Mutagenicity of 5-aza-2′-deoxycytidine is mediated by the mammalian DNA methyltransferase

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 9, 1997, Pages 4681-4685

  Jackson Grusby, Laurie ^a   Laird, Peter W ^a,b   Magge, Suresh N ^a   Moeller, Benjamin J ^a   Jaenisch, Rudolf ^a  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Cancer; Chemotherapy; DNA methylation; Transgenic mice

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA METHYLTRANSFERASE;

ANIMAL TISSUE; ARTICLE; CANCER CHEMOTHERAPY; DNA METHYLATION; MOLECULAR MODEL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; DINUCLEOSIDE PHOSPHATES; DNA METHYLATION; METHYLTRANSFERASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, CHEMICAL; MODELS, GENETIC; MUTAGENESIS; MUTAGENS;

EID: 0031001563     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.9.4681     Document Type: Article

References (23)

1. Piskala, A. & Sorm, F. (1964) Collect. Czech. Chem. Commun. 29, 2060.
2. Jones, P. A. (1985) Cell 40, 485-486.
3. Jones, P. A. (1996) Cancer Res. 56, 2463-2467.
4. Laird, P. W., Jackson-Grusby, L., Fazeli, A., Dickinson, S. L., Jung, W. E., Li, E., Weinberg, R. A. & Jaenisch, R. (1995) Cell 81, 197-205.
5. Bird, A. P. (1986) Nature (London) 321, 209-213.
6. Santi, D. V., Garrett, C. E. & Barr, P. J. (1983) Cell 33, 9-10.
7. Santi, D. V., Norment, A. & Garrett, C. E. (1984) Proc. Natl. Acad. Sci. USA 81, 6993-6997.
8. Jüttermann, R., Li, E. & Jaenisch, R. (1994) Proc. Natl. Acad. Sci. USA 91, 11797-11801.
9. Cupples, C. G. & Miller, J. H. (1989) Proc. Natl. Acad. Sci. USA 86, 5345-5349.
10. Levin, D. E. & Ames, B. N. (1986) Environ. Mutagen. 8, 9-28.
11. Bhagwat, A. S. & Roberts, R. J. (1987) J. Bacteriol. 169, 1537-1546.
12. Kohler, S. W., Provost, G. S., Fieck, A., Kretz, P. L., Bullock, W. O., Sorge, J. A., Putman, D. L. & Short, J. M. (1991) Proc. Natl. Acad. Sci. USA 88, 7958-7962.
13. Lei, H., Oh, S., Jüttermann, R., Jaenisch, R., Goss, K. A. & Li, E. (1996) Development (Cambridge, U.K.) 122, 3195-3205.
14. Short, J. M., Fernandez, J. M., Sorge, J. A. & Huse, W. D. (1988) Nucleic Acids Res. 16, 7583-7600.
15. Kohler, S. W., Provost, G. S., Fieck, A., Kretz, P. L., Bullock, W. O., Putman, D. L., Sorge, J. A. & Short, J. M. (1991) Environ. Mol. Mutagen. 18, 316-321.
16. Nishino, H., Knoll, A., Buettner, V. L., Frisk, C. S., Maruta, Y., Haavik, J. & Sommer, S. S. (1995) Oncogene 11, 263-270.
17. Jones, P. A. & Taylor, S. M. (1980) Cell 20, 85-93.
18. Walsh, C. T. (1984) Annu. Rev. Biochem. 53, 493-535.
19. Lindahl, T. (1993) Nature (London) 362, 709-715.
20. Loeb, L. A. (1985) Cell 40, 483-484.
21. Limonta, M., Colombo, T., Damia, G., Catapano, C. V., Conter, V., Gervasoni, M., Masera, G., Liso, V., Specchia, G., Giudici, G. & D'Incalci, M. (1993) Leuk. Res. 17, 977-982.
22. Kunz, B. A., Henson, E. S., Roche, H., Ramotar, D., Nunoshiba, T. & Demple, B. (1994) Proc. Natl. Acad. Sci. USA 91, 8165-8169.
23. Beisler, J. A. (1978) J. Med. Chem. 21, 204-208.