Predicting skin sensitisation using a decision tree integrated testing strategy with an in silico model and in chemico/in vitro assays

Regulatory Toxicology and Pharmacology

Volumn 76, Issue , 2016, Pages 30-38

  Macmillan, Donna S ^a   Canipa, Steven J ^a   Chilton, Martyn L ^a   Williams, Richard V ^a   Barber, Christopher G ^a  

^a LHASA LIMITED   (United Kingdom)

Author keywords

Derek Nexus; DPRA; H CLAT; In silico assessment; Integrated testing strategy; KeratinoSens; LuSens; Skin sensitisation; U SENS

Indexed keywords

ARTICLE; ASSAY; COMPUTER MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; DECISION TREE; DIIRECT PEPTIDE REACTIVITY TEST; HUMAN CELL LINE ACTIVATION TEST; IN VITRO STUDY; MYELOID U937 SKIN SENSITISATION TEST; PREDICTION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SKIN SENSITIZATION; ANIMAL; ANIMAL TESTING ALTERNATIVE; CHEMISTRY; COMPUTER SIMULATION; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, IRRITANT; DRUG EFFECTS; FACTUAL DATABASE; HUMAN; KNOWLEDGE BASE; PROCEDURES; REPRODUCIBILITY; SKIN; SOFTWARE; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; WORKFLOW;

IRRITANT AGENT;

ANIMAL TESTING ALTERNATIVES; ANIMALS; COMPUTER SIMULATION; DATABASES, FACTUAL; DECISION TREES; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, IRRITANT; HUMANS; IRRITANTS; KNOWLEDGE BASES; REPRODUCIBILITY OF RESULTS; SKIN; SKIN IRRITANCY TESTS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP; WORKFLOW;

EID: 84955254565     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2016.01.009     Document Type: Article

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