Aberrant rabi 11-dependent trafficking of the neuronal glutamate transporter EAACl causes oxidative stress and cell death in huntington's disease

Journal of Neuroscience

Volumn 30, Issue 13, 2010, Pages 4552-4561

  Li, Xueyi ^a   Valencia, Antonio ^a   Sapp, Ellen ^a   Masso, Nicholas ^a   Alexander, Jonathan ^a   Reeves, Patrick ^a   Kegel, Kimberly B ^a   Aronin, Neil ^b   Difiglia, Marian ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; GLUTAMATE TRANSPORTER; GLUTAMATE TRANSPORTER EAAC1; GLUTATHIONE; HUNTINGTIN; RAB11 PROTEIN; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; EXCITATORY AMINO ACID TRANSPORTER 3; HD PROTEIN, HUMAN; HUNTINGTON PROTEIN, MOUSE; NERVE PROTEIN; NUCLEAR PROTEIN; RAB PROTEIN; SLC1A1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CELL; CELL DEATH; CELL SURFACE; CELL SURVIVAL; CONTROLLED STUDY; ENDOSOME; EXON; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; MITOCHONDRION; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; SYNTHESIS; ANIMAL; BRAIN CORTEX; CELL CULTURE; GENE TARGETING; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN TRANSPORT;

ANIMALS; CELL DEATH; CELLS, CULTURED; CEREBRAL CORTEX; CYSTEINE; EXCITATORY AMINO ACID TRANSPORTER 3; GENE KNOCK-IN TECHNIQUES; GLUTATHIONE; HUMANS; HUNTINGTON DISEASE; MICE; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 77950682093     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5865-09.2010     Document Type: Article

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