Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 8, Issue 5, 2012, Pages 712-720

  Hoen, Esther N M Nolte 't ^a   van der Vlist, Els J ^a   Aalberts, Marian ^a   Mertens, Hendrik C H ^a   Bosch, Berend Jan ^b   Bartelink, Willem ^b   Mastrobattista, Enrico ^c   van Gaal, Ethlinn V B ^c   Stoorvogel, Willem ^a   Arkesteijn, Ger J A ^b   Wauben, Marca H M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Biomarkers; Cellular membrane vesicles; Dendritic cells; Exosomes; Flow cytometry; Microvesicles; Nanovesicles

Indexed keywords

CELLULAR MEMBRANES; DENDRITIC CELLS; EXOSOMES; MICROVESICLES; NANOVESICLES;

BIOMARKERS; CELL CULTURE; CELL MEMBRANES; FLOW CYTOMETRY; FLUORESCENCE; LIPOSOMES;

MEMBRANES;

LIPOSOME; NANOPARTICLE; POLYCARBONATE;

ANIMAL CELL; ARTICLE; BODY FLUID; CELL CULTURE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; DENDRITIC CELL; EXOSOME; FLOW CYTOMETRY; FLUORESCENCE; MOUSE; NONHUMAN; PHENOTYPE; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SUPERNATANT; VIRION;

ANIMALS; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; DENDRITIC CELLS; ENDOSOMES; EXOSOMES; FLOW CYTOMETRY; HUMANS; LIPOSOMES; MICE; MICE, INBRED C57BL; NANOPARTICLES; SEMEN; VIRION;

EID: 84862677632     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2011.09.006     Document Type: Article

References (39)

1. Thery C., Ostrowski M., Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009, 9:581-593.
2. Cocucci E., Racchetti G., Meldolesi J. Shedding microvesicles: artifacts no more. Trends Cell Biol 2009, 19:43-51.
3. Raposo G., Nijman H.W., Stoorvogel W., Liejendekker R., Harding C.V., Melief C.J., et al. B lymphocytes secrete antigen-presenting vesicles. J Exp Med 1996, 183:1161-1172.
4. Puddu P., Puddu G.M., Cravero E., Muscari S., Muscari A. The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseases. Can J Cardiol 2010, 26:140-145.
5. Chironi G.N., Boulanger C.M., Simon A., Dignat-George F., Freyssinet J.M., Tedgui A. Endothelial microparticles in diseases. Cell Tissue Res 2009, 335:143-151.
6. Nomura S. Dynamic role of microparticles in type 2 diabetes mellitus. Curr Diabetes Rev 2009, 5:245-251.
7. Clayton A., Mason M.D. Exosomes in tumour immunity. Curr Oncol 2009, 16:46-49.
8. Escudier B., Dorval T., Chaput N., Andre F., Caby M.P., Novault S., et al. Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med 2005, 3:10.
9. Nolte-'t Hoen E.N., Buschow S.I., Anderton S.M., Stoorvogel W., Wauben M.H., Activated T. cells recruit exosomes secreted by dendritic cells via LFA-1. Blood 2009, 113:1977-1981.
10. Morelli A.E., Larregina A.T., Shufesky W.J., Sullivan M.L., Stolz D.B., Papworth G.D., et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 2004, 104:3257-3266.
11. Beyer C., Pisetsky D.S. The role of microparticles in the pathogenesis of rheumatic diseases. Nat Rev Rheumatol 2009, 6:21-29.
12. Sullivan R., Saez F., Girouard J., Frenette G. Role of exosomes in sperm maturation during the transit along the male reproductive tract. Blood Cells Mol Dis 2005, 35:1-10.
13. Kim S.H., Lechman E.R., Bianco N., Menon R., Keravala A., Nash J., et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol 2005, 174:6440-6448.
14. Zhang H.G., Grizzle W.E. Exosomes and cancer: ae newly described pathway of immune suppression. Clin Cancer Res 2011.
15. Mathivanan S., Simpson R.J. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics 2009, 9:4997-5000.
16. Keller S., Ridinger J., Rupp A.K., Janssen J.W., Altevogt P. Body fluid derived exosomes as a novel template for clinical diagnostics. J Transl Med 2011, 9:86.
17. Chaput N., Taieb J., Schartz N., Flament C., Novault S., Andre F., et al. The potential of exosomes in immunotherapy of cancer. Blood Cells Mol Dis 2005, 35:111-115.
18. Iero M., Valenti R., Huber V., Filipazzi P., Parmiani G., Fais S., et al. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ 2008, 15:80-88.
19. Yuana Y., Oosterkamp T.H., Bahatyrova S., Ashcroft B., Garcia Rodriguez P., Bertina R.M., et al. Atomic force microscopy: a novel approach to the detection of nanosized blood microparticles. J Thromb Haemost 2010, 8:315-323.
20. Gyorgy B., Modos K., Pallinger E., Paloczi K., Pasztoi M., Misjak P., et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters. Blood 2011, 117:e39-48.
21. Dragovic R.A., Gardiner C., Brooks A.S., Tannetta D.S., Ferguson D.J., Hole P., et al. Sizing and phenotyping of cellulars vesicles using Nanoparticle Tracking Analysis. Nanomedicine 2011.
22. Filipe V., Hawe A., Jiskoot W. Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res 2010, 27:796-810.
23. Lacroix R., Robert S., Poncelet P., Kasthuri R.S., Key N.S., Dignat-George F. Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop. J Thromb Haemost 2010, 8:2571-2574.
24. Orozco A.F., Lewis D.E. Flow cytometric analysis of circulating microparticles in plasma. Cytometry A 2010, 77:502-514.
25. Freyssinet J.M., Toti F. Membrane microparticle determination: at least seeing what's being sized!. J Thromb Haemost 2010, 8:311-314.
26. Shapiro H.M. Practical Flow Cytometry 2003, Wiley Liss, New York. 4th ed.
27. Steen H.B. Flow cytometer for measurement of the light scattering of viral and other submicroscopic particles. Cytometry A 2004, 57:94-99.
28. Lutz M.B., Kukutsch N., Ogilvie A.L., Rossner S., Koch F., Romani N., et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J Immunol Methods 1999, 223:77-92.
29. Lauwen M.M., Zwaveling S., de Quartel L., Ferreira Mota S.C., Grashorn J.A., Melief C.J., et al. Self-tolerance does not restrict the CD4+ T-helper response against the p53 tumor antigen. Cancer Res 2008, 68:893-900.
30. Buschow S.I., Nolte-'t Hoen E.N., van Niel G., Pols M.S., ten Broeke T., Lauwen M., et al. MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic 2009, 10:1528-1542.
31. Bosch B.J., van der Zee R., de Haan C.A., Rottier P.J. The coronavirus spike protein is a class I virus fusion protein: structural and functional characterization of the fusion core complex. J Virol 2003, 77:8801-8811.
32. Barcena M., Oostergetel G.T., Bartelink W., Faas F.G., Verkleij A., Rottier P.J., et al. Cryo-electron tomography of mouse hepatitis virus: insights into the structure of the coronavirion. Proc Natl Acad Sci U S A 2009, 106:582-587.
33. Kerker M., Chew H., McNulty P.J., Kratohvil J.P., Cooke D.D., Sculley M., et al. Light scattering and fluorescence by small particles having internal structure. J Histochem Cytochem 1979, 27:250-263.
34. van Gaal E.V., Spierenburg G., Hennink W.E., Crommelin D.J., Mastrobattista E. Flow cytometry for rapid size determination and sorting of nucleic acid containing nanoparticles in biological fluids. J Control Release 2010, 141:328-338.
35. Sahlen G.E., Egevad L., Ahlander A., Norlen B.J., Ronquist G., Nilsson B.O. Ultrastructure of the secretion of prostasomes from benign and malignant epithelial cells in the prostate. Prostate 2002, 53:192-199.
36. Blanchard N., Lankar D., Faure F., Regnault A., Dumont C., Raposo G., et al. TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J Immunol 2002, 168:3235-3241.
37. Stoorvogel W., Kleijmeer M.J., Geuze H.J., Raposo G. The biogenesis and functions of exosomes. Traffic 2002, 3:321-330.
38. Segura E., Amigorena S., Thery C. Mature dendritic cells secrete exosomes with strong ability to induce antigen-specific effector immune responses. Blood Cells Mol Dis 2005, 35:89-93.
39. Zwicker J.I. Tissue factor-bearing microparticles and cancer. Semin Thromb Hemost 2008, 34:195-198.