Evaluating the performance of integrated approaches for hazard identification of skin sensitizing chemicals

Regulatory Toxicology and Pharmacology

Volumn 69, Issue 3, 2014, Pages 371-379

  van der Veen, Jochem W ^a,b   Rorije, Emiel ^b   Emter, Roger ^c   Natsch, Andreas ^c   van Loveren, Henk ^a,b   Ezendam, Janine ^b  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^c GIVAUDAN SCHWEIZ AG   (Switzerland)

Author keywords

Adverse outcome pathway; Allergic contact dermatitis; Animal free testing; DPRA; Integrated testing strategy; Keratinocytes; LLNA; QSAR; Skin sensitization

Indexed keywords

1,4 BENZOQUINONE; 2 MERCAPTOBENZOTHIAZOLE; 2 PROPANOL; 5 CHLORO 2 METHYL 4 ISOTHIAZOLIN 3 ONE; ACRYLIC ACID ETHYL ESTER; BENZOCAINE; CHLOROBENZENE; CINNAMALDEHYDE; CINNAMYL ALCOHOL; CITRAL; COBALT CHLORIDE; COSMETIC; DIPHENCYPRONE; ETHYLENE GLYCOL DIMETHACRYLATE; EUGENOL; GERMALL 115; HYDROXYCITRONELLAL; ISOEUGENOL; LACTIC ACID; MALEIC ACID DIETHYL ESTER; METHACRYLIC ACID METHYL ESTER; NICKEL CHLORIDE; OXAZOLONE; PHENYLENEDIAMINE; RESORCINOL; SALICYLIC ACID; SALICYLIC ACID METHYL ESTER; TERT BUTYLHYDROQUINONE; THIRAM; DANGEROUS GOODS;

ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; GENE EXPRESSION; HAZARD ASSESSMENT; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; MEASUREMENT ACCURACY; PREDICTIVE VALUE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RELIABILITY; SENSITIVITY AND SPECIFICITY; SKIN SENSITIZATION; ANIMAL TESTING ALTERNATIVE; CELL LINE; DANGEROUS GOODS; DRUG EFFECTS; PROCEDURES; SKIN; SKIN TEST;

ANIMALIA;

ANIMAL TESTING ALTERNATIVES; CELL LINE; HAZARDOUS SUBSTANCES; HUMANS; SKIN; SKIN TESTS;

EID: 84904062513     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2014.04.018     Document Type: Article

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