wang K, Yuen ST, Xu J, Lee SP, Yan HH, Shi ST, et al. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer. Nat Genet. 2014;46:573-82.
    • (2014) Nat Genet , vol.46 , pp. 573-582
    • Wang, K.1    Yuen, S.T.2    Xu, J.3    Lee, S.P.4    Yan, H.H.5    Shi, S.T.6
  • 42
    • 84907270779 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of gastric adenocarcinoma
    • Cancer Genome Atlas Research Network. Comprehensive molecular characterization of gastric adenocarcinoma. Nature. 2014;513:202-9.
    • (2014) Nature , vol.513 , pp. 202-209
  • 43
    • 0037537477 scopus 로고    scopus 로고
    • Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer
    • Chan AO, Lam SK, Wong BC, Wong WM, Yuen MF, Yeung YH, et al. Promoter methylation of E-cadherin gene in gastric mucosa associated with Helicobacter pylori infection and in gastric cancer. Gut. 2003;52:502-6.
    • (2003) Gut , vol.52 , pp. 502-506
    • Chan, A.O.1    Lam, S.K.2    Wong, B.C.3    Wong, W.M.4    Yuen, M.F.5    Yeung, Y.H.6
  • 44
    • 84876921470 scopus 로고    scopus 로고
    • FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect
    • Asada K, Ando T, Niwa T, Nanjo S, Watanabe N, Okochi-Takada E, et al. FHL1 on chromosome X is a single-hit gastrointestinal tumor-suppressor gene and contributes to the formation of an epigenetic field defect. Oncogene. 2013;32:2140-9.
    • (2013) Oncogene , vol.32 , pp. 2140-2149
    • Asada, K.1    Ando, T.2    Niwa, T.3    Nanjo, S.4    Watanabe, N.5    Okochi-Takada, E.6
  • 45
    • 58149468085 scopus 로고    scopus 로고
    • The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae
    • Nakajima T, Yamashita S, Maekita T, Niwa T, Nakazawa K, Ushijima T. The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae. Int J Cancer. 2009;124:905-10.
    • (2009) Int J Cancer , vol.124 , pp. 905-910
    • Nakajima, T.1    Yamashita, S.2    Maekita, T.3    Niwa, T.4    Nakazawa, K.5    Ushijima, T.6
  • 47
    • 64249160168 scopus 로고    scopus 로고
    • DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect
    • Ando T, Yoshida T, Enomoto S, Asada K, Tatematsu M, Ichinose M, et al. DNA methylation of microRNA genes in gastric mucosae of gastric cancer patients: its possible involvement in the formation of epigenetic field defect. Int J Cancer. 2009;124:2367-74.
    • (2009) Int J Cancer , vol.124 , pp. 2367-2374
    • Ando, T.1    Yoshida, T.2    Enomoto, S.3    Asada, K.4    Tatematsu, M.5    Ichinose, M.6
  • 48
    • 78649787634 scopus 로고    scopus 로고
    • Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect
    • Suzuki H, Yamamoto E, Nojima M, Kai M, Yamano HO, Yoshikawa K, et al. Methylation-associated silencing of microRNA-34b/c in gastric cancer and its involvement in an epigenetic field defect. Carcinogenesis. 2010;31:2066-73.
    • (2010) Carcinogenesis , vol.31 , pp. 2066-2073
    • Suzuki, H.1    Yamamoto, E.2    Nojima, M.3    Kai, M.4    Yamano, H.O.5    Yoshikawa, K.6
  • 49
    • 33845325205 scopus 로고    scopus 로고
    • Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers
    • Nakajima T, Maekita T, Oda I, Gotoda T, Yamamoto S, Umemura S, et al. Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers. Cancer Epidemiol Biomarkers Prev. 2006;15:2317-21.
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 2317-2321
    • Nakajima, T.1    Maekita, T.2    Oda, I.3    Gotoda, T.4    Yamamoto, S.5    Umemura, S.6
  • 50
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin
    • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer. 1953;6:963-8.
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 51
    • 65649154690 scopus 로고    scopus 로고
    • Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells
    • Machado AM, Figueiredo C, Touati E, Maximo V, Sousa S, Michel V, et al. Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. Clin Cancer Res. 2009;15:2995-3002.
    • (2009) Clin Cancer Res , vol.15 , pp. 2995-3002
    • Machado, A.M.1    Figueiredo, C.2    Touati, E.3    Maximo, V.4    Sousa, S.5    Michel, V.6
  • 52
    • 34247185194 scopus 로고    scopus 로고
    • The role of Helicobacter pylori CagA in gastric carcinogenesis
    • Hatakeyama M. The role of Helicobacter pylori CagA in gastric carcinogenesis. Int J Hematol. 2006;84:301-8.
    • (2006) Int J Hematol , vol.84 , pp. 301-308
    • Hatakeyama, M.1
  • 53
    • 34147180434 scopus 로고    scopus 로고
    • Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
    • Matsumoto Y, Marusawa H, Kinoshita K, Endo Y, Kou T, Morisawa T, et al. Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med. 2007;13:470-6.
    • (2007) Nat Med , vol.13 , pp. 470-476
    • Matsumoto, Y.1    Marusawa, H.2    Kinoshita, K.3    Endo, Y.4    Kou, T.5    Morisawa, T.6
  • 54
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek Jr RM, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002;2:28-37.
    • (2002) Nat Rev Cancer , vol.2 , pp. 28-37
    • Peek, R.M.1    Blaser, M.J.2
  • 55
    • 0032524036 scopus 로고    scopus 로고
    • Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil
    • Sugiyama A, Maruta F, Ikeno T, Ishida K, Kawasaki S, Katsuyama T, et al. Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil. Cancer Res. 1998;58:2067-9.
    • (1998) Cancer Res , vol.58 , pp. 2067-2069
    • Sugiyama, A.1    Maruta, F.2    Ikeno, T.3    Ishida, K.4    Kawasaki, S.5    Katsuyama, T.6
  • 56
    • 0033693704 scopus 로고    scopus 로고
    • Increased cell proliferation in chronic Helicobacter pylori positive gastritis and gastric carcinoma--correlation between immuno-histochemistry and Tv image cytometry
    • Szaleczky E, Pronai L, Molnar B, Berczi L, Feher J, Tulassay Z. Increased cell proliferation in chronic Helicobacter pylori positive gastritis and gastric carcinoma--correlation between immuno-histochemistry and Tv image cytometry. Anal Cell Pathol. 2000;20:131-9.
    • (2000) Anal Cell Pathol , vol.20 , pp. 131-139
    • Szaleczky, E.1    Pronai, L.2    Molnar, B.3    Berczi, L.4    Feher, J.5    Tulassay, Z.6
  • 58
    • 0031699639 scopus 로고    scopus 로고
    • Altered expression of membrane inhibitors of complement in human gastric epithelium during Helicobacter-associated gastritis
    • Sasaki M, Joh T, Tada T, Okada N, Yokoyama Y, Itoh M. Altered expression of membrane inhibitors of complement in human gastric epithelium during Helicobacter-associated gastritis. Histopathology. 1998;33:554-60.
    • (1998) Histopathology , vol.33 , pp. 554-560
    • Sasaki, M.1    Joh, T.2    Tada, T.3    Okada, N.4    Yokoyama, Y.5    Itoh, M.6
  • 60
    • 67650706157 scopus 로고    scopus 로고
    • Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race
    • Loh M, Koh KX, Yeo BH, Song CM, Chia KS, Zhu F, et al. Meta-analysis of genetic polymorphisms and gastric cancer risk: variability in associations according to race. Eur J Cancer. 2009;45:2562-8.
    • (2009) Eur J Cancer , vol.45 , pp. 2562-2568
    • Loh, M.1    Koh, K.X.2    Yeo, B.H.3    Song, C.M.4    Chia, K.S.5    Zhu, F.6
  • 61
    • 84883753150 scopus 로고    scopus 로고
    • Interleukin-1beta induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis
    • Shigematsu Y, Niwa T, Rehnberg E, Toyoda T, Yoshida S, Mori A, et al. Interleukin-1beta induced by Helicobacter pylori infection enhances mouse gastric carcinogenesis. Cancer Lett. 2013;340:141-7.
    • (2013) Cancer Lett , vol.340 , pp. 141-147
    • Shigematsu, Y.1    Niwa, T.2    Rehnberg, E.3    Toyoda, T.4    Yoshida, S.5    Mori, A.6
  • 62
    • 34147221687 scopus 로고    scopus 로고
    • Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer
    • Chan AO, Chu KM, Huang C, Lam KF, Leung SY, Sun YW, et al. Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer. Gut. 2007;56:595-7.
    • (2007) Gut , vol.56 , pp. 595-597
    • Chan, A.O.1    Chu, K.M.2    Huang, C.3    Lam, K.F.4    Leung, S.Y.5    Sun, Y.W.6
  • 63
    • 41049086674 scopus 로고    scopus 로고
    • E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines
    • Qian X, Huang C, Cho CH, Hui WM, Rashid A, Chan AO. E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. Cancer Lett. 2008;263:107-13.
    • (2008) Cancer Lett , vol.263 , pp. 107-113
    • Qian, X.1    Huang, C.2    Cho, C.H.3    Hui, W.M.4    Rashid, A.5    Chan, A.O.6
  • 64
    • 0030606284 scopus 로고    scopus 로고
    • Helicobacter pylori extract stimulates inflammatory nitric oxide production
    • Tsuji S, Kawano S, Tsujii M, Takei Y, Tanaka M, Sawaoka H, et al. Helicobacter pylori extract stimulates inflammatory nitric oxide production. Cancer Lett. 1996;108:195-200.
    • (1996) Cancer Lett , vol.108 , pp. 195-200
    • Tsuji, S.1    Kawano, S.2    Tsujii, M.3    Takei, Y.4    Tanaka, M.5    Sawaoka, H.6
  • 65
    • 0033404952 scopus 로고    scopus 로고
    • Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production
    • Hmadcha A, Bedoya FJ, Sobrino F, Pintado E. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production. J Exp Med. 1999;190:1595-604.
    • (1999) J Exp Med , vol.190 , pp. 1595-1604
    • Hmadcha, A.1    Bedoya, F.J.2    Sobrino, F.3    Pintado, E.4
  • 66
    • 77949275834 scopus 로고    scopus 로고
    • Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication
    • Nakajima T, Enomoto S, Yamashita S, Ando T, Nakanishi Y, Nakazawa K, et al. Persistence of a component of DNA methylation in gastric mucosae after Helicobacter pylori eradication. J Gastroenterol. 2010;45:37-44.
    • (2010) J Gastroenterol , vol.45 , pp. 37-44
    • Nakajima, T.1    Enomoto, S.2    Yamashita, S.3    Ando, T.4    Nakanishi, Y.5    Nakazawa, K.6
  • 67
    • 84855968457 scopus 로고    scopus 로고
    • Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction
    • Katsurano M, Niwa T, Yasui Y, Shigematsu Y, Yamashita S, Takeshima H, et al. Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction. Oncogene. 2012;31:342-51.
    • (2012) Oncogene , vol.31 , pp. 342-351
    • Katsurano, M.1    Niwa, T.2    Yasui, Y.3    Shigematsu, Y.4    Yamashita, S.5    Takeshima, H.6
  • 68
    • 49749222804 scopus 로고
    • Virus particles in cultured lymphoblasts from Burkitt's lymphoma
    • Epstein MA, Achong BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet. 1964;1:702-3.
    • (1964) Lancet , vol.1 , pp. 702-703
    • Epstein, M.A.1    Achong, B.G.2    Barr, Y.M.3
  • 69
    • 0028577894 scopus 로고
    • Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein
    • Imai S, Koizumi S, Sugiura M, Tokunaga M, Uemura Y, Yamamoto N, et al. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci U S A. 1994;91:9131-5.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 9131-9135
    • Imai, S.1    Koizumi, S.2    Sugiura, M.3    Tokunaga, M.4    Uemura, Y.5    Yamamoto, N.6
  • 70
    • 0028146198 scopus 로고
    • Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach
    • Fukayama M, Hayashi Y, Iwasaki Y, Chong J, Ooba T, Takizawa T, et al. Epstein-Barr virus-associated gastric carcinoma and Epstein-Barr virus infection of the stomach. Lab Invest. 1994;71:73-81.
    • (1994) Lab Invest , vol.71 , pp. 73-81
    • Fukayama, M.1    Hayashi, Y.2    Iwasaki, Y.3    Chong, J.4    Ooba, T.5    Takizawa, T.6
  • 71
    • 50149086269 scopus 로고    scopus 로고
    • Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms
    • Uozaki H, Fukayama M. Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms. Int J Clin Exp Pathol. 2008;1:198-216.
    • (2008) Int J Clin Exp Pathol , vol.1 , pp. 198-216
    • Uozaki, H.1    Fukayama, M.2
  • 72
    • 33845457109 scopus 로고    scopus 로고
    • p73 gene promoter methylation in Epstein-Barr virus-associated gastric carcinoma
    • Ushiku T, Chong JM, Uozaki H, Hino R, Chang MS, Sudo M, et al. p73 gene promoter methylation in Epstein-Barr virus-associated gastric carcinoma. Int J Cancer. 2007;120:60-6.
    • (2007) Int J Cancer , vol.120 , pp. 60-66
    • Ushiku, T.1    Chong, J.M.2    Uozaki, H.3    Hino, R.4    Chang, M.S.5    Sudo, M.6
  • 74
    • 82655181474 scopus 로고    scopus 로고
    • Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes
    • Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, et al. Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res. 2011;71:7187-97.
    • (2011) Cancer Res , vol.71 , pp. 7187-7197
    • Matsusaka, K.1    Kaneda, A.2    Nagae, G.3    Ushiku, T.4    Kikuchi, Y.5    Hino, R.6
  • 75
    • 22344443201 scopus 로고    scopus 로고
    • Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis
    • Burgos JS. Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis. Med Oncol. 2005;22:113-21.
    • (2005) Med Oncol , vol.22 , pp. 113-121
    • Burgos, J.S.1
  • 76
    • 0035064887 scopus 로고    scopus 로고
    • Molecular diagnosis of Epstein-Barr virus-related diseases
    • Gulley ML. Molecular diagnosis of Epstein-Barr virus-related diseases. J Mol Diagn. 2001;3:1-10.
    • (2001) J Mol Diagn , vol.3 , pp. 1-10
    • Gulley, M.L.1
  • 78
    • 33644875827 scopus 로고    scopus 로고
    • Frequent hypermethylation of RASSF1A and TSLC1, and high viral load of Epstein-Barr virus DNA in nasopharyngeal carcinoma and matched tumor-adjacent tissues
    • Zhou L, Jiang W, Ren C, Yin Z, Feng X, Liu W, et al. Frequent hypermethylation of RASSF1A and TSLC1, and high viral load of Epstein-Barr virus DNA in nasopharyngeal carcinoma and matched tumor-adjacent tissues. Neoplasia. 2005;7:809-15.
    • (2005) Neoplasia , vol.7 , pp. 809-815
    • Zhou, L.1    Jiang, W.2    Ren, C.3    Yin, Z.4    Feng, X.5    Liu, W.6
  • 79
    • 33846941189 scopus 로고    scopus 로고
    • The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation
    • Seng TJ, Low JS, Li H, Cui Y, Goh HK, Wong ML, et al. The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation. Oncogene. 2007;26:934-44.
    • (2007) Oncogene , vol.26 , pp. 934-944
    • Seng, T.J.1    Low, J.S.2    Li, H.3    Cui, Y.4    Goh, H.K.5    Wong, M.L.6
  • 82
    • 84884660293 scopus 로고    scopus 로고
    • EBV-positive diffuse large B-cell lymphoma of the elderly
    • Ok CY, Papathomas TG, Medeiros LJ, Young KH. EBV-positive diffuse large B-cell lymphoma of the elderly. Blood. 2013;122:328-40.
    • (2013) Blood , vol.122 , pp. 328-340
    • Ok, C.Y.1    Papathomas, T.G.2    Medeiros, L.J.3    Young, K.H.4
  • 83
    • 67650899059 scopus 로고    scopus 로고
    • Epstein-Barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim
    • Paschos K, Smith P, Anderton E, Middeldorp JM, White RE, Allday MJ. Epstein-Barr virus latency in B cells leads to epigenetic repression and CpG methylation of the tumour suppressor gene Bim. PLoS Pathog. 2009;5:e1000492.
    • (2009) PLoS Pathog , vol.5
    • Paschos, K.1    Smith, P.2    Anderton, E.3    Middeldorp, J.M.4    White, R.E.5    Allday, M.J.6
  • 84
    • 84927948951 scopus 로고    scopus 로고
    • Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma
    • Zhang T, Ma J, Nie K, Yan J, Liu Y, Bacchi CE, et al. Hypermethylation of the tumor suppressor gene PRDM1/Blimp-1 supports a pathogenetic role in EBV-positive Burkitt lymphoma. Blood Cancer J. 2014;4:e261.
    • (2014) Blood Cancer J , vol.4
    • Zhang, T.1    Ma, J.2    Nie, K.3    Yan, J.4    Liu, Y.5    Bacchi, C.E.6
  • 85
    • 84893711405 scopus 로고    scopus 로고
    • Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization
    • Hansen KD, Sabunciyan S, Langmead B, Nagy N, Curley R, Klein G, et al. Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. Genome Res. 2014;24:177-84.
    • (2014) Genome Res , vol.24 , pp. 177-184
    • Hansen, K.D.1    Sabunciyan, S.2    Langmead, B.3    Nagy, N.4    Curley, R.5    Klein, G.6
  • 86
    • 0037162536 scopus 로고    scopus 로고
    • The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases
    • Tsai CN, Tsai CL, Tse KP, Chang HY, Chang YS. The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc Natl Acad Sci U S A. 2002;99:10084-9.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10084- 10089
    • Tsai, C.N.1    Tsai, C.L.2    Tse, K.P.3    Chang, H.Y.4    Chang, Y.S.5
  • 87
    • 33846227472 scopus 로고    scopus 로고
    • Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH-terminal kinase signaling
    • Tsai CL, Li HP, Lu YJ, Hsueh C, Liang Y, Chen CL, et al. Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH-terminal kinase signaling. Cancer Res. 2006;66:11668-76.
    • (2006) Cancer Res , vol.66 , pp. 11668-11676
    • Tsai, C.L.1    Li, H.P.2    Lu, Y.J.3    Hsueh, C.4    Liang, Y.5    Chen, C.L.6
  • 88
    • 66149101689 scopus 로고    scopus 로고
    • Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma
    • Hino R, Uozaki H, Murakami N, Ushiku T, Shinozaki A, Ishikawa S, et al. Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma. Cancer Res. 2009;69:2766-74.
    • (2009) Cancer Res , vol.69 , pp. 2766-2774
    • Hino, R.1    Uozaki, H.2    Murakami, N.3    Ushiku, T.4    Shinozaki, A.5    Ishikawa, S.6
  • 89
    • 80052476882 scopus 로고    scopus 로고
    • Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma
    • Leonard S, Wei W, Anderton J, Vockerodt M, Rowe M, Murray PG, et al. Epigenetic and transcriptional changes which follow Epstein-Barr virus infection of germinal center B cells and their relevance to the pathogenesis of Hodgkin's lymphoma. J Virol. 2011;85:9568-77.
    • (2011) J Virol , vol.85 , pp. 9568-9577
    • Leonard, S.1    Wei, W.2    Anderton, J.3    Vockerodt, M.4    Rowe, M.5    Murray, P.G.6
  • 90
    • 77951622187 scopus 로고    scopus 로고
    • Viral hepatocarcinogenesis
    • Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene. 2010;29:2309-24.
    • (2010) Oncogene , vol.29 , pp. 2309-2324
    • Tsai, W.L.1    Chung, R.T.2
  • 91
    • 33645214725 scopus 로고    scopus 로고
    • Review of genetic and epigenetic alterations in hepatocarcinogenesis
    • Herath NI, Leggett BA, MacDonald GA. Review of genetic and epigenetic alterations in hepatocarcinogenesis. J Gastroenterol Hepatol. 2006;21:15-21.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 15-21
    • Herath, N.I.1    Leggett, B.A.2    MacDonald, G.A.3
  • 92
    • 0037663314 scopus 로고    scopus 로고
    • Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene
    • Paterlini-Brechot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, et al. Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene. Oncogene. 2003;22:3911-6.
    • (2003) Oncogene , vol.22 , pp. 3911-3916
    • Paterlini-Brechot, P.1    Saigo, K.2    Murakami, Y.3    Chami, M.4    Gozuacik, D.5    Mugnier, C.6
  • 93
    • 84862976633 scopus 로고    scopus 로고
    • Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators
    • Fujimoto A, Totoki Y, Abe T, Boroevich KA, Hosoda F, Nguyen HH, et al. Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators. Nat Genet. 2012;44:760-4.
    • (2012) Nat Genet , vol.44 , pp. 760-764
    • Fujimoto, A.1    Totoki, Y.2    Abe, T.3    Boroevich, K.A.4    Hosoda, F.5    Nguyen, H.H.6
  • 94
    • 84887607042 scopus 로고    scopus 로고
    • Comprehensive genome sequencing of the liver cancer genome
    • Nakagawa H, Shibata T. Comprehensive genome sequencing of the liver cancer genome. Cancer Lett. 2013;340:234-40.
    • (2013) Cancer Lett , vol.340 , pp. 234-240
    • Nakagawa, H.1    Shibata, T.2
  • 95
  • 96
    • 84885060120 scopus 로고    scopus 로고
    • Emerging concepts in immunity to hepatitis C virus infection
    • Rosen HR. Emerging concepts in immunity to hepatitis C virus infection. J Clin Invest. 2013;123:4121-30.
    • (2013) J Clin Invest , vol.123 , pp. 4121-4130
    • Rosen, H.R.1
  • 97
    • 0033765496 scopus 로고    scopus 로고
    • Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma
    • Kondo Y, Kanai Y, Sakamoto M, Mizokami M, Ueda R, Hirohashi S. Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis--A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma. Hepatology. 2000;32:970-9.
    • (2000) Hepatology , vol.32 , pp. 970-979
    • Kondo, Y.1    Kanai, Y.2    Sakamoto, M.3    Mizokami, M.4    Ueda, R.5    Hirohashi, S.6
  • 98
    • 79952705527 scopus 로고    scopus 로고
    • Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake
    • Lambert MP, Paliwal A, Vaissiere T, Chemin I, Zoulim F, Tommasino M, et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol. 2011;54:705-15.
    • (2011) J Hepatol , vol.54 , pp. 705-715
    • Lambert, M.P.1    Paliwal, A.2    Vaissiere, T.3    Chemin, I.4    Zoulim, F.5    Tommasino, M.6
  • 99
    • 79956081820 scopus 로고    scopus 로고
    • Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis
    • Gao P, Wong CC, Tung EK, Lee JM, Wong CM, Ng IO. Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis. J Hepatol. 2011;54:1177-84.
    • (2011) J Hepatol , vol.54 , pp. 1177-1184
    • Gao, P.1    Wong, C.C.2    Tung, E.K.3    Lee, J.M.4    Wong, C.M.5    Ng, I.O.6
  • 102
    • 33845303143 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma
    • Yuan Y, Wang J, Li J, Wang L, Li M, Yang Z, et al. Frequent epigenetic inactivation of spleen tyrosine kinase gene in human hepatocellular carcinoma. Clin Cancer Res. 2006;12:6687-95.
    • (2006) Clin Cancer Res , vol.12 , pp. 6687-6695
    • Yuan, Y.1    Wang, J.2    Li, J.3    Wang, L.4    Li, M.5    Yang, Z.6
  • 103
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology. 2008;47:908-18.
    • (2008) Hepatology , vol.47 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 105
    • 84910054193 scopus 로고    scopus 로고
    • Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis
    • Hlady RA, Tiedemann RL, Puszyk W, Zendejas I, Roberts LR, Choi JH, et al. Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis. Oncotarget. 2014;5:9425-43.
    • (2014) Oncotarget , vol.5 , pp. 9425-9443
    • Hlady, R.A.1    Tiedemann, R.L.2    Puszyk, W.3    Zendejas, I.4    Roberts, L.R.5    Choi, J.H.6
  • 106
    • 34848881905 scopus 로고    scopus 로고
    • Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
    • Calvisi DF, Ladu S, Gorden A, Farina M, Lee JS, Conner EA, et al. Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest. 2007;117:2713-22.
    • (2007) J Clin Invest , vol.117 , pp. 2713-2722
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3    Farina, M.4    Lee, J.S.5    Conner, E.A.6
  • 107
    • 58149310908 scopus 로고    scopus 로고
    • Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A
    • Zheng DL, Zhang L, Cheng N, Xu X, Deng Q, Teng XM, et al. Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A. J Hepatol. 2009;50:377-87.
    • (2009) J Hepatol , vol.50 , pp. 377-387
    • Zheng, D.L.1    Zhang, L.2    Cheng, N.3    Xu, X.4    Deng, Q.5    Teng, X.M.6
  • 108
    • 70449105202 scopus 로고    scopus 로고
    • Human papilloma viruses and cancer in the post-vaccine era
    • Galani E, Christodoulou C. Human papilloma viruses and cancer in the post-vaccine era. Clin Microbiol Infect. 2009;15:977-81.
    • (2009) Clin Microbiol Infect , vol.15 , pp. 977-981
    • Galani, E.1    Christodoulou, C.2
  • 109
    • 84896739532 scopus 로고    scopus 로고
    • Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial
    • Verhoef VM, Bosgraaf RP, van Kemenade FJ, Rozendaal L, Heideman DA, Hesselink AT, et al. Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial. Lancet Oncol. 2014;15:315-22.
    • (2014) Lancet Oncol , vol.15 , pp. 315-322
    • Verhoef, V.M.1    Bosgraaf, R.P.2    Kemenade, F.J.3    Rozendaal, L.4    Heideman, D.A.5    Hesselink, A.T.6
  • 110
    • 72549102589 scopus 로고    scopus 로고
    • Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications
    • Chung CH, Gillison ML. Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res. 2009;15:6758-62.
    • (2009) Clin Cancer Res , vol.15 , pp. 6758-6762
    • Chung, C.H.1    Gillison, M.L.2
  • 112
    • 0037421589 scopus 로고    scopus 로고
    • Epidemiologic classification of human papillomavirus types associated with cervical cancer
    • Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med. 2003;348:518-27.
    • (2003) N Engl J Med , vol.348 , pp. 518-527
    • Munoz, N.1    Bosch, F.X.2    Sanjose, S.3    Herrero, R.4    Castellsague, X.5    Shah, K.V.6
  • 114
    • 33748365200 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa
    • Kato K, Hara A, Kuno T, Mori H, Yamashita T, Toida M, et al. Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. J Cancer Res Clin Oncol. 2006;132:735-43.
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 735-743
    • Kato, K.1    Hara, A.2    Kuno, T.3    Mori, H.4    Yamashita, T.5    Toida, M.6
  • 115
    • 33344455657 scopus 로고    scopus 로고
    • Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing
    • Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, et al. Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing. Br J Cancer. 2006;94:561-8.
    • (2006) Br J Cancer , vol.94 , pp. 561-568
    • Shaw, R.J.1    Liloglou, T.2    Rogers, S.N.3    Brown, J.S.4    Vaughan, E.D.5    Lowe, D.6
  • 116
    • 84872844803 scopus 로고    scopus 로고
    • Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    • Colacino JA, Dolinoy DC, Duffy SA, Sartor MA, Chepeha DB, Bradford CR, et al. Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics. PLoS One. 2013;8:e54742.
    • (2013) PLoS One , vol.8
    • Colacino, J.A.1    Dolinoy, D.C.2    Duffy, S.A.3    Sartor, M.A.4    Chepeha, D.B.5    Bradford, C.R.6
  • 117
    • 84873939792 scopus 로고    scopus 로고
    • Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma
    • Lechner M, Fenton T, West J, Wilson G, Feber A, Henderson S, et al. Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma. Genome Med. 2013;5:15.
    • (2013) Genome Med , vol.5 , pp. 15
    • Lechner, M.1    Fenton, T.2    West, J.3    Wilson, G.4    Feber, A.5    Henderson, S.6
  • 118
    • 79958725682 scopus 로고    scopus 로고
    • Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis
    • Sartor MA, Dolinoy DC, Jones TR, Colacino JA, Prince ME, Carey TE, et al. Genome-wide methylation and expression differences in HPV(+) and HPV(-) squamous cell carcinoma cell lines are consistent with divergent mechanisms of carcinogenesis. Epigenetics. 2011;6:777-87.
    • (2011) Epigenetics , vol.6 , pp. 777-787
    • Sartor, M.A.1    Dolinoy, D.C.2    Jones, T.R.3    Colacino, J.A.4    Prince, M.E.5    Carey, T.E.6
  • 119
    • 62849122233 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability
    • Richards KL, Zhang B, Baggerly KA, Colella S, Lang JC, Schuller DE, et al. Genome-wide hypomethylation in head and neck cancer is more pronounced in HPV-negative tumors and is associated with genomic instability. PLoS One. 2009;4:e4941.
    • (2009) PLoS One , vol.4
    • Richards, K.L.1    Zhang, B.2    Baggerly, K.A.3    Colella, S.4    Lang, J.C.5    Schuller, D.E.6
  • 121
    • 2542429289 scopus 로고    scopus 로고
    • Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors
    • Widschwendter A, Gattringer C, Ivarsson L, Fiegl H, Schneitter A, Ramoni A, et al. Analysis of aberrant DNA methylation and human papillomavirus DNA in cervicovaginal specimens to detect invasive cervical cancer and its precursors. Clin Cancer Res. 2004;10:3396-400.
    • (2004) Clin Cancer Res , vol.10 , pp. 3396-3400
    • Widschwendter, A.1    Gattringer, C.2    Ivarsson, L.3    Fiegl, H.4    Schneitter, A.5    Ramoni, A.6
  • 122
    • 70350443290 scopus 로고    scopus 로고
    • Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis
    • Overmeer RM, Henken FE, Bierkens M, Wilting SM, Timmerman I, Meijer CJ, et al. Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis. J Pathol. 2009;219:327-36.
    • (2009) J Pathol , vol.219 , pp. 327-336
    • Overmeer, R.M.1    Henken, F.E.2    Bierkens, M.3    Wilting, S.M.4    Timmerman, I.5    Meijer, C.J.6
  • 124
    • 49449087807 scopus 로고    scopus 로고
    • Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC
    • Overmeer RM, Henken FE, Snijders PJ, Claassen-Kramer D, Berkhof J, Helmerhorst TJ, et al. Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC. J Pathol. 2008;215:388-97.
    • (2008) J Pathol , vol.215 , pp. 388-397
    • Overmeer, R.M.1    Henken, F.E.2    Snijders, P.J.3    Claassen-Kramer, D.4    Berkhof, J.5    Helmerhorst, T.J.6
  • 125
    • 77957339798 scopus 로고    scopus 로고
    • Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse
    • Lai HC, Lin YW, Huang RL, Chung MT, Wang HC, Liao YP, et al. Quantitative DNA methylation analysis detects cervical intraepithelial neoplasms type 3 and worse. Cancer. 2010;116:4266-74.
    • (2010) Cancer , vol.116 , pp. 4266-4274
    • Lai, H.C.1    Lin, Y.W.2    Huang, R.L.3    Chung, M.T.4    Wang, H.C.5    Liao, Y.P.6
  • 126
    • 0034665332 scopus 로고    scopus 로고
    • Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma
    • Eads CA, Lord RV, Kurumboor SK, Wickramasinghe K, Skinner ML, Long TI, et al. Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma. Cancer Res. 2000;60:5021-6.
    • (2000) Cancer Res , vol.60 , pp. 5021-5026
    • Eads, C.A.1    Lord, R.V.2    Kurumboor, S.K.3    Wickramasinghe, K.4    Skinner, M.L.5    Long, T.I.6
  • 127
    • 33845333815 scopus 로고    scopus 로고
    • Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue
    • Yan PS, Venkataramu C, Ibrahim A, Liu JC, Shen RZ, Diaz NM, et al. Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin Cancer Res. 2006;12:6626-36.
    • (2006) Clin Cancer Res , vol.12 , pp. 6626-6636
    • Yan, P.S.1    Venkataramu, C.2    Ibrahim, A.3    Liu, J.C.4    Shen, R.Z.5    Diaz, N.M.6
  • 128
    • 84875641446 scopus 로고    scopus 로고
    • Methylation profiling defines an extensive field defect in histologically normal prostate tissues associated with prostate cancer
    • Yang B, Bhusari S, Kueck J, Weeratunga P, Wagner J, Leverson G, et al. Methylation profiling defines an extensive field defect in histologically normal prostate tissues associated with prostate cancer. Neoplasia. 2013;15:399-408.
    • (2013) Neoplasia , vol.15 , pp. 399-408
    • Yang, B.1    Bhusari, S.2    Kueck, J.3    Weeratunga, P.4    Wagner, J.5    Leverson, G.6
  • 129
    • 84929161026 scopus 로고    scopus 로고
    • Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome
    • Yamanoi K, Arai E, Tian Y, Takahashi Y, Miyata S, Sasaki H, et al. Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome. Carcinogenesis. 2015;36:509-20.
    • (2015) Carcinogenesis , vol.36 , pp. 509-520
    • Yamanoi, K.1    Arai, E.2    Tian, Y.3    Takahashi, Y.4    Miyata, S.5    Sasaki, H.6
  • 130
    • 84866173068 scopus 로고    scopus 로고
    • Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection
    • Nanjo S, Asada K, Yamashita S, Nakajima T, Nakazawa K, Maekita T, et al. Identification of gastric cancer risk markers that are informative in individuals with past H. pylori infection. Gastric Cancer. 2012;15:382-8.
    • (2012) Gastric Cancer , vol.15 , pp. 382-388
    • Nanjo, S.1    Asada, K.2    Yamashita, S.3    Nakajima, T.4    Nakazawa, K.5    Maekita, T.6
  • 131
    • 84925352632 scopus 로고    scopus 로고
    • IGSF4 methylation as an independent marker of human papillomavirus-positive oropharyngeal squamous cell carcinoma
    • Chen KM, Stephen JK, Havard S, Mahan M, Divine G, Worsham MJ. IGSF4 methylation as an independent marker of human papillomavirus-positive oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. 2015;141:257-63.
    • (2015) JAMA Otolaryngol Head Neck Surg , vol.141 , pp. 257-263
    • Chen, K.M.1    Stephen, J.K.2    Havard, S.3    Mahan, M.4    Divine, G.5    Worsham, M.J.6
  • 132
    • 84939793486 scopus 로고    scopus 로고
    • Detection of nasopharyngeal carcinoma in Morocco (North Africa) using a multiplex methylation-specific PCR biomarker assay
    • Nawaz I, Moumad K, Martorelli D, Ennaji MM, Zhou X, Zhang Z, et al. Detection of nasopharyngeal carcinoma in Morocco (North Africa) using a multiplex methylation-specific PCR biomarker assay. Clin Epigenetics. 2015;7:89.
    • (2015) Clin Epigenetics , vol.7 , pp. 89
    • Nawaz, I.1    Moumad, K.2    Martorelli, D.3    Ennaji, M.M.4    Zhou, X.5    Zhang, Z.6
  • 133
    • 84877095575 scopus 로고    scopus 로고
    • Clinical correlates of promoter hypermethylation of four target genes in head and neck cancer: a cooperative group correlative study
    • Roh JL, Wang XV, Manola J, Sidransky D, Forastiere AA, Koch WM. Clinical correlates of promoter hypermethylation of four target genes in head and neck cancer: a cooperative group correlative study. Clin Cancer Res. 2013;19:2528-40.
    • (2013) Clin Cancer Res , vol.19 , pp. 2528-2540
    • Roh, J.L.1    Wang, X.V.2    Manola, J.3    Sidransky, D.4    Forastiere, A.A.5    Koch, W.M.6
  • 134
    • 84896990832 scopus 로고    scopus 로고
    • Cancer diagnostic classifiers based on quantitative DNA methylation
    • Lorincz AT. Cancer diagnostic classifiers based on quantitative DNA methylation. Expert Rev Mol Diagn. 2014;14:293-305.
    • (2014) Expert Rev Mol Diagn , vol.14 , pp. 293-305
    • Lorincz, A.T.1
  • 135
    • 84908003764 scopus 로고    scopus 로고
    • Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions - a Taiwanese Gynecologic Oncology Group (TGOG) study
    • Lin H, Chen TC, Chang TC, Cheng YM, Chen CH, Chu TY, et al. Methylated ZNF582 gene as a marker for triage of women with Pap smear reporting low-grade squamous intraepithelial lesions - a Taiwanese Gynecologic Oncology Group (TGOG) study. Gynecol Oncol. 2014;135:64-8.
    • (2014) Gynecol Oncol , vol.135 , pp. 64-68
    • Lin, H.1    Chen, T.C.2    Chang, T.C.3    Cheng, Y.M.4    Chen, C.H.5    Chu, T.Y.6
  • 136
    • 84961291208 scopus 로고    scopus 로고
    • Methylation of viral and host genes and severity of cervical lesions associated with human papillomavirus type 16
    • Louvanto K, Franco EL, Ramanakumar AV, Vasiljevic N, Scibior-Bentkowska D, Koushik A, et al. Methylation of viral and host genes and severity of cervical lesions associated with human papillomavirus type 16. Int J Cancer. 2015;136:E638-45.
    • (2015) Int J Cancer , vol.136 , pp. E638-E645
    • Louvanto, K.1    Franco, E.L.2    Ramanakumar, A.V.3    Vasiljevic, N.4    Scibior-Bentkowska, D.5    Koushik, A.6
  • 137
    • 84954397254 scopus 로고    scopus 로고
    • Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)
    • Luttmer R, De Strooper LM, Berkhof J, Snijders PJ, Dijkstra MG, Uijterwaal MH, et al. Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study). Int J Cancer. 2015. doi: 10.1002/ijc.29824.
    • (2015) Int J Cancer
    • Luttmer, R.1    De Strooper, L.M.2    Berkhof, J.3    Snijders, P.J.4    Dijkstra, M.G.5    Uijterwaal, M.H.6
  • 139
    • 1842583637 scopus 로고    scopus 로고
    • Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma
    • Wong TS, Kwong DL, Sham JS, Wei WI, Kwong YL, Yuen AP. Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma. Clin Cancer Res. 2004;10:2401-6.
    • (2004) Clin Cancer Res , vol.10 , pp. 2401-2406
    • Wong, T.S.1    Kwong, D.L.2    Sham, J.S.3    Wei, W.I.4    Kwong, Y.L.5    Yuen, A.P.6
  • 140
    • 0036494563 scopus 로고    scopus 로고
    • Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic mice
    • Eads CA, Nickel AE, Laird PW. Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic mice. Cancer Res. 2002;62:1296-9.
    • (2002) Cancer Res , vol.62 , pp. 1296-1299
    • Eads, C.A.1    Nickel, A.E.2    Laird, P.W.3
  • 141
    • 84941633771 scopus 로고    scopus 로고
    • Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation
    • Hatano Y, Semi K, Hashimoto K, Lee MS, Hirata A, Tomita H, et al. Reducing DNA methylation suppresses colon carcinogenesis by inducing tumor cell differentiation. Carcinogenesis. 2015;36:719-29.
    • (2015) Carcinogenesis , vol.36 , pp. 719-729
    • Hatano, Y.1    Semi, K.2    Hashimoto, K.3    Lee, M.S.4    Hirata, A.5    Tomita, H.6
  • 144
    • 84886924910 scopus 로고    scopus 로고
    • Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas
    • Peters SL, Hlady RA, Opavska J, Klinkebiel D, Novakova S, Smith LM, et al. Essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas. Mol Cell Biol. 2013;33:4321-33.
    • (2013) Mol Cell Biol , vol.33 , pp. 4321-4333
    • Peters, S.L.1    Hlady, R.A.2    Opavska, J.3    Klinkebiel, D.4    Novakova, S.5    Smith, L.M.6
  • 145
    • 84863176405 scopus 로고    scopus 로고
    • Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains
    • Trowbridge JJ, Sinha AU, Zhu N, Li M, Armstrong SA, Orkin SH. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains. Genes Dev. 2012;26:344-9.
    • (2012) Genes Dev , vol.26 , pp. 344-349
    • Trowbridge, J.J.1    Sinha, A.U.2    Zhu, N.3    Li, M.4    Armstrong, S.A.5    Orkin, S.H.6
  • 146
    • 67449100703 scopus 로고    scopus 로고
    • Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus
    • Baba S, Yamada Y, Hatano Y, Miyazaki Y, Mori H, Shibata T, et al. Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus. Cancer Sci. 2009;100:1186-91.
    • (2009) Cancer Sci , vol.100 , pp. 1186-1191
    • Baba, S.1    Yamada, Y.2    Hatano, Y.3    Miyazaki, Y.4    Mori, H.5    Shibata, T.6
  • 147
    • 61549106628 scopus 로고    scopus 로고
    • Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice
    • Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, et al. Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila). 2008;1:233-40.
    • (2008) Cancer Prev Res (Phila) , vol.1 , pp. 233-240
    • Yoo, C.B.1    Chuang, J.C.2    Byun, H.M.3    Egger, G.4    Yang, A.S.5    Dubeau, L.6
  • 148
    • 31544458225 scopus 로고    scopus 로고
    • Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer
    • McCabe MT, Low JA, Daignault S, Imperiale MJ, Wojno KJ, Day ML. Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer. Cancer Res. 2006;66:385-92.
    • (2006) Cancer Res , vol.66 , pp. 385-392
    • McCabe, M.T.1    Low, J.A.2    Daignault, S.3    Imperiale, M.J.4    Wojno, K.J.5    Day, M.L.6
  • 149
    • 34247506661 scopus 로고    scopus 로고
    • 5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer
    • Zorn CS, Wojno KJ, McCabe MT, Kuefer R, Gschwend JE, Day ML. 5-aza-2'-deoxycytidine delays androgen-independent disease and improves survival in the transgenic adenocarcinoma of the mouse prostate mouse model of prostate cancer. Clin Cancer Res. 2007;13:2136-43.
    • (2007) Clin Cancer Res , vol.13 , pp. 2136-2143
    • Zorn, C.S.1    Wojno, K.J.2    McCabe, M.T.3    Kuefer, R.4    Gschwend, J.E.5    Day, M.L.6
  • 150
    • 84863130872 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer
    • Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, et al. DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Mol Cancer Ther. 2012;11:370-82.
    • (2012) Mol Cancer Ther , vol.11 , pp. 370-382
    • Chen, M.1    Shabashvili, D.2    Nawab, A.3    Yang, S.X.4    Dyer, L.M.5    Brown, K.D.6
  • 151
  • 152
    • 65349152488 scopus 로고    scopus 로고
    • Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement
    • Cuzick J, Otto F, Baron JA, Brown PH, Burn J, Greenwald P, et al. Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement. Lancet Oncol. 2009;10:501-7.
    • (2009) Lancet Oncol , vol.10 , pp. 501-507
    • Cuzick, J.1    Otto, F.2    Baron, J.A.3    Brown, P.H.4    Burn, J.5    Greenwald, P.6
  • 153
    • 0031985225 scopus 로고    scopus 로고
    • Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis
    • Barnes CJ, Cameron IL, Hardman WE, Lee M. Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis. Br J Cancer. 1998;77:573-80.
    • (1998) Br J Cancer , vol.77 , pp. 573-580
    • Barnes, C.J.1    Cameron, I.L.2    Hardman, W.E.3    Lee, M.4
  • 154
    • 0032938016 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection
    • Tseng GY, Lin HJ, Lin HY, Perng CL, Lee FY, Lo WC, et al. Effect of non-steroidal anti-inflammatory drugs on gastric and duodenal prostaglandin concentrations in patients with Helicobacter pylori infection. Hepatogastroenterology. 1999;46:1000-4.
    • (1999) Hepatogastroenterology , vol.46 , pp. 1000-1004
    • Tseng, G.Y.1    Lin, H.J.2    Lin, H.Y.3    Perng, C.L.4    Lee, F.Y.5    Lo, W.C.6
  • 155
    • 84912072883 scopus 로고    scopus 로고
    • Development and classes of epigenetic drugs for cancer
    • Dhanak D, Jackson P. Development and classes of epigenetic drugs for cancer. Biochem Biophys Res Commun. 2014;455:58-69.
    • (2014) Biochem Biophys Res Commun , vol.455 , pp. 58-69
    • Dhanak, D.1    Jackson, P.2
  • 156
    • 84912080765 scopus 로고    scopus 로고
    • Compendium of aberrant DNA methylation and histone modifications in cancer
    • Hattori N, Ushijima T. Compendium of aberrant DNA methylation and histone modifications in cancer. Biochem Biophys Res Commun. 2014;455:3-9.
    • (2014) Biochem Biophys Res Commun , vol.455 , pp. 3-9
    • Hattori, N.1    Ushijima, T.2
  • 157
    • 40949157661 scopus 로고    scopus 로고
    • Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome
    • Cheng AS, Culhane AC, Chan MW, Venkataramu CR, Ehrich M, Nasir A, et al. Epithelial progeny of estrogen-exposed breast progenitor cells display a cancer-like methylome. Cancer Res. 2008;68:1786-96.
    • (2008) Cancer Res , vol.68 , pp. 1786-1796
    • Cheng, A.S.1    Culhane, A.C.2    Chan, M.W.3    Venkataramu, C.R.4    Ehrich, M.5    Nasir, A.6
  • 160
    • 84877574817 scopus 로고    scopus 로고
    • The future of epigenetic therapy in solid tumours--lessons from the past
    • Azad N, Zahnow CA, Rudin CM, Baylin SB. The future of epigenetic therapy in solid tumours--lessons from the past. Nat Rev Clin Oncol. 2013;10:256-66.
    • (2013) Nat Rev Clin Oncol , vol.10 , pp. 256-266
    • Azad, N.1    Zahnow, C.A.2    Rudin, C.M.3    Baylin, S.B.4
  • 161
    • 70349971704 scopus 로고    scopus 로고
    • Frequent occurrence of RASSF1A promoter hypermethylation and Merkel cell polyomavirus in Merkel cell carcinoma
    • Helmbold P, Lahtz C, Enk A, Herrmann-Trost P, Marsch W, Kutzner H, et al. Frequent occurrence of RASSF1A promoter hypermethylation and Merkel cell polyomavirus in Merkel cell carcinoma. Mol Carcinog. 2009;48:903-9.
    • (2009) Mol Carcinog , vol.48 , pp. 903-909
    • Helmbold, P.1    Lahtz, C.2    Enk, A.3    Herrmann-Trost, P.4    Marsch, W.5    Kutzner, H.6


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