Evaluation of combinations of in vitro sensitization test descriptors for the artificial neural network-based risk assessment model of skin sensitization

Journal of Applied Toxicology

Volumn 35, Issue 11, 2015, Pages 1333-1347

  Hirota, Morihiko ^a   Fukui, Shiho ^b   Okamoto, Kenji ^b   Kurotani, Satoru ^c   Imai, Noriyasu ^c   Fujishiro, Miyuki ^d   Kyotani, Daiki ^d   Kato, Yoshinao ^e   Kasahara, Toshihiko ^f   Fujita, Masaharu ^f   Toyoda, Akemi ^g   Sekiya, Daisuke ^h   Watanabe, Shinichi ^h   Seto, Hirokazu ⁱ   Takenouchi, Osamu ^j   Ashikaga, Takao ^a   Miyazawa, Masaaki ^j  

^a SHISEIDO RESEARCH CENTER   (Japan)

^b KANEBO LTD   (Japan)

^c Cutaneous Research Section   (Japan)

^d NIKKOL Group Cosmos Technical Center Co   (Japan)

^e Nippon Menard Cosmetic Co Ltd   (Japan)

^f FUJIFILM CORPORATION   (Japan)

^g POLA CHEMICAL INDUSTRIES INC   (Japan)

^h LION CORPORATION   (Japan)

ⁱ P and G Japan KK   (Japan)

^j KAO CORPORATION   (Japan)

more..

Author keywords

ARE; Artificial neural network; DPRA; H CLAT; JCIA; Risk assessment; SH test; Skin sensitization

Indexed keywords

1 NAPHTHOL; 1,4 BENZOQUINONE; 1,4 DIHYDROQUINONE; 2 AMINOPHENOL; 2 HEXENAL; 3 AMINOPHENOL; 4 CHLOROANILINE; BENZOYL PEROXIDE; BENZYL BROMIDE; BISPHENOL A BIS(2 HYDROXYPROPYL) ETHER DIMETHACRYLATE; CHLOROQUINE; CHLOROTHALONIL; COBALT CHLORIDE; CYSTEINE; DICHROMATE POTASSIUM; DIETHYLENETRIAMINE; DIPHENCYPRONE; DODECYL GALLATE; FORMALDEHYDE; GALLIC ACID PROPYL ESTER; GLUTARALDEHYDE; GLYOXAL; LYSINE; MALEIC ACID DIETHYL ESTER; MALEIC ANHYDRIDE; OXAZOLONE; PHTHALIC ANHYDRIDE; RESORCINOL; SALICYLIC ACID BENZYL ESTER; TOSYLCHLORAMIDE SODIUM; UNCLASSIFIED DRUG;

ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ARTIFICIAL NEURAL NETWORK; BREAST CARCINOMA; CELL VIABILITY; COMPUTER MODEL; COSMETIC INDUSTRY; DENDRITIC CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; RISK ASSESSMENT; SKIN SENSITIZATION; ANIMAL TESTING ALTERNATIVE; CELL LINE; LOCAL LYMPH NODE ASSAY; METABOLISM; PROCEDURES; SENSITIVITY AND SPECIFICITY; SKIN; SKIN TEST;

ANIMAL TESTING ALTERNATIVES; CELL LINE; DENDRITIC CELLS; HUMANS; LOCAL LYMPH NODE ASSAY; NEURAL NETWORKS (COMPUTER); RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN; SKIN TESTS;

EID: 84942418338     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3105     Document Type: Article

References (45)

1. Aiba S, Terunuma A, Manome H, Tagami H. 1997. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur. J. Immunol. 27: 3031-3038.
2. Aiba S, Tagami H. 1998. Dendritic cell activation induced by various stimuli, e.g.exposure to microorganisms, their products, cytokines, and simple chemicals as well as adhesion to extracellular matrix. J. Dermatol. Sci. 20: 1-13.
3. Api AM, Basketter DA, Cadby PA, Cano MF, Ellis G, Gerberick GF, Griem P, McNamee PM, Ryan CA, Safford R. 2008. Dermal sensitization quantitative risk assessment (QRA) for fragrance ingredients. Regul. Toxicol. Pharmacol. 52: 3-23.
4. Ashikaga T, Sakaguchi H, Sono S, Kosaka N, Ishikawa M, Nukada Y, Miyazawa M, Ito Y, Nishiyama N, Itagaki H. 2010. A comparative evaluation of in vitro skin sensitization tests: The human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA). Altern. Lab. Anim. 38: 275-284.
5. Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, Miyazawa M, Ito Y, Suzuki H, Toyoda H. 2006. Development of an in vitro skin sensitization test using human cell lines: the human cell line activation test (h-CLAT). I. Optimization of the h-CLAT protocol. Toxicol. In Vitro 20: 767-773.
6. Azam P, Peiffer JL, Chamousset D, Tissier MH, Bonnet PA, Vian L, Fabre I, Ourlin JC. 2006. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol. Appl. Pharmacol. 212: 14-23.
7. Basketter DA. 2010. Methyldibromoglutaronitrile: skin sensitization and quantitative risk assessment. Cutan. Ocul. Toxicol. 29: 4-9.
8. Basketter DA, Evans P, Fielder RJ, Gerberick GF, Dearman RJ, Kimber I. 2002. Local lymph node assay - validation, conduct and use in practice. Food Chem. Toxicol. 40: 593-598.
9. Basketter DA, Kimber I. 2011. Predictive tests for irritants and allergens and their use in quantitative risk assessment. In Contact Dermatitis, 5th edn, chapter 13, Johansen JD, Frosch PF, Lepoittevin J-P (eds). Springer: Berlin; 229-240.
10. Basketter DA, Sanders D, Jowsey IR. 2007. The skin sensitization potential of resorcinol: Experience with the local lymph node assay. Contact Dermatitis 56: 196-200.
11. Basketter DA, Scholes EW. 1992. Comparison of the local lymph node assay with the guinea-pig maximazation test for the detection of a range of contact allergens. Food Chem. Toxicol. 30: 65-69.
12. Bauch C, Kolle SN, Ramirez T, Eltze T, Fabian E, Mehling A, Teubner W, van Ravenzwaay B, Landsiedel R. 2012. Putting the parts together: combining in vitro methods to test for skin sensitizing potentials. Regul. Toxicol. Pharmacol. 63: 489-504.
13. Boisleve F, Kerdine-Romer S, Rougier-Larzat N, Pallardy M. 2004. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-alpha and MAPK. J. Invest. Dermatol. 123: 494-502.
14. Emter R, Ellis G, Natsch A. 2010. Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol. Appl. Pharmacol. 245: 281-290.
15. Gerberick GF, Ryan CA, Kern PS, Dearman RJ, Kimber I, Patlewicz GY, Basketter DA. 2004a. A chemical dataset for evaluation of alternative approaches to skin-sensitization testing. Contact Dermatitis 50: 274-288.
16. Gerberick GF, Vassallo JD, Bailey RE, Chaney JE, Morrall SW, Lepoittevin JP. 2004b. Development of a peptide reactivity assay for screening contact allergens. Toxicol. Sci. 81: 332-343.
17. Gerberick GF, Ryan CA, Kern PS, Schlatter H, Dearman RJ, Kimber I, Patlewicz GY, Basketter DA. 2005. Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis 16: 157-202.
18. Gerberick GF, Vassallo JD, Foertsch LM, Price BB, Chaney JG, Lepoittevin JP. 2007. Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol. Sci. 97: 417-427.
19. Hirota M, Kouzuki H, Ashikaga T, Sono S, Tsujita K, Sasa H, Aiba S. 2013. Artificial neural network analysis of data from multiple in vitro assays for prediction of skin sensitization potency of chemicals. Toxicol. In Vitro 27: 1233-1246.
20. Jaworska J, Harol A, Kern PS, Gerberick GF. 2011. Integrating non-animal test information into an adaptive testing strategy - skin sensitization proof of concept case. ALTEX 28: 211-225.
21. Jaworska J, Dancik Y, Kern PS, Gerberick GF, Natsch A. 2013. Bayesian integratd testing strategy to assess skin sensitization potency: from theory to practice. J. Appl. Toxicol. DOI: 10.1002/jat.2869
22. Jowsey IR, Basketter DA, Westmoreland C, Kimber I. 2006. A future approach to measuring relative skin sensitizing potency: a proposal. J. Appl. Toxicol. 26: 341-350.
23. Kern PS, Gerberick GF, Ryan CA, Kimber I, Aptula A, Basketter DA. 2010. Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis 21: 8-32.
24. Kimber I, Basketter DA, Butler M, Gamer A, Garrigue JL, Gerberick GF, Newsome C, Steiling W, Vohr HW. 2003. Classification of contact allergens according to potency: proposals. Food Chem. Toxicol. 41: 1799-1809.
25. Magnusson B, Kligman AM. 1969. The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol. 52: 268-276.
26. Maxwell G, Aeby P, Ashikaga T, Bessou-Touya S, Diembeck W, Gerberick F, Kern P, Marrec-Fairley M, Ovigne JM, Sakaguchi H, Schroeder K, Tailhardat M, Teissier S, Winkler P. 2011. Skin sensitisation: the Colipa strategy for developing and evaluating non-animal test methods for risk assessment. ALTEX 28: 50-55.
27. Mossmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65: 55-63.
28. National Toxicology Program. 2014. NICEATM LLNA Database
29. Natsch A, Emter R. 2008. Skin sensitizers induce antioxidant response element dependent genes: Application to the in vitro testing of the sensitization potential of chemicals. Toxicol. Sci. 102: 110-119.
30. Natsch A, Emter R, Ellis G. 2009. Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing. Toxicol. Sci. 107: 106-121.
31. Nukada Y, Ashikaga T, Miyazawa M, Hirota M, Sakaguchi H, Sasa H, Nishiyama N. 2012. Predition of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency. Toxicol. In Vitro 26: 1150-1160.
32. Nukada Y, Miyazawa M, Saitou K, Sakaguchi H, Nishiyama N. 2013. Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals. Toxicol. In Vitro 27: 609-618.
33. Organization for Economic Cooperation and Development. 1992. OECD Guideline for Testing Chemicals. Guideline no. 406. skin sensitization. Organization for Economic Cooperation and Development: Paris, 1992.
34. Organization for Economic Cooperation and Development. 2010. OECD Guideline for Testing Chemicals. Guideline no. 429. skin sensitization: the Local lymph node assay. Organization for Economic Cooperation and Development: Paris, 2010.
35. Organization for Economic Cooperation and Development. 2012. The adverse outcome pathway for skin sensitisation initiated by covalent binding for proteins. Part 1: Scientific evidence. OECD Environment, Health and Safety Publications Series on Testing and Assessment 168: 1-59.
36. Organization for Economic Cooperation and Development. 2013. OECD Guideline for testing chemicals. DRAFT PROPOSAL FOR A NEW TEST GUIDELINE. In Vitro Skin Sensitization: Direct Peptide Reactivity Assay (DPRA). Paris: http://www.oecd.org/env/ehs/testing/OECD_draft%20TG_DPRA_13Nov2013.pdf
37. Python F, Goebel C, Aeby P. 2007. Assessment of the U937 cell line for the detection of contact allergens. Toxicol. Appl. Pharmacol. 220: 113-124.
38. Richter A, Schmucker SS, Esser PR, Traska V, Weber V, Dietz L, Thierse HJ, Pennino D, Cavani A, Martin SF. 2013. Human T cell priming assay (hTCPA) for the identification of contact allergens based on naive T cells and DC--IFN-γ and TNF-α readout. Toxicol. In Vitro 27: 1180-1185.
39. Ryan CA, Cruse LW, Skinner RA, Dearman RJ, Kimber I, Gerberick GF. 2002. Examination of a vehicle for use with water soluble materials in the murine local lymph node assay. Food Chem. Toxicol. 40: 1719-1725.
40. Sakaguchi H, Ashikaga T, Miyazawa M, Yoshida Y, Ito Y, Yoneyama K, Hirota M, Itagaki H, Toyoda H, Suzuki H. 2006. Development of an in vitro skin sensitization test using human cell lines; human cellline activation test (h-CLAT). II. An inter-laboratory study of the h-CLAT. Toxicol. In Vitro 20: 774-784.
41. Suzuki M, Hirota M, Hagino S, Itagaki H, Aiba S. 2009. Evaluation of changes of cell-surface thiols as a new biomarker for in vitro sensitization test. Toxicol. In Vitro 23: 687-696.
42. Takenouchi O, Fukui S, Okamoto K, Kurotani S, Imai N, Fujishiro M, Kyotani D, Kato Y, Kasahara T, Fujita M, Toyoda A, Sekiya D, Watanabe S, Seto H, Hirota M, Ashikaga T, Miyazawa M. Accepted. Test battery with h-CLAT, DPRA, and DEREK based on a 139 chemical dataset for predicting skin sensitizing potential and potency of chemicals. J. Appl. Toxicol.
43. Tsujita-Inoue K, Hirota M, Ashikaga T, Atobe T, Kouzuki H, Aiba S. 2014. Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays. Toxicol. In Vitro 28: 626-639.
44. United Nations. 2009. Globally Harmonized System of Classification and Labeling of Chemicals (GHS), 3rd revised edn. United Nations: New York and Geneva.
45. Vocanson M, Achachi A, Mutez V, Cluzel-Tailhardat M, Varlet BL, Rozières A, Fournier P, Nicolas JF. 2014. Human T cell priming assay: depletion of peripheral blood lymphocytes in CD25(+) cells improves the in vitro detection of weak allergen-specific T cells. EXS 104: 89-100.