The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation

Oncogene

Volumn 26, Issue 6, 2007, Pages 934-944

  Seng, T J ^a   Low, J S W ^a   Li, H ^a,b   Cui, Y ^b   Goh, H K ^a   Wong, M L Y ^c   Srivastava, G ^c   Sidransky, D ^d   Califano, J ^d   Steenbergen, R D M ^e   Rha, S Y ^f   Tan, J ^a   Hsieh, W S ^a,g   Ambinder, R F ^a,g   Lin, X ^b   Chan, A T C ^b   Tao, Q ^a,b,g,h  

^a Johns Hopkins Singapore   (Singapore)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^f Yonsei University College of Medicine   (South Korea)

^g JOHNS HOPKINS UNIVERSITY   (United States)

^h CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

8p22; Cervical carcinoma; DLC1; Esophageal carcinoma; Methylation; Nasopharyngeal carcinoma; Tumor suppressor gene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BIOLOGICAL MARKER;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CARCINOGENESIS; CHINA; CONTROLLED STUDY; DLC1 GENE; DOWN REGULATION; EPIGENETICS; ESOPHAGUS CARCINOMA; GENE CONTROL; GENE DELETION; GENE FUNCTION; GENE IDENTIFICATION; GENE SILENCING; GENETIC TRANSCRIPTION; HEMIZYGOSITY; HUMAN; HUMAN CELL; MOUSE; NASOPHARYNX CARCINOMA; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; SOUTHEAST ASIA; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE; UTERINE CERVIX CARCINOMA;

BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMOSOMES, HUMAN, PAIR 8; DNA METHYLATION; ESOPHAGEAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MOLECULAR SEQUENCE DATA; NASOPHARYNGEAL NEOPLASMS; PROMOTER REGIONS (GENETICS); TUMOR SUPPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 33846941189     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209839     Document Type: Article

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