A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells

Cutaneous and Ocular Toxicology

Volumn 29, Issue 3, 2010, Pages 171-192

  McKim Jr , James M ^a   Keller III, Don J ^a   Gorski, Joel R ^b  

^a CeeTox Inc   (United States)

^b NAMSA (North American Science Associates Inc)   (United States)

Author keywords

chemicals; gene expression; in vitro methods; nonanimal methods; peptide binding; safety testing; Skin sensitization

Indexed keywords

CHEMICAL SENSITIZER; CHROMIUM; DERMATOLOGICAL AGENT; GLUTATHIONE; NICKEL; PEPTIDE; SILVER; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; CYTOCHROME P450 1A1; HAPTEN; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; KEAP1 PROTEIN, HUMAN; MAFF PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR MAFF;

ALGORITHM; ARTICLE; CELL FREE SYSTEM; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; IN VITRO STUDY; LOCAL LYMPH NODE ASSAY; PROTEIN BINDING; SCREENING; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SKIN CELL; SKIN SENSITIZATION; SOLUBILITY; ANIMAL; CELL LINE; CHEMISTRY; DNA RESPONSIVE ELEMENT; DRUG EFFECT; GENE EXPRESSION; KERATINOCYTE; METABOLISM; METHODOLOGY; SKIN ALLERGY; TOXICITY TESTING;

ANIMALS; CELL LINE; CYTOCHROME P-450 CYP1A1; DERMATITIS, ALLERGIC CONTACT; GENE EXPRESSION; GLUTATHIONE; HAPTENS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KERATINOCYTES; LOCAL LYMPH NODE ASSAY; MAFF TRANSCRIPTION FACTOR; NUCLEAR PROTEINS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TOXICITY TESTS;

EID: 77955116693     PISSN: 15569527     EISSN: 15569535     Source Type: Journal    
DOI: 10.3109/15569527.2010.483869     Document Type: Article

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