-
1
-
-
82855176833
-
Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells
-
M. Saitou, S. Kagiwada, and K. Kurimoto Epigenetic reprogramming in mouse pre-implantation development and primordial germ cells Development 139 2012 15 31
-
(2012)
Development
, vol.139
, pp. 15-31
-
-
Saitou, M.1
Kagiwada, S.2
Kurimoto, K.3
-
2
-
-
0035839126
-
Epigenetic reprogramming in mammalian development
-
W. Reik, W. Dean, and J. Walter Epigenetic reprogramming in mammalian development Science 293 2001 1089 1093
-
(2001)
Science
, vol.293
, pp. 1089-1093
-
-
Reik, W.1
Dean, W.2
Walter, J.3
-
3
-
-
77957970498
-
Epigenetic modifications in pluripotent and differentiated cells
-
A. Meissner Epigenetic modifications in pluripotent and differentiated cells Nat. Biotechnol. 28 2010 1079 1088
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 1079-1088
-
-
Meissner, A.1
-
4
-
-
79952795854
-
Role of epigenetics in developmental biology and transgenerational inheritance
-
M.K. Skinner Role of epigenetics in developmental biology and transgenerational inheritance Birth Defects Res. C Embryo Today 93 2011 51 55
-
(2011)
Birth Defects Res. C Embryo Today
, vol.93
, pp. 51-55
-
-
Skinner, M.K.1
-
6
-
-
84912144554
-
Epigenetic regulation leading to induced pluripotency drives cancer development in vivo
-
K. Ohnishi, K. Semi, and Y. Yamada Epigenetic regulation leading to induced pluripotency drives cancer development in vivo Biochem. Biophys. Res. Commun. 2014 10.1016/j.bbrc.2014.07.020
-
(2014)
Biochem. Biophys. Res. Commun.
-
-
Ohnishi, K.1
Semi, K.2
Yamada, Y.3
-
7
-
-
0038444085
-
Fidelity of the methylation pattern and its variation in the genome
-
T. Ushijima, N. Watanabe, and E. Okochi Fidelity of the methylation pattern and its variation in the genome Genome Res. 13 2003 868 874
-
(2003)
Genome Res.
, vol.13
, pp. 868-874
-
-
Ushijima, T.1
Watanabe, N.2
Okochi, E.3
-
8
-
-
14644396228
-
Detection and interpretation of altered methylation patterns in cancer cells
-
T. Ushijima Detection and interpretation of altered methylation patterns in cancer cells Nat. Rev. Cancer 5 2005 223 231
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 223-231
-
-
Ushijima, T.1
-
9
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
A.P. Feinberg, and B. Vogelstein Hypomethylation distinguishes genes of some human cancers from their normal counterparts Nature 301 1983 89 92
-
(1983)
Nature
, vol.301
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
10
-
-
0027537296
-
CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene
-
N. Ohtani-Fujita, T. Fujita, and A. Aoike CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene Oncogene 8 1993 1063 1067
-
(1993)
Oncogene
, vol.8
, pp. 1063-1067
-
-
Ohtani-Fujita, N.1
Fujita, T.2
Aoike, A.3
-
12
-
-
13444270332
-
CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas
-
M. Abe, M. Ohira, and A. Kaneda CpG island methylator phenotype is a strong determinant of poor prognosis in neuroblastomas Cancer Res. 65 2005 828 834
-
(2005)
Cancer Res.
, vol.65
, pp. 828-834
-
-
Abe, M.1
Ohira, M.2
Kaneda, A.3
-
13
-
-
0028022785
-
Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines
-
Y. Hoshikawa, H.J. Kwon, and M. Yoshida Trichostatin A induces morphological changes and gelsolin expression by inhibiting histone deacetylase in human carcinoma cell lines Exp. Cell Res. 214 1994 189 197
-
(1994)
Exp. Cell Res.
, vol.214
, pp. 189-197
-
-
Hoshikawa, Y.1
Kwon, H.J.2
Yoshida, M.3
-
14
-
-
0035839136
-
Translating the histone code
-
T. Jenuwein, and C.D. Allis Translating the histone code Science 293 2001 1074 1080
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
15
-
-
84886099830
-
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer
-
C. Plass, S.M. Pfister, and A.M. Lindroth Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer Nat. Rev. Genet. 14 2013 765 780
-
(2013)
Nat. Rev. Genet.
, vol.14
, pp. 765-780
-
-
Plass, C.1
Pfister, S.M.2
Lindroth, A.M.3
-
18
-
-
0023848637
-
Reduced genomic 5-methylcytosine content in human colonic neoplasia
-
A.P. Feinberg, C.W. Gehrke, and K.C. Kuo Reduced genomic 5-methylcytosine content in human colonic neoplasia Cancer Res. 48 1988 1159 1161
-
(1988)
Cancer Res.
, vol.48
, pp. 1159-1161
-
-
Feinberg, A.P.1
Gehrke, C.W.2
Kuo, K.C.3
-
19
-
-
0021950948
-
Hypomethylation of DNA from benign and malignant human colon neoplasms
-
S.E. Goelz, B. Vogelstein, and S.R. Hamilton Hypomethylation of DNA from benign and malignant human colon neoplasms Science 228 1985 187 190
-
(1985)
Science
, vol.228
, pp. 187-190
-
-
Goelz, S.E.1
Vogelstein, B.2
Hamilton, S.R.3
-
20
-
-
84862502196
-
Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization
-
Y. Matsuda, S. Yamashita, and Y.C. Lee Hypomethylation of Alu repetitive elements in esophageal mucosa, and its potential contribution to the epigenetic field for cancerization Cancer Causes Control 23 2012 865 873
-
(2012)
Cancer Causes Control
, vol.23
, pp. 865-873
-
-
Matsuda, Y.1
Yamashita, S.2
Lee, Y.C.3
-
21
-
-
78349292907
-
Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae
-
T. Yoshida, S. Yamashita, and T. Takamura-Enya Alu and Satalpha hypomethylation in Helicobacter pylori-infected gastric mucosae Int. J. Cancer 128 2011 33 39
-
(2011)
Int. J. Cancer
, vol.128
, pp. 33-39
-
-
Yoshida, T.1
Yamashita, S.2
Takamura-Enya, T.3
-
22
-
-
0029957792
-
The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation
-
C. De Smet, O. De Backer, and I. Faraoni The activation of human gene MAGE-1 in tumor cells is correlated with genome-wide demethylation Proc. Natl. Acad. Sci. USA 93 1996 7149 7153
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 7149-7153
-
-
De Smet, C.1
De Backer, O.2
Faraoni, I.3
-
23
-
-
0038387946
-
Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma
-
B. Cho, H. Lee, and S. Jeong Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma Biochem. Biophys. Res. Commun. 307 2003 52 63
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.307
, pp. 52-63
-
-
Cho, B.1
Lee, H.2
Jeong, S.3
-
24
-
-
0035902856
-
Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma
-
M. Cho, H. Uemura, and S.C. Kim Hypomethylation of the MN/CA9 promoter and upregulated MN/CA9 expression in human renal cell carcinoma Br. J. Cancer 85 2001 563 567
-
(2001)
Br. J. Cancer
, vol.85
, pp. 563-567
-
-
Cho, M.1
Uemura, H.2
Kim, S.C.3
-
25
-
-
0142182088
-
Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells
-
Y. Akiyama, C. Maesawa, and S. Ogasawara Cell-type-specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells Am. J. Pathol. 163 2003 1911 1919
-
(2003)
Am. J. Pathol.
, vol.163
, pp. 1911-1919
-
-
Akiyama, Y.1
Maesawa, C.2
Ogasawara, S.3
-
26
-
-
0042674172
-
Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma
-
N. Sato, A. Maitra, and N. Fukushima Frequent hypomethylation of multiple genes overexpressed in pancreatic ductal adenocarcinoma Cancer Res. 63 2003 4158 4166
-
(2003)
Cancer Res.
, vol.63
, pp. 4158-4166
-
-
Sato, N.1
Maitra, A.2
Fukushima, N.3
-
27
-
-
16844384464
-
Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays
-
M. Nishigaki, K. Aoyagi, and I. Danjoh Discovery of aberrant expression of R-RAS by cancer-linked DNA hypomethylation in gastric cancer using microarrays Cancer Res. 65 2005 2115 2124
-
(2005)
Cancer Res.
, vol.65
, pp. 2115-2124
-
-
Nishigaki, M.1
Aoyagi, K.2
Danjoh, I.3
-
28
-
-
0032480226
-
DNA hypomethylation leads to elevated mutation rates
-
R.Z. Chen, U. Pettersson, and C. Beard DNA hypomethylation leads to elevated mutation rates Nature 395 1998 89 93
-
(1998)
Nature
, vol.395
, pp. 89-93
-
-
Chen, R.Z.1
Pettersson, U.2
Beard, C.3
-
29
-
-
0242584449
-
Induction of tumors in mice by genomic hypomethylation
-
F. Gaudet, J.G. Hodgson, and A. Eden Induction of tumors in mice by genomic hypomethylation Science 300 2003 489 492
-
(2003)
Science
, vol.300
, pp. 489-492
-
-
Gaudet, F.1
Hodgson, J.G.2
Eden, A.3
-
30
-
-
0029011539
-
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
A. Merlo, J.G. Herman, and L. Mao 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers Nat. Med. 1 1995 686 692
-
(1995)
Nat. Med.
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
-
31
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
M.F. Kane, M. Loda, and G.M. Gaida Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines Cancer Res. 57 1997 808 811
-
(1997)
Cancer Res.
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
Loda, M.2
Gaida, G.M.3
-
32
-
-
0029114538
-
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas
-
K. Yoshiura, Y. Kanai, and A. Ochiai Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas Proc Natl. Acad. Sci. USA 92 1995 7416 7419
-
(1995)
Proc Natl. Acad. Sci. USA
, vol.92
, pp. 7416-7419
-
-
Yoshiura, K.1
Kanai, Y.2
Ochiai, A.3
-
33
-
-
0027723111
-
Methylation profiles of genomic DNA of mouse developmental brain detected by restriction landmark genomic scanning (RLGS) method
-
J. Kawai, S. Hirotsune, and K. Hirose Methylation profiles of genomic DNA of mouse developmental brain detected by restriction landmark genomic scanning (RLGS) method Nucleic Acids Res. 21 1993 5604 5608
-
(1993)
Nucleic Acids Res.
, vol.21
, pp. 5604-5608
-
-
Kawai, J.1
Hirotsune, S.2
Hirose, K.3
-
34
-
-
0030909356
-
Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors
-
T. Ushijima, K. Morimura, and Y. Hosoya Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors Proc. Natl. Acad. Sci. USA 94 1997 2284 2289
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 2284-2289
-
-
Ushijima, T.1
Morimura, K.2
Hosoya, Y.3
-
35
-
-
0031050736
-
Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR
-
M.L. Gonzalgo, G. Liang, and C.H. Spruck 3rd Identification and characterization of differentially methylated regions of genomic DNA by methylation-sensitive arbitrarily primed PCR Cancer Res. 57 1997 594 599
-
(1997)
Cancer Res.
, vol.57
, pp. 594-599
-
-
Gonzalgo, M.L.1
Liang, G.2
Spruck, C.H.3
-
36
-
-
84878204291
-
Enrichment of methylated DNA by methyl-CpG immunoprecipitation
-
M. Sonnet, C. Baer, and M. Rehli Enrichment of methylated DNA by methyl-CpG immunoprecipitation Methods Mol. Biol. 971 2013 201 212
-
(2013)
Methods Mol. Biol.
, vol.971
, pp. 201-212
-
-
Sonnet, M.1
Baer, C.2
Rehli, M.3
-
37
-
-
84862266444
-
Complete pipeline for Infinium((R)) Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation
-
N. Touleimat, and J. Tost Complete pipeline for Infinium((R)) Human Methylation 450K BeadChip data processing using subset quantile normalization for accurate DNA methylation estimation Epigenomics 4 2012 325 341
-
(2012)
Epigenomics
, vol.4
, pp. 325-341
-
-
Touleimat, N.1
Tost, J.2
-
38
-
-
27144500218
-
Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis
-
A. Meissner, A. Gnirke, and G.W. Bell Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis Nucleic Acids Res. 33 2005 5868 5877
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 5868-5877
-
-
Meissner, A.1
Gnirke, A.2
Bell, G.W.3
-
39
-
-
84866919003
-
Amplification-free whole-genome bisulfite sequencing by post-bisulfite adaptor tagging
-
F. Miura, Y. Enomoto, and R. Dairiki Amplification-free whole-genome bisulfite sequencing by post-bisulfite adaptor tagging Nucleic Acids Res. 40 2012 e136
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. 136
-
-
Miura, F.1
Enomoto, Y.2
Dairiki, R.3
-
40
-
-
70350710509
-
Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis
-
S. Yamashita, K. Hosoya, and K. Gyobu Development of a novel output value for quantitative assessment in methylated DNA immunoprecipitation-CpG island microarray analysis DNA Res. 16 2009 275 286
-
(2009)
DNA Res.
, vol.16
, pp. 275-286
-
-
Yamashita, S.1
Hosoya, K.2
Gyobu, K.3
-
41
-
-
0033563165
-
Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
-
M. Toyota, C. Ho, and N. Ahuja Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification Cancer Res. 59 1999 2307 2312
-
(1999)
Cancer Res.
, vol.59
, pp. 2307-2312
-
-
Toyota, M.1
Ho, C.2
Ahuja, N.3
-
42
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
H. Noushmehr, D.J. Weisenberger, and K. Diefes Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma Cancer Cell 17 2010 510 522
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
43
-
-
84896739200
-
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
-
S.C. Mack, H. Witt, and R.M. Piro Epigenomic alterations define lethal CIMP-positive ependymomas of infancy Nature 506 2014 445 450
-
(2014)
Nature
, vol.506
, pp. 445-450
-
-
Mack, S.C.1
Witt, H.2
Piro, R.M.3
-
44
-
-
0033229890
-
Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype
-
M. Toyota, N. Ahuja, and H. Suzuki Aberrant methylation in gastric cancer associated with the CpG island methylator phenotype Cancer Res. 59 1999 5438 5442
-
(1999)
Cancer Res.
, vol.59
, pp. 5438-5442
-
-
Toyota, M.1
Ahuja, N.2
Suzuki, H.3
-
45
-
-
19944428803
-
Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma
-
C. An, I.S. Choi, and J.C. Yao Prognostic significance of CpG island methylator phenotype and microsatellite instability in gastric carcinoma Clin. Cancer Res. 11 2005 656 663
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 656-663
-
-
An, C.1
Choi, I.S.2
Yao, J.C.3
-
46
-
-
84912088844
-
DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer
-
Y. Toiyama, Y. Okugawa, and A. Goel DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer Biochem. Biophys. Res. Commun. 455 2014 43 57
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.455
, pp. 43-57
-
-
Toiyama, Y.1
Okugawa, Y.2
Goel, A.3
-
47
-
-
36549016091
-
Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones
-
J. Tanaka, T. Watanabe, and T. Kanazawa Left-Sided microsatellite unstable colorectal cancers show less frequent methylation of hMLH1 and CpG island methylator phenotype than right-sided ones J. Surg. Oncol. 96 2007 611 618
-
(2007)
J. Surg. Oncol.
, vol.96
, pp. 611-618
-
-
Tanaka, J.1
Watanabe, T.2
Kanazawa, T.3
-
48
-
-
84880879970
-
Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas
-
K. Asada, M. Abe, and T. Ushijima Clinical application of the CpG island methylator phenotype to prognostic diagnosis in neuroblastomas J. Hum. Genet. 58 2013 428 433
-
(2013)
J. Hum. Genet.
, vol.58
, pp. 428-433
-
-
Asada, K.1
Abe, M.2
Ushijima, T.3
-
50
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
S. Turcan, D. Rohle, and A. Goenka IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype Nature 483 2012 479 483
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
-
51
-
-
84878152241
-
Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor
-
J.K. Killian, S.Y. Kim, and M. Miettinen Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor Cancer Discov. 3 2013 648 657
-
(2013)
Cancer Discov.
, vol.3
, pp. 648-657
-
-
Killian, J.K.1
Kim, S.Y.2
Miettinen, M.3
-
52
-
-
77956095231
-
Active DNA demethylation: Many roads lead to Rome
-
S.C. Wu, and Y. Zhang Active DNA demethylation: many roads lead to Rome Nat. Rev. Mol. Cell Biol. 11 2010 607 620
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 607-620
-
-
Wu, S.C.1
Zhang, Y.2
-
53
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
M. Tahiliani, K.P. Koh, and Y. Shen Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 Science 324 2009 930 935
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
-
55
-
-
80052461558
-
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
S. Ito, L. Shen, and Q. Dai Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine Science 333 2011 1300 1303
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
Shen, L.2
Dai, Q.3
-
56
-
-
78650175023
-
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
-
M. Ko, Y. Huang, and A.M. Jankowska Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 Nature 468 2010 839 843
-
(2010)
Nature
, vol.468
, pp. 839-843
-
-
Ko, M.1
Huang, Y.2
Jankowska, A.M.3
-
57
-
-
84866419591
-
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma
-
C.G. Lian, Y. Xu, and C. Ceol Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma Cell 150 2012 1135 1146
-
(2012)
Cell
, vol.150
, pp. 1135-1146
-
-
Lian, C.G.1
Xu, Y.2
Ceol, C.3
-
58
-
-
84866908544
-
TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases
-
C.H. Hsu, K.L. Peng, and M.L. Kang TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases Cell Rep. 2 2012 568 579
-
(2012)
Cell Rep.
, vol.2
, pp. 568-579
-
-
Hsu, C.H.1
Peng, K.L.2
Kang, M.L.3
-
59
-
-
20144388146
-
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
-
M.F. Fraga, E. Ballestar, and A. Villar-Garea Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer Nat. Genet. 37 2005 391 400
-
(2005)
Nat. Genet.
, vol.37
, pp. 391-400
-
-
Fraga, M.F.1
Ballestar, E.2
Villar-Garea, A.3
-
60
-
-
72849148472
-
Global levels of histone modifications predict prostate cancer recurrence
-
J. Ellinger, P. Kahl, and J. von der Gathen Global levels of histone modifications predict prostate cancer recurrence Prostate 70 2010 61 69
-
(2010)
Prostate
, vol.70
, pp. 61-69
-
-
Ellinger, J.1
Kahl, P.2
Von Der Gathen, J.3
-
61
-
-
77950510166
-
Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: Results from RTOG 9704
-
A. Manuyakorn, R. Paulus, and J. Farrell Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704 J. Clin. Oncol. 28 2010 1358 1365
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1358-1365
-
-
Manuyakorn, A.1
Paulus, R.2
Farrell, J.3
-
62
-
-
44349131472
-
Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation
-
Y. Kondo, L. Shen, and A.S. Cheng Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation Nat. Genet. 40 2008 741 750
-
(2008)
Nat. Genet.
, vol.40
, pp. 741-750
-
-
Kondo, Y.1
Shen, L.2
Cheng, A.S.3
-
63
-
-
79955948524
-
Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation
-
S.Y. Jo, E.M. Granowicz, and I. Maillard Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation Blood 117 2011 4759 4768
-
(2011)
Blood
, vol.117
, pp. 4759-4768
-
-
Jo, S.Y.1
Granowicz, E.M.2
Maillard, I.3
-
64
-
-
78049307486
-
H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM
-
M.W. Chen, K.T. Hua, and H.J. Kao H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM Cancer Res. 70 2010 7830 7840
-
(2010)
Cancer Res.
, vol.70
, pp. 7830-7840
-
-
Chen, M.W.1
Hua, K.T.2
Kao, H.J.3
-
65
-
-
0019506468
-
Increased histone acetylation and deacetylation in rat ascites hepatoma cells
-
K. Horiuchi, D. Fujimoto, and M. Fukushima Increased histone acetylation and deacetylation in rat ascites hepatoma cells Cancer Res. 41 1981 1488 1491
-
(1981)
Cancer Res.
, vol.41
, pp. 1488-1491
-
-
Horiuchi, K.1
Fujimoto, D.2
Fukushima, M.3
-
66
-
-
0023195737
-
Effects of trichostatins on differentiation of murine erythroleukemia cells
-
M. Yoshida, S. Nomura, and T. Beppu Effects of trichostatins on differentiation of murine erythroleukemia cells Cancer Res. 47 1987 3688 3691
-
(1987)
Cancer Res.
, vol.47
, pp. 3688-3691
-
-
Yoshida, M.1
Nomura, S.2
Beppu, T.3
-
67
-
-
84912119120
-
Somatic alterations and dysregulation of epigenetic modifiers in cancers
-
S. Aumann, and O. Abdel-Wahab Somatic alterations and dysregulation of epigenetic modifiers in cancers Biochem. Biophys. Res. Commun. 2014 10.1016/j.bbrc.2014.08.004
-
(2014)
Biochem. Biophys. Res. Commun.
-
-
Aumann, S.1
Abdel-Wahab, O.2
-
68
-
-
67349145955
-
Frequent TET2 mutations in systemic mastocytosis: Clinical, KITD816V and FIP1L1-PDGFRA correlates
-
A. Tefferi, R.L. Levine, and K.H. Lim Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates Leukemia 23 2009 900 904
-
(2009)
Leukemia
, vol.23
, pp. 900-904
-
-
Tefferi, A.1
Levine, R.L.2
Lim, K.H.3
-
69
-
-
67651065502
-
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
-
O. Abdel-Wahab, A. Mullally, and C. Hedvat Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies Blood 114 2009 144 147
-
(2009)
Blood
, vol.114
, pp. 144-147
-
-
Abdel-Wahab, O.1
Mullally, A.2
Hedvat, C.3
-
70
-
-
78649990315
-
Cancer-associated IDH mutations: Biomarker and therapeutic opportunities
-
K.E. Yen, M.A. Bittinger, and S.M. Su Cancer-associated IDH mutations: biomarker and therapeutic opportunities Oncogene 29 2010 6409 6417
-
(2010)
Oncogene
, vol.29
, pp. 6409-6417
-
-
Yen, K.E.1
Bittinger, M.A.2
Su, S.M.3
-
71
-
-
72049125350
-
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
-
L. Dang, D.W. White, and S. Gross Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
-
(2009)
Nature
, vol.462
, pp. 739-744
-
-
Dang, L.1
White, D.W.2
Gross, S.3
-
72
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
W. Xu, H. Yang, and Y. Liu Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases Cancer Cell 19 2011 17 30
-
(2011)
Cancer Cell
, vol.19
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
-
73
-
-
79953176952
-
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
-
X.J. Yan, J. Xu, and Z.H. Gu Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia Nat. Genet. 43 2011 309 315
-
(2011)
Nat. Genet.
, vol.43
, pp. 309-315
-
-
Yan, X.J.1
Xu, J.2
Gu, Z.H.3
-
74
-
-
84898545028
-
The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
-
D.A. Russler-Germain, D.H. Spencer, and M.A. Young The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers Cancer Cell 25 2014 442 454
-
(2014)
Cancer Cell
, vol.25
, pp. 442-454
-
-
Russler-Germain, D.A.1
Spencer, D.H.2
Young, M.A.3
-
75
-
-
78650454078
-
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas
-
C.J. Sneeringer, M.P. Scott, and K.W. Kuntz Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas Proc. Natl. Acad. Sci. USA 107 2010 20980 20985
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 20980-20985
-
-
Sneeringer, C.J.1
Scott, M.P.2
Kuntz, K.W.3
-
76
-
-
77955087290
-
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
-
G. Nikoloski, S.M. Langemeijer, and R.P. Kuiper Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes Nat. Genet. 42 2010 665 667
-
(2010)
Nat. Genet.
, vol.42
, pp. 665-667
-
-
Nikoloski, G.1
Langemeijer, S.M.2
Kuiper, R.P.3
-
77
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
R.D. Morin, N.A. Johnson, and T.M. Severson Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin Nat. Genet. 42 2010 181 185
-
(2010)
Nat. Genet.
, vol.42
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
-
78
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
G.L. Dalgliesh, K. Furge, and C. Greenman Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 463 2010 360 363
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
-
79
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
G. van Haaften, G.L. Dalgliesh, and H. Davies Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat. Genet. 41 2009 521 523
-
(2009)
Nat. Genet.
, vol.41
, pp. 521-523
-
-
Van Haaften, G.1
Dalgliesh, G.L.2
Davies, H.3
-
80
-
-
84862777348
-
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
-
J. Schwartzentruber, A. Korshunov, and X.Y. Liu Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma Nature 482 2012 226 231
-
(2012)
Nature
, vol.482
, pp. 226-231
-
-
Schwartzentruber, J.1
Korshunov, A.2
Liu, X.Y.3
-
81
-
-
84867606428
-
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma
-
D. Sturm, H. Witt, and V. Hovestadt Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma Cancer Cell 22 2012 425 437
-
(2012)
Cancer Cell
, vol.22
, pp. 425-437
-
-
Sturm, D.1
Witt, H.2
Hovestadt, V.3
-
82
-
-
75649094543
-
Aberrant DNA methylation in contrast with mutations
-
T. Ushijima, and K. Asada Aberrant DNA methylation in contrast with mutations Cancer Sci. 101 2010 300 305
-
(2010)
Cancer Sci.
, vol.101
, pp. 300-305
-
-
Ushijima, T.1
Asada, K.2
-
83
-
-
84912072883
-
Development and classes of epigenetic drugs for cancer
-
D. Dhanak, and P. Jackson Development and classes of epigenetic drugs for cancer Biochem. Biophys. Res. Commun. 2014 10.1016/j.bbrc.2014.07.006
-
(2014)
Biochem. Biophys. Res. Commun.
-
-
Dhanak, D.1
Jackson, P.2
-
84
-
-
0013773866
-
5-Azacytidine, a new, highly effective cancerostatic
-
F. Sorm, A. Piskala, and A. Cihak 5-Azacytidine, a new, highly effective cancerostatic Experientia 20 1964 202 203
-
(1964)
Experientia
, vol.20
, pp. 202-203
-
-
Sorm, F.1
Piskala, A.2
Cihak, A.3
-
85
-
-
0014241870
-
Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice
-
F. Sorm, and J. Vesely Effect of 5-aza-2'-deoxycytidine against leukemic and hemopoietic tissues in AKR mice Neoplasma 15 1968 339 343
-
(1968)
Neoplasma
, vol.15
, pp. 339-343
-
-
Sorm, F.1
Vesely, J.2
-
86
-
-
0018581647
-
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
-
S.M. Taylor, and P.A. Jones Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine Cell 17 1979 771 779
-
(1979)
Cell
, vol.17
, pp. 771-779
-
-
Taylor, S.M.1
Jones, P.A.2
-
87
-
-
0019857236
-
Phase i study on 5-aza-2'-deoxycytidine in children with acute leukemia
-
G.E. Rivard, R.L. Momparler, and J. Demers Phase I study on 5-aza-2'-deoxycytidine in children with acute leukemia Leuk. Res. 5 1981 453 462
-
(1981)
Leuk. Res.
, vol.5
, pp. 453-462
-
-
Rivard, G.E.1
Momparler, R.L.2
Demers, J.3
-
88
-
-
10744233452
-
Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
-
J.P. Issa, G. Garcia-Manero, and F.J. Giles Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies Blood 103 2004 1635 1640
-
(2004)
Blood
, vol.103
, pp. 1635-1640
-
-
Issa, J.P.1
Garcia-Manero, G.2
Giles, F.J.3
-
89
-
-
0037093195
-
Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
-
L.R. Silverman, E.P. Demakos, and B.L. Peterson Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B J. Clin. Oncol. 20 2002 2429 2440
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 2429-2440
-
-
Silverman, L.R.1
Demakos, E.P.2
Peterson, B.L.3
-
90
-
-
33646071894
-
Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
-
H. Kantarjian, J.P. Issa, and C.S. Rosenfeld Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study Cancer 106 2006 1794 1803
-
(2006)
Cancer
, vol.106
, pp. 1794-1803
-
-
Kantarjian, H.1
Issa, J.P.2
Rosenfeld, C.S.3
-
91
-
-
84655163371
-
Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer
-
R.A. Juergens, J. Wrangle, and F.P. Vendetti Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer Cancer Discov. 1 2011 598 607
-
(2011)
Cancer Discov.
, vol.1
, pp. 598-607
-
-
Juergens, R.A.1
Wrangle, J.2
Vendetti, F.P.3
-
92
-
-
84877574817
-
The future of epigenetic therapy in solid tumours-lessons from the past
-
N. Azad, C.A. Zahnow, and C.M. Rudin The future of epigenetic therapy in solid tumours-lessons from the past Nat. Rev. Clin. Oncol. 10 2013 256 266
-
(2013)
Nat. Rev. Clin. Oncol.
, vol.10
, pp. 256-266
-
-
Azad, N.1
Zahnow, C.A.2
Rudin, C.M.3
-
93
-
-
0035525781
-
Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: A case report
-
R.L. Piekarz, R. Robey, and V. Sandor Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report Blood 98 2001 2865 2868
-
(2001)
Blood
, vol.98
, pp. 2865-2868
-
-
Piekarz, R.L.1
Robey, R.2
Sandor, V.3
-
94
-
-
73949128107
-
Histone deacetylase inhibitors in cancer therapy
-
A.A. Lane, and B.A. Chabner Histone deacetylase inhibitors in cancer therapy J. Clin. Oncol. 27 2009 5459 5468
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 5459-5468
-
-
Lane, A.A.1
Chabner, B.A.2
-
95
-
-
33846783261
-
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase
-
S. Kubicek, R.J. O'Sullivan, and E.M. August Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase Mol. Cell 25 2007 473 481
-
(2007)
Mol. Cell
, vol.25
, pp. 473-481
-
-
Kubicek, S.1
O'Sullivan, R.J.2
August, E.M.3
-
96
-
-
80051543424
-
Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1
-
H.S. Cho, J.D. Kelly, and S. Hayami Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1 Neoplasia 13 2011 676 684
-
(2011)
Neoplasia
, vol.13
, pp. 676-684
-
-
Cho, H.S.1
Kelly, J.D.2
Hayami, S.3
-
97
-
-
84870573126
-
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
-
M.T. McCabe, H.M. Ott, and G. Ganji EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations Nature 492 2012 108 112
-
(2012)
Nature
, vol.492
, pp. 108-112
-
-
McCabe, M.T.1
Ott, H.M.2
Ganji, G.3
-
98
-
-
84877324084
-
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
-
S.K. Knutson, N.M. Warholic, and T.J. Wigle Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2 Proc. Natl. Acad. Sci. USA 110 2013 7922 7927
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 7922-7927
-
-
Knutson, S.K.1
Warholic, N.M.2
Wigle, T.J.3
-
99
-
-
84876222028
-
Selective inhibition of tumor oncogenes by disruption of super-enhancers
-
J. Loven, H.A. Hoke, and C.Y. Lin Selective inhibition of tumor oncogenes by disruption of super-enhancers Cell 153 2013 320 334
-
(2013)
Cell
, vol.153
, pp. 320-334
-
-
Loven, J.1
Hoke, H.A.2
Lin, C.Y.3
-
101
-
-
34047190317
-
Epigenetic field for cancerization
-
T. Ushijima Epigenetic field for cancerization J. Biochem. Mol. Biol. 40 2007 142 150
-
(2007)
J. Biochem. Mol. Biol.
, vol.40
, pp. 142-150
-
-
Ushijima, T.1
-
102
-
-
85027908629
-
Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study
-
Published Online First: 2 June 2014
-
K. Asada, T. Nakajima, and T. Shimazu Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study Gut 2014 Published Online First: 2 June 2014
-
(2014)
Gut
-
-
Asada, K.1
Nakajima, T.2
Shimazu, T.3
-
103
-
-
83355163991
-
Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer
-
J.D. Warren, W. Xiong, and A.M. Bunker Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer BMC Med. 9 2011 133
-
(2011)
BMC Med.
, vol.9
, pp. 133
-
-
Warren, J.D.1
Xiong, W.2
Bunker, A.M.3
-
104
-
-
84862870008
-
The epigenetic promise for prostate cancer diagnosis
-
L. Van Neste, J.G. Herman, and G. Otto The epigenetic promise for prostate cancer diagnosis Prostate 72 2012 1248 1261
-
(2012)
Prostate
, vol.72
, pp. 1248-1261
-
-
Van Neste, L.1
Herman, J.G.2
Otto, G.3
-
105
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
M.E. Hegi, A.C. Diserens, and T. Gorlia MGMT gene silencing and benefit from temozolomide in glioblastoma N. Engl. J. Med. 352 2005 997 1003
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
106
-
-
79953217628
-
5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer
-
R. Jover, T.P. Nguyen, and L. Perez-Carbonell 5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer Gastroenterology 140 2011 1174 1181
-
(2011)
Gastroenterology
, vol.140
, pp. 1174-1181
-
-
Jover, R.1
Nguyen, T.P.2
Perez-Carbonell, L.3
|