Filling the concept with data: Integrating data from different in vitro and in silico assays on skin sensitizers to explore the battery approach for animal-free skin sensitization testing

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 106-121

  Natsch, Andreas ^a   Emter, Roger ^a   Ellis, Graham ^b  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

^b Givaudan SA   (Switzerland)

Author keywords

Antioxidant response element; Battery approach; Electrophile response element; In vitro testing; Peptide reactivity; Skin sensitization

Indexed keywords

1 NAPHTHOL; 2 AMINOPHENOL; 2 HEXENAL; 3 AMINOPHENOL; 4 VINYLPYRIDINE; ALDEHYDE DERIVATIVE; ANETHOLE; BENZYL BROMIDE; BENZYLIDENEACETONE; CINNAMALDEHYDE; CITRAL; DIETHYL SULFATE; DIPHENCYPRONE; DODECYL GALLATE; ETHYLENEDIAMINE; FORMALDEHYDE; GALLIC ACID PROPYL ESTER; GLYOXAL; ISOEUGENOL; LUCIFERASE; MALEIC ACID DIETHYL ESTER; OCTANOL; OXAZOLONE; PHENYLENEDIAMINE; PHTHALIC ANHYDRIDE; SALICYLIC ACID BENZYL ESTER; THIRAM; TRIMELLITIC ANHYDRIDE; UNINDEXED DRUG; WATER;

ACCURACY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL ASSAY; COMPUTER MODEL; CONTROLLED STUDY; CORRELATION ANALYSIS; ELECTROPHILIC STRESS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LOCAL LYMPH NODE ASSAY; PARTITION COEFFICIENT; PREDICTION; PROCESS OPTIMIZATION; PROTEIN BINDING; SCORING SYSTEM; SIMULATION; SKIN SENSITIZATION; TISSUE METABOLISM;

ANIMAL TESTING ALTERNATIVES; CELL LINE, TUMOR; COMPUTER SIMULATION; COSMETICS; DATABASES AS TOPIC; DERMATITIS, ALLERGIC CONTACT; FEMALE; HUMANS; LOCAL LYMPH NODE ASSAY; PEPTIDES; REGRESSION ANALYSIS; SKIN TESTS; STATISTICS, NONPARAMETRIC;

ANIMALIA;

EID: 58049202229     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn204     Document Type: Article

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