A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: A homeostatic mechanism in inflammation

Immunity

Volumn 5, Issue 6, 1996, Pages 653-666

  Coxon, Angela ^b   Rieu, Phillipe ^a   Barkalow, Fern J ^b   Askari, Sanaz ^b   Sharpe, Arlene H ^b   Von Andrian, Ulrich H ^b   Arnaout, M Amin ^a   Mayadas, Tanya N ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; DIPHENYLIODONIUM SALT; INTEGRIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; THIOGLYCOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ADHESION; CHRONIC GRANULOMATOUS DISEASE; CONTROLLED STUDY; HOMEOSTASIS; HUMAN; HUMAN CELL; INFLAMMATION; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL;

EID: 0030483324     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80278-2     Document Type: Article

References (73)

1. Abbas, A.K. (1996). Die and let live: eliminating dangerous lymphocytes. Cell 84, 655-657.
2. Afford, S.C., Pongracz, J., Stockley, R.A., Crocker, J., and Burnett, D. (1992). The induction of human IL-6 of apoptosis in the promonocytic cell line U937 and human neutrophils. J. Biol. Chem. 267, 21612-21616.
3. Anderson, D.C., and Springer, T.A. (1987). Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins. Annu. Rev. Med. 38, 175-194.
4. Anderson, D.C., Schmalsteig, F.C., Finegold, M.J., Hughes B.J., Rothlein, R., Miller, L.J., Kohl, S., Tosi, M.F., Jacobs, R.L., Waldrop, T.C., et al. (1985). The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features. J. Infect. Dis. 152, 668-689.
5. Arbones, M.L., Ord, D.C., Ley, K., Ratech, H., Maynard-Curry, C., Otten, G., Capon, D.J., and Tedder, T.F. (1994). Lymphocyte homing and leukocyte rolling and migration are impaired in L-selectin (CD62L)-deficient mice. Immunity 1, 247-260.
6. Arnaout, M.A. (1990a). Leukocyte adhesion molecule deficiency: its structural basis, pathophysiology and implications for modulating the inflammatory response. Immunol. Rev. 114, 145-180.
7. Arnaout, M.A. (1990b). Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood 75, 1037-1050.
8. Arnaout, M.A., Pitt, J., Cohen, H.J., Melamed, J., Rosen, F.S., and Colten, H.R. (1982). Deficiency of a granulocyte-membrane glycoprotein (gp 150) in a boy with recurrent bacterial infections. N. Engl. J. Med. 306, 693-699.
9. Arnaout, M.A., Todd, R.F., III, Dana, N., Melamed, J., Schlossman, S.F., and Colten, H.R. (1983). Inhibition of phagocytosis of complement C3- or immunoglobultin G-coated particles and of iC3b binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mo1). J. Clin. Invest. 72, 171-179.
10. Arnaout, M.A., Lanier, L.L., and Faller, D.V. (1988). Relative contribution of the leukocyte molecules Mo1, LFA-1, p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J. Cell Physiol. 137, 305-309.
11. Babior, B.M. (1992). The respiratory burst oxidase. Adv. Enzymol. Relat. Areas Mol. Biol. 65, 49-95.
12. Baehner, R.L., and Nathan, D.G. (1968). Quantitative nitroblue tetrazolium test in chronic granulomatous disease. New Eng. J. Med. 278, 971-976.
13. Bullard, D.C., Scharffetter-Kochanek, K., McArthur, M.J., Chosay, J.G., McBride, M.E., Montgomery, C.A., and Beaudet, A.L. (1996). A polygenic mouse model of psoriasiform skin disease in CD18-deficient mice. Proc. Natl. Acad. Sci. USA 93, 2116-2121.
14. Busciglio, J., and Yankner, B.A. (1995). Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378, 776-779.
15. Buttke, T.M., and Sandstrom, P.A. (1994). Oxidative stress as a mediator of apoptosis. Immunol. Today 15, 7-10.
16. Carlos, T.M., and Harlan, J.M. (1994). Leukocyte-endothelial adhesion molecules. Blood 84, 2068-2101.
17. Chapes, S.K., and Haskill, S. (1983). Evidence for granulocyte-mediated macrophage activation after C. parvum immunization. Cell. Immunol. 75, 367-377.
18. Colotta, F., Re, F., Polentarutti, N., Sozzani, S., and Mantovani, A. (1992). Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products. Blood 80, 2012-2020.
19. Cox, G., Crossley, J., and Xing, Z. (1995). Macrophage engulfment of apoptotic neutrophils contributes to the resolution of acute pulmonary inflammation in vivo. Am. J. Resp. Cell Mol. Biol. 12, 232-237.
20. Cross, A.R (1990). Inhibitors of the leukocyte superoxide generating oxidase: mechanisms of action and methods for their elucidation. Free Radic. Biol. Med. 8, 71-93.
21. Dinauer, M.C., Pierce, E.A., Bruns, G.A., Curnulle, J.T., and Orkin, S.H. (1990). Human neutrophil cytochrome b light chain (p22-phox): gene structure, chromosomal location, and mutations in cytochrome-negative autosomal recessive chronic granulomatous disease. J. Clin. Invest. 86, 1729-1737.
22. Dransfield, I., Buckle, A.-M., Savill, J.S., McDowall, A., Haslett, C., and Hogg, N. (1994). Neutrophil apoptosis is associated with a reduction in CD16(FcγRIII) expression. J. Immunol. 153, 1254-1263.
23. Fadok, V.A., Savill, J.S., Haslett, C., Bratton, D.L., Doherty, D.E., Campbell, P.A., and Henson, P.M. (1992). Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells. J. Immunol. 149, 4029-4035.
24. Fallman, M., Andersson, R., and Andersson, T. (1993). Signaling properties of CR3 (CD11b/CD18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles. J. Immunol. 151, 330-338.
25. Firestein, G.S., Yeo, M., and Zvaifler, N.J. (1995). Apoptosis in rheumatoid arthritis synovium. J. Clin. Invest. 96, 1631-1638.
26. Frenette, P.S., Mayadas, T.N., Rayburn, H., Hynes, R.O., and Wagner, D.D. (1996). Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectin. Cell 84, 563-574.
27. Gaboury, J.P., and Kubes, P. (1994). Reductions in physiologic shear rates lead to CD11/CD18-dependent, selectin-independent leukocyte rolling in vivo. Blood 83, 345-350.
28. Giger, U., Boxer, L.A., Simpson, P.J., Lucchesi, B.R., and Todd, R.F., III (1987). Deficiency of leukocyte surface glycoproteins Mo1, LFA-1, and Leu-M5 in a dog with recurrent bacterial infections: an animal model. Blood 69, 1622-1630.
29. Gottlieb, R.A., Giesing, H.A., Zhu, J.Y., Engler, R.L., and Babior, B.M. (1995). Cell acidification in apoptosis: granulocyte colony-stimulating factor delays programmed cell death in neutrophils by up-regulating the vacuolar H+-ATPase. Proc. Natl. Acad. Sci. USA 92, 5965-5968.
30. Gresham, H.D., Graham, I.L., Anderson, D.C., and Brown, E.J. (1991). Leukocyte adhesion-deficient neutrophils fail to amplify phagocytic function in response to stimulation: evidence for CD11b/CD18-dependent and -independent mechanisms for phagocytosis. J. Clin. Invest. 88, 588-597.
31. Grigg, J.M., Savill, J.S., Saraff, C., Haslett, C., and Silverman, M. (1991). Neutrophil apoptosis and clearance by macrophages in the lungs of neonates with pulmonary inflammation. Lancet 338, 720-722.
32. Henderson, W.R., and Klebanoff, S.J. (1983). Leukotriene production and inactivation by normal, chronic granulomatous disease and myeloperoxidase-deficient neutrophils. J. Biol. Chem. 258, 13522-13527.
33. Henson, P.M. (1991). Resolution of inflammation: a perspective. Chest (Suppl). 99, 2S-5S.
34. Hockenbery, D.M., Oltvai, Z.N., Yin, X.-M., Milliman, C.L., and Korsmeyer, S.J. (1993). Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251.
35. Iwai, K., Miyawaki, T., Takizawa, T., Konno, A., Ohta, K., Yachie, A., Seki, H., and Taniguchi, N. (1994). Differential expression of bcl-2 and susceptibility to anti-Fas-mediated cell death in peripheral blood lymphocytes, monocytes, and neutrophils. Blood 84, 1201-1208.
36. phox mouse knock-out model of chronic granulomatous disease. J. Exp. Med. 182, 751-758.
37. Kehrli, M.E., Schmalsteig, F.C., Anderson, D.C., Van Der Maaten, M.J., Hughes, B.J., Ackermann, M.R., Wilhelmsen, C.L., Brown, G.B., Stevens, M.G., and Whetstone, C.A. (1990). Molecular definition of the bovine granulocytopathy syndrome: identification of deficiency of the Mac-1 (CD11b/CD18) glycoprotein. Am. J. Vet. Res. 51, 1826-1836.
38. Lagasse, E., and Weissman, I.L. (1994). bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages. J. Exp. Med. 179, 1047-1052.
39. Laird, P.W., Zijderveld, A., Linders, K., Rudnicki, M.A., Jaenisch, R., and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucl. Acids Res. 19, 4293.
40. Lee A., Whyte, M.K.B., and Haslett, C. (1993). Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators. J. Leuk. Biol. 54, 283-288.
41. Lewinsohn, D.M., Bargatze, R.F., and Butcher, E.C. (1987). Leukocyte-endothelial cell recognition: evidence of a common molecular mechanism shared by neutrophils, lymphocytes, and other leukocytes. J. Immunol. 138, 4313-4321.
42. Ley, K., and Gaehtgens, P. (1991). Endothelial, not hemodynamic, differences are responsible for preferential leukocyte rolling in rat mesenteric venules. Circ. Res. 69, 1034-1041.
43. Li, E., Bestor, T.H., and Jaenisch, R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926.
44. Liles, W.C., and Klebanoff, S.J. (1995). Regulation of apoptosis in neutrophils: Fas track to death? J. Immunol. 155, 3289-3291.
45. Liles, W.C., Kiener, P.A., Ledbetter, J.A., Aruffo, A., and Klebanoff, S.J. (1996). Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for regulation of apoptosis in neutrophils. J. Exp. Med. 184, 429-440.
46. Mayadas, T.N., Johnson, R.C., Rayburn, H., Hynes, R.O., and Wagner, D.D. (1993). Leukocyte rolling and extravasation are severely compromised in P-selectin-deficient mice. Cell 74, 541-554.
47. Mentzer, S.J., Faller, D.V., and Burakoff, S.J. (1986). Inerferon-γ induction of LFA-1 mediated homotypic adhesion of human monocytes. J. Immunol. 137, 108-113.
48. Mulligan, M.S., Till, G.O., Smith, C.W., Anderson, D.C., Miyasaka, M., Tamatani, T., Todd, R.F., III, Issekutz, T.B., and Ward, P.A. (1994). Role of leukocyte adhesion molecules in lung and dermal vascular injury after thermal trauma of skin. Am. J. Pathol. 144, 1008-1015.
49. Nathan, C., Srimal, S., Farber, C., Sanchez, E., Kabbash, L., Asch, A., Gailit, J., and Wright, S.D. (1989). Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins. J. Cell Biol. 109, 1341-1349.
50. Pemberton, M., Anderson, G., Vaclav, V., Justus, D.E., and Ross, G.D. (1993). Microvascular effects of complement blockade with soluble recombinant CR1 on ischemia/reperfusion injury of skeletal muscle. J. Immunol. 150, 5104-5113.
51. Petty, H.R., and Todd, R.F., III (1993). Receptor-receptor interactions of complement receptor 3 in neutrophil membranes. J. Leuk. Biol. 54, 492-494.
52. Pollock, J.D., Williams, D.A., Gifford, M.A.C., Li, L.L., Du, X., Fisherman, J., Orkin, S.H., Doerschuk, C.M., and Dinauer, M.C. (1995). Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocytes superoxide production. Nature Genet. 9, 202-208.
53. Priess, A.R. (1988). A versatile video image analysis system for microcirculatory research. Int. J. Microcirc. Clin. Exp. 7, 327-345.
54. Pytela, R. (1988). Amino acid sequence of the murine Mac-1 α chain reveals homology with the integrin family and an additional domain related to von Willebrand factor. EMBO J. 7, 1371-1378.
55. Rieu, P., Ueda, T., Haruta, I., Sharma, C.P., and Arnaout, M.A. (1994). The A-domain of β2 integrin CR3 (CD11b/CD18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor NIF. J. Cell Biol. 127, 2081-2091.
56. Sanui, H., Yoshida, S.-i., Nomoto, K., Ohhara, R., and Adachi, Y. (1982). Peritoneal macrophages which phagocytose autologous polymorphonuclear leukocytes in guinea-pigs. I. Induction by irritants and microorganisms and inhibition by colchicine. Br. J. Exp. Pathol. 63, 278-284.
57. Savill, J.S., Wyllie, A.H., Henson, J.E., Wolport, M.J., Henson, P.M., and Haslett, C. (1989). Macrophage phagocytosis of aging neutrophils in inflammation: programmed cell death in the neutrophil leads to its recognition by macrophages. J. Clin. Invest. 83, 865-875.
58. Savill, J., Dransfield, I., Hogg, N., and Haslett, C. (1990). Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature 343, 170-173.
59. Schmits, R., Kundig, T.M., Baker, D.M., Shumaker, G., Simard, J.J.L., Duncan, G., Wakeham, A., Shahinian, A., van der Heiden, A., Bachmann, M.F., Ohashi, P.S., Mak, T.W., and Hickstein, D.D. (1996). LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183, 1415-1426.
60. Squier, M.K.T., Sehnert, A.J., and Cohen, J.J. (1995). Apoptosis in leukocytes. J. Leuk. Biol. 57, 2-10.
61. Stossel, T.P. (1986). Oil-droplet method for measuring phagocytosis. Meth. Enzymol. 132, 192-198.
62. Stuehr, D.J., Fasehun, O.A., Kwon, N.S., Gross, S.S., Gonzalez, J.A., Levi, R., and Nathan, C.F. (1991). Inhibition of macrophage and endothelial cell nitric oxide synthetase by diphenylene iodonium and its analogs. FASEB J. 5, 98-103.
63. Thompson, C.B. (1995). Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.
64. Um, H.-D., Orenstein, J.M., and Wahl, S.M. (1996). Fas mediates apoptosis in human monocytes by a reactive oxygen intermediate dependent pathway. J. Immunol. 156, 3469-3477.
65. von Andrian, U.H., Hansell, P., Chambers, J.D., Berger, E.M., Torres Filho, I., Butcher, E.C., and Arfors, K.E. (1992). L-selectin function is required for β2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo. Am. J. Physiol. 263, H1034-H1044.
66. von Andrian, U.H., Berger, E.M., Ramezani, L., Chambers, J.D., Ochs, H.D., Harlan, J.M., Paulson, J.C., Etzioni, J.C., and Arfors, K.-E. (1993). In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes. J. Clin. Invest. 91, 2893-2897.
67. Voncken, J.W., van Schaick, H., Kaartinen, V., Deemer, K., Coates, T., Landing, B., Pattengale, P., Dorseil, O., Bokoch, G.M., Groffen, J., and Heisterkamp, N. (1995). Increased neutrophil respiratory burst in bcr-null mutants. Cell 80, 719-728.
68. Watson, R.W.G., Redmond, H.P., Wang, J.H., Condron, C., and Bouchier-Hayes, D. (1996). Neutrophils undergo apoptosis following ingestion of Escherichia coli. J. Immunol. 156, 3986-3992.
69. Whyte, M.K.B., Hardwick, S.J., Meagher, L.C., Savill, J.S., and Haslett, C. (1993). Transient elevations of cytosolic free calcium retard subsequent apoptosis of neutrophils in vitro. J. Clin. Invest. 92, 446-455.
70. Wilson, R.W., Ballantyne, C.M., Wayne Smith, C., Montgomery, C., Bradley, A., O'Brien, W.E., and Beaudet, A.L. (1993). Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151, 1571-1578.
71. Witte, T., Dumoulin, F.-L., Gessner, J.E., Schubert, J., Gotze, O., Neumann, C., Todd, R.F., III, Deicher, H., and Schmidt, R.E. (1993). Defect of a complement receptor 3 epitope in a patient with systemic lupus erythematosus. J. Clin. Invest. 92, 1181-1187.
72. Yousefi, S., Green, D.R., Blaser, K., and Simon, H.-U. (1994). Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils. Proc. Natl. Acad. Sci. USA 91, 10868-10872.
73. Zhou, M.J., and Brown, E.J. (1994). CR3 (Mac-1, αmβ2, CD11b/CD18) and Fc(γ)RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc(γ)RII and tyrosine phosphorylation. J. Cell Biol. 125, 1407-1416.