Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer

Cancer Research

Volumn 66, Issue 1, 2006, Pages 385-392

  McCabe, Michael T ^a,b   Low, Jonathan A ^a   Daignault, Stephanie ^a   Imperiale, Michael J ^a,b   Wojno, Kirk J ^a   Day, Mark L ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE INHIBITOR; GENE PRODUCT; MESSENGER RNA; PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F1; VIRUS LARGE T ANTIGEN;

ADVANCED CANCER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BK VIRUS; CARCINOGENESIS; CARCINOMA IN SITU; CONTROLLED STUDY; DNA METHYLATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYMPH NODE METASTASIS; MALE; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROTEIN EXPRESSION; SIMIAN VIRUS 40; SURVIVAL TIME; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE; VIRUS ONCOGENE;

ANIMALS; ANTIGENS, VIRAL, TUMOR; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CELL GROWTH PROCESSES; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION; HUMANS; MALE; MICE; MICE, INBRED C57BL; PROSTATE; PROSTATIC NEOPLASMS; TRANSGENES;

EID: 31544458225     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-2020     Document Type: Article

References (49)

1. Lee WH, Morton RA, Epstein JI, et al. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis. Proc Natl Acad Sci U S A 1994; 91:11733-7.
2. Zhu X Leav I, Leung YK, et al. Dynamic regulation of estrogen receptor-β expression by DNA methylation during prostate cancer development and metastasis. Am J Pathol 2004;164:2003-12.
3. Kuzmin I, Gillespie JW, Protopopov A, et al. The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells. Cancer Res 2002;62:3498-502.
4. Bastian PJ, Yegnasubramanian S, Palapattu GS, et al. Molecular biomarker in prostate cancer: the role of CpG island hypermethylation. Eur Urol 2004;46:698-708.
5. Patra SK, Patra A, Zhao H, Dahiya R. DNA methyltransferase and demethylase in human prostate cancer. Mol Carcinog 2002;33:163-71.
6. Fang JY, Cheng ZH, Chen YX, et al. Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer. World J Gastroenterol 2004;10:3394-8.
7. Mizuno S, Chijiwa T, Okamura T, et al. Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia. Blood 2001;97:1172-9.
8. Robertson KD, Uzvolgyi E, Liang G, et al. The human DNA methyltransferases (DNMTs) 1, 3a and 3b:coordinate mRNA expression in normal tissues and overexpression in tumors. Nucleic Acids Res 1999;27: 2291-8.
9. Biniszkiewicz D, Gribnau J, Ramsahoye B, et al. Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality. Mol Cell Biol 2002;22:2124-35.
10. Wu J, Issa JP, Herman J, Bassett DE, Jr., Nelkin BD, Baylin SB. Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells. Proc Natl Acad Sci U S A 1993;90:8891-5.
11. Vertino PM, Yen RW, Gao J, Baylin SB. De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)- methyltransferase. Mol Cell Biol 1996;16:4555-65.
12. Bakin AV, Curran T. Role of DNA 5-methylcytosine transferase in cell transformation by fos. Science 1999; 283:387-90.
13. Laird PW, Jackson-Grusby L, Fazeli A, et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 1995;81:197-205.
14. Li E, Bestor TH, Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992;69:915-26.
15. Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW. DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol 2002;22:2906-17.
16. Eads CA, Nickel AE, Laird PW. Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice. Cancer Res 2002;62:1296-9.
17. Belinsky SA, Klinge DM, Stidley CA, et al. Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer. Cancer Res 2003; 63:7089-93.
18. Kimura H, Nakamura T, Ogawa T, Tanaka S, Shiota K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res 2003;31: 3101-13.
19. McCabe MT, Davis JN, Day ML. Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway. Cancer Res 2005;65:3624-32.
20. Greenberg NM, DeMayo F, Finegold MJ, et al. Prostate cancer in a transgenic mouse. Proc Natl Acad Sci U S A 1995;92:3439-43.
21. Low J, Humes HD, Szczypka M, Imperiale M. BKV and SV40 infection of human kidney tubular epithelial cells in vitro. Virology 2004;323:182-8.
22. Crawford L, Harlow E. Uniform nomenclature for monoclonal antibodies directed against virus-coded proteins of simian virus 40 and polyoma virus. J Virol 1982;41:709.
23. Harlow E, Crawford LV, Pim DC, Williamson NM. Monoclonal antibodies specific for simian virus 40 tumor antigens. J Virol 1981;39:861-9.
24. Seif I, Khoury G, Dhar R. The genome of human papovavirus BKV. Cell 1979;18:963-77.
25. Helt AM, Galloway DA. Mechanisms by which DNA tumor virus oncoproteins target the Rb family of pocket proteins. Carcinogenesis 2003;34:159-69.
26. Gingrich JR, Barrios RJ, Morton RA, et al. Metastatic prostate cancer in a transgenic mouse. Cancer Res 1996; 56:4096-102.
27. Momparler RL. Pharmacology of 5-aza-2′-deoxycytidine. In: Skoda J, Langen P, editors. Antimetabolites in biochemistry, biology and medicine. New York: Pergamon Press; 1979. p. 33-41.
28. 6-alkylguanine-DNA alkyltransferase: role in carcinogenesis and chemotherapy. BioEssays 2002;24:255-66.
29. 6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 1999;59:793-7.
30. 6- methylguanine-DNA methyltransferase gene. Nucleic Acids Res 1991;19:163-7.
31. 6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 1997;17:5612-9.
32. Phillips SM, Barton CM, Lee SJ, et al. Loss of the retinoblastoma susceptibility gene (RB1) is a frequent and early event in prostatic tumorigenesis. Br J Cancer 1994;70:1252-7.
33. Slack A, Cervoni N, Pinard M, Szyf M. DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J Biol Chem 1999;274:10105-12.
34. Etoh T, Kanai Y, Ushijima S, et al. Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am J Pathol 2004;164: 689-99.
35. + and methylation-tolerant mismatch repair compromised cellsfacts and models. Mutat Res 1997;381:227-41.
36. Monini P, Rotola A, Di Luca D, et al. DNA rearrangements impairing BK virus productive infection in urinary tract tumors. Virology 1995;214:273-9.
37. Das D, Shah RB, Imperiale MJ. Detection and expression of human BK virus sequences in neoplastic prostate tissues. Oncogene 2004;23:7031-46.
38. Rivard GE, Momparler RL, Deniers J, et al. Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia. Leuk Res 1981;5:453-62.
39. Abele R, Clavel M, Dodion P, et al. The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas. Eur J Cancer Clin Oncol 1987; 23:1921-4.
40. Issa JP, Garcia-Manero G, Giles FJ, et al. Phase I study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′- deoxycytidine (decitabine) in hematopoietic malignancies. Blood 2004;103: 1635-40.
41. Eden A, Gaudet F, Waghmare A, Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003;300:455.
42. Gaudet F, Hodgson JG, Eden A, et al. Induction of tumors in mice by genomic hypomethylation. Science 2003;300:489-92.
43. Yoo CB, Cheng JC, Jones PA. Zebularine: a new drug for epigenetic therapy. Biochem Soc Trans 2004; 32:910-2.
44. 1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues. J Med Chem 1991;34:3280-4.
45. Cheng JC, Weisenberger DJ, Gonzales FA, et al. Continuous zebularine treatment effectively sustains demethylation in human bladder cancer cells. Mol Cell Biol 2004;34:1270-8.
46. Thomas TJ, Messner RP. Effects of lupus-inducing drugs on the B to Z transition of synthetic DNA. Arthritis Rheum 1986;29:638-45.
47. Fang MZ, Wang Y, Ai N, et al. Tea polyphenol (-)-epigallocatechin-3- gallate inhibits DNA methyltransferase and reactivates methytation-silenced genes in cancer cell lines. Cancer Res 2003;63:7563-70.
48. Lodygin D, Epanchintsev A, Menssen A, Diebold J, Hermeking H. Functional epigenomics identifies genes frequently silenced in prostate cancer. Cancer Res 2005; 65:4218-27.
49. Yu YP, Paranjpe S, Nelson J, et al. High throughput screening of methylation status of genes in prostate cancer using an oligonucleotide methylation array. Carcinogenesis 2005;26:471-9.