Predictive performance of the human cell line activation test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients

Journal of Toxicological Sciences

Volumn 38, Issue 4, 2013, Pages 599-609

  Takenouchi, Osamu ^a   Miyazawa, Masaaki ^a   Saito, Kazutoshi ^a   Ashikaga, Takao ^b   Sakaguchi, Hitoshi ^a  

^a KAO CORPORATION   (Japan)

^b SHISEIDO RESEARCH CENTER   (Japan)

Author keywords

Applicability domain; H clat; Lipophilic sensitizing chemicals; Skin sensitization

Indexed keywords

CD86 ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; OCTANOL;

ARTICLE; CELL ACTIVATION; CONTACT DERMATITIS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; MEASUREMENT ACCURACY; PARTITION COEFFICIENT; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SKIN SENSITIZATION; SOLUBILITY;

EID: 84879653354     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.38.599     Document Type: Article

References (33)

1. Aiba, S., Manome, H., Nakagawa, S., Mollah, Z.U.A., Mizuashi, M., Ohtani, T., Yumiko, Y. and Tagami, H. (2003): p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene. J. Invest. Dermatol., 120, 390-399.
2. Aptula, A.O., Patlewicz, G. and Roberts, D.W. (2005): Skin sensitization: reaction mechanistic applicability domains for structure-activity relationships. Chem. Res. Toxicol., 18, 1420-1426.
3. Ashikaga, T., Sakaguchi, H., Okamoto, K., Mizuno, M., Sato, J., Yamada, T., Yoshida, M., Ota, N., Hasegawa, S., Kodama, T., Okamoto, Y., Kuwahara, H., Kosaka, N., Sono, S. and Ohno, Y. (2008): Assessment of the human Cell Line Activation Test (h-CLAT) for skin sensitization; results of the first Japanese inter-laboratory study. AATEX., 13, 27-35.
4. Ashikaga, T., Sakaguchi, H., Sono, S., Kosaka, N., Ishikawa, M., Nukada, Y., Miyazawa, M., Ito, Y., Nishiyama, N. and Itagaki, H. (2010): A comparative evaluation of in vitro skin sensitisation tests: the human cell-line activation test (h-CLAT) versus the local lymph node assay (LLNA). ATLA, 38, 275-284.
5. Basketter, D.A., Dearman, R.J., Hilton, J. and Kimber, I. (1997): Dinitrohalobenzenes: evaluation of relative skin sensitization potential using the local lymph node assay. Contact Dermatitis, 36, 97-100.
6. Boogaard, P.J., Denneman, M.A. and Van Sittert, N.J., (2000): Dermal penetration and metabolism of five glycidyl ethers in human, rat and mouse skin. Xenobiotica, 30, 469-483.
7. Casati, S., Aeby, P., Kimber, I., Maxwell, G., Ovigne, J.M. Roggen, E., Rovida, C., Tosti, L. and Basketter, D., (2009): Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation. ATLA, 37, 305-312.
8. Chipinda, I., Ruwona, T.B., Templeton, S.P. and Siegel, P.D. (2011): Use of the human monocytic leukemia THP-1 cell line and coincubation with microsomes to identify and differentiate hapten and prohapten sensitizers. Toxicology, 280, 135-143.
9. Cooper, J.A., Saracci, R. and Cole, P. (1979): Describing the validity of carcinogen screening tests. Br. J. Cancer, 39, 87-89.
10. dos Santos, G.G., Reinders, J., Ouwehand, K., Rustemeyer, T., Scheper, R.J. and Gibbs, S. (2009): Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol. Appl. Pharmacol., 236, 372-382.
11. Emter, R., Ellis, G. and Natsch, A. (2010): Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol. Appl. Pharmacol., 245, 281-290.
12. Foussereau, J., Samsoen, M. and Hecht. M, T., (1983): Occupational dermatitis to Ampholyt G in hospital personnel. Contact Dermatitis, 9, 233-234.
13. Gerberick, G.F., Vassallo, J.D., Bailey, R.E., Chaney, J.G., Morrall, S.W. and Lepoittevin, J.P. (2004): Development of a peptide reactivity assay for screening contact allergens. Toxicol. Sci., 81, 332-343.
14. Gerberick, G.F., Ryan, C.A., Kern, P.S., Schlatter, H., Dearman, R.J., Kimber, I., Patlewicz, G.Y. and Basketter, D.A. (2005): Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods. Dermatitis, 16, 157-202.
15. Gerberick, G.F., Cindy, A.R, Rebecca, J.D. and Kimber, I. (2007): Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals. Methods, 41, 54-60.
16. Gerberick, G.F., Vassallo, J.D., Foertsch, L.M., Price, B.B., Chaney, J.G. and Lepoittevin, J.P. (2007b): Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol. Sci., 97, 417-427.
17. Gerberick, G.F., Troutman, J.A., Foertsch, L.M., Vassallo, J.D., Quijano, M., Dobson, R.L.M., Goebel, C. and Lepoittevin, J.P. (2009): Investigation of peptide reactivity of prohapten skin sensitizers using a peroxidase-peroxide oxidation system. Toxicol. Sci., 112, 164-174.
18. Hilal, S.H., Karickhoff, S.W. and Carreira, L.A. (2004): Prediction of the solubility, activity coefficient and liquid/liquid partition coefficient of organic compounds. QSAR Comb. Sci., 23, 709720.
19. Jaworska, J., Harol, A., Kern, P.S. and Gerberick, G.F. (2011): Integrating non-animal test information into an adaptive testing strategy-skin sensitization proof of concept case. ALTEX, 28, 211-225.
20. Kern, P.S., Gerberick, G.F., Ryan, C.A., Kimber, I., Aptula, A. and Basketter, D.A. (2010): Local lymph node data for the evaluation of skin sensitization alternatives: a second compilation. Dermatitis, 21, 8-32.
21. Kimber, I., Basketter, D.A., Gerberick, G.F., Cindy, A.R. and Rebecca, J.D. (2011): Chemical allergy: translating biology into hazard characterization. Toxicol. Sci., 120, S238-S268.
22. Machatha, S.G. and Yalkowsky, S.H. (2005): Comparison of the octanol/water partition coefficients calculated by ClogP, ACDlogP and KowWin to experimentally determined values. Int. J. Pharm., 294, 185-192.
23. Nacht, S., Yeung, D., Joseph, N., Beasley, J.N., Anjo, M.D. and Maibach, H.I,. (1981): Benzoyl peroxide: percutaneous penetration and metabolic disposition. J. Am. Acad. Dermatol., 4, 31-37.
24. Natsch, A., Gfeller, H., Rothaupt, M. and Ellis, G. (2007): Utility and limitations of a peptide reactivity assay to predict fragranc allergens in vitro. Toxicol. In Vitro, 21, 1220-1226.
25. Natsch, A., Emter, R. and Ellis, G. (2009): Filling the concept with data: integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animalfree skin sensitization testing. Toxicol. Sci., 107, 106-121.
26. Nukada, Y., Miyazawa, M., Saitou, K., Sakaguchi, H. and Nishiyama, N. (2013): Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals. Toxicol. In Vitro, 27, 609-618.
27. Nukada, Y., Ashikaga, T., Sakaguchi, H., Sono, S., Mugita, N., Hirota, M., Miyazawa, M., Ito, Y., Sasa, H. and Nishiyama, N. (2011): Predictive performance for human skin sensitizing potential of the human cell line activation test (h-CLAT). Contact Dermatitis, 65, 343-353.
28. Nukada, Y., Ashikaga, T., Miyazawa, M., Hirota, M., Sakaguchi, H., Sasa, H. and Nishiyama, N. (2012): Prediction of skin sensitization potency of chemicals by human Cell Line Activation Test (h-CLAT) and an attempt at classifying skin sensitization potency. Toxicol. In Vitro, 26, 1150-1160.
29. OECD (2000): Guidance document on aquatic toxicity testing of difficult substances and mixture. Series on testing and assessment, No. 23, adopted September 2000. Paris: Organisation for Economic Co-operation and Development.
30. Peiser, M., Tralau, T., Heidler, J., Api, A.M., Arts, J.H.E., Basketter, D.A., English, J., Diepgen, T.L., Fuhlbrigge, R.C., Gaspari, A.A., Johansen, J.D., Karlberg, A.T., Kimber, I., Lepoittevin, J.P., Liebsch, M., Maibach, H.I., Martin, S.F., Merk, H.F., Platzek, T., Rustemeyer, T., Schnuch, A., Vandebriel, R.J., White, I.R. and Luch, A. (2012): Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Cell. Mol. Life Sci., 69, 763-781.
31. Sakaguchi, H., Ashikaga, T., Miyazawa, M., Yoshida, Y., Ito, Y., Yoneyama, K., Hirota, M., Itagaki, H., Toyoda, H. and Suzuki, H. (2006): Development of an in vitro skin sensitization test using human cell lines; human Cell Line Activation Test (h-CLAT) II. An inter-laboratory study of the h-CLAT. Toxicol. In Vitro, 20, 774-784.
32. Sakaguchi, H., Ryan, C., Ovigne, J.M., Schroeder, K.R. and Ashikaga, T. (2010): Predicting skin sensitization potential and inter-laboratory reproducibility of a human Cell Line Activation Test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials. Toxicol. In Vitro, 24, 1810-1820.
33. Tetko, I.V. and Bruneau, P. (2004): Application of ALOGPS to predict 1-octanol/water distribution coefficients, logP, and logD, of AstraZeneca in-house database. J. Pharm. Sci., 93, 3103-3110.