-
1
-
-
80053144962
-
A decade of exploring the cancer epigenome-biological and translational implications
-
Baylin, S.B. et al. (2011) A decade of exploring the cancer epigenome-biological and translational implications. Nat. Rev. Cancer, 11, 726-734.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 726-734
-
-
Baylin, S.B.1
-
2
-
-
67449100703
-
Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus
-
Baba, S. et al. (2009) Global DNA hypomethylation suppresses squamous carcinogenesis in the tongue and esophagus. Cancer Sci., 100, 1186-1191.
-
(2009)
Cancer Sci.
, vol.100
, pp. 1186-1191
-
-
Baba, S.1
-
3
-
-
26444473234
-
Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis
-
Yamada, Y. et al. (2005) Opposing effects of DNA hypomethylation on intestinal and liver carcinogenesis. Proc. Natl. Acad. Sci. USA, 102, 13580-13585.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13580-13585
-
-
Yamada, Y.1
-
4
-
-
77956276643
-
Suppressive effect of global DNA hypomethylation on gastric carcinogenesis
-
Tomita, H. et al. (2010) Suppressive effect of global DNA hypomethylation on gastric carcinogenesis. Carcinogenesis, 31, 1627-1633.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1627-1633
-
-
Tomita, H.1
-
5
-
-
79958221485
-
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice
-
Oghamian, S. et al. (2011) Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis, 32, 829-835.
-
(2011)
Carcinogenesis
, vol.32
, pp. 829-835
-
-
Oghamian, S.1
-
6
-
-
0032480226
-
DNA hypomethylation leads to elevated mutation rates
-
Chen, R.Z. et al. (1998) DNA hypomethylation leads to elevated mutation rates. Nature, 395, 89-93.
-
(1998)
Nature
, vol.395
, pp. 89-93
-
-
Chen, R.Z.1
-
7
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
Eden, A. et al. (2003) Chromosomal instability and tumors promoted by DNA hypomethylation. Science, 300, 455.
-
(2003)
Science
, vol.300
, pp. 455
-
-
Eden, A.1
-
8
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
Gaudet, F. et al. (2003) Induction of tumors in mice by genomic hypomethylation. Science, 300, 489-492.
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
-
9
-
-
0037112430
-
Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice
-
Yamada, Y. et al. (2002) Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice. Cancer Res., 62, 6367-6370.
-
(2002)
Cancer Res.
, vol.62
, pp. 6367-6370
-
-
Yamada, Y.1
-
10
-
-
0018581647
-
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
-
Taylor, S.M. et al. (1979) Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell, 17, 771-779.
-
(1979)
Cell
, vol.17
, pp. 771-779
-
-
Taylor, S.M.1
-
11
-
-
79952092841
-
Hypomethylating agents and other novel strategies in myelodysplastic syndromes
-
Garcia-Manero, G. et al. (2011) Hypomethylating agents and other novel strategies in myelodysplastic syndromes. J. Clin. Oncol., 29, 516-523.
-
(2011)
J. Clin. Oncol.
, vol.29
, pp. 516-523
-
-
Garcia-Manero, G.1
-
12
-
-
84655163371
-
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
-
Juergens, R.A. et al. (2011) Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer. Cancer Discov., 1, 598-607.
-
(2011)
Cancer Discov.
, vol.1
, pp. 598-607
-
-
Juergens, R.A.1
-
13
-
-
84863337757
-
Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
-
Tsai, H.C. et al. (2012) Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells. Cancer Cell, 21, 430-446.
-
(2012)
Cancer Cell
, vol.21
, pp. 430-446
-
-
Tsai, H.C.1
-
14
-
-
4644229375
-
The role of Cdx genes in the mammalian gut
-
Beck, F. (2004) The role of Cdx genes in the mammalian gut. Gut, 53, 1394-1396.
-
(2004)
Gut
, vol.53
, pp. 1394-1396
-
-
Beck, F.1
-
15
-
-
16244388032
-
The role of Cdx proteins in intestinal development and cancer
-
Guo, R.J. et al. (2004) The role of Cdx proteins in intestinal development and cancer. Cancer Biol. Ther., 3, 593-601.
-
(2004)
Cancer Biol. Ther.
, vol.3
, pp. 593-601
-
-
Guo, R.J.1
-
16
-
-
84857120620
-
Cdx function is required for maintenance of intestinal identity in the adult
-
Hryniuk, A. et al. (2012) Cdx function is required for maintenance of intestinal identity in the adult. Dev. Biol., 363, 426-437.
-
(2012)
Dev. Biol.
, vol.363
, pp. 426-437
-
-
Hryniuk, A.1
-
17
-
-
0030795415
-
CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium
-
Silberg, D.G. et al. (1997) CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Gastroenterology, 113, 478-486.
-
(1997)
Gastroenterology
, vol.113
, pp. 478-486
-
-
Silberg, D.G.1
-
18
-
-
0031587766
-
Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression
-
Vider, B.Z. et al. (1997) Human colorectal carcinogenesis is associated with deregulation of homeobox gene expression. Biochem. Biophys. Res. Commun., 232, 742-748.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.232
, pp. 742-748
-
-
Vider, B.Z.1
-
19
-
-
17344392128
-
Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis
-
Mallo, G.V. et al. (1997) Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int. J. Cancer, 74, 35-44.
-
(1997)
Int. J. Cancer
, vol.74
, pp. 35-44
-
-
Mallo, G.V.1
-
20
-
-
60549115231
-
Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1
-
Chan, C.W. et al. (2009) Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. Proc. Natl. Acad. Sci. USA, 106, 1936-1941.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 1936-1941
-
-
Chan, C.W.1
-
21
-
-
79952717492
-
Hypoxia and lineage specification of cell linederived colorectal cancer stem cells
-
Yeung, T.M. et al. (2011) Hypoxia and lineage specification of cell linederived colorectal cancer stem cells. Proc. Natl. Acad. Sci. USA, 108, 4382-4387.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 4382-4387
-
-
Yeung, T.M.1
-
22
-
-
84859036709
-
Villin expression is frequently lost in poorly differentiated colon cancer
-
Arango, D. et al. (2012) Villin expression is frequently lost in poorly differentiated colon cancer. Am. J. Pathol., 180, 1509-1521.
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 1509-1521
-
-
Arango, D.1
-
23
-
-
84884774935
-
Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors
-
Ashley, N. et al. (2013) Stem cell differentiation and lumen formation in colorectal cancer cell lines and primary tumors. Cancer Res., 73, 5798-5809.
-
(2013)
Cancer Res.
, vol.73
, pp. 5798-5809
-
-
Ashley, N.1
-
24
-
-
0037184038
-
DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines
-
Suh, E.R. et al. (2002) DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. J. Biol. Chem., 277, 35795-35800.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 35795-35800
-
-
Suh, E.R.1
-
25
-
-
9244242523
-
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis
-
Xu, X.L. et al. (2004) Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis. World J. Gastroenterol., 10, 3441-3454.
-
(2004)
World J. Gastroenterol.
, vol.10
, pp. 3441-3454
-
-
Xu, X.L.1
-
26
-
-
0347635513
-
Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines
-
Wong, N.A. et al. (2004) Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Proc. Natl. Acad. Sci. USA, 101, 574-579.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 574-579
-
-
Wong, N.A.1
-
27
-
-
0029803192
-
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
-
Lei, H. et al. (1996) De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development, 122, 3195-3205.
-
(1996)
Development
, vol.122
, pp. 3195-3205
-
-
Lei, H.1
-
28
-
-
80051807119
-
Genetic ablation of a candidate tumor suppressor gene, Rest, does not promote mouse colon carcinogenesis
-
Hatano, Y. et al. (2011) Genetic ablation of a candidate tumor suppressor gene, Rest, does not promote mouse colon carcinogenesis. Cancer Sci., 102, 1659-1664.
-
(2011)
Cancer Sci.
, vol.102
, pp. 1659-1664
-
-
Hatano, Y.1
-
29
-
-
75149137841
-
CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium
-
Kakizaki, F. et al. (2010) CDX transcription factors positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium. Gastroenterology, 138, 627-635.
-
(2010)
Gastroenterology
, vol.138
, pp. 627-635
-
-
Kakizaki, F.1
-
30
-
-
84864131103
-
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers
-
Muñoz, J. et al. (2012) The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J., 31, 3079-3091.
-
(2012)
EMBO J.
, vol.31
, pp. 3079-3091
-
-
Muñoz, J.1
-
31
-
-
84870724894
-
Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium
-
Hirata, A. et al. (2013) Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium. Development, 140, 66-75.
-
(2013)
Development
, vol.140
, pp. 66-75
-
-
Hirata, A.1
-
32
-
-
33645825196
-
Suppression of intestinal neoplasia by deletion of Dnmt3b
-
Lin, H. et al. (2006) Suppression of intestinal neoplasia by deletion of Dnmt3b. Mol. Cell. Biol., 26, 2976-2983.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 2976-2983
-
-
Lin, H.1
-
33
-
-
20544447734
-
Notch signals control the fate of immature progenitor cells in the intestine
-
Fre, S. et al. (2005) Notch signals control the fate of immature progenitor cells in the intestine. Nature, 435, 964-968.
-
(2005)
Nature
, vol.435
, pp. 964-968
-
-
Fre, S.1
-
34
-
-
20544460148
-
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
-
van Es, J.H., et al. (2005) Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature, 435, 959-63.
-
(2005)
Nature
, vol.435
, pp. 959-963
-
-
van Es, J.H.1
-
35
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker, N. et al. (2007) Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature, 449, 1003-1007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
-
36
-
-
33846569960
-
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
-
Ohm, J.E. et al. (2007) A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat. Genet., 39, 237-242.
-
(2007)
Nat. Genet.
, vol.39
, pp. 237-242
-
-
Ohm, J.E.1
-
37
-
-
33846649587
-
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
-
Schlesinger, Y. et al. (2007) Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat. Genet., 39, 232-236.
-
(2007)
Nat. Genet.
, vol.39
, pp. 232-236
-
-
Schlesinger, Y.1
-
38
-
-
33846576622
-
Epigenetic stem cell signature in cancer
-
Widschwendter, M. et al. (2007) Epigenetic stem cell signature in cancer. Nat. Genet., 39, 157-158.
-
(2007)
Nat. Genet.
, vol.39
, pp. 157-158
-
-
Widschwendter, M.1
-
39
-
-
32844459336
-
The Polycomb group protein EZH2 directly controls DNA methylation
-
Viré, E. et al. (2006) The Polycomb group protein EZH2 directly controls DNA methylation. Nature, 439, 871-874.
-
(2006)
Nature
, vol.439
, pp. 871-874
-
-
Viré, E.1
-
40
-
-
84855968457
-
Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction
-
Katsurano, M. et al. (2012) Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction. Oncogene, 31, 342-351.
-
(2012)
Oncogene
, vol.31
, pp. 342-351
-
-
Katsurano, M.1
-
41
-
-
84937965634
-
Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer
-
Abu-Remaileh, M. et al. (2015) Chronic inflammation induces a novel epigenetic program that is conserved in intestinal adenomas and in colorectal cancer. Cancer Res, 75, 2120-2130.
-
(2015)
Cancer Res
, vol.75
, pp. 2120-2130
-
-
Abu-Remaileh, M.1
-
42
-
-
5444227862
-
Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach
-
Gius, D. et al. (2004) Distinct effects on gene expression of chemical and genetic manipulation of the cancer epigenome revealed by a multimodality approach. Cancer Cell, 6, 361-371.
-
(2004)
Cancer Cell
, vol.6
, pp. 361-371
-
-
Gius, D.1
-
43
-
-
84877619075
-
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
-
Sadanandam, A. et al. (2013) A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nat. Med., 19, 619-625.
-
(2013)
Nat. Med.
, vol.19
, pp. 619-625
-
-
Sadanandam, A.1
-
44
-
-
0035190672
-
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon
-
Hinoi, T. et al. (2001) Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am. J. Pathol., 159, 2239-2248.
-
(2001)
Am. J. Pathol.
, vol.159
, pp. 2239-2248
-
-
Hinoi, T.1
-
45
-
-
57749112183
-
Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status
-
Lugli, A. et al. (2008) Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Mod. Pathol., 21, 1403-1412.
-
(2008)
Mod. Pathol.
, vol.21
, pp. 1403-1412
-
-
Lugli, A.1
-
46
-
-
68049113677
-
Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer
-
Baba, Y. et al. (2009) Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer. Clin. Cancer Res., 15, 4665-4673.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 4665-4673
-
-
Baba, Y.1
-
47
-
-
84895928210
-
Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency
-
Dawson, H. et al. (2014) Possible role of Cdx2 in the serrated pathway of colorectal cancer characterized by BRAF mutation, high-level CpG Island methylator phenotype and mismatch repair-deficiency. Int. J. Cancer, 134, 2342-2351.
-
(2014)
Int. J. Cancer
, vol.134
, pp. 2342-2351
-
-
Dawson, H.1
-
48
-
-
84912058804
-
Cdx1 and Cdx2 function as tumor suppressors
-
Hryniuk, A. et al. (2014) Cdx1 and Cdx2 function as tumor suppressors. J. Biol. Chem., 289, 33343-33354.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 33343-33354
-
-
Hryniuk, A.1
|