A role for the C3a anaphylatoxin receptor in the effector phase of asthma

Nature

Volumn 406, Issue 6799, 2000, Pages 998-1001

  Humbles, Alison A ^a   Lu, Bao ^a   Nilsson, Christy A ^a   Lilly, Craig ^b   Israel, Elliot ^b   Fujiwara, Yuko ^a   Gerard, Norma P ^a   Gerard, Craig ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHYLATOXIN; COMPLEMENT COMPONENT C3A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BLOOD VESSEL PERMEABILITY; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; EFFECTOR CELL; HOST RESISTANCE; IMMUNE RESPONSE; LEUKOCYTE ACTIVATION; LIGAND BINDING; MEDIATOR RELEASE; MOUSE; MUCUS SECRETION; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION;

ANIMALS; ANTIGENS, CD; ASTHMA; COMPLEMENT C3A; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; LUNG; MALE; MEMBRANE PROTEINS; METHACHOLINE CHLORIDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PLETHYSMOGRAPHY; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT;

EID: 0034739041     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35023175     Document Type: Article

References (27)

1. Burrows, B., Martinez, F. D., Halonen, M., Barbee, R. A. & Cline, M. G. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl. J. Med. 320, 271-277 (1989).
2. Gerard, N. P. in Asthma (eds Barnes, P. J., Grunstein, M. M., Leff, A. R. & Woolcock, A. J.) 639-651 (Lippincott-Raven, Philadelphia, 1997).
3. Medzhitov, R. & Janeway, C. A. Jr. Innate immunity: The virtues of a nonclonal system at recognition. Cell 91, 295-298 (1997).
4. Höpken, U. E., Lu, B., Gerard, N. P. & Gerard, C. The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 383, 86-89 (1996).
5. Höpken, U. E., Lu, B., Gerard, N. P. & Gerard, C. Impaired inflammatory responses in the reverse Arthus Reaction through genetic deletion of the C5a receptor. J. Exp. Med. 186, 749-756 (1997).
6. Osaka, H. et al. Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration. Neuroscience 88, 1073-1082 (1999).
7. Bhatia, M. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and pancreatitis-associated lung injury. Am. J. Physiol. (submitted).
8. Tornetta, M. A., Foley, J. J., Sarau, H. M. & Arnes, R. S. The mouse anaphylatoxin C3a receptor. J. Immunol. 158, 5277-5282 (1997).
9. Hsu, M. H. et al. Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene. Immunogenetics 47, 64-72 (1997).
10. Chao, T. H. et al. Role of the second extracellular loop of human C3a receptor in agonist binding and receptor function. J. Biol. Chem. 274, 9721-9728 (1999).
11. Fischer, W. H. et al. Regulation of the B cell response to T-dependent antigens by classical pathway complement. J. Immunol. 157, 549-556 (1996).
12. Daffern, P. J. et al. C3a is a chemotaxin for human eosinophils but not for neutrophils. I. C3a stimulation of neutrophils is secondary to eosinophil activation. J. Exp. Med. 181, 2119-2127 (1995).
13. Nilsson, G. et al. C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway. J. Immunol. 157, 1693-1698 (1996).
14. Stimler-Gerard, N. P. & Galli, S. I. Mast cells in anaphylatoxin-induced spasmogenic activity. J. Immunol. 138, 1908-1913 (1987).
15. Stimler, N. P., Gerard, C. & O'Flaherty, J. T. in Platelet Activating Factor (eds Benveniste, J & Arnoux, B.) 195-203 (Elsevier, Amsterdam, 1983).
16. Hamelmann, E. et al. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography. Am. J. Respir. Crit. Care Med. 156, 766-775 (1992).
17. Martin, T. R., Gerard, N. P., Galli, S. J. & Drazen, J. M. Pulmonary responses to bronchoconstrictor agonists in the mouse. J. Appl. Physiol. 64, 2318-2323 (1988).
18. Smith, J. K., Chi, D. S., Krish, G., Reynolds, S. & Cambron, G. Effect of exercise on complement activity. Ann. Allergy 65, 304-310 (1990).
19. Onodera, H. et al. Complement system in status asthmatics: analysis of anti-complementary effects induced by methylprendisolone. Arerugi 41, 1567-1574 (1997).
20. Pepys, J. & Hutchcroft, B. J. Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am. J. Respir. Crit. Care Med. 112, 829-859 (1975).
21. Bradley, B. I., et al. Eosinophils, T-lymphocytes, mast cells, neutrophils and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J. Allergy Clin. Immunol. 88, 661-674 (1991).
22. Drazen, J. M. Asthma therapy with agents preventing leukotriene synthesis or action. Proc. Assoc. Am. Physicians 111, 547-559 (1999).
23. Barnes, P. J. & Belvisi, M. G. in Asthma (eds Barnes, P. J., Grunstein, M. M., Leff, A. R. & Woolcock, A. J.) 1051-1063 (Lippincott-Raven, Philadelphia, 1997).
24. Mattoli, S., Soloperto, M., Marini, M. & Fasoli, A. Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J. Allergy Clin. Immunol. 88, 376-384 (1991).
25. Schwartz, L. B. et al. Generation of C3a anaphylatoxin from human C3 by mast cell tryptase. J. Immunol. 130, 1891-1895 (1983).
26. Humbles, A. A. et al. Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo. J. Exp. Med. 186, 601-612 (1997).
27. American Thoracic Society. Lung function testing: selection of reference values and interpretative strategies. Am. Rev. Respir. Dis. 144, 1202-1218 (1991).