Skin sensitization risk assessment model using artificial neural network analysis of data from multiple in vitro assays

Toxicology in Vitro

Volumn 28, Issue 4, 2014, Pages 626-639

  Tsujita Inoue, Kyoko ^a   Hirota, Morihiko ^a   Ashikaga, Takao ^a   Atobe, Tomomi ^a   Kouzuki, Hirokazu ^a   Aiba, Setsuya ^b  

^a SHISEIDO RESEARCH CENTER   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antioxidant response element, ARE; Artificial neural network; H CLAT; Risk assessment; SH test; Skin sensitization

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; 1,4 BENZOQUINONE; 2 AMINOPHENOL; 2 MERCAPTOBENZOTHIAZOLE; 2 NITRO 1,4 PHENYLENEDIAMINE; 3 AMINOPHENOL; 4 CHLOROANILINE; ABIETIC ACID; BENZOYL PEROXIDE; CINNAMALDEHYDE; CINNAMYL ALCOHOL; CITRAL; COBALT CHLORIDE; DICHROMATE POTASSIUM; DIPHENCYPRONE; ETHYLENEDIAMINE; EUGENOL; FORMALDEHYDE; GALLIC ACID PROPYL ESTER; GLUTARALDEHYDE; ISOEUGENOL; MALEIC ANHYDRIDE; NICKEL SULFATE; OCTANOL; OXAZOLONE; PHENYLENEDIAMINE; PHTHALIC ANHYDRIDE; RESORCINOL; WATER; ALLERGEN;

ACCURACY; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; ARTIFICIAL NEURAL NETWORK; COMPARATIVE STUDY; COMPUTER MODEL; CONTROLLED STUDY; CYTOTOXICITY; EPIDERMIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPID SOLUBILITY; LOCAL LYMPH NODE ASSAY; MATHEMATICAL ANALYSIS; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PREDICTION; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SKIN ABSORPTION; SKIN PENETRATION; SKIN SENSITIZATION; TOXICITY TESTING; BIOASSAY; CONTACT DERMATITIS; IMMUNOLOGY;

ALLERGENS; ANTIOXIDANT RESPONSE ELEMENTS; BIOLOGICAL ASSAY; DERMATITIS, CONTACT; HUMANS; NEURAL NETWORKS (COMPUTER); RISK ASSESSMENT;

EID: 84893741457     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2014.01.003     Document Type: Article

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