Genetic instability and aberrant DNA methylation in chronic hepatitis and cirrhosis - A comprehensive study of loss of heterozygosity and microsatellite instability at 39 loci and DNA hypermethylation on 8 CpG islands in microdissected specimens from patients with hepatocellular carcinoma

Hepatology

Volumn 32, Issue 5, 2000, Pages 970-979

  Kondo, Yutaka ^a,b   Kanai, Yae ^a   Sakamoto, Michiie ^a   Mizokami, Masashi ^b   Ueda, Ryuzo ^b   Hirohashi, Setsuo ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16;

ADULT; AGED; ARTICLE; CHROMOSOMAL LOCALIZATION; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; FEMALE; GENETIC ANALYSIS; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MALE; MICROSATELLITE INSTABILITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

EID: 0033765496     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2000.19797     Document Type: Article

References (50)

1. Clonal origin of atypical adenomatous hyperplasia of the liver and clonal identity with hepatocellular carcinoma
2. Clonal growth of hepatitis B virus-integrated hepatocytes in cirrhotic liver nodules
3. Allele-specific hypermethylation of the retinoblastoma tumor suppressor gene
4. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
5. Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas
6. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
7. The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas
8. p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma
9. High frequency of p16INK4A gene alterations in hepatocellular carcinoma
10. Detection of aberrant p16 methylation in the plasma and serum of liver cancer patients
11. CpG island methylator phenotype in colorectal cancer
12. Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
13. Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
14. Methylation and silencing of the Thrombospondin-1 promoter in human cancer
15. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
16. Specific induction of uncoiling and recombination by azacytidine in classical satellite-containing constitutive heterochromatin
17. Hypomethylation of classical satellite DNA and chromosome instability in lymphoblastoid cell lines
18. DNA hypomethylation leads to elevated mutation rates
19. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
20. Regional DNA hypermethylation at D17S5 precedes 17p structural changes in the progression of renal tumors
21. DNA hypermethylation is associated with 17p allelic loss in neural tumors
22. Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis
23. DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis
24. p53 and chromosome 3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus
25. Molecular genetic studies of early breast cancer evolution
26. Aberrant DNA methylation precedes loss of heterozygosity on chromosome 16 in chronic hepatitis and liver cirrhosis
27. Molecular cloning: A laboratory manual
28. A second-generation linkage map of the human genome
29. Comprehensive allelotyping of human hepatocellular carcinoma
30. Microsatellite instability associated with hepatocarcinogenesis
31. Reaction of sodium bisulfite with uracil, cytosine, and their derivatives
32. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
33. COBRA: A sensitive and quantitative DNA methylation assay
34. Frequent loss in chromosome 8p loci in liver cirrhosis accompanying hepatocellular carcinoma
35. Loss of heterozygosity of the retinoblastoma gene in liver cirrhosis accompanying hepatocellular carcinoma
36. Loss of the tumor suppressor p53 gene at the liver cirrhosis stage in Japanese patients with hepatocellular carcinoma
37. Pathology and molecular mechanisms of multistage human hepatocarcinogenesis
38. Different mutations of the p53 gene in nodule-in-nodule hepatocellular carcinoma as evidence for multistage progression
39. L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer
40. MYCL genotypes and loss of heterozygosity in non-small-cell lung cancer
41. E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle
42. Close correlation between mutations of E2F4 and hMSH3 genes in colorectal cancers with microsatellite instability
43. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
44. Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis
45. Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
46. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair in defective human tumor cell lines
47. Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma
48. The insertion of foreign DNA into mammalian genomes and its consequences: A concept in oncogenesis
49. Chromosomal insertion of foreign (adenovirus type 12, plasmid, or bacteriophage lambda) DNA is associated with enhanced methylation of cellular DNA segments
50. Insertion of foreign DNA into an established mammalian genome can alter the methylation of cellular DNA sequences