Predicting skin sensitizer potency based on in vitro data from keratinosens and kinetic peptide binding: Global versus domain-based assessment

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 319-332

  Natsch, Andreas ^a   Emter, Roger ^a   Gfeller, Hans ^a   Haupt, Tina ^a   Ellis, Graham ^b  

^a GIVAUDAN SCHWEIZ AG   (Switzerland)

^b Givaudan SA   (Switzerland)

Author keywords

Applicability domains; Cytotoxicity; In vitro testing; KeratinoSensTM; Multiple regression; Nrf2; Peptide binding; Rate constants; Skin sensitization; TIMES SS

Indexed keywords

PEPTIDE; TRANSCRIPTION FACTOR NRF2; PEPTIDE FRAGMENT;

ACCURACY; ARTICLE; ASSAY; BINDING KINETICS; CYTOTOXICITY; HUMAN; IN VITRO STUDY; LOCAL LYMPH NODE ASSAY; MULTIPLE REGRESSION; PREDICTION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN INDUCTION; SKIN SENSITIZATION; ANIMAL TESTING ALTERNATIVE; CELL LINE; CHEMICAL DATABASE; CHEMISTRY; DRUG EFFECTS; KERATINOCYTE; KINETICS; PREDICTIVE VALUE; REGRESSION ANALYSIS; RISK ASSESSMENT; THEORETICAL MODEL;

ANIMAL TESTING ALTERNATIVES; CELL LINE; DATABASES, CHEMICAL; HUMANS; KERATINOCYTES; KINETICS; LOCAL LYMPH NODE ASSAY; MODELS, THEORETICAL; PEPTIDE FRAGMENTS; PREDICTIVE VALUE OF TESTS; REGRESSION ANALYSIS; RISK ASSESSMENT;

EID: 84924664140     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu229     Document Type: Article

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