Epigenetic clustering of gastric carcinomas based on dna methylation profiles at the precancerous stage: Its correlation with tumor aggressiveness and patient outcome

Carcinogenesis

Volumn 36, Issue 5, 2015, Pages 509-520

  Yamanoi, Kazuhiro ^a,b   Arai, Eri ^a   Tian, Ying ^a   Takahashi, Yoriko ^c   Miyata, Sayaka ^c   Sasaki, Hiroki ^a   Chiwaki, Fumiko ^a   Ichikawa, Hitoshi ^a   Sakamoto, Hiromi ^a   Kushima, Ryoji ^d   Katai, Hitoshi ^d   Yoshida, Teruhiko ^a   Sakamoto, Michiie ^b   Kanai, Yae ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c Mitsui Knowledge Industry Co   (Japan)

^d NATIONAL CANCER CENTER HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TUMOR MARKER;

ADAM23 GENE; ADULT; AGED; AMER2 GENE; ARTICLE; CANCER PROGNOSIS; CANCER TISSUE; CCL28 GENE; COL23A1 GENE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DTX1 GENE; EPIGENETICS; FEMALE; GPSM1 GENE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OLFM4 GENE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRECANCER; PRIORITY JOURNAL; RECURRENCE FREE SURVIVAL; STOMACH CARCINOGENESIS; STOMACH CARCINOMA; STOMACH MUCOSA; CANCER GRADING; CANCER STAGING; CASE CONTROL STUDY; COMPARATIVE STUDY; ENZYME IMMUNOASSAY; FOLLOW UP; GASTRIC MUCOSA; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH TUMOR; SURVIVAL RATE; TUMOR RECURRENCE; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CASE-CONTROL STUDIES; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FOLLOW-UP STUDIES; GASTRIC MUCOSA; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PRECANCEROUS CONDITIONS; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STOMACH NEOPLASMS; SURVIVAL RATE;

EID: 84929161026     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgv013     Document Type: Article

References (50)

1. Jemel, A. et al. (2007) Cancer statistics. CA Cancer J. Clin., 57, 43-66.
2. Matsuda, T. et al. (2009) Cancer incidence and incidence rates in Japan in 2003: based on data from 13 population-based cancer registries in the Monitoring of Cancer Incidence in Japan (MCIJ) Project. Jpn. J. Clin. Oncol., 39, 850-858.
3. Clements, W.M. et al. (2002) Beta-Catenin mutation is a frequent cause of Wnt pathway activation in gastric cancer. Cancer Res., 62, 3503-3506.
4. Li, V.S. et al. (2005) Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer, 5, 29.
5. Marx, A.H. et al. (2009) HER-2 amplification is highly homogenous in gastric cancer. Hum. Pathol., 40, 769-777.
6. Corso, G. et al. (2013) Somatic mutations and deletions of the E-cadherin gene predict poor survival of patients with gastric cancer. J. Clin. Oncol., 31, 868-875.
7. Fenoglio-Preiser, C.M. et al. (2003) TP53 and gastric carcinoma: a review. Hum. Mutat., 21, 258-270.
8. Wang, K. et al. (2011) Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer. Nat. Genet., 43, 1219-1223.
9. Zang, Z.J. et al. (2012) Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat. Genet., 44, 570-574.
10. You, J.S. et al. (2012) Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell, 22, 9-20.
11. Kanai, Y. (2010) Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci., 101, 36-45.
12. Yoshiura, K. et al. (1995) Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc. Natl. Acad. Sci. U. S. A., 92, 7416-7419.
13. Etoh, T. et al. (2004) Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol., 164, 689-699.
14. Waki, T. et al. (2003) Promoter methylation status of DAP-kinase and RUNX3 genes in neoplastic and non-neoplastic gastric epithelia. Cancer Sci., 94, 360-364.
15. Nojima, M. et al. (2007) Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer. Oncogene, 26, 4699-4713.
16. Sato, T. et al. (2014) Epigenetic clustering of lung adenocarcinomas based on DNA methylation profiles in adjacent lung tissue: Its correlation with smoking history and chronic obstructive pulmonary disease. Int. J. Cancer, 135, 319-334.
17. Sato, T. et al. (2013) DNA methylation profiles at precancerous stages associated with recurrence of lung adenocarcinoma. PLoS One, 8, e59444.
18. Arai, E. et al. (2010) DNA methylation profiles in precancerous tissue and cancers: carcinogenetic risk estimation and prognostication based on DNA methylation status. Epigenomics, 2, 467-481.
19. Ushijima, T. et al. (2012) Molecular pathways: involvement of Helicobacter pylori-triggered inflammation in the formation of an epigenetic field defect, and its usefulness as cancer risk and exposure markers. Clin. Cancer Res., 18, 923-929.
20. Matsusaka, K. et al. (2011) Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes. Cancer Res., 71, 7187-7197.
21. Ramachandran, K. et al. (2012) DNA methylation and field cancerization. Epigenomics, 4, 243-245.
22. Arai, E. et al. (2012) Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas. Carcinogenesis, 33, 1487-1493.
23. Arai, E. et al. (2009) Genome-wide DNA methylation profiles in both precancerous conditions and clear cell renal cell carcinomas are correlated with malignant potential and patient outcome. Carcinogenesis, 30, 214-221.
24. Nishiyama, N. et al. (2010) Genome-wide DNA methylation profiles in urothelial carcinomas and urothelia at the precancerous stage. Cancer Sci., 101, 231-240.
25. Nagashio, R. et al. (2011) Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage. Int. J. Cancer, 129, 1170-1179.
26. Peng, D.F. et al. (2006) DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas. Carcinogenesis, 27, 1160-1168.
27. Cheng, Y. et al. (2014) Analysis of DNA methylation patterns associated with the gastric cancer genome. Oncol. Lett., 7, 1021-1026.
28. Kim, J.G. et al. (2013) Comprehensive DNA methylation and extensive mutation analyses reveal an association between the CpG island methylator phenotype and oncogenic mutations in gastric cancers. Cancer Lett., 330, 33-40.
29. Bibikova, M. et al. (2009) Genome-wide DNA methylation profiling using Infinium® assay. Epigenomics, 1, 177-200.
30. Washington, K. (2010) 7th edition of the AJCC cancer staging manual: stomach. Ann. Surg. Oncol., 17, 3077-3079.
31. Fléjou, J.F. (2011) [WHO Classification of digestive tumors: the fourth edition]. Ann. Pathol., 31(5 Suppl), S27-S31.
32. Sobin, L. H. et al. (2009) International Union Against Cancer (UICC). TNM Classification of Malignant Tumors. 7th edn. Wiley, New York, NY.
33. Lu, B. et al. (2014) Helicobacter pylori eradication for preventing gastric cancer. World J. Gastroenterol., 20, 5660-5665.
34. Tahara, T. et al. (2013) Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. Cancer Prev. Res. (Phila)., 6, 1093-1100.
35. Shull, A.Y. et al. (2013) Somatic mutations, allele loss, and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients. PLoS One, 8, e58731.
36. Guo, Q. et al. (2013) Detection of hypermethylated fibrillin-1 in the stool samples of colorectal cancer patients. Med. Oncol., 30, 695.
37. Richter, T.M. et al. (2005) Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines. Cancer Cell Int., 5, 29.
38. Bethge, N. et al. (2014) Colorectal cancer DNA methylation marker panel validated with high performance in Non-Hodgkin lymphoma. Epigenetics, 9, 428-436.
39. Ashktorab, H. et al. (2013) Toward a comprehensive and systematic methylome signature in colorectal cancers. Epigenetics, 8, 807-815.
40. Oster, B. et al. (2011) Identification and validation of highly frequent CpG island hypermethylation in colorectal adenomas and carcinomas. Int. J. Cancer, 129, 2855-2866.
41. Park, J. et al. (2004) Aberrant methylation of integrin alpha4 gene in human gastric cancer cells. Oncogene, 23, 3474-3480.
42. Hu, C. et al. (2011) The expression of ADAM23 and its correlation with promoter methylation in non-small-cell lung carcinoma. Int. J. Exp. Pathol., 92, 333-339.
43. Verbisck, N.V. et al. (2009) ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis. Cancer Res., 69, 5546-5552.
44. Kobayashi, D. et al. (2007) Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. Cancer Sci., 98, 334-340.
45. Pfister, A.S. et al. (2012) Amer2 protein is a novel negative regulator of Wnt/ß-catenin signaling involved in neuroectodermal patterning. J. Biol. Chem., 287, 1734-1741.
46. Shao, S. et al. (2014) A role for activator of G-protein signaling 3 (AGS3) in multiple myeloma. Int. J. Hematol., 99, 57-68.
47. Facciabene, A. et al. (2011) Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature, 475, 226-230.
48. Huber, R.M. et al. (2013) Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival. PLoS One, 8, e57793.
49. Spivey, K.A. et al. (2010) Collagen XXIII: a potential biomarker for the detection of primary and recurrent non-small cell lung cancer. Cancer Epidemiol. Biomarkers Prev., 19, 1362-1372.
50. Banyard, J. et al. (2007) Collagen XXIII expression is associated with prostate cancer recurrence and distant metastases. Clin. Cancer Res., 13, 2634-2642.