Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis

Journal of Immunology

Volumn 173, Issue 7, 2004, Pages 4708-4714

  Boos, Laura ^a   Campbell, Iain L ^b   Ames, Robert ^c   Wetsel, Rick A ^d   Barnum, Scott R ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF SYDNEY   (Australia)

^c GLAXOSMITHKLINE   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOATTRACTANT; GLIAL FIBRILLARY ACIDIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C3A GENE; C3A RECEPTOR GENE; CENTRAL NERVOUS SYSTEM; CHEMOTAXIS; CHRONIC INFLAMMATION; CONTROLLED STUDY; DEMYELINATING DISEASE; GENE; GENE DELETION; GENE EXPRESSION; GLIA CELL; IMMUNOHISTOCHEMISTRY; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SPINAL CORD; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TRANSGENIC MOUSE;

EID: 4644328027     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.7.4708     Document Type: Article

References (44)

1. Drouin, S. M., J. Kildsgaard, J. Haviland, J. Zabner, H. P. Jia, P. B. McCray, Jr., B. F. Tack, and R. A. Wetsel. 2001. Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J. Immunol. 166:2025.
2. Schraufstatter, I. U., K. Trieu, L. Sikora, P. Sriramarao, and R. DiScipio. 2002. Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J. Immunol. 169:2102.
3. Monsinjon, T., P. Gasque, P. Chan, A. Ischenko, J. J. Brady, and M. C. Fontaine. 2003. Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells. FASEB J. 17:1003.
4. Ember, J. A., M. A. Jagels, and T. E. Hugli. 1998. Characterization of complement anaphylatoxina and their biological responses. In The Human Complement System in Health and Disease. J. E. Volanakis, and M. M. Frank, eds. Marcel Dekker, New York, p. 241.
5. Reca, R., D. Mastellos, M. Majka, L. Marquez, J. Ratajczak, S. Franchini, A. Glodek, M. Honczarenko, L. A. Spruce, A. Janowska-Wieczorek, et al. 2003. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood 101:3784.
6. Martin, U., D. Bock, L. Arseniev, M. A. Tornetta, R. S. Ames, W. Bautsch, J. Kohl, A. Ganser, and A. Klos. 1997. The human C3a receptor is expressed on neutrophils and monocytes, but not on B or T lymphocytes. J. Exp. Med. 186:199.
7. Werfel, T., K. Kirchhoff, M. Wittmann, G. Begemann, A. Kapp, F. Heidenreich, O, Gotze, and J. Zwirner. 2000. Activated human T lymphocytes express a functional C3a receptor. J. Immunol. 165:6599.
8. Gutzmer, R., M. Lisewski, J. Zwirner, S. Mommert, C. Diesel, M. Wittmann, A. Kapp, and T. Werfel. 2004. Human monocyte-derived dendritic cells are chemoattracted to C3a after up-regulation of the C3a receptor with interferons. Immunology 111:435.
9. Gasque, P., S. K. Singhrao, J. W. Neal, P. Wang, S. Sayah, M. Fontaine, and B. P. Morgan. 1998. The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and nonmyeloid cells in inflamed human central nervous system: analysis in multiple sclerosis and bacterial meningitis. J. Immunol. 160:3543.
10. Davoust, N., J. Jones, P. F. Stahel, R. S. Ames, and S. R. Barnum. 1999. Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. Glia 26:201.
11. Van Beek, J., M. Bernaudin, E. Petit, P. Gasque, A. Nouvelot, E. T. MacKenzie, and M, Fontaine. 2000. Expression of receptors for complement anaphylatoxins C3a and C5a following permanent focal cerebral ischemia in the mouse. Exp. Neurol. 161:373.
12. Barnum, S. R., R. S. Ames, P. R. Maycox, S. J. Hadingham, J. Meakin, D. Harrison, and A. A. Parsons. 2002. Expression of the complement C3a and C5a receptors after permanent focal ischemia: an alternative interpretation. Glia 38:169.
13. Nataf, S., P. F. Stahel, N. Davoust, and S. R. Barnum. 1999. Complement anaphylatoxin receptors on neurons: new tricks for old receptors? Trends Neurosci. 22:397.
14. Ames, R. S., Y. Li, H. M. Sarau, P. Nuthulaganti, J. J. Foley, C. Ellis, Z. Zeng, K. Su, A. J. Jurewicz, R. P. Hertzberg, et al. 1996. Molecular cloning and characterization of the human anaphylatoxin C3a receptor. J. Biol. Chem. 271:20231.
15. Crass, T., U. Raffetseder, U. Martin, M. Grove, A. Klos, J. Kohl, and W. Bautsch. 1996. Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. Eur. J. Immunol. 26:1944.
16. Roglic, A., E. R. Prossnitz, S. L. Cavanagh, Z. Pan, A. Zou, and R. D. Ye. 1996. cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. Biochim. Biophys. Acta 1305:39.
17. Tornetta, M. A., J. J. Foley, H. M. Sarau, and R. S. Ames. 1997. The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression. J. Immunol. 158:5277.
18. Hollmann, T. J., D. L. Haviland, J. Kildsgaard, K. Watts, and R. A. Wetsel. 1998. Cloning, expression, sequence determination, and chromosome localization of the mouse complement C3a anaphylatoxin receptor gene. Mol. Immunol. 35:137.
19. Settmacher, B., D. Bock, H. Saad, S. Gartner, C. Rneinheimer, J. Kohl, W. Bautsch, and A. Klos. 1999. Modulation of C3a activity: internalization of the human C3a receptor and its inhibition by C5a. J. Immunol. 162:7409.
20. 2+]i signaling in mouse microglia. J. Neurosci. 17:615.
21. Sayah, S., A. C. Jauneau, C. Patte, M. C. Tonon, H. Vaudry, and M. Fontaine. 2003. Two different transduction pathways are activated by C3a and C5a anaphylatoxins on astrocytes. Brain Res. Mol. Brain Res. 112:53.
22. Legler, D. F., M. Loetscher, S. A. Jones, C. A. Dahinden, M. Arock, and B. Moser. 1996. Expression of high- and low-affinity receptors for C3a on the human mast cell line, HMC-1. Eur. J. Immunol. 26:753.
23. Kretzschmar, T., A. Jeromin, C. Gietz, W. Bautsch, A. Klos, J. Kohl, G. Rechkemmer, and D. Bitter-Suermann. 1993. Chronic myelogenous leukemia-derived basophilic granulocytes express a functional active receptor for the anaphylatoxin C3a. Eur. J. Immunol. 23:558.
24. Sayah, S., A. M. Ischenko, A. Zhakhov, A. S. Bonnard, and M. Fontaine. 1999. Expression of cytokines by human astrocytomas following stimulation by C3a and C5a anaphylatoxins: specific increase in interleukin-6 mRNA expression. J. Neurochem. 72:2426.
25. Jauneau, A. C., A. Ischenko, P. Chan, and M. Fontaine. 2003. Complement component anaphylatoxins upregulate chemokine expression by human astrocytes. FEBS Lett. 537:17.
26. Elsner, J., M. Oppermann, W. Czech, G. Dobos, E. Schopf, J. Norgauer, and A. Kapp. 1994. C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils. Eur. J. Immunol. 24:518.
27. Elsner, J., M. Oppermann, W. Czech, and A. Kapp. 1994. C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins. Blood 83:3324.
28. Petering, H., J. Kohl, A. Weyergraf, Y. Dulkys, D. Kimmig, R. Smolarski, A. Kapp, and J. Elsner. 2000. Characterization of synthetic C3a analog peptides on human eosinophils in comparison to the native complement component C3a, J. Immunol 164:3783.
29. DiScipio, R. G., P. J. Daffern, M. A. Jagels, D. H. Broide, and P. Sriramarao. 1999. A comparison of C3a and C5a-mediated stable adhesion of rolling eosinophils in postcapillary venules and transendothelial migration in vitro and in vivo. J. Immunol. 162:1127.
30. Drouin, S. M., D. B. Corry, T. J. Hollman, J. Kildsgaard, and R. A. Wetsel. 2002. Absence of the complement anaphylatoxin C3a receptor suppresses Th2 effector functions in a murine model of pulmonary allergy. J. Immunol. 169:5926.
31. Takabayashi, T., E. Vannier, J. F. Burke, R. G. Tompkins, J. A. Gelfand, and B. D. Clark. 1998. Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells. J. Infect. Dis. 177:1622.
32. Takabayashi, T., E. Vannier, B. D. Clark, N. H. Margolis, C. A. Dinarello, I. F. Burke, and I. A. Gelfand. 1996. A new biologic role for C3a and C3a desArg: regulation of TNF-α and IL-1β synthesis. J. Immunol. 156:3455.
33. Fischer, W. H., and T. E. Hugli. 1997. Regulation of B cell functions by C3a and C3a(desArg): suppression of TNF-α, 1L-6, and the polyclonal immune response. J. Immunol. 159:4279.
34. Fischer, W. H., M. A. Jagels, and T. E. Hugli. 1999. Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg). J. Immunol. 162:453.
35. Heese, K., C. Hock, and U. Otten. 1998. Inflammatory signals induce neurotrophin expression in human microglial cells. J. Neurochem. 70:699.
36. Francis, K., B. M. Lewis, H. Akatsu, P. N. Monk, S. A. Cain, M. F. Scanlon, B. P. Morgan, J. Ham, and P. Gasque. 2003. Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation. FASEB J. 17:2266.
37. Kildsgaard, J., T. J. Hollmann, K. W. Matthews, K. Bian, F. Murad, and R. A. Wetsel. 2000. Cutting edge: targeted disruption of the C3a receptor gene demonstrates a novel protective anti-inflammatory role for C3a in endotoxinshock. J. Immunol. 165:5406.
38. Akiyama, H., S. Barger, S. Barnum, B. Bradt, J. Bauer, G. M. Cole, N. R. Cooper, P. Eikelenboom, M. Emmerling, B. L. Fiebich, et al. 2000. Inflammation and Alzheimer's disease. Neurobiol. Aging 21:383.
39. Stalder, A. K., M. J. Carson, A. Pagenstecher, V. C. Asensio, C. Kincaid, M. Benedict, H. C. Powell, E. Masliah, and I. L. Campbell. 1998. Late-onset chronic inflammatory encephalopathy in immune-competent and severe combined immune-deficient (SCID) mice with astrocyte-targeted expression of tumor necrosis factor. Am. J. Pathol 153:767.
40. McCarthy, K. D., and J. de Vellis. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85:890.
41. Reiman, R., C. Gerard, I. L. Campbell, and S. R. Barnum. 2002. Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis. Eur. J. Immunol. 32:1157.
42. Nataf, S., N. Davoust, R. S. Ames, and S. R. Barnum. 1999. Human T cells express the C5a receptor and are chemoattracted to C5a. J. Immunol. 162:4018.
43. Nataf, S., N. Davoust, and S. R. Barnum. 1998. Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis. J. Neuroimmunol. 91:147.
44. Francis, K., J. Van Beek, C. Canova, J. W. Neal, and P. Gasque. 2003. Innate immunity and brain inflammation: the key role of complement. Expert Rev. Mol. Med. 5:1.