C3aR inhibition reduces neurodegeneration in experimental lupus

Lupus

Volumn 19, Issue 1, 2010, Pages 73-82

  Jacob, A ^a   Bao, L ^a   Brorson, J ^a   Quigg, R J ^a   Alexander, J J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Anaphylatoxins; Brain; Complement; Inflammation; Systemic lupus erythematosus

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CASPASE 3; COMPLEMENT COMPONENT C3A; DNA; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GLUTAMATE RECEPTOR 1; INDUCIBLE NITRIC OXIDE SYNTHASE; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN C3AR; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; EXPERIMENTAL MODEL; MALE; MOUSE; MURPHY ROTHS LARGE LYMPHOPROLIFERATIVE MOUSE; NERVE CELL EXCITABILITY; NERVE CELL PLASTICITY; NEUROMODULATION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; COMPLEMENT ACTIVATION; GLIOSIS; INTERFERON-GAMMA; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MICE; MICE, INBRED MRL LPR; NEURODEGENERATIVE DISEASES; NEURONS; NITRIC OXIDE SYNTHASE TYPE II; RECEPTORS, AMPA; RECEPTORS, COMPLEMENT; SIGNAL TRANSDUCTION;

EID: 74949125415     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203309348978     Document Type: Article

References (41)

1. Huizinga TW, Diamond B. Lupus and the central nervous system. Lupus 2008 ; 17: 376-379.
2. Coray T., Yan F., Lin AH, et al. Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer s mice. Proc Natl Acad Sci USA 2002 ; 99: 10837-10842.
3. Tenner AJ, Fonseca MI The double-edged flower: Roles of complement protein C1q in neurodegenerative diseases. Adv Exp Med Biol 2006 ; 586: 153-176.
4. Tenner AJ Complement in Alzheimer s disease: Opportunities for modulating protective and pathogenic events. Neurobiol Aging 2001 ; 22: 849-861.
5. Davoust N., Nataf S., Reiman R., Holers V., Campbell IL, Barnum SR Central nervous system-targeted expression of the complement inhibitor sCrry prevents experimental allergic encephalomyelitis. J Immunol 1999 ; 163: 6551-6556.
6. Alexander JJ, Quigg RJ Systemic lupus erythematosus and the brain: What mice are telling us. Neurochem Int 2007 ; 50: 5-11.
7. van Beek J., Bernaudin M., Petit E., et al. Expression of receptors for complement anaphylatoxins C3a and C5a following permanent focal cerebral ischemia in the mouse. Exp Neurol 2000 ; 161: 373-382.
8. Barnum SR, Ames RS, Maycox PR, et al. Expression of the complement C3a and C5a receptors after permanent focal ischemia: An alternative interpretation. Glia 2002 ; 38: 169-173.
9. Chenoweth DE, Cooper SW, Hugli TE, Stewart RW, Blackstone EH, Kirklin JW Complement activation during cardiopulmonary bypass: Evidence for generation of C3a and C5a anaphylatoxins. N Engl J Med 1981 ; 304: 497-503.
10. Belmont HM, Hopkins P., Edelson HS, et al. Complement activation during systemic lupus erythematosus. C3a and C5a anaphylatoxins circulate during exacerbations of disease. Arthritis Rheum 1986 ; 29: 1085-1089.
11. Alexander JJ, Jacob A., Bao L., MacDonald RL, Quigg RJ Complement-dependent apoptosis and inflammatory gene changes in murine lupus cerebritis. J Immunol 2005 ; 175: 8312-8319.
12. Alexander JJ, Bao L., Jacob A., Kraus DM, Holers VM, Quigg RJ Administration of the soluble complement inhibitor, Crry-Ig, reduces inflammation and aquaporin 4 expression in lupus cerebritis. Biochim Biophys Acta 2003 ; 1639: 169-176.
13. van Beek J., Nicole O., Ali C., et al. Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death. Neuroreport 2001 ; 12 (2). 289-293. ( Proc Natl Acad Sci USA 1993 ; 90: 1756-1760 ).
14. Watanabe-Fukunaga R., Brannan CI, Copeland NG, Jenkins NA, Nagata S. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 1992 ; 356: 314-317.
15. Davoust N., Jones J., Stahel PF, Ames RS, Barnum SR Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. Glia 1999 ; 26: 201-211.
16. Gasque P., Singhrao SK, Neal JW, et al. The receptor for complement anaphylatoxin C3a is expressed by myeloid cells and non-myeloid cells in inflamed human central nervous system: Analysis in multiple sclerosis and bacterial meningitis. J Immunol 1998 ; 160: 3543-3554.
17. Ischenko A., Sayah S., Patte C., et al. Expression of a functional anaphylatoxin C3a receptor by astrocytes. J Neurochem 1998 ; 71: 2487-2496.
18. Nataf S., Stahel PF, Davoust N., Barnum SR Complement anaphylatoxin receptors on neurons: new tricks for old receptors? Trends Neurosci 1999 ; 22: 397-402.
19. van Beek J., Bernaudin M., Petit E., et al. Expression of receptors for complement anaphylatoxins C3a and C5a following permanent focal cerebral ischemia in the mouse. Exp Neurol 2000 ; 161: 373-382.
20. Alexander JJ, Jacob A., Vezina P., Sekine H., Gilkeson GS, Quigg RJ Absence of functional alternative complement pathway alleviates lupus cerebritis. Eur J Immunol 2007 ; 37: 1691-1701.
21. Eng LF, Ghirnikar RS, Lee YL Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem Res 2000 ; 25: 1439-1451.
22. Sakic B., Maric I., Koeberle PD, et al. Increased TUNEL staining in brains of autoimmune Fas-deficient mice. J Neuroimmunol 2000 ; 104: 147-154.
23. Downward J. PI 3-kinase, Akt and cell survival. Semin Cell Dev Biol 2004 ; 15: 177-182.
24. Scheid MP, Woodgett JR Unravelling the activation mechanisms of protein kinase B/Akt. FEBS Lett 2003 ; 546: 108-112.
25. Sulis ML, Parsons R. PTEN: From pathology to biology. Trends Cell Biol 2003 ; 13: 478-483.
26. Vazquez F., Ramaswamy S., Nakamura N., Sellers WR Phosphorylation of the PTEN tail regulates protein stability and function. Mol Cell Biol 2000 ; 20: 5010-5018.
27. Goswami R., Kilkus J., Dawson SA, Dawson G. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. J Neurosci Res 1999 ; 57: 884-893.
28. Harada N., Hatano E., Koizumi N., et al. Akt activation protects rat liver from ischemia/reperfusion injury. J Surg Res 2004 ; 121: 159-170.
29. Shintani F., Kanba S., Nakaki T., et al. Interleukin-1 beta augments release of norepinephrine, dopamine, and serotonin in the rat anterior hypothalamus. J Neurosci 1993 ; 13: 3574-3581.
30. Hirohata S., Miyamoto T. Elevated levels of interleukin-6 in cerebrospinal fluid from patients with systemic lupus erythematosus and central nervous system involvement. Arthritis Rheum 1990 ; 33: 644-649.
31. Bao L., Osawe I., Haas M., Quigg RJ Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. J Immunol 2005 ; 175: 1947-1955.
32. Jacob A., Hensley LK, Safratowich BD, Quigg RJ, Alexander JJ The role of the complement cascade in endotoxin-induced septic encephalopathy. Lab Invest 2007 ; 87: 1186-1194.
33. Eng LF, Yu AC, Lee YL Astrocytic response to injury. Prog Brain Res 1992 ; 94: 353-365.
34. Baechler EC, Batliwalla FM, Karypis G., et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci USA 2003 ; 100: 2610-2615.
35. Bennett L., Palucka AK, Arce E., et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003 ; 197: 711-723.
36. Vikman K., Robertson B., Grant G., Liljeborg A., Kristensson K. Interferon-gamma receptors are expressed at synapses in the rat superficial dorsal horn and lateral spinal nucleus. J Neurocytol 1998 ; 27: 749-759.
37. Wang Y., Zhou CF Involvement of interferon-gamma and its receptor in the activation of astrocytes in the mouse hippocampus following entorhinal deafferentation. Glia 2005 ; 50: 56-65. (Pubitemid 40516820)
38. Mizuno T., Zhang G., Takeuchi H., et al. Interferon-gamma directly induces neurotoxicity through a neuron specific, calcium-permeable complex of IFN-gamma receptor and AMPA GluR1 receptor. FASEB J 2008 ; 22: 1797-1806.
39. Vikman KS, Owe-Larsson B., Brask J., Kristensson KS, Hill RH Interferon-gamma-induced changes in synaptic activity and AMPA receptor clustering in hippocampal cultures. Brain Res 2001 ; 896: 18-29.
40. Neumann H., Schmidt H., Cavalie A., Jenne D., Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med 1997 ; 185: 305-316.
41. Alexander JJ, Zwingmann C., Quigg R. MRL/lpr mice have alterations in brain metabolism as shown with [(1)H-(13)C] NMR spectroscopy. Neurochem Int 2005 ; 47: 143-151.