Large-scale proteomics and phosphoproteomics of urinary exosomes

Journal of the American Society of Nephrology

Volumn 20, Issue 2, 2009, Pages 363-379

  Gonzales, Patricia A ^a,e   Pisitkun, Trairak ^a   Hoffert, Jason D ^a   Tchapyjnikov, Dmitry ^a   Star, Robert A ^b   Kleta, Robert ^c,d,f   Wang, Nam Sun ^e   Knepper, Mark A ^a,d  

^a Laboratory of Kidney and Electrolyte Metabolism NHBLI   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

^e UNIVERSITY OF MARYLAND   (United States)

^f UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE; SODIUM CHLORIDE COTRANSPORTER; SODIUM POTASSIUM CHLORIDE COTRANSPORTER; THIAZIDE DIURETIC AGENT;

ARTICLE; BARTTER SYNDROME; DIAGNOSTIC VALUE; EXOSOME; HUMAN; IMMUNOBLOTTING; KIDNEY EPITHELIUM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; PROTEOMICS; UNINDEXED SEQUENCE; URINE;

EID: 59949097474     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008040406     Document Type: Article

References (28)

1. Pisitkun T, Shen RF, Knepper MA: Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A 101: 13368-13373, 2004
2. Zhou H, Yuen PS, Pisitkun T, Gonzales PA, Yasuda H, Dear JW, Gross P, Knepper P, Star RA: Collection, storage, preservation, and normalization of human urinary exosomes for biomarker discovery. Kidney Int 69: 1471-1476, 2006
3. Cheruvanky A, Zhou H, Pisitkun T, Kopp JB, Knepper MA, Yuen PS, Star RA: Rapid isolation of urinary exosomal biomarkers using a nanomembrane ultrafiltration concentrator. Am J Physiol Renal Physiol 292: F1657-F1661, 2007
4. Hoffert JD, Wang G, Pisitkun T, Shen RF, Knepper MA: An automated platform for analysis of phosphoproteomic datasets: Application to kidney collecting duct phosphoproteins. J Proteome Res 6: 35013509, 2007
5. Williams RL, Urbé S: The emerging shape of the ESCRT machinery. Nat Rev Mol Cell Biol 8: 355-368, 2007
6. Forgac M: Vacuolar ATPases: Rotary proton pumps in physiology and pathophysiology. Nat Rev Mol Cell Biol 8: 917-929, 2007
7. Gluck SL, Underhill DM, lyori M, Holliday LS, Kostrominova TY, Lee BS: Physiology and biochemistry of the kidney vacuolar H +-ATPase. Annu Rev Physiol 58: 427-445, 1996
8. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP: Renal vacuolar H+-ATPase. Physiol Rev 84: 1263-1314, 2004
9. Simon DB, Karet FE, Hamdan JM, Di Pietro A, Sanjad SA, Lifton RP: Barrier's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na-K-2Cl cotransporter NKCC2. Nat Genet 13: 183-188, 1996
10. Kleta R, Bockenhauer D: Bartter syndromes and other salt-losing tubulopathies. Nephron Physiol 104: 73-80, 2006
11. Hoffert JD, Pisitkun T, Wang G, Shen RF, Knepper MA: Quantitative phosphoproteomics of vasopressin-sensitive renal cells: Regulation of aquaporin-2 phosphorylation at two sites. Proc Natl Acad Sci U S A 103: 7159-7164, 2006
12. Chen WG, White FM: Proteomic analysis of cellular signaling. Expert Rev Proteomics 1: 343-354, 2004
13. Beausoleil SA, Villen J, Gerber SA, Rush J, Gygi SP: A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Nat Biotechnol 24: 1285-1292, 2006
14. Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H: WNK1 regulates phosphorylation of cation-chloride- coupled cotransporters via the STE20-related kinases, SPAK and OSR1. J Biol Chem 280: 42635-42693, 2005
15. Simon DB, Nelson-Williams C, Bia MJ, Ellison D, Karet FE, Molina AM, Vaara I, Iwata F, Cushner HM, Koolen M, Gainza FJ, Gitleman HJ, Lifton RP: Gitelman's variant ofBartter's syndrome, inherited hypokal-aemic alkalosis, is caused by mutations in the thiazide-sensitive Na-Cl cotransporter. Nat Genet 12: 24-30, 1996
16. Kuwahara M, Fushimi K, Terada Y, Bai L, Marumo F, Sasaki S: cAMP-dependent phosphorylation stimulates water permeability of aquaporin-collecting duct water channel protein expressed in Xenopus oocytes. J Biol Chem 270: 10384-10387, 1995
17. Gimenez I, Forbush B: Regulatory phosphorylation sites in the N-terminus of the renal Na-K-Cl cotransporter (NKCC2). Am J Physiol Renal Physiol 289: F1341-F1345, 2005
18. Villen J, Beausoleil SA, Gerber SA, Gygi SP: Large-scale phosphorylation analysis of mouse liver. Proc Natl Acad Sci U S A 104: 1488-1493, 2007
19. Lees-Miller SP, Anderson CW: Two human 90-kDa heat shock proteins are phosphorylated in vivo at conserved serines that are phosphory-lated in vitro by casein kinase II. J Biol Chem 264: 2431-2437, 1989
20. Christensen B, Nielsen MS, Haselmann KF, Petersen TE, Sorensen ES: Post-translationally modified residues of native human osteopontin are located in clusters: Identification of 36 phosphorylation and five O-glycosylation sites and their biological implications. Biochem J390: 285-292, 2005
21. Hoorn EJ, Pisitkun T, Zietse R, Gross P, Frokiaer J, Wang NS, Gonzales PA, Star RA, Knepper MA: Prospects for urinary proteomics: Exosomes as a source of urinary biomarkers. Nephrology(Carlton) 10: 283-290, 2005
22. Gonzales P, Pisitkun T, Knepper MA: Urinary exosomes: Is there a future? Nephrol Dial Transplant 23: 1799-1801, 2008
23. Pisitkun T, Johnstone R, Knepper MA: Discovery of urinary biomarkers. Mol Cell Proteomics 5: 1760-1771, 2006
24. Pisitkun T, Hoffert JD, Yu MJ, Knepper MA: Tandem mass spectrometry in physiology. Physiology (Bethesda) 22: 390-400, 2007
25. Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP: The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A 102: 13616-13621, 2005
26. Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED: Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A 98: 4221-4226, 2001
27. Sadygov RG, Cociorva D, Yates JR 3rd: Large-scale database search ing using tandem mass spectra: Looking up the answer in the back of the book. Nat Methods 1: 195-202, 2004
28. Tanner S, Shu H, Frank A, Wang LC, Zandi E, Mumby M, Pevzner P, Bafna V: InsPecT: Identification of posttranslationally modified peptides from tandem mass spectra. Anal Chem 77: 4626-4639, 2005