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Volumn 360, Issue , 2016, Pages 141-152

Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease

Author keywords

Alzheimer's disease; Biomarkers; Diagnostic; miRNAs; Nanovesicles

Indexed keywords

BIOLOGICAL MARKER; MICRORNA;

EID: 84955516883     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2015.12.005     Document Type: Review
Times cited : (112)

References (152)
  • 1
    • 0141962590 scopus 로고    scopus 로고
    • Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid
    • C. Admyre, J. Grunewald, J. Thyberg, S. Gripenbäck, G. Tornling, A. Eklund, and et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid Eur. Respir. J. 22 2003 578 583
    • (2003) Eur. Respir. J. , vol.22 , pp. 578-583
    • Admyre, C.1    Grunewald, J.2    Thyberg, J.3    Gripenbäck, S.4    Tornling, G.5    Eklund, A.6
  • 3
    • 53349177064 scopus 로고    scopus 로고
    • Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles
    • S. Alais, S. Simoes, D. Baas, S. Lehmann, G. Raposo, J.L. Darlix, and P. Leblanc Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles Biol. Cell. 100 2008 603 615
    • (2008) Biol. Cell. , vol.100 , pp. 603-615
    • Alais, S.1    Simoes, S.2    Baas, D.3    Lehmann, S.4    Raposo, G.5    Darlix, J.L.6    Leblanc, P.7
  • 4
    • 70349991886 scopus 로고    scopus 로고
    • LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
    • J. Alegre-Abarrategui, H. Christian, M.M. Lufino, R. Mutihac, L.L. Venda, O. Ansorge, and R. Wade-Martins LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model Hum. Mol. Genet. 18 2009 4022 4034
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 4022-4034
    • Alegre-Abarrategui, J.1    Christian, H.2    Lufino, M.M.3    Mutihac, R.4    Venda, L.L.5    Ansorge, O.6    Wade-Martins, R.7
  • 5
    • 84871695724 scopus 로고    scopus 로고
    • MicroRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF)
    • P.N. Alexandrov, P. Dua, J.M. Hill, S. Bhattacharjee, Y. Zhao, and W.J. Lukiw microRNA (miRNA) speciation in Alzheimer's disease (AD) cerebrospinal fluid (CSF) and extracellular fluid (ECF) Int. J. Biochem. Mol. Biol. 3 2012 365 373
    • (2012) Int. J. Biochem. Mol. Biol. , vol.3 , pp. 365-373
    • Alexandrov, P.N.1    Dua, P.2    Hill, J.M.3    Bhattacharjee, S.4    Zhao, Y.5    Lukiw, W.J.6
  • 6
    • 84867575631 scopus 로고    scopus 로고
    • Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers
    • M.L. Alvarez, M. Khosroheidari, R. Kanchi Ravi, and J.K. Distefano Comparison of protein, microRNA, and mRNA yields using different methods of urinary exosome isolation for the discovery of kidney disease biomarkers Kidney Int. 82 2012 1024 1032
    • (2012) Kidney Int. , vol.82 , pp. 1024-1032
    • Alvarez, M.L.1    Khosroheidari, M.2    Kanchi Ravi, R.3    Distefano, J.K.4
  • 9
    • 84866426167 scopus 로고    scopus 로고
    • Exosomes: Vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?
    • S.A. Bellingham, B.B. Guo, B.M. Coleman, and A.F. Hill Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases? Front. Physiol. 3 2012 124
    • (2012) Front. Physiol. , vol.3 , pp. 124
    • Bellingham, S.A.1    Guo, B.B.2    Coleman, B.M.3    Hill, A.F.4
  • 11
    • 0036533633 scopus 로고    scopus 로고
    • TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex
    • N. Blanchard, D. Lankar, F. Faure, A. Regnault, C. Dumont, G. Raposo, and C. Hivroz TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex J. Immunol. 168 2002 3235 3241
    • (2002) J. Immunol. , vol.168 , pp. 3235-3241
    • Blanchard, N.1    Lankar, D.2    Faure, F.3    Regnault, A.4    Dumont, C.5    Raposo, G.6    Hivroz, C.7
  • 12
    • 33644927263 scopus 로고    scopus 로고
    • Exosomes and HIV gag bud from endosome-like domains of the T cell plasma membrane
    • A.M. Booth, Y. Fang, J.K. Fallon, J.M. Yang, J.E. Hildreth, and S.J. Gould Exosomes and HIV gag bud from endosome-like domains of the T cell plasma membrane J. Cell Biol. 172 2006 932 935
    • (2006) J. Cell Biol. , vol.172 , pp. 932-935
    • Booth, A.M.1    Fang, Y.2    Fallon, J.K.3    Yang, J.M.4    Hildreth, J.E.5    Gould, S.J.6
  • 14
    • 84874443222 scopus 로고    scopus 로고
    • The immunosuppressive effect of mesenchymal stromal cells on B lymphocytes is mediated by membrane vesicles
    • M. Budoni, A. Fierabracci, R. Luciano, S. Petrini, V. Di Ciommo, and M. Muraca The immunosuppressive effect of mesenchymal stromal cells on B lymphocytes is mediated by membrane vesicles Cell Transplant. 22 2013 369 379
    • (2013) Cell Transplant. , vol.22 , pp. 369-379
    • Budoni, M.1    Fierabracci, A.2    Luciano, R.3    Petrini, S.4    Di Ciommo, V.5    Muraca, M.6
  • 15
    • 84905986686 scopus 로고    scopus 로고
    • Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology
    • K. Burgos, I. Malenica, R. Metpally, A. Courtright, B. Rakela, T. Beach, and et al. Profiles of extracellular miRNA in cerebrospinal fluid and serum from patients with Alzheimer's and Parkinson's diseases correlate with disease status and features of pathology PLoS One 9 2014 e106174
    • (2014) PLoS One , vol.9
    • Burgos, K.1    Malenica, I.2    Metpally, R.3    Courtright, A.4    Rakela, B.5    Beach, T.6
  • 18
    • 75749091133 scopus 로고    scopus 로고
    • Microfluidic isolation and transcriptome analysis of serum microvesicles
    • C. Chen, J. Skog, C.H. Hsu, R.T. Lessard, L. Balaj, T. Wurdinger, and et al. Microfluidic isolation and transcriptome analysis of serum microvesicles Lab Chip 10 2010 505 511
    • (2010) Lab Chip , vol.10 , pp. 505-511
    • Chen, C.1    Skog, J.2    Hsu, C.H.3    Lessard, R.T.4    Balaj, L.5    Wurdinger, T.6
  • 19
    • 84883492783 scopus 로고    scopus 로고
    • The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies
    • L. Cheng, C.Y. Quek, X. Sun, S.A. Bellingham, and A.F. Hill The detection of microRNA associated with Alzheimer's disease in biological fluids using next-generation sequencing technologies Front. Genet. 4 2013 150
    • (2013) Front. Genet. , vol.4 , pp. 150
    • Cheng, L.1    Quek, C.Y.2    Sun, X.3    Bellingham, S.A.4    Hill, A.F.5
  • 20
    • 85016304525 scopus 로고    scopus 로고
    • Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood
    • (e-pub ahead of print)
    • L. Cheng, R.A. Sharples, B.J. Scicluna, and A.F. Hill Exosomes provide a protective and enriched source of miRNA for biomarker profiling compared to intracellular and cell-free blood J. Extracell. Vesicles 3 2014 10.3402/jev.v3.23743 (e-pub ahead of print)
    • (2014) J. Extracell. Vesicles , vol.3
    • Cheng, L.1    Sharples, R.A.2    Scicluna, B.J.3    Hill, A.F.4
  • 21
    • 84865008239 scopus 로고    scopus 로고
    • TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways
    • A.S. Chen-Plotkin, T.L. Unger, M.D. Gallagher, E. Bill, L.K. Kwong, L. Volpicelli-Daley, and et al. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways J Neurosci. 32 2012 11213 11227
    • (2012) J Neurosci. , vol.32 , pp. 11213-11227
    • Chen-Plotkin, A.S.1    Unger, T.L.2    Gallagher, M.D.3    Bill, E.4    Kwong, L.K.5    Volpicelli-Daley, L.6
  • 23
    • 0035166047 scopus 로고    scopus 로고
    • Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry
    • A. Clayton, J. Court, H. Navabi, M. Adams, M.D. Mason, J.A. Hobot, and et al. Analysis of antigen presenting cell derived exosomes, based on immuno-magnetic isolation and flow cytometry J. Immunol. Methods 247 2001 163 174
    • (2001) J. Immunol. Methods , vol.247 , pp. 163-174
    • Clayton, A.1    Court, J.2    Navabi, H.3    Adams, M.4    Mason, M.D.5    Hobot, J.A.6
  • 25
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • J.P.P. Cogswell, J. Ward, I.A. Taylor, M. Waters, Y. Shi, B. Cannon, and et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways J. Alzheimers Dis. 14 2008 27 41
    • (2008) J. Alzheimers Dis. , vol.14 , pp. 27-41
    • Cogswell, J.P.P.1    Ward, J.2    Taylor, I.A.3    Waters, M.4    Shi, Y.5    Cannon, B.6
  • 26
    • 57649217285 scopus 로고    scopus 로고
    • The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology
    • S.L. Cole, and R. Vassar The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology J. Biol. Chem. 283 2008 29621 29625
    • (2008) J. Biol. Chem. , vol.283 , pp. 29621-29625
    • Cole, S.L.1    Vassar, R.2
  • 27
    • 84901310774 scopus 로고    scopus 로고
    • The potential of microRNAs as biofluid markers of neurodegenerative diseases - A systematic review
    • P.B. Danborg, A.H. Simonsen, G. Waldemar, and N.H. Heegaard The potential of microRNAs as biofluid markers of neurodegenerative diseases - a systematic review Biomarkers 19 2014 259 268
    • (2014) Biomarkers , vol.19 , pp. 259-268
    • Danborg, P.B.1    Simonsen, A.H.2    Waldemar, G.3    Heegaard, N.H.4
  • 28
    • 84930677807 scopus 로고    scopus 로고
    • MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer's disease
    • J. Denk, K. Boelmans, C. Siegismund, D. Lassner, S. Arlt, and H. Jahn MicroRNA profiling of CSF reveals potential biomarkers to detect Alzheimer's disease PLoS One 10 2015 e0126423
    • (2015) PLoS One , vol.10
    • Denk, J.1    Boelmans, K.2    Siegismund, C.3    Lassner, D.4    Arlt, S.5    Jahn, H.6
  • 29
    • 84930959713 scopus 로고    scopus 로고
    • Serum MicroRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer's disease
    • H. Dong, J. Li, L. Huang, X. Chen, D. Li, T. Wang, and et al. Serum MicroRNA profiles serve as novel biomarkers for the diagnosis of Alzheimer's disease Dis. Markers 11 2015 625659
    • (2015) Dis. Markers , vol.11 , pp. 625659
    • Dong, H.1    Li, J.2    Huang, L.3    Chen, X.4    Li, D.5    Wang, T.6
  • 31
    • 84923809909 scopus 로고    scopus 로고
    • Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles
    • J.S. Dudani, D.R. Gossett, H.T. Tse, R.J. Lamm, R.P. Kulkarni, and D.D. Carlo Rapid inertial solution exchange for enrichment and flow cytometric detection of microvesicles Biomicrofluidics 9 2015 014112
    • (2015) Biomicrofluidics , vol.9 , pp. 014112
    • Dudani, J.S.1    Gossett, D.R.2    Tse, H.T.3    Lamm, R.J.4    Kulkarni, R.P.5    Carlo, D.D.6
  • 32
    • 77952648551 scopus 로고    scopus 로고
    • Cell-produced α-synuclein is secreted in a calcium dependent manner by exosomes and impacts neuronal survival
    • E. Emmanouilidou, K. Melachroinou, T. Roumeliotis, S.D. Garbis, M. Ntzouni, L.H. Margaritis, and et al. Cell-produced α-synuclein is secreted in a calcium dependent manner by exosomes and impacts neuronal survival J. Neurosci. 30 2010 6838 6851
    • (2010) J. Neurosci. , vol.30 , pp. 6838-6851
    • Emmanouilidou, E.1    Melachroinou, K.2    Roumeliotis, T.3    Garbis, S.D.4    Ntzouni, M.5    Margaritis, L.H.6
  • 33
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • J.M. Escola, M.J. Kleijmeer, W. Stoorvogel, J.M. Griffith, O. Yoshie, and H.J. Geuze Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes J. Biol. Chem. 273 1998 20121 20127
    • (1998) J. Biol. Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1    Kleijmeer, M.J.2    Stoorvogel, W.3    Griffith, J.M.4    Yoshie, O.5    Geuze, H.J.6
  • 36
    • 84931577633 scopus 로고    scopus 로고
    • Identification of pre clinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study
    • (e1)
    • M.S. Fiandaca, D. Kapogiannis, M. Mapstone, A. Boxer, E. Eitan, J.B. Schwartz, and et al. Identification of pre clinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: a case-control study Alzheimers Dement. 11 2015 600 607 (e1)
    • (2015) Alzheimers Dement. , vol.11 , pp. 600-607
    • Fiandaca, M.S.1    Kapogiannis, D.2    Mapstone, M.3    Boxer, A.4    Eitan, E.5    Schwartz, J.B.6
  • 37
    • 70350772348 scopus 로고    scopus 로고
    • MicroRNAs potentiate neural development
    • S.K. Fineberg, K.S. Kosik, and B.L. Davidson MicroRNAs potentiate neural development Neuron 64 2009 303 309
    • (2009) Neuron , vol.64 , pp. 303-309
    • Fineberg, S.K.1    Kosik, K.S.2    Davidson, B.L.3
  • 38
    • 84860369464 scopus 로고    scopus 로고
    • Blood serum miRNA: Non-invasive biomarkers for Alzheimer's disease
    • H. Geekiyanage, G.A. Jicha, P.T. Nelson, and C. Chan Blood serum miRNA: non-invasive biomarkers for Alzheimer's disease Exp. Neurol. 235 2012 491 496
    • (2012) Exp. Neurol. , vol.235 , pp. 491-496
    • Geekiyanage, H.1    Jicha, G.A.2    Nelson, P.T.3    Chan, C.4
  • 39
    • 77954385676 scopus 로고    scopus 로고
    • The propagation of prion-like protein inclusions in neurodegenerative diseases
    • M. Goedert, F. Clavaguera, and M. Tolnay The propagation of prion-like protein inclusions in neurodegenerative diseases Trends Neurosci. 33 2010 317 325
    • (2010) Trends Neurosci. , vol.33 , pp. 317-325
    • Goedert, M.1    Clavaguera, F.2    Tolnay, M.3
  • 41
    • 35448956015 scopus 로고    scopus 로고
    • Evidence for secretion of Cu, Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis
    • C. Gomes, S. Keller, P. Altevogt, and J. Costa Evidence for secretion of Cu, Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis Neurosci. Lett. 428 2007 43 46
    • (2007) Neurosci. Lett. , vol.428 , pp. 43-46
    • Gomes, C.1    Keller, S.2    Altevogt, P.3    Costa, J.4
  • 44
    • 84922340030 scopus 로고    scopus 로고
    • The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes
    • B.B. Guo, S.A. Bellingham, and A.F. Hill The neutral sphingomyelinase pathway regulates packaging of the prion protein into exosomes J. Biol. Chem. 290 2015 3455 3467
    • (2015) J. Biol. Chem. , vol.290 , pp. 3455-3467
    • Guo, B.B.1    Bellingham, S.A.2    Hill, A.F.3
  • 45
    • 32544435900 scopus 로고    scopus 로고
    • Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: A follow-up study
    • O. Hansson, H. Zetterberg, P. Buchhave, E. Londos, K. Blennow, and L. Minthon Association between CSF biomarkers and incipient Alzheimer's disease in patients with mild cognitive impairment: a follow-up study Lancet Neurol. 5 2006 228 234
    • (2006) Lancet Neurol. , vol.5 , pp. 228-234
    • Hansson, O.1    Zetterberg, H.2    Buchhave, P.3    Londos, E.4    Blennow, K.5    Minthon, L.6
  • 46
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • C. Harding, J. Heuser, and P. Stahl Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes J. Cell Biol. 97 1983 329 339
    • (1983) J. Cell Biol. , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 47
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the aetiology of Alzheimer's disease
    • J. Hardy, and D. Allsop Amyloid deposition as the central event in the aetiology of Alzheimer's disease Trends Pharmacol. 12 1991 383 388
    • (1991) Trends Pharmacol. , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 48
    • 84877117884 scopus 로고    scopus 로고
    • A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls
    • S.S. Hebert, W.X. Wang, Q. Zhu, and P.T. Nelson A study of small RNAs from cerebral neocortex of pathology-verified Alzheimer's disease, dementia with lewy bodies, hippocampal sclerosis, frontotemporal lobar dementia, and non-demented human controls J. Alzheimers Dis. 35 2013 335 348
    • (2013) J. Alzheimers Dis. , vol.35 , pp. 335-348
    • Hebert, S.S.1    Wang, W.X.2    Zhu, Q.3    Nelson, P.T.4
  • 50
    • 77955944561 scopus 로고    scopus 로고
    • Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice
    • T. Huang, Y. Liu, M. Huang, X. Zhao, and L. Cheng Wnt1-cre-mediated conditional loss of Dicer results in malformation of the midbrain and cerebellum and failure of neural crest and dopaminergic differentiation in mice J. Mol. Cell Biol. 2 2010 152 163
    • (2010) J. Mol. Cell Biol. , vol.2 , pp. 152-163
    • Huang, T.1    Liu, Y.2    Huang, M.3    Zhao, X.4    Cheng, L.5
  • 51
    • 57849130395 scopus 로고    scopus 로고
    • Detection of microRNA expression in human peripheral blood microvesicles
    • M.P. Hunter, N. Ismail, X. Zhang, B.D. Aguda, E.J. Lee, L. Yu, and et al. Detection of microRNA expression in human peripheral blood microvesicles PLoS One 3 2008 e3694
    • (2008) PLoS One , vol.3
    • Hunter, M.P.1    Ismail, N.2    Zhang, X.3    Aguda, B.D.4    Lee, E.J.5    Yu, L.6
  • 53
    • 84860388339 scopus 로고    scopus 로고
    • MicroRNAs in neuronal function and dysfunction
    • H.I. Im, and P.J. Kenny MicroRNAs in neuronal function and dysfunction Trends Neurosci. 35 2012 325 334
    • (2012) Trends Neurosci. , vol.35 , pp. 325-334
    • Im, H.I.1    Kenny, P.J.2
  • 55
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes)
    • R.M. Johnstone, M. Adam, J.R. Hammond, L. Orr, and C. Turbide Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes) J. Biol. Chem. 262 1987 9412 9420
    • (1987) J. Biol. Chem. , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 56
    • 69149102628 scopus 로고    scopus 로고
    • Mouradian MM.Repression of alpha-synuclein expression and toxicity by microRNA-7
    • E. Junn, K.W. Lee, B.S. Jeong, T.W. Chan, and J.Y. Im Mouradian MM.Repression of alpha-synuclein expression and toxicity by microRNA-7 Proc. Natl. Acad. Sci. U. S. A. 4 2009 13052 13057
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.4 , pp. 13052-13057
    • Junn, E.1    Lee, K.W.2    Jeong, B.S.3    Chan, T.W.4    Im, J.Y.5
  • 57
    • 70350708160 scopus 로고    scopus 로고
    • Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    • Y. Kawase-Koga, G. Otaegi, and T. Sun Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system Dev. Dyn. 238 2009 2800 2812
    • (2009) Dev. Dyn. , vol.238 , pp. 2800-2812
    • Kawase-Koga, Y.1    Otaegi, G.2    Sun, T.3
  • 58
    • 0034307476 scopus 로고    scopus 로고
    • Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
    • K.B. Kegel, M. Kim, E. Sapp, C. McIntyre, J.G. Castaño, N. Aronin, and M. DiFiglia Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy J. Neurosci. 20 2000 7268 7278
    • (2000) J. Neurosci. , vol.20 , pp. 7268-7278
    • Kegel, K.B.1    Kim, M.2    Sapp, E.3    McIntyre, C.4    Castaño, J.G.5    Aronin, N.6    DiFiglia, M.7
  • 59
    • 35348979185 scopus 로고    scopus 로고
    • CD24 is a marker of exosomes secreted into urine and amniotic fluid
    • S. Keller, C. Rupp, A. Stoeck, S. Runz, M. Fogel, S. Lugert, and et al. CD24 is a marker of exosomes secreted into urine and amniotic fluid Kidney Int. 72 2007 1095 1102
    • (2007) Kidney Int. , vol.72 , pp. 1095-1102
    • Keller, S.1    Rupp, C.2    Stoeck, A.3    Runz, S.4    Fogel, M.5    Lugert, S.6
  • 61
    • 78249275505 scopus 로고    scopus 로고
    • MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders
    • A.H. Kim, M. Reimers, B. Maher, V. Williamson, O. McMichael, J.L. McClay, and et al. MicroRNA expression profiling in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders Schizophr. Res. 124 2010 183 191
    • (2010) Schizophr. Res. , vol.124 , pp. 183-191
    • Kim, A.H.1    Reimers, M.2    Maher, B.3    Williamson, V.4    McMichael, O.5    McClay, J.L.6
  • 65
    • 78751703517 scopus 로고    scopus 로고
    • Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity
    • G. Lachenal, K. Pernet-Gallay, M. Chivet, F.J. Hemming, A. Belly, G. Bodon, and et al. Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity Mol. Cell. Neurosci. 46 2011 409 418
    • (2011) Mol. Cell. Neurosci. , vol.46 , pp. 409-418
    • Lachenal, G.1    Pernet-Gallay, K.2    Chivet, M.3    Hemming, F.J.4    Belly, A.5    Bodon, G.6
  • 66
    • 84866524463 scopus 로고    scopus 로고
    • Proteolytic potential of the MSC exosome proteome: Implications for an exosome-mediated delivery of therapeutic proteasome
    • R.C. Lai, S.S. Tan, B.J. The, S.K. Sze, F. Arslan, K.P. de Kleijn, and et al. Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome Int. J. Proteome 2012 971907
    • (2012) Int. J. Proteome
    • Lai, R.C.1    Tan, S.S.2    The, B.J.3    Sze, S.K.4    Arslan, F.5    De Kleijn, K.P.6
  • 68
    • 84906791239 scopus 로고    scopus 로고
    • Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: The need of larger datasets
    • P. Lau, C.S. Frigerio, and B. De Strooper Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets Ageing Res. Rev. 17 2014 43 53
    • (2014) Ageing Res. Rev. , vol.17 , pp. 43-53
    • Lau, P.1    Frigerio, C.S.2    De Strooper, B.3
  • 70
    • 2642530235 scopus 로고    scopus 로고
    • Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization
    • K. Laulagnier, C. Motta, S. Hamdi, S. Roy, F. Fauvelle, J.F. Pageaux, and et al. Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization Biochem. J. 380 2004 161 171
    • (2004) Biochem. J. , vol.380 , pp. 161-171
    • Laulagnier, K.1    Motta, C.2    Hamdi, S.3    Roy, S.4    Fauvelle, F.5    Pageaux, J.F.6
  • 71
    • 84928045368 scopus 로고    scopus 로고
    • In situ single step detection of exosome microRNA using molecular beacon
    • J.H. Lee, J.A. Kim, M.H. Kwon, J.Y. Kang, and W.J. Rhee In situ single step detection of exosome microRNA using molecular beacon Biomaterials 54 Jun. 2015 116 125
    • (2015) Biomaterials , vol.54 , pp. 116-125
    • Lee, J.H.1    Kim, J.A.2    Kwon, M.H.3    Kang, J.Y.4    Rhee, W.J.5
  • 73
    • 77950682093 scopus 로고    scopus 로고
    • Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease
    • X. Li, A. Valencia, E. Sapp, N. Masso, J. Alexander, P. Reeves, and et al. Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease J. Neurosci. 30 2010 4552 4561
    • (2010) J. Neurosci. , vol.30 , pp. 4552-4561
    • Li, X.1    Valencia, A.2    Sapp, E.3    Masso, N.4    Alexander, J.5    Reeves, P.6
  • 75
    • 0037008677 scopus 로고    scopus 로고
    • Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking
    • Y. Li, L.S. Chin, A.I. Levey, and L. Li Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking J. Biol. Chem. 277 2002 28212 28221
    • (2002) J. Biol. Chem. , vol.277 , pp. 28212-28221
    • Li, Y.1    Chin, L.S.2    Levey, A.I.3    Li, L.4
  • 76
    • 84862187574 scopus 로고    scopus 로고
    • Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA
    • W.J. Lukiw, P.N. Alexandrov, Y. Zhao, J.M. Hill, and S. Bhattacharjee Spreading of Alzheimer's disease inflammatory signaling through soluble micro-RNA Neuroreport 23 2012 621 626
    • (2012) Neuroreport , vol.23 , pp. 621-626
    • Lukiw, W.J.1    Alexandrov, P.N.2    Zhao, Y.3    Hill, J.M.4    Bhattacharjee, S.5
  • 84
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer's disease brain neocortex: Validation study
    • P.T. Nelson, and W.X. Wang MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study J. Alzheimers Dis. 21 2010 75 79
    • (2010) J. Alzheimers Dis. , vol.21 , pp. 75-79
    • Nelson, P.T.1    Wang, W.X.2
  • 88
    • 58149375393 scopus 로고    scopus 로고
    • Davidson the bifunctional microRNA miR-9/miR-9∗regulates REST and CoREST and is downregulated in Huntington's disease
    • A.N. Packer, Y. Xing, S.Q. Harper, L. Jones, and B.L. Davidson Davidson the bifunctional microRNA miR-9/miR-9∗regulates REST and CoREST and is downregulated in Huntington's disease J. Neurosci. 28 2008 14341 14346
    • (2008) J. Neurosci. , vol.28 , pp. 14341-14346
    • Packer, A.N.1    Xing, Y.2    Harper, S.Q.3    Jones, L.4    Davidson, B.L.5
  • 89
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • B.T. Pan, K. Teng, C. Wu, M. Adam, and R.M. Johnstone Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes J. Cell Biol. 101 1985 942 948
    • (1985) J. Cell Biol. , vol.101 , pp. 942-948
    • Pan, B.T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 90
    • 84880341728 scopus 로고    scopus 로고
    • More than cell dust: Microparticles isolated from cerebrospinal fluid of brain injured patients are messengers carrying mRNAs, miRNAs and proteins
    • S. Patz, C. Trattnig, G. Grünbacher, B. Ebner, C. Gülly, A. Novak, and et al. More than cell dust: microparticles isolated from cerebrospinal fluid of brain injured patients are messengers carrying mRNAs, miRNAs and proteins J. Neurotrauma 30 2013 1232 1242
    • (2013) J. Neurotrauma , vol.30 , pp. 1232-1242
    • Patz, S.1    Trattnig, C.2    Grünbacher, G.3    Ebner, B.4    Gülly, C.5    Novak, A.6
  • 92
    • 34249736846 scopus 로고    scopus 로고
    • MicroRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder
    • D.O. Perkins, C.D. Jeffries, L.F. Jarskog, J.M. Thomson, K. Woods, M.A. Newman, and et al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder Genome Biol. 8 2007 R27
    • (2007) Genome Biol. , vol.8 , pp. R27
    • Perkins, D.O.1    Jeffries, C.D.2    Jarskog, L.F.3    Thomson, J.M.4    Woods, K.5    Newman, M.A.6
  • 93
    • 4444226979 scopus 로고    scopus 로고
    • Identification and proteomic profiling of exosomes in human urine
    • T. Pisitkun, R.F. Shen, and M.A. Knepper Identification and proteomic profiling of exosomes in human urine Proc. Natl. Acad. Sci. U. S. A. 101 2004 13368 13373
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 13368-13373
    • Pisitkun, T.1    Shen, R.F.2    Knepper, M.A.3
  • 94
    • 0035902194 scopus 로고    scopus 로고
    • Shattuck lecture - Neurodegenerative diseases and prions
    • S.B. Prusiner Shattuck lecture - neurodegenerative diseases and prions N. Engl. J. Med. 344 2001 1516 1526
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1516-1526
    • Prusiner, S.B.1
  • 96
    • 0030687649 scopus 로고    scopus 로고
    • Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation
    • G. Raposo, D. Tenza, S. Mecheri, R. Peronet, C. Bonnerot, and C. Desaymard Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation Mol. Biol. Cell 8 1997 2631 2645
    • (1997) Mol. Biol. Cell , vol.8 , pp. 2631-2645
    • Raposo, G.1    Tenza, D.2    Mecheri, S.3    Peronet, R.4    Bonnerot, C.5    Desaymard, C.6
  • 99
    • 84875903418 scopus 로고    scopus 로고
    • Neuroimaging and other biomarkers for Alzheimer's Disease: The changing landscape of early detection
    • S. Risacher, and A. Saykin Neuroimaging and other biomarkers for Alzheimer's Disease: the changing landscape of early detection Annu. Rev. Clin. Psychol. 9 2012 18.1 18.28
    • (2012) Annu. Rev. Clin. Psychol. , vol.9 , pp. 181-1828
    • Risacher, S.1    Saykin, A.2
  • 100
    • 84859712858 scopus 로고    scopus 로고
    • CSF biomarkers for amyloid and tau pathology in Alzheimer's disease
    • H. Rosenmann CSF biomarkers for amyloid and tau pathology in Alzheimer's disease J. Mol. Neurosci. 47 2012 1 14
    • (2012) J. Mol. Neurosci. , vol.47 , pp. 1-14
    • Rosenmann, H.1
  • 101
    • 84892156798 scopus 로고    scopus 로고
    • Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease
    • C. Sala Frigerio, P. Lau, E. Salta, J. Tournoy, K. Bossers, R. Vandenberghe, and et al. Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease Neurology 81 2013 2103 2106
    • (2013) Neurology , vol.81 , pp. 2103-2106
    • Sala Frigerio, C.1    Lau, P.2    Salta, E.3    Tournoy, J.4    Bossers, K.5    Vandenberghe, R.6
  • 102
    • 84922195168 scopus 로고    scopus 로고
    • Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau
    • I. Santa-Maria, M.E. Alaniz, N. Renwick, C. Cela, T.A. Fulga, D. Van Vactor, and et al. Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau J. Clin. Invest. 125 2015 681 686
    • (2015) J. Clin. Invest. , vol.125 , pp. 681-686
    • Santa-Maria, I.1    Alaniz, M.E.2    Renwick, N.3    Cela, C.4    Fulga, T.A.5    Van Vactor, D.6
  • 103
    • 84930661401 scopus 로고    scopus 로고
    • MicroRNA-Seq data analysis pipeline to identify blood biomarkers for Alzheimer's Disease from public data
    • J. Satoh, Y. Kino, and S. Niida MicroRNA-Seq data analysis pipeline to identify blood biomarkers for Alzheimer's Disease from public data Biomark. Insights 10 2015 21 31
    • (2015) Biomark. Insights , vol.10 , pp. 21-31
    • Satoh, J.1    Kino, Y.2    Niida, S.3
  • 104
    • 84858269210 scopus 로고    scopus 로고
    • Molecular network of microRNA targets in Alzheimer's disease brains
    • J. Satoh Molecular network of microRNA targets in Alzheimer's disease brains Exp. Neurol. 235 2012 436 446
    • (2012) Exp. Neurol. , vol.235 , pp. 436-446
    • Satoh, J.1
  • 106
    • 54549117073 scopus 로고    scopus 로고
    • The mycobacterial glycopeptidolipids: Structure, function, and their ro le in pathogenesis
    • J.S. Schorey, and L. Sweet The mycobacterial glycopeptidolipids: structure, function, and their ro le in pathogenesis Glycobiology 18 2008 832 841
    • (2008) Glycobiology , vol.18 , pp. 832-841
    • Schorey, J.S.1    Sweet, L.2
  • 107
    • 1942494040 scopus 로고    scopus 로고
    • Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation
    • L.F. Sempere, S. Freemantle, I. Pitha-Rowe, E. Moss, E. Dmitrovsky, and V. Ambros Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation Genome Biol. 5 2004 R13
    • (2004) Genome Biol. , vol.5 , pp. R13
    • Sempere, L.F.1    Freemantle, S.2    Pitha-Rowe, I.3    Moss, E.4    Dmitrovsky, E.5    Ambros, V.6
  • 108
    • 77951762023 scopus 로고    scopus 로고
    • Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy
    • S. Sharma, H. Rasool, V. Palanisamy, C. Mathisen, M. Schmidt, D. Wong, and J. Gimzewski Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy ACS Nano 4 2010 1921 1926
    • (2010) ACS Nano , vol.4 , pp. 1921-1926
    • Sharma, S.1    Rasool, H.2    Palanisamy, V.3    Mathisen, C.4    Schmidt, M.5    Wong, D.6    Gimzewski, J.7
  • 111
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • J. Skog, T. Wurdinger, S. van Rijn, D.H. Meijer, L. Gainche, M. Sena-Esteves, and et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers Nat. Cell Biol. 10 2008 1470 1476
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1470-1476
    • Skog, J.1    Wurdinger, T.2    Van Rijn, S.3    Meijer, D.H.4    Gainche, L.5    Sena-Esteves, M.6
  • 112
    • 84892584524 scopus 로고    scopus 로고
    • Circulating miR-125b as a biomarker of Alzheimer's disease
    • L. Tan, J.T. Yu, Q.Y. Liu, M.S. Tan, W. Zhang, N. Hu, and et al. Circulating miR-125b as a biomarker of Alzheimer's disease J. Neurol. Sci. 336 2014 52 56
    • (2014) J. Neurol. Sci. , vol.336 , pp. 52-56
    • Tan, L.1    Yu, J.T.2    Liu, Q.Y.3    Tan, M.S.4    Zhang, W.5    Hu, N.6
  • 113
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • B.J. Tauro, D.W. Greeninga, R.A. Mathiasa, H. Jia, S. Mathivanana, A.M. Scottc, and R.J. Simpson Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes Methods 56 2012 293 304
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greeninga, D.W.2    Mathiasa, R.A.3    Jia, H.4    Mathivanana, S.5    Scottc, A.M.6    Simpson, R.J.7
  • 114
    • 31144445302 scopus 로고    scopus 로고
    • Pregnancy-associated exosomes and their modulation of T cell signaling
    • D.D. Taylor, S. Akyol, and C. Gercel-Taylor Pregnancy-associated exosomes and their modulation of T cell signaling J. Immunol. 176 2006 1534 1542
    • (2006) J. Immunol. , vol.176 , pp. 1534-1542
    • Taylor, D.D.1    Akyol, S.2    Gercel-Taylor, C.3
  • 115
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • C. Théry, M. Ostrowski, and E. Segura Membrane vesicles as conveyors of immune responses Nat. Rev Immunol. 9 2009 581 593
    • (2009) Nat. Rev Immunol. , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 117
    • 0040089526 scopus 로고    scopus 로고
    • Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73
    • C. Théry, A. Regnault, J. Garin, J. Wolfers, L. Zitvogel, P. Ricciardi-Castagnoli, and et al. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73 J. Cell Biol. 147 1999 599 610
    • (1999) J. Cell Biol. , vol.147 , pp. 599-610
    • Théry, C.1    Regnault, A.2    Garin, J.3    Wolfers, J.4    Zitvogel, L.5    Ricciardi-Castagnoli, P.6
  • 118
  • 120
    • 84923547728 scopus 로고    scopus 로고
    • Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM)
    • M. Tu, F. Wei, J. Yang, and D. Wong Detection of exosomal biomarker by electric field-induced release and measurement (EFIRM) J. Vis. Exp. 95 2015 e52439
    • (2015) J. Vis. Exp. , vol.95
    • Tu, M.1    Wei, F.2    Yang, J.3    Wong, D.4
  • 121
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J.J. Lee, and J.O. Lotvall Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nat. Cell Biol. 9 2007 654 659
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 125
    • 33947709328 scopus 로고    scopus 로고
    • Packaging of prions into exosomes is associated with a novel pathway of PrP processing
    • L.J. Vella, R.A. Sharples, V.A. Lawson, C.L. Masters, R. Cappai, and A.F. Hill Packaging of prions into exosomes is associated with a novel pathway of PrP processing J. Pathol. 211 2007 582 590
    • (2007) J. Pathol. , vol.211 , pp. 582-590
    • Vella, L.J.1    Sharples, R.A.2    Lawson, V.A.3    Masters, C.L.4    Cappai, R.5    Hill, A.F.6
  • 126
    • 84875250937 scopus 로고    scopus 로고
    • Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
    • V.L. Villemagne, S. Burnham, P. Bourgeat, B. Brown, K.A. Ellis, O. Salvado, and et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study Lancet Neurol. 12 2013 357 367
    • (2013) Lancet Neurol. , vol.12 , pp. 357-367
    • Villemagne, V.L.1    Burnham, S.2    Bourgeat, P.3    Brown, B.4    Ellis, K.A.5    Salvado, O.6
  • 127
    • 5344277556 scopus 로고    scopus 로고
    • Deciphering the molecular basis of memory failure in Alzheimer's disease
    • D.M. Walsh, and D.J. Selkoe Deciphering the molecular basis of memory failure in Alzheimer's disease Neuron 44 2004 181 193
    • (2004) Neuron , vol.44 , pp. 181-193
    • Walsh, D.M.1    Selkoe, D.J.2
  • 128
    • 77951862119 scopus 로고    scopus 로고
    • Cellular prion protein released on exosomes from macrophages binds to Hsp70
    • G. Wang, X. Zhou, Y. Bai, Z. Zhang, and D. Zhao Cellular prion protein released on exosomes from macrophages binds to Hsp70 Acta Biochim. Biophys. Sin. 42 2010 345 350
    • (2010) Acta Biochim. Biophys. Sin. , vol.42 , pp. 345-350
    • Wang, G.1    Zhou, X.2    Bai, Y.3    Zhang, Z.4    Zhao, D.5
  • 129
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • W.X. Wang, B.W. Rajeev, A.J. Stromberg, N. Ren, G. Tang, Q. Huang, and et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 J. Neurosci. 28 2008 1213 1223
    • (2008) J. Neurosci. , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6
  • 130
    • 79955650319 scopus 로고    scopus 로고
    • Increasing the predictive accuracy of amyloid-beta blood-borne biomarkers in Alzheimer's disease
    • A.D. Watt, K.A. Perez, N.G. Faux, K.E. Pike, C.C. Rowe, P. Bourgeat, and et al. Increasing the predictive accuracy of amyloid-beta blood-borne biomarkers in Alzheimer's disease J. Alzheimers Dis. 24 2011 47 59
    • (2011) J. Alzheimers Dis. , vol.24 , pp. 47-59
    • Watt, A.D.1    Perez, K.A.2    Faux, N.G.3    Pike, K.E.4    Rowe, C.C.5    Bourgeat, P.6
  • 132
    • 84880290282 scopus 로고    scopus 로고
    • Derepression of FOXO3a death axis by microRNA-132 and 2212 causes neuronal apoptosis in Alzheimer's disease
    • H.K. Wong, T. Veremeyko, N. Patel, C.A. Lemere, D.M. Walsh, C. Esau, and et al. Derepression of FOXO3a death axis by microRNA-132 and 2212 causes neuronal apoptosis in Alzheimer's disease Hum. Mol. Genet. 22 2013 3077 3092
    • (2013) Hum. Mol. Genet. , vol.22 , pp. 3077-3092
    • Wong, H.K.1    Veremeyko, T.2    Patel, N.3    Lemere, C.A.4    Walsh, D.M.5    Esau, C.6
  • 135
    • 33646161950 scopus 로고    scopus 로고
    • Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery
    • H. Zhou, P.S. Yuen, T. Pisitkun, P.A. Gonzales, H. Yasuda, J.W. Dear, and et al. Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery Kidney Int. 69 2006 1471 1476
    • (2006) Kidney Int. , vol.69 , pp. 1471-1476
    • Zhou, H.1    Yuen, P.S.2    Pisitkun, T.3    Gonzales, P.A.4    Yasuda, H.5    Dear, J.W.6
  • 136
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccinedendritic cell-derived exosomes
    • L. Zitvogel, A. Regnault, A. Lozier, J. Wolfers, C. Flament, D. Tenza, and et al. Eradication of established murine tumors using a novel cell-free vaccinedendritic cell-derived exosomes Nat. Med. 4 1998 594 600
    • (1998) Nat. Med. , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3    Wolfers, J.4    Flament, C.5    Tenza, D.6
  • 137
  • 138
    • 84860381680 scopus 로고    scopus 로고
    • MicroRNA networks surrounding APP and amyloid-beta metabolism-implications for Alzheimer's disease
    • N. Schonrock, M. Matamales, L.M. Ittner, and J. Gotz MicroRNA networks surrounding APP and amyloid-beta metabolism-implications for Alzheimer's disease Exp. Neurol. 235 2012 447 454
    • (2012) Exp. Neurol. , vol.235 , pp. 447-454
    • Schonrock, N.1    Matamales, M.2    Ittner, L.M.3    Gotz, J.4
  • 139
    • 70349558133 scopus 로고    scopus 로고
    • MiR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation
    • X. Wang, P. Liu, H. Zhu, Y. Xu, C. Ma, X. Dai, and et al. miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation Brain Res. Bull. 80 2009 268 273
    • (2009) Brain Res. Bull. , vol.80 , pp. 268-273
    • Wang, X.1    Liu, P.2    Zhu, H.3    Xu, Y.4    Ma, C.5    Dai, X.6
  • 140
    • 84929048523 scopus 로고    scopus 로고
    • Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease
    • H. Luo, Q. Wu, X. Ye, Y. Xiong, J. Zhu, J. Xu, and et al. Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of Alzheimer's disease PLoS One 9 2014 e101725
    • (2014) PLoS One , vol.9
    • Luo, H.1    Wu, Q.2    Ye, X.3    Xiong, Y.4    Zhu, J.5    Xu, J.6
  • 141
    • 84923233764 scopus 로고    scopus 로고
    • Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease
    • S. Garza-Manero, C. Arias, F. Bermúdez-Rattoni, L. Vaca, and A. Zepeda Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease Front. Cell. Neurosci. 9 2015 53
    • (2015) Front. Cell. Neurosci. , vol.9 , pp. 53
    • Garza-Manero, S.1    Arias, C.2    Bermúdez-Rattoni, F.3    Vaca, L.4    Zepeda, A.5
  • 143
    • 84948656562 scopus 로고    scopus 로고
    • Dysregulation and diagnostic potential of microRNA in Alzheimer's disease
    • Y. Pan, E. Terpstra, Y. Wang, F. Qiao, J. Wang, Y. Tong, and et al. Dysregulation and diagnostic potential of microRNA in Alzheimer's disease J. Alzheimers Dis. 49 2015 1 12
    • (2015) J. Alzheimers Dis. , vol.49 , pp. 1-12
    • Pan, Y.1    Terpstra, E.2    Wang, Y.3    Qiao, F.4    Wang, J.5    Tong, Y.6
  • 146
    • 84933498386 scopus 로고    scopus 로고
    • Gene panels and primers for next generation sequencing studies on neurodegenerative disorders
    • V.V. Giau, S.S. An, E. Bagyinszky, and S.Y. Kim Gene panels and primers for next generation sequencing studies on neurodegenerative disorders Mol. Cell. Toxicol. 11 2015 89 143
    • (2015) Mol. Cell. Toxicol. , vol.11 , pp. 89-143
    • Giau, V.V.1    An, S.S.2    Bagyinszky, E.3    Kim, S.Y.4
  • 147
    • 77953312769 scopus 로고    scopus 로고
    • Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation
    • J. Nunez-Iglesias, C.C. Liu, T.E. Morgan, C.E. Finch, and X.J. Zhou Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation PloS One 5 2010 e8898
    • (2010) PloS One , vol.5
    • Nunez-Iglesias, J.1    Liu, C.C.2    Morgan, T.E.3    Finch, C.E.4    Zhou, X.J.5
  • 148
    • 77952336221 scopus 로고    scopus 로고
    • Aberrant microRNA expression in the brains of neurodegenerative diseases: MiR-29a decreased in Alzheimer disease brains targets neurone navigator 3
    • M. Shioya, S. Obayashi, H. Tabunoki, K. Arima, Y. Saito, T. Ishida, and J. Satoh Aberrant microRNA expression in the brains of neurodegenerative diseases: MiR-29a decreased in Alzheimer disease brains targets neurone navigator 3 Neuropathol. Appl. Neurobiol. 36 2010 320 330
    • (2010) Neuropathol. Appl. Neurobiol. , vol.36 , pp. 320-330
    • Shioya, M.1    Obayashi, S.2    Tabunoki, H.3    Arima, K.4    Saito, Y.5    Ishida, T.6    Satoh, J.7
  • 149
    • 79451474371 scopus 로고    scopus 로고
    • Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: White matter versus gray matter
    • W.X. Wang, Q. Huang, Y. Hu, A.J. Stromberg, and P.T. Nelson Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter Acta Neuropathol. 121 2011 193 205
    • (2011) Acta Neuropathol. , vol.121 , pp. 193-205
    • Wang, W.X.1    Huang, Q.2    Hu, Y.3    Stromberg, A.J.4    Nelson, P.T.5
  • 150
    • 33846282302 scopus 로고    scopus 로고
    • The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
    • J. Shen, and R.J. Kelleher The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism Proc. Natl. Acad. Sci. U. S. A. 104 2007 403 409
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 403-409
    • Shen, J.1    Kelleher, R.J.2
  • 151
    • 0141631876 scopus 로고    scopus 로고
    • A microRNA array reveals extensive regulation of microRNAs during brain development
    • A.M. Krichevsky, K.S. King, C.P. Donahue, K. Khrapko, and K.S. Kosik A microRNA array reveals extensive regulation of microRNAs during brain development RNA 9 2003 1274 1281
    • (2003) RNA , vol.9 , pp. 1274-1281
    • Krichevsky, A.M.1    King, K.S.2    Donahue, C.P.3    Khrapko, K.4    Kosik, K.S.5
  • 152
    • 77949995894 scopus 로고    scopus 로고
    • MicroRNA-146a and human disease
    • L. Li, X.P. Chen, and Y.J. Li microRNA-146a and human disease Scand. J. Immunol. 71 2010 227 231
    • (2010) Scand. J. Immunol. , vol.71 , pp. 227-231
    • Li, L.1    Chen, X.P.2    Li, Y.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.