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Volumn 2, Issue 3, 2015, Pages 268-284

Etiology, pathogenesis, antivirals and vaccines of hand, foot, and mouth disease

Author keywords

Antivirals; Enterovirus; Etiology; Foot and mouth disease; Hand; Innate immunity; Pathogenesis; Tropisms; Vaccine; Virus host interaction

Indexed keywords


EID: 84954142611     PISSN: 20955138     EISSN: 2053714X     Source Type: Journal    
DOI: 10.1093/nsr/nwv038     Document Type: Review
Times cited : (36)

References (189)
  • 1
    • 78049398279 scopus 로고    scopus 로고
    • Virology, epidemiology, pathogenesis, and control of enterovirus 71
    • Solomon, T, Lewthwaite, P and Perera, D et al. Virology, epidemiology, pathogenesis, and control of enterovirus 71. Lancet Infect Dis 2010; 10: 778-90.
    • (2010) Lancet Infect Dis , vol.10 , pp. 778-790
    • Solomon, T.1    Lewthwaite, P.2    Perera, D.3
  • 2
    • 84896492664 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease in China, 2008-12: an epidemiological study
    • Xing, W, Liao, Q and Viboud, C et al. Hand, foot, and mouth disease in China, 2008-12: an epidemiological study. Lancet Infect Dis 2014; 14: 308-18.
    • (2014) Lancet Infect Dis , vol.14 , pp. 308-318
    • Xing, W.1    Liao, Q.2    Viboud, C.3
  • 3
    • 0033598405 scopus 로고    scopus 로고
    • Neurologic complications in children with enterovirus 71 infection
    • Huang, CC, Liu, CC and Chang, YC et al. Neurologic complications in children with enterovirus 71 infection. N Engl J Med 1999; 341: 936-42.
    • (1999) N Engl J Med , vol.341 , pp. 936-942
    • Huang, C.C.1    Liu, C.C.2    Chang, Y.C.3
  • 4
    • 0000695241 scopus 로고
    • Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A Coxsackie virus
    • Robinson, CR, Doane, FW and Rhodes, AJ. Report of an outbreak of febrile illness with pharyngeal lesions and exanthem: Toronto, summer 1957; isolation of group A Coxsackie virus. Can Med Assoc J 1958; 79: 615-21.
    • (1958) Can Med Assoc J , vol.79 , pp. 615-621
    • Robinson, C.R.1    Doane, F.W.2    Rhodes, A.J.3
  • 5
    • 0343547260 scopus 로고
    • 'Hand, foot, and mouth disease' associated with Coxsackie A5 virus
    • Flewett, TH, Warin, RP and Clarke, SK. 'Hand, foot, and mouth disease' associated with Coxsackie A5 virus. J Clin Pathol 1963; 16: 53-5.
    • (1963) J Clin Pathol , vol.16 , pp. 53-55
    • Flewett, T.H.1    Warin, R.P.2    Clarke, S.K.3
  • 6
    • 0014417067 scopus 로고
    • Hand-foot-and-mouth syndrome in humans: coxackie A10 infections in New Zealand
    • Duff, MF. Hand-foot-and-mouth syndrome in humans: coxackie A10 infections in New Zealand. Br Med J 1968; 2: 661-4.
    • (1968) Br Med J , vol.2 , pp. 661-664
    • Duff, M.F.1
  • 7
    • 0018772867 scopus 로고
    • Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria
    • Chumakov, M, Voroshilova, M and Shindarov, L et al. Enterovirus 71 isolated from cases of epidemic poliomyelitis-like disease in Bulgaria. Arch Virol 1979; 60: 329-40.
    • (1979) Arch Virol , vol.60 , pp. 329-340
    • Chumakov, M.1    Voroshilova, M.2    Shindarov, L.3
  • 8
    • 0019968201 scopus 로고
    • Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978
    • Nagy, G, Takátsy, S and Kukán, E et al. Virological diagnosis of enterovirus type 71 infections: experiences gained during an epidemic of acute CNS diseases in Hungary in 1978. Arch Virol 1982; 71: 217-27.
    • (1982) Arch Virol , vol.71 , pp. 217-227
    • Nagy, G.1    Takátsy, S.2    Kukán, E.3
  • 9
    • 0018884181 scopus 로고
    • Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system
    • Ishimaru, Y, Nakano, S and Yamaoka, K et al. Outbreaks of hand, foot, and mouth disease by enterovirus 71. High incidence of complication disorders of central nervous system. Arch Dis Child 1980; 55: 583-8.
    • (1980) Arch Dis Child , vol.55 , pp. 583-588
    • Ishimaru, Y.1    Nakano, S.2    Yamaoka, K.3
  • 10
    • 0032493525 scopus 로고    scopus 로고
    • Deaths among children during an outbreak of hand, foot, and mouth disease-Taiwan, Republic of China, April-July 1998
    • Centers for Disease Control and Prevention (CDC). Deaths among children during an outbreak of hand, foot, and mouth disease-Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep 1998; 47: 629-32.
    • (1998) MMWR Morb Mortal Wkly Rep , vol.47 , pp. 629-632
  • 11
    • 0033598371 scopus 로고    scopus 로고
    • An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group
    • Ho, M, Chen, ER and Hsu, KH et al. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med 1999; 341: 929-35.
    • (1999) N Engl J Med , vol.341 , pp. 929-935
    • Ho, M.1    Chen, E.R.2    Hsu, K.H.3
  • 12
    • 0034458548 scopus 로고    scopus 로고
    • Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group
    • Chan, LG, Parashar, UD and Lye, MS et al. Deaths of children during an outbreak of hand, foot, and mouth disease in sarawak, malaysia: clinical and pathological characteristics of the disease. For the Outbreak Study Group. Clin Infect Dis 2000; 31: 678-83.
    • (2000) Clin Infect Dis , vol.31 , pp. 678-683
    • Chan, L.G.1    Parashar, U.D.2    Lye, M.S.3
  • 13
    • 0035245224 scopus 로고    scopus 로고
    • Neurologicalmanifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia
    • McMinn, P, Stratov, I and Nagarajan, L et al. Neurologicalmanifestations of enterovirus 71 infection in children during an outbreak of hand, foot, and mouth disease in Western Australia. Clin Infect Dis 2001; 32: 236-42.
    • (2001) Clin Infect Dis , vol.32 , pp. 236-242
    • McMinn, P.1    Stratov, I.2    Nagarajan, L.3
  • 14
    • 0037240370 scopus 로고    scopus 로고
    • Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore
    • Chan, KP, Goh, KT and Chong, CY et al. Epidemic hand, foot and mouth disease caused by human enterovirus 71, Singapore. Emerg Infect Dis 2003; 9: 78-85.
    • (2003) Emerg Infect Dis , vol.9 , pp. 78-85
    • Chan, K.P.1    Goh, K.T.2    Chong, C.Y.3
  • 16
    • 84869786224 scopus 로고    scopus 로고
    • Enterovirus 71-associated hand, foot, and mouth disease, Southern Vietnam, 2011
    • Khanh, TH, Sabanathan, S and Thanh, TT et al. Enterovirus 71-associated hand, foot, and mouth disease, Southern Vietnam, 2011. Emerg Infect Dis 2012; 18: 2002-5.
    • (2012) Emerg Infect Dis , vol.18 , pp. 2002-2005
    • Khanh, T.H.1    Sabanathan, S.2    Thanh, T.T.3
  • 17
    • 78649635618 scopus 로고    scopus 로고
    • The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains
    • Wu, Y, Yeo, A and Phoon, MC et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. Int J Infect Dis 2010; 14: e1076-81.
    • (2010) Int J Infect Dis , vol.14 , pp. e1076-e1081
    • Wu, Y.1    Yeo, A.2    Phoon, M.C.3
  • 18
    • 84954129152 scopus 로고    scopus 로고
    • National Health and Family Planning Commission of the People's Republic of China, 2008
    • China, HMoPsRo. Guidelines for Hand-foot-mouth disease prevention and control (2008). National Health and Family Planning Commission of the People's Republic of China, 2008.
    • (2008)
  • 19
    • 84974728057 scopus 로고    scopus 로고
    • Picornarviridae: the viruses and their replication
    • David, PMH and Knipe, M (eds), 6th edn. Philadelphia: Lippincott Williams & Wilkins
    • Racaniello, VR. Picornarviridae: the viruses and their replication. In David, PMH and Knipe, M (eds). Fielda Virology, 6th edn. Philadelphia: Lippincott Williams & Wilkins, 2013.
    • (2013) Fielda Virology
    • Racaniello, V.R.1
  • 20
    • 0016257919 scopus 로고
    • An apparently new enterovirus isolated from patients with disease of the central nervous system
    • Schmidt, NJ, Lennette, EH and Ho, HH. An apparently new enterovirus isolated from patients with disease of the central nervous system. J Infect Dis 1974; 129: 304-9.
    • (1974) J Infect Dis , vol.129 , pp. 304-309
    • Schmidt, N.J.1    Lennette, E.H.2    Ho, H.H.3
  • 21
    • 0023712771 scopus 로고
    • Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement
    • Gilbert, GL, Dickson, KE and Waters, MJ et al. Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement. Pediatr Infect Dis J 1988; 7: 484-8.
    • (1988) Pediatr Infect Dis J , vol.7 , pp. 484-488
    • Gilbert, G.L.1    Dickson, K.E.2    Waters, M.J.3
  • 22
    • 0033036335 scopus 로고    scopus 로고
    • Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia
    • AbuBakar, S, Chee, HY and Al-Kobaisi, MF et al. Identification of enterovirus 71 isolates from an outbreak of hand, foot and mouth disease (HFMD) with fatal cases of encephalomyelitis in Malaysia. Virus Res 1999; 61: 1-9.
    • (1999) Virus Res , vol.61 , pp. 1-9
    • AbuBakar, S.1    Chee, H.Y.2    Al-Kobaisi, M.F.3
  • 23
    • 0030599951 scopus 로고    scopus 로고
    • Epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease in England and Wales
    • Bendig, JW and Fleming, DM. Epidemiological, virological, and clinical features of an epidemic of hand, foot, and mouth disease in England and Wales. Commun Dis Rep CDR Rev 1996; 6: R81-6.
    • (1996) Commun Dis Rep CDR Rev , vol.6 , pp. R81-R86
    • Bendig, J.W.1    Fleming, D.M.2
  • 24
    • 36249015540 scopus 로고    scopus 로고
    • Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005
    • Tu, PV, Thao, NT and Perera, D et al. Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005. Emerg Infect Dis 2007; 13: 1733-41.
    • (2007) Emerg Infect Dis , vol.13 , pp. 1733-1741
    • Tu, P.V.1    Thao, N.T.2    Perera, D.3
  • 25
    • 84896909452 scopus 로고    scopus 로고
    • Coxsackievirus A16: epidemiology, diagnosis, and vaccine
    • Mao, Q, Wang, Y and Yao, X et al. Coxsackievirus A16: epidemiology, diagnosis, and vaccine. Hum Vaccin Immunother 2014; 10: 360-7.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 360-367
    • Mao, Q.1    Wang, Y.2    Yao, X.3
  • 26
    • 67650047737 scopus 로고    scopus 로고
    • Enterovirus 71 outbreak in the People's Republic of China in 2008
    • Yang, F, Ren, L and Xiong, Z et al. Enterovirus 71 outbreak in the People's Republic of China in 2008. J Clin Microbiol 2009; 47: 2351-2.
    • (2009) J Clin Microbiol , vol.47 , pp. 2351-2352
    • Yang, F.1    Ren, L.2    Xiong, Z.3
  • 27
    • 77951991686 scopus 로고    scopus 로고
    • An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China
    • Zhang, Y, Zhu, Z and Yang, W et al. An emerging recombinant human enterovirus 71 responsible for the 2008 outbreak of hand foot and mouth disease in Fuyang city of China. Virol J 2010; 7: 94.
    • (2010) Virol J , vol.7 , pp. 94
    • Zhang, Y.1    Zhu, Z.2    Yang, W.3
  • 28
    • 0036242282 scopus 로고    scopus 로고
    • An overview of the evolution of enterovirus 71 and its clinical and public health significance
    • McMinn, PC. An overview of the evolution of enterovirus 71 and its clinical and public health significance. FEMS Microbiol Rev 2002; 26: 91-107.
    • (2002) FEMS Microbiol Rev , vol.26 , pp. 91-107
    • McMinn, P.C.1
  • 29
    • 84924171446 scopus 로고    scopus 로고
    • Comparative epidemiology and virology of fatal and nonfatal cases of hand, foot and mouth disease in mainland China from 2008 to 2014
    • Liu, SL, Pan, H and Liu, P et al. Comparative epidemiology and virology of fatal and nonfatal cases of hand, foot and mouth disease in mainland China from 2008 to 2014. Rev Med Virol 2015; 25: 115-28.
    • (2015) Rev Med Virol , vol.25 , pp. 115-128
    • Liu, S.L.1    Pan, H.2    Liu, P.3
  • 30
    • 77956624160 scopus 로고    scopus 로고
    • Recombination among picornaviruses
    • Lukashev, AN. Recombination among picornaviruses. RevMed Virol 2010; 20: 327-37.
    • (2010) RevMed Virol , vol.20 , pp. 327-337
    • Lukashev, A.N.1
  • 31
    • 3542990869 scopus 로고    scopus 로고
    • Recombinant human enterovirus 71 in hand, foot and mouth disease patients
    • Chan, YF and AbuBaker, S. Recombinant human enterovirus 71 in hand, foot and mouth disease patients. Emerg Infect Dis 2004; 10: 1468-70.
    • (2004) Emerg Infect Dis , vol.10 , pp. 1468-1470
    • Chan, Y.F.1    AbuBaker, S.2
  • 32
    • 79960853501 scopus 로고    scopus 로고
    • Circulating coxsackievirus A16 identified as recombinant type A human enterovirus, China
    • Zhao, K, Han, X and Wang, G et al. Circulating coxsackievirus A16 identified as recombinant type A human enterovirus, China. Emerg Infect Dis 2011; 17: 1537-40.
    • (2011) Emerg Infect Dis , vol.17 , pp. 1537-1540
    • Zhao, K.1    Han, X.2    Wang, G.3
  • 33
    • 84896909452 scopus 로고    scopus 로고
    • Coxsackievirus A16: epidemiology, diagnosis, and vaccine
    • Mao, Q, Wang, Y and Yao, X et al. Coxsackievirus A16: epidemiology, diagnosis, and vaccine. Hum Vaccin Immunother 2014; 10: 360-7.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 360-367
    • Mao, Q.1    Wang, Y.2    Yao, X.3
  • 34
    • 79959844992 scopus 로고    scopus 로고
    • Complete genome analysis of coxsackievirus A2, A4, A5, and A10 strains isolated from hand, foot, and mouth disease patients in China revealing frequent recombination of human enterovirus A
    • Hu, YF, Yang, F and Du, J et al. Complete genome analysis of coxsackievirus A2, A4, A5, and A10 strains isolated from hand, foot, and mouth disease patients in China revealing frequent recombination of human enterovirus A. J Clin Microbiol 2011; 49: 2426-34.
    • (2011) J Clin Microbiol , vol.49 , pp. 2426-2434
    • Hu, Y.F.1    Yang, F.2    Du, J.3
  • 35
    • 84863023355 scopus 로고    scopus 로고
    • Recombination of human coxsackievirus B5 in hand, foot, and mouth disease patients, China
    • Han, JF, Jiang, T and Fan, XL et al. Recombination of human coxsackievirus B5 in hand, foot, and mouth disease patients, China. Emerg Infect Dis 2012; 18: 351-3.
    • (2012) Emerg Infect Dis , vol.18 , pp. 351-353
    • Han, J.F.1    Jiang, T.2    Fan, X.L.3
  • 36
    • 75649151742 scopus 로고    scopus 로고
    • Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China
    • Zhang, Y, Wang, D and Yan, D et al. Molecular evidence of persistent epidemic and evolution of subgenotype B1 coxsackievirus A16-associated hand, foot, and mouth disease in China. J Clin Microbiol 2010; 48: 619-22.
    • (2010) J Clin Microbiol , vol.48 , pp. 619-622
    • Zhang, Y.1    Wang, D.2    Yan, D.3
  • 37
    • 79953866955 scopus 로고    scopus 로고
    • Molecular phylogeny of Coxsackievirus A16 in Shenzhen, China, from 2005 to 2009
    • Zong, W, He, Y and Yu, S et al. Molecular phylogeny of Coxsackievirus A16 in Shenzhen, China, from 2005 to 2009. J Clin Microbiol 2011; 49: 1659-61.
    • (2011) J Clin Microbiol , vol.49 , pp. 1659-1661
    • Zong, W.1    He, Y.2    Yu, S.3
  • 38
    • 77949394259 scopus 로고    scopus 로고
    • Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene
    • Tee, KK, Lam, TT and Chan, YF et al. Evolutionary genetics of human enterovirus 71: origin, population dynamics, natural selection, and seasonal periodicity of the VP1 gene. J Virol 2010; 84: 3339-50.
    • (2010) J Virol , vol.84 , pp. 3339-3350
    • Tee, K.K.1    Lam, T.T.2    Chan, Y.F.3
  • 39
    • 4444328062 scopus 로고    scopus 로고
    • Enterovirus 71 isolated from a case of acute flaccid paralysis in India represents a new genotype
    • Deshpande, JM, Nadkami, SS and Francis, PP. Enterovirus 71 isolated from a case of acute flaccid paralysis in India represents a new genotype. Curr Sci 2003; 84: 1350-3.
    • (2003) Curr Sci , vol.84 , pp. 1350-1353
    • Deshpande, J.M.1    Nadkami, S.S.2    Francis, P.P.3
  • 40
    • 84894260487 scopus 로고    scopus 로고
    • Molecular epidemiology of enterovirus 71 infection in the central region of Taiwan from 2002 to 2012
    • Wu, WH, Kuo, TC and Lin, YT et al. Molecular epidemiology of enterovirus 71 infection in the central region of Taiwan from 2002 to 2012. PLoS One 2013; 8: e83711.
    • (2013) PLoS One , vol.8
    • Wu, W.H.1    Kuo, T.C.2    Lin, Y.T.3
  • 41
    • 23744510743 scopus 로고    scopus 로고
    • Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China
    • Li, L, He, Y and Yang, H et al. Genetic characteristics of human enterovirus 71 and coxsackievirus A16 circulating from 1999 to 2004 in Shenzhen, People's Republic of China. J Clin Microbiol 2005; 43: 3835-9.
    • (2005) J Clin Microbiol , vol.43 , pp. 3835-3839
    • Li, L.1    He, Y.2    Yang, H.3
  • 42
    • 62949234335 scopus 로고    scopus 로고
    • An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China
    • Zhang, Y, Tan, XJ and Wang, HY et al. An outbreak of hand, foot, and mouth disease associated with subgenotype C4 of human enterovirus 71 in Shandong, China. J Clin Virol 2009; 44: 262-7.
    • (2009) J Clin Virol , vol.44 , pp. 262-267
    • Zhang, Y.1    Tan, X.J.2    Wang, H.Y.3
  • 43
    • 84890790365 scopus 로고    scopus 로고
    • Changing aetiology of hand, foot and mouth disease in Linyi, China, 2009-2011
    • Du, J, Wang, X and Hu, Y et al. Changing aetiology of hand, foot and mouth disease in Linyi, China, 2009-2011. Clin Microbiol Infect 2013; 20: O47-9.
    • (2013) Clin Microbiol Infect , vol.20 , pp. O47-O49
    • Du, J.1    Wang, X.2    Hu, Y.3
  • 44
    • 79961229290 scopus 로고    scopus 로고
    • Enterovirus coinfection during an outbreak of hand, foot, and mouth disease in Shandong, China
    • Yang, F, Du, J and Hu, Y et al. Enterovirus coinfection during an outbreak of hand, foot, and mouth disease in Shandong, China. Clin Infect Dis 2011; 53: 400-1.
    • (2011) Clin Infect Dis , vol.53 , pp. 400-401
    • Yang, F.1    Du, J.2    Hu, Y.3
  • 45
    • 84879248830 scopus 로고    scopus 로고
    • Epidemics and frequent recombination within species in outbreaks of human enterovirus B-associated hand, foot and mouth disease in Shandong China in 2010 and 2011
    • Zhang, T, Du, J and Xue, Y et al. Epidemics and frequent recombination within species in outbreaks of human enterovirus B-associated hand, foot and mouth disease in Shandong China in 2010 and 2011. PLoS One 2013; 8: e67157.
    • (2013) PLoS One , vol.8
    • Zhang, T.1    Du, J.2    Xue, Y.3
  • 46
    • 84907877723 scopus 로고    scopus 로고
    • Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China
    • Liu, X, Mao, N and Yu, Wet al. Genetic characterization of emerging coxsackievirus A12 associated with hand, foot and mouth disease in Qingdao, China. Arch Virol 2014; 159: 2497-502.
    • (2014) Arch Virol , vol.159 , pp. 2497-2502
    • Liu, X.1    Mao, N.2    Yu, W.3
  • 47
    • 84873143468 scopus 로고    scopus 로고
    • Picornavirus and enterovirus diversity with associated human diseases
    • Tapparel, C, Siegrist, F and Petty, TJ et al. Picornavirus and enterovirus diversity with associated human diseases. Infect Genet Evol 2013; 14: 282-93.
    • (2013) Infect Genet Evol , vol.14 , pp. 282-293
    • Tapparel, C.1    Siegrist, F.2    Petty, T.J.3
  • 48
    • 84902338534 scopus 로고    scopus 로고
    • Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012
    • Puenpa, J, Mauleekoonphairoj, J and Linsuwanon, P et al. Prevalence and characterization of enterovirus infections among pediatric patients with hand foot mouth disease, herpangina and influenza like illness in Thailand, 2012. PLoS One 2014; 9: e98888.
    • (2014) PLoS One , vol.9
    • Puenpa, J.1    Mauleekoonphairoj, J.2    Linsuwanon, P.3
  • 49
    • 70249116475 scopus 로고    scopus 로고
    • Coxsackievirus A6 and hand, foot, and mouth disease, Finland
    • Osterback, R, Vuorinen, T and Linna, M et al. Coxsackievirus A6 and hand, foot, and mouth disease, Finland. Emerg Infect Dis 2009; 15: 1485-8.
    • (2009) Emerg Infect Dis , vol.15 , pp. 1485-1488
    • Osterback, R.1    Vuorinen, T.2    Linna, M.3
  • 50
    • 79959573078 scopus 로고    scopus 로고
    • Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009
    • Lo, SH, Huang, YC and Huang, CG et al. Clinical and epidemiologic features of Coxsackievirus A6 infection in children in northern Taiwan between 2004 and 2009. J Microbiol Immunol Infect 2011; 44: 252-7.
    • (2011) J Microbiol Immunol Infect , vol.44 , pp. 252-257
    • Lo, S.H.1    Huang, Y.C.2    Huang, C.G.3
  • 51
    • 84859345486 scopus 로고    scopus 로고
    • Notes from the field: severe hand, foot, and mouth disease associated with coxsackievirus A6-Alabama, Connecticut, California, and Nevada, November 2011-February 2012
    • Centers for Disease Control and Prevention (CDC). Notes from the field: severe hand, foot, and mouth disease associated with coxsackievirus A6-Alabama, Connecticut, California, and Nevada, November 2011-February 2012. MMWR Morb Mortal Wkly Rep 2012; 61: 213-4.
    • (2012) MMWR Morb Mortal Wkly Rep , vol.61 , pp. 213-214
  • 52
    • 84866532006 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease caused by coxsackievirus a6
    • Flett, K, Youngster, I and Huang, J et al. Hand, foot, and mouth disease caused by coxsackievirus a6. Emerg Infect Dis 2012; 18: 1702-4.
    • (2012) Emerg Infect Dis , vol.18 , pp. 1702-1704
    • Flett, K.1    Youngster, I.2    Huang, J.3
  • 53
    • 84856405504 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011
    • Fujimoto, T, Iizuka, S and Enomoto, M et al. Hand, foot, and mouth disease caused by coxsackievirus A6, Japan, 2011. Emerg Infect Dis 2012; 18: 337-9.
    • (2012) Emerg Infect Dis , vol.18 , pp. 337-339
    • Fujimoto, T.1    Iizuka, S.2    Enomoto, M.3
  • 54
    • 84885640784 scopus 로고    scopus 로고
    • Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection
    • Lott, JP, Liu, K and Landry, ML et al. Atypical hand-foot-and-mouth disease associated with coxsackievirus A6 infection. J Am Acad Dermatol 2013; 69: 736-41.
    • (2013) J Am Acad Dermatol , vol.69 , pp. 736-741
    • Lott, J.P.1    Liu, K.2    Landry, M.L.3
  • 55
    • 84875362268 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease outbreak and coxsackievirus A6, northern Spain, 2011
    • Montes, M, Artieda, J and Pineiro, LD et al. Hand, foot, and mouth disease outbreak and coxsackievirus A6, northern Spain, 2011. Emerg Infect Dis 2013; 19: 676-8.
    • (2013) Emerg Infect Dis , vol.19 , pp. 676-678
    • Montes, M.1    Artieda, J.2    Pineiro, L.D.3
  • 56
    • 84875342894 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand, 2012
    • Puenpa, J, Chieochansin, T and Linsuwanon, P et al. Hand, foot, and mouth disease caused by coxsackievirus A6, Thailand, 2012. Emerg Infect Dis 2013; 19: 641-3.
    • (2013) Emerg Infect Dis , vol.19 , pp. 641-643
    • Puenpa, J.1    Chieochansin, T.2    Linsuwanon, P.3
  • 57
    • 84922415011 scopus 로고    scopus 로고
    • Hand, foot, and mouth disease outbreak caused by coxsackievirus A6, China, 2013
    • Han, JF, Xu, S and Zhang, Y et al. Hand, foot, and mouth disease outbreak caused by coxsackievirus A6, China, 2013. J Infect 2014; 69: 303-5.
    • (2014) J Infect , vol.69 , pp. 303-305
    • Han, J.F.1    Xu, S.2    Zhang, Y.3
  • 58
    • 84926135871 scopus 로고    scopus 로고
    • Hand, foot and mouth disease caused by coxsackievirus A6, Beijing, 2013
    • Hongyan, G, Chengjie, M and Qiaozhi, Y et al. Hand, foot and mouth disease caused by coxsackievirus A6, Beijing, 2013. Pediatr Infect Dis J 2014; 33: 1302-3.
    • (2014) Pediatr Infect Dis J , vol.33 , pp. 1302-1303
    • Hongyan, G.1    Chengjie, M.2    Qiaozhi, Y.3
  • 59
    • 84922415004 scopus 로고    scopus 로고
    • Epidemic characteristics of hand, foot, and mouth disease in southern China, 2013: coxsackievirus A6 has emerged as the predominant causative agent
    • Li, JL, Yuan, J and Yang, F et al. Epidemic characteristics of hand, foot, and mouth disease in southern China, 2013: coxsackievirus A6 has emerged as the predominant causative agent. J Infect 2014; 69: 299-303.
    • (2014) J Infect , vol.69 , pp. 299-303
    • Li, J.L.1    Yuan, J.2    Yang, F.3
  • 60
    • 84897030989 scopus 로고    scopus 로고
    • Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014
    • Sinclair, C, Gaunt, E and Simmonds, P et al. Atypical hand, foot, and mouth disease associated with coxsackievirus A6 infection, Edinburgh, United Kingdom, January to February 2014. Euro Surveill 2014; 19: 20745.
    • (2014) Euro Surveill , vol.19 , pp. 20745
    • Sinclair, C.1    Gaunt, E.2    Simmonds, P.3
  • 61
    • 84918787038 scopus 로고    scopus 로고
    • Severe hand, foot, and mouth disease and coxsackievirus A6-Shenzhen, China
    • Yang, F, Yuan, J andWang, X et al. Severe hand, foot, and mouth disease and coxsackievirus A6-Shenzhen, China. Clin Infect Dis 2014; 59: 1504-5.
    • (2014) Clin Infect Dis , vol.59 , pp. 1504-1505
    • Yang, F.1    Yuan, J.2    Wang, X.3
  • 62
    • 84892146649 scopus 로고    scopus 로고
    • Coxsackievirus A6-induced handfoot-mouth disease
    • Stewart, CL, Chu, EY and Introcaso, CE et al. Coxsackievirus A6-induced handfoot-mouth disease. JAMA Dermatol 2013; 149: 1419-21.
    • (2013) JAMA Dermatol , vol.149 , pp. 1419-1421
    • Stewart, C.L.1    Chu, E.Y.2    Introcaso, C.E.3
  • 63
    • 84903560571 scopus 로고    scopus 로고
    • Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature
    • Downing, C, Ramirez-Fort, MK and Doan, HQ et al. Coxsackievirus A6 associated hand, foot and mouth disease in adults: clinical presentation and review of the literature. J Clin Virol 2014; 60: 381-6.
    • (2014) J Clin Virol , vol.60 , pp. 381-386
    • Downing, C.1    Ramirez-Fort, M.K.2    Doan, H.Q.3
  • 64
    • 84908293194 scopus 로고    scopus 로고
    • Atypical hand, foot, and mouth disease: eczema coxsackium can also occur in adults
    • Harris, PN, Wang, AD and Yin, Met al. Atypical hand, foot, and mouth disease: eczema coxsackium can also occur in adults. Lancet Infect Dis 2014; 14: 1043.
    • (2014) Lancet Infect Dis , vol.14 , pp. 1043
    • Harris, P.N.1    Wang, A.D.2    Yin, M.3
  • 65
    • 84886554467 scopus 로고    scopus 로고
    • Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6-and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China
    • He, YQ, Chen, L and Xu, WB et al. Emergence, circulation, and spatiotemporal phylogenetic analysis of coxsackievirus a6-and coxsackievirus a10-associated hand, foot, and mouth disease infections from 2008 to 2012 in Shenzhen, China. J Clin Microbiol 2013; 51: 3560-6.
    • (2013) J Clin Microbiol , vol.51 , pp. 3560-3566
    • He, Y.Q.1    Chen, L.2    Xu, W.B.3
  • 66
    • 42949119231 scopus 로고    scopus 로고
    • The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways
    • Wong, KT, Munisamy, B and Ong, KC et al. The distribution of inflammation and virus in human enterovirus 71 encephalomyelitis suggests possible viral spread by neural pathways. J Neuropathol Exp Neurol 2008; 67: 162-9.
    • (2008) J Neuropathol Exp Neurol , vol.67 , pp. 162-169
    • Wong, K.T.1    Munisamy, B.2    Ong, K.C.3
  • 68
    • 68349134833 scopus 로고    scopus 로고
    • Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People's Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study
    • Yang, Y, Wang, H and Gong, E et al. Neuropathology in 2 cases of fatal enterovirus type 71 infection from a recent epidemic in the People's Republic of China: a histopathologic, immunohistochemical, and reverse transcription polymerase chain reaction study. Hum Pathol 2009; 40: 1288-95.
    • (2009) Hum Pathol , vol.40 , pp. 1288-1295
    • Yang, Y.1    Wang, H.2    Gong, E.3
  • 69
    • 0035101611 scopus 로고    scopus 로고
    • Pathologic studies of fatal cases in outbreak of hand, foot, and mouth disease, Taiwan
    • Shieh, WJ, Jung, SM and Hsueh, C et al. Pathologic studies of fatal cases in outbreak of hand, foot, and mouth disease, Taiwan. Emerg Infect Dis 2001; 7: 146-8.
    • (2001) Emerg Infect Dis , vol.7 , pp. 146-148
    • Shieh, W.J.1    Jung, S.M.2    Hsueh, C.3
  • 70
    • 0142030092 scopus 로고    scopus 로고
    • Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases
    • Chong, CY, Chan, KP and Shah, VA et al. Hand, foot and mouth disease in Singapore: a comparison of fatal and non-fatal cases. Acta Paediatr 2003; 92: 1163-9.
    • (2003) Acta Paediatr , vol.92 , pp. 1163-1169
    • Chong, C.Y.1    Chan, K.P.2    Shah, V.A.3
  • 71
    • 0031674713 scopus 로고    scopus 로고
    • Fatal enterovirus 71 encephalomyelitis
    • Lum, LC, Wong, KT and Lam, SK et al. Fatal enterovirus 71 encephalomyelitis. J Pediatr 1998; 133: 795-8.
    • (1998) J Pediatr , vol.133 , pp. 795-798
    • Lum, L.C.1    Wong, K.T.2    Lam, S.K.3
  • 72
    • 51849119351 scopus 로고    scopus 로고
    • Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis
    • Wang, SM, Lei, HY and Yu, CK et al. Acute chemokine response in the blood and cerebrospinal fluid of children with enterovirus 71-associated brainstem encephalitis. J Infect Dis 2008; 198: 1002-6.
    • (2008) J Infect Dis , vol.198 , pp. 1002-1006
    • Wang, S.M.1    Lei, H.Y.2    Yu, C.K.3
  • 73
    • 84879537715 scopus 로고    scopus 로고
    • Comparative study of the cytokine/ chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease
    • Zhang, Y, Liu, H and Wang, L et al. Comparative study of the cytokine/ chemokine response in children with differing disease severity in enterovirus 71-induced hand, foot, and mouth disease. PLoS One 2013; 8: e67430.
    • (2013) PLoS One , vol.8
    • Zhang, Y.1    Liu, H.2    Wang, L.3
  • 74
    • 84907807174 scopus 로고    scopus 로고
    • IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection
    • Chen, Z, Li, R and Xie, Z et al. IL-6, IL-10 and IL-13 are associated with pathogenesis in children with Enterovirus 71 infection. Int J Clin Exp Med 2014; 7: 2718-23.
    • (2014) Int J Clin Exp Med , vol.7 , pp. 2718-2723
    • Chen, Z.1    Li, R.2    Xie, Z.3
  • 75
    • 84901821168 scopus 로고    scopus 로고
    • Serum cytokine profiles of children with human enterovirus 71-associated hand, foot, and mouth disease
    • Han, J, Wang, Y and Gan, X et al. Serum cytokine profiles of children with human enterovirus 71-associated hand, foot, and mouth disease. J Med Virol 2014; 86: 1377-85.
    • (2014) J Med Virol , vol.86 , pp. 1377-1385
    • Han, J.1    Wang, Y.2    Gan, X.3
  • 76
    • 77953644816 scopus 로고    scopus 로고
    • EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes
    • Tung, WH, Lee, IT and Hsieh, HL et al. EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-kappaB in rat brain astrocytes. J Cell Physiol 2010; 224: 376-86.
    • (2010) J Cell Physiol , vol.224 , pp. 376-386
    • Tung, W.H.1    Lee, I.T.2    Hsieh, H.L.3
  • 77
    • 34548382986 scopus 로고    scopus 로고
    • EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK JNK, NF-kappaB in vascular smooth muscle cells
    • Tung, WH, Sun, CC and Hsieh, HL et al. EV71 induces VCAM-1 expression via PDGF receptor, PI3-K/Akt, p38 MAPK JNK, NF-kappaB in vascular smooth muscle cells. Cell Signal 2007; 19: 2127-37.
    • (2007) Cell Signal , vol.19 , pp. 2127-2137
    • Tung, W.H.1    Sun, C.C.2    Hsieh, H.L.3
  • 78
    • 79952583787 scopus 로고    scopus 로고
    • Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model
    • Khong, WX, Foo, DG and Trasti, SL et al. Sustained high levels of interleukin-6 contribute to the pathogenesis of enterovirus 71 in a neonate mouse model. J Virol 2011; 85: 3067-76.
    • (2011) J Virol , vol.85 , pp. 3067-3076
    • Khong, W.X.1    Foo, D.G.2    Trasti, S.L.3
  • 79
    • 80052286633 scopus 로고    scopus 로고
    • Pathogenesis study of enterovirus 71 infection in rhesus monkeys
    • Zhang, Y, Cui, W and Liu, L et al. Pathogenesis study of enterovirus 71 infection in rhesus monkeys. Lab Invest 2011; 91: 1337-50.
    • (2011) Lab Invest , vol.91 , pp. 1337-1350
    • Zhang, Y.1    Cui, W.2    Liu, L.3
  • 80
    • 84883418885 scopus 로고    scopus 로고
    • Transgenic mouse model for the study of enterovirus 71 neuropathogenesis
    • Fujii, K, Nagata, N and Sato, Y et al. Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci USA 2013; 110: 14753-8.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 14753-14758
    • Fujii, K.1    Nagata, N.2    Sato, Y.3
  • 81
    • 18344378418 scopus 로고    scopus 로고
    • Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71
    • Nagata, N, Shimizu, H and Ami, Y et al. Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71. J Med Virol 2002; 67: 207-16.
    • (2002) J Med Virol , vol.67 , pp. 207-216
    • Nagata, N.1    Shimizu, H.2    Ami, Y.3
  • 82
    • 48849117686 scopus 로고    scopus 로고
    • The molecular basis of mouse adaptation by human enterovirus 71
    • Chua, BH, Phuektes, P and Sanders, SA et al. The molecular basis of mouse adaptation by human enterovirus 71. J Gen Virol 2008; 89: 1622-32.
    • (2008) J Gen Virol , vol.89 , pp. 1622-1632
    • Chua, B.H.1    Phuektes, P.2    Sanders, S.A.3
  • 83
    • 84875112670 scopus 로고    scopus 로고
    • Adaptation of enterovirus 71 to adult interferon deficient mice
    • Caine, EA, Partidos, CD and Santangelo, JD et al. Adaptation of enterovirus 71 to adult interferon deficient mice. PLoS One 2013; 8: e59501.
    • (2013) PLoS One , vol.8
    • Caine, E.A.1    Partidos, C.D.2    Santangelo, J.D.3
  • 84
    • 84900420876 scopus 로고    scopus 로고
    • Animal models of enterovirus 71 infection: applications and limitations
    • Wang, YF and Yu, CK. Animal models of enterovirus 71 infection: applications and limitations. J Biomed Sci 2014; 21: 31.
    • (2014) J Biomed Sci , vol.21 , pp. 31
    • Wang, Y.F.1    Yu, C.K.2
  • 85
    • 79960838029 scopus 로고    scopus 로고
    • A mouse muscle-adapted enterovirus 71 strain with increased virulence in mice
    • Wang, W, Duo, J and Liu, J et al. A mouse muscle-adapted enterovirus 71 strain with increased virulence in mice. Microbes Infect 2011; 13: 862-70.
    • (2011) Microbes Infect , vol.13 , pp. 862-870
    • Wang, W.1    Duo, J.2    Liu, J.3
  • 86
    • 67650446350 scopus 로고    scopus 로고
    • Scavenger receptor B2 is a cellular receptor for enterovirus 71
    • Yamayoshi, S, Yamashita, Y and Li, J et al. Scavenger receptor B2 is a cellular receptor for enterovirus 71. Nat Med 2009; 15: 798-801.
    • (2009) Nat Med , vol.15 , pp. 798-801
    • Yamayoshi, S.1    Yamashita, Y.2    Li, J.3
  • 87
    • 67650491431 scopus 로고    scopus 로고
    • Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71
    • Nishimura, Y, Shimojima, M and Tano, Y et al. Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. NatMed 2009; 15: 794-7.
    • (2009) NatMed , vol.15 , pp. 794-797
    • Nishimura, Y.1    Shimojima, M.2    Tano, Y.3
  • 88
    • 80655125503 scopus 로고    scopus 로고
    • Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity
    • Yang, SL, Chou, YT and Wu, CN et al. Annexin II binds to capsid protein VP1 of enterovirus 71 and enhances viral infectivity. J Virol 2011; 85: 11809-20.
    • (2011) J Virol , vol.85 , pp. 11809-11820
    • Yang, S.L.1    Chou, Y.T.2    Wu, C.N.3
  • 89
    • 84899489845 scopus 로고    scopus 로고
    • Cell and tissue tropism of enterovirus 71 and other enteroviruses infections
    • Lin, JY and Shih, SR. Cell and tissue tropism of enterovirus 71 and other enteroviruses infections. J Biomed Sci 2014; 21: 18.
    • (2014) J Biomed Sci , vol.21 , pp. 18
    • Lin, J.Y.1    Shih, S.R.2
  • 90
    • 84874324124 scopus 로고    scopus 로고
    • Cellular receptors for human enterovirus species a
    • Nishimura, Y and Shimizu, H. Cellular receptors for human enterovirus species a. Front Microbiol 2012; 3: 105.
    • (2012) Front Microbiol , vol.3 , pp. 105
    • Nishimura, Y.1    Shimizu, H.2
  • 91
    • 84881227572 scopus 로고    scopus 로고
    • Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection
    • Lin, HY, Yang, YT and Yu, SL et al. Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection. J Virol 2013; 87: 9064-76.
    • (2013) J Virol , vol.87 , pp. 9064-9076
    • Lin, H.Y.1    Yang, Y.T.2    Yu, S.L.3
  • 92
    • 78650957391 scopus 로고    scopus 로고
    • The essential role of clathrinmediated endocytosis in the infectious entry of human enterovirus 71
    • Hussain, KM, Leong, KL and Ng, MM et al. The essential role of clathrinmediated endocytosis in the infectious entry of human enterovirus 71. J Biol Chem 2011; 286: 309-21.
    • (2011) J Biol Chem , vol.286 , pp. 309-321
    • Hussain, K.M.1    Leong, K.L.2    Ng, M.M.3
  • 93
    • 34548191213 scopus 로고    scopus 로고
    • Retrograde axonal transport: a major transmission route of enterovirus 71 in mice
    • Chen, CS, Yao, YC and Lin, SC et al. Retrograde axonal transport: a major transmission route of enterovirus 71 in mice. J Virol 2007; 81: 8996-9003.
    • (2007) J Virol , vol.81 , pp. 8996-9003
    • Chen, C.S.1    Yao, Y.C.2    Lin, S.C.3
  • 94
    • 84874742838 scopus 로고    scopus 로고
    • Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71
    • Yamayoshi, S, Ohka, S and Fujii, K et al. Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71. J Virol 2013; 87: 3335-47.
    • (2013) J Virol , vol.87 , pp. 3335-3347
    • Yamayoshi, S.1    Ohka, S.2    Fujii, K.3
  • 95
    • 84874378993 scopus 로고    scopus 로고
    • Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71
    • Lin, YW, Yu, SL and Shao, HY et al. Human SCARB2 transgenic mice as an infectious animal model for enterovirus 71. PLoS One 2013; 8: e57591.
    • (2013) PLoS One , vol.8
    • Lin, Y.W.1    Yu, S.L.2    Shao, H.Y.3
  • 96
    • 84857799253 scopus 로고    scopus 로고
    • Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice
    • Liu, J, Dong, W and Quan, X et al. Transgenic expression of human P-selectin glycoprotein ligand-1 is not sufficient for enterovirus 71 infection in mice. Arch Virol 2012; 157: 539-43.
    • (2012) Arch Virol , vol.157 , pp. 539-543
    • Liu, J.1    Dong, W.2    Quan, X.3
  • 97
    • 0344303621 scopus 로고    scopus 로고
    • Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region
    • Dobrikova, E, Florez, P and Bradrick, S et al. Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region. Proc Natl Acad Sci USA 2003; 100: 15125-30.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15125-15130
    • Dobrikova, E.1    Florez, P.2    Bradrick, S.3
  • 98
    • 84864574433 scopus 로고    scopus 로고
    • Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection
    • Cordey, S, Petty, TJ and Schibler, M et al. Identification of site-specific adaptations conferring increased neural cell tropism during human enterovirus 71 infection. PLoS Pathog 2012; 8: e1002826.
    • (2012) PLoS Pathog , vol.8
    • Cordey, S.1    Petty, T.J.2    Schibler, M.3
  • 99
    • 84855932977 scopus 로고    scopus 로고
    • Modification of the untranslated regions of human enterovirus 71 impairs growth in a cell-specificmanner
    • Kok, CC, Phuektes, P and Bek, E et al. Modification of the untranslated regions of human enterovirus 71 impairs growth in a cell-specificmanner. J Virol 2012; 86: 542-52.
    • (2012) J Virol , vol.86 , pp. 542-552
    • Kok, C.C.1    Phuektes, P.2    Bek, E.3
  • 100
    • 80055119062 scopus 로고    scopus 로고
    • A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice
    • Yeh, MT, Wang, SW and Yu, CK et al. A single nucleotide in stem loop II of 5'-untranslated region contributes to virulence of enterovirus 71 in mice. PLoS One 2011; 6: e27082.
    • (2011) PLoS One , vol.6
    • Yeh, M.T.1    Wang, S.W.2    Yu, C.K.3
  • 101
    • 84863115198 scopus 로고    scopus 로고
    • Intrinsic antiviral immunity
    • Yan, N and Chen, ZJ. Intrinsic antiviral immunity. Nat Immunol 2012; 13: 214-22.
    • (2012) Nat Immunol , vol.13 , pp. 214-222
    • Yan, N.1    Chen, Z.J.2
  • 102
    • 84877047634 scopus 로고    scopus 로고
    • MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation
    • Kuo, RL, Kao, LT and Lin, SJ et al. MDA5 plays a crucial role in enterovirus 71 RNA-mediated IRF3 activation. PLoS One 2013; 8: e63431.
    • (2013) PLoS One , vol.8
    • Kuo, R.L.1    Kao, L.T.2    Lin, S.J.3
  • 103
    • 84923849700 scopus 로고    scopus 로고
    • TLR3 signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71 infection
    • Zhu, K, Yang, J and Luo, K et al. TLR3 signaling in macrophages is indispensable for the protective immunity of invariant natural killer T cells against enterovirus 71 infection. PLoS Pathog 2015; 11: e1004613.
    • (2015) PLoS Pathog , vol.11
    • Zhu, K.1    Yang, J.2    Luo, K.3
  • 104
    • 28044445892 scopus 로고    scopus 로고
    • Type I interferons protect mice against enterovirus 71 infection
    • Liu, ML, Lee, YP and Wang, YF et al. Type I interferons protect mice against enterovirus 71 infection. J Gen Virol 2005; 86: 3263-9.
    • (2005) J Gen Virol , vol.86 , pp. 3263-3269
    • Liu, M.L.1    Lee, Y.P.2    Wang, Y.F.3
  • 105
    • 77955006559 scopus 로고    scopus 로고
    • The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses
    • Lei, X, Liu, X and Ma, Y et al. The 3C protein of enterovirus 71 inhibits retinoid acid-inducible gene I-mediated interferon regulatory factor 3 activation and type I interferon responses. J Virol 2010; 84: 8051-61.
    • (2010) J Virol , vol.84 , pp. 8051-8061
    • Lei, X.1    Liu, X.2    Ma, Y.3
  • 106
    • 84894522449 scopus 로고    scopus 로고
    • Enterovirus 2Apro targets MDA5 and MAVS in infected cells
    • Feng, Q, Langereis, MA and Lork, M et al. Enterovirus 2Apro targets MDA5 and MAVS in infected cells. J Virol 2014; 88: 3369-78.
    • (2014) J Virol , vol.88 , pp. 3369-3378
    • Feng, Q.1    Langereis, M.A.2    Lork, M.3
  • 107
    • 84876002925 scopus 로고    scopus 로고
    • Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses
    • Wang, B, Xi, X and Lei, X et al. Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses. PLoS Pathog 2013; 9: e1003231.
    • (2013) PLoS Pathog , vol.9
    • Wang, B.1    Xi, X.2    Lei, X.3
  • 108
    • 79953279338 scopus 로고    scopus 로고
    • The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling
    • Mukherjee, A, Morosky, SA and Delorme-Axford, E et al. The coxsackievirus B 3C protease cleaves MAVS and TRIF to attenuate host type I interferon and apoptotic signaling. PLoS Pathog 2011; 7: e1001311.
    • (2011) PLoS Pathog , vol.7
    • Mukherjee, A.1    Morosky, S.A.2    Delorme-Axford, E.3
  • 109
    • 80052278508 scopus 로고    scopus 로고
    • Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3
    • Lei, X, Sun, Z and Liu, X et al. Cleavage of the adaptor protein TRIF by enterovirus 71 3C inhibits antiviral responses mediated by Toll-like receptor 3. J Virol 2011; 85: 8811-8.
    • (2011) J Virol , vol.85 , pp. 8811-8818
    • Lei, X.1    Sun, Z.2    Liu, X.3
  • 110
    • 84873053639 scopus 로고    scopus 로고
    • Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses
    • Lei, X, Xiao, X and Xue, Q et al. Cleavage of interferon regulatory factor 7 by enterovirus 71 3C suppresses cellular responses. J Virol 2013; 87: 1690-8.
    • (2013) J Virol , vol.87 , pp. 1690-1698
    • Lei, X.1    Xiao, X.2    Xue, Q.3
  • 111
    • 84866505640 scopus 로고    scopus 로고
    • Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice
    • Lee, YP, Wang, YF and Wang, JR et al. Enterovirus 71 blocks selectively type I interferon production through the 3C viral protein in mice. J Med Virol 2012; 84: 1779-89.
    • (2012) J Med Virol , vol.84 , pp. 1779-1789
    • Lee, Y.P.1    Wang, Y.F.2    Wang, J.R.3
  • 112
    • 84921981380 scopus 로고    scopus 로고
    • Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex
    • Lei, X, Han, N and Xiao, X et al. Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex. J Virol 2014; 88: 9830-41.
    • (2014) J Virol , vol.88 , pp. 9830-9841
    • Lei, X.1    Han, N.2    Xiao, X.3
  • 113
    • 80052675403 scopus 로고    scopus 로고
    • Enterovirus 71 2C protein inhibits TNFalpha-mediated activation of NF-kappaB by suppressing IkappaB kinase beta phosphorylation
    • Zheng, Z, Li, H and Zhang, Z et al. Enterovirus 71 2C protein inhibits TNFalpha-mediated activation of NF-kappaB by suppressing IkappaB kinase beta phosphorylation. J Immunol 2011; 187: 2202-12.
    • (2011) J Immunol , vol.187 , pp. 2202-2212
    • Zheng, Z.1    Li, H.2    Zhang, Z.3
  • 114
    • 84897836190 scopus 로고    scopus 로고
    • Mechanisms underlying the inhibition of interferon signaling by viruses
    • Devasthanam, AS. Mechanisms underlying the inhibition of interferon signaling by viruses. Virulence 2014; 5: 270-7.
    • (2014) Virulence , vol.5 , pp. 270-277
    • Devasthanam, A.S.1
  • 115
    • 84861309966 scopus 로고    scopus 로고
    • Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1
    • Lu, J, Yi, L and Zhao, J et al. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1. J Virol 2012; 86: 3767-76.
    • (2012) J Virol , vol.86 , pp. 3767-3776
    • Lu, J.1    Yi, L.2    Zhao, J.3
  • 116
    • 79957501648 scopus 로고    scopus 로고
    • Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir
    • Hung, HC, Wang, HC and Shih, SR et al. Synergistic inhibition of enterovirus 71 replication by interferon and rupintrivir. J Infect Dis 2011; 203: 1784-90.
    • (2011) J Infect Dis , vol.203 , pp. 1784-1790
    • Hung, H.C.1    Wang, H.C.2    Shih, S.R.3
  • 117
    • 54449095457 scopus 로고    scopus 로고
    • Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication
    • Lin, JY, Li, ML and Huang, PN et al. Heterogeneous nuclear ribonuclear protein K interacts with the enterovirus 71 5' untranslated region and participates in virus replication. J Gen Virol 2008; 89: 2540-9.
    • (2008) J Gen Virol , vol.89 , pp. 2540-2549
    • Lin, J.Y.1    Li, M.L.2    Huang, P.N.3
  • 118
    • 58549088736 scopus 로고    scopus 로고
    • Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation
    • Lin, JY, Li, ML and Shih, SR. Far upstream element binding protein 2 interacts with enterovirus 71 internal ribosomal entry site and negatively regulates viral translation. Nucleic Acids Res 2009; 37: 47-59.
    • (2009) Nucleic Acids Res , vol.37 , pp. 47-59
    • Lin, J.Y.1    Li, M.L.2    Shih, S.R.3
  • 119
    • 66149116780 scopus 로고    scopus 로고
    • hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication
    • Lin, JY, Shih, SR and Pan, M et al. hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication. J Virol 2009; 83: 6106-14.
    • (2009) J Virol , vol.83 , pp. 6106-6114
    • Lin, J.Y.1    Shih, S.R.2    Pan, M.3
  • 120
    • 83755205412 scopus 로고    scopus 로고
    • Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growth
    • Huang, PN, Lin, JY and Locker, N et al. Far upstream element binding protein 1 binds the internal ribosomal entry site of enterovirus 71 and enhances viral translation and viral growth. Nucleic Acids Res 2011; 39: 9633-48.
    • (2011) Nucleic Acids Res , vol.39 , pp. 9633-9648
    • Huang, P.N.1    Lin, J.Y.2    Locker, N.3
  • 121
    • 84926430577 scopus 로고    scopus 로고
    • The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71
    • Leong, SY, Ong, BK and Chu, JJ. The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71. PLoS Pathog 2015; 11: e1004686.
    • (2015) PLoS Pathog , vol.11
    • Leong, S.Y.1    Ong, B.K.2    Chu, J.J.3
  • 122
    • 70349659010 scopus 로고    scopus 로고
    • Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation
    • Weng, KF, Li, ML and Hung, CT et al. Enterovirus 71 3C protease cleaves a novel target CstF-64 and inhibits cellular polyadenylation. PLoS Pathog 2009; 5: e1000593.
    • (2009) PLoS Pathog , vol.5
    • Weng, K.F.1    Li, M.L.2    Hung, C.T.3
  • 123
    • 84859594211 scopus 로고    scopus 로고
    • The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta
    • Greninger, AL, Knudsen, GM and Betegon, M et al. The 3A protein from multiple picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta. J Virol 2011; 86: 3605-16.
    • (2011) J Virol , vol.86 , pp. 3605-3616
    • Greninger, A.L.1    Knudsen, G.M.2    Betegon, M.3
  • 124
    • 79551707738 scopus 로고    scopus 로고
    • Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity
    • Arita, M, Kojima, H and Nagano, T et al. Phosphatidylinositol 4-kinase III beta is a target of enviroxime-like compounds for antipoliovirus activity. J Virol 2011; 85: 2364-72.
    • (2011) J Virol , vol.85 , pp. 2364-2372
    • Arita, M.1    Kojima, H.2    Nagano, T.3
  • 125
    • 84910620039 scopus 로고    scopus 로고
    • Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface
    • Roulin, PS, Lotzerich, Mand Torta, F et al. Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface. Cell Host Microbe 2014; 16: 677-90.
    • (2014) Cell Host Microbe , vol.16 , pp. 677-690
    • Roulin, P.S.1    Lotzerich Mand Torta, F.2
  • 126
    • 77953280422 scopus 로고    scopus 로고
    • Viral reorganization of the secretory pathway generates distinct organelles for RNA replication
    • Hsu, NY, Ilnytska, O and Belov, G et al. Viral reorganization of the secretory pathway generates distinct organelles for RNA replication. Cell 2010; 141: 799-811.
    • (2010) Cell , vol.141 , pp. 799-811
    • Hsu, N.Y.1    Ilnytska, O.2    Belov, G.3
  • 127
    • 34247149857 scopus 로고    scopus 로고
    • Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication
    • Tang, WF, Yang, SY and Wu, BW et al. Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication. J Biol Chem 2007; 282: 5888-98.
    • (2007) J Biol Chem , vol.282 , pp. 5888-5898
    • Tang, W.F.1    Yang, S.Y.2    Wu, B.W.3
  • 128
    • 7244250180 scopus 로고    scopus 로고
    • Identification of genes involved in the host response to enterovirus 71 infection
    • Shih, SR, Stollar, V and Lin, JY et al. Identification of genes involved in the host response to enterovirus 71 infection. J Neurovirol 2004; 10: 293-304.
    • (2004) J Neurovirol , vol.10 , pp. 293-304
    • Shih, S.R.1    Stollar, V.2    Lin, J.Y.3
  • 129
    • 33644863314 scopus 로고    scopus 로고
    • Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection
    • Leong, WF and Chow, VT. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. Cell Microbiol 2006; 8: 565-80.
    • (2006) Cell Microbiol , vol.8 , pp. 565-580
    • Leong, W.F.1    Chow, V.T.2
  • 130
    • 84926483231 scopus 로고    scopus 로고
    • Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication
    • Kuo, RL, Lin, YH and Wang, RY et al. Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication. J Proteome Res 2015; 14: 1818-30.
    • (2015) J Proteome Res , vol.14 , pp. 1818-1830
    • Kuo, R.L.1    Lin, Y.H.2    Wang, R.Y.3
  • 131
    • 77954549997 scopus 로고    scopus 로고
    • Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach
    • Cui, L, Guo, X and Qi, Y et al. Identification of microRNAs involved in the host response to enterovirus 71 infection by a deep sequencing approach.JBiomed Biotechnol 2010; 2010: 425939.
    • (2010) JBiomed Biotechnol , vol.2010
    • Cui, L.1    Guo, X.2    Qi, Y.3
  • 132
    • 80555129518 scopus 로고    scopus 로고
    • Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-footand-mouth disease
    • Cui, L, Qi, Y and Li, H et al. Serum microRNA expression profile distinguishes enterovirus 71 and coxsackievirus 16 infections in patients with hand-footand-mouth disease. PLoS One 2011; 6: e27071.
    • (2011) PLoS One , vol.6
    • Cui, L.1    Qi, Y.2    Li, H.3
  • 133
    • 84878016291 scopus 로고    scopus 로고
    • MicroRNA-23b inhibits enterovirus 71 replication through downregulation of EV71 VPl protein
    • Wen, BP, Dai, HJ and Yang, YH et al. MicroRNA-23b inhibits enterovirus 71 replication through downregulation of EV71 VPl protein. Intervirology 2013; 56: 195-200.
    • (2013) Intervirology , vol.56 , pp. 195-200
    • Wen, B.P.1    Dai, H.J.2    Yang, Y.H.3
  • 134
    • 84877346016 scopus 로고    scopus 로고
    • Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome
    • Zheng, Z, Ke, X and Wang, M et al. Human microRNA hsa-miR-296-5p suppresses enterovirus 71 replication by targeting the viral genome. J Virol 2013; 87: 5645-56.
    • (2013) J Virol , vol.87 , pp. 5645-5656
    • Zheng, Z.1    Ke, X.2    Wang, M.3
  • 135
    • 84896838762 scopus 로고    scopus 로고
    • Inhibition of miR-146a prevents enterovirusinduced death by restoring the production of type I interferon
    • Ho, BC, Yu, IS and Lu, LF et al. Inhibition of miR-146a prevents enterovirusinduced death by restoring the production of type I interferon. Nat Commun 2014; 5: 3344.
    • (2014) Nat Commun , vol.5 , pp. 3344
    • Ho, B.C.1    Yu, I.S.2    Lu, L.F.3
  • 136
    • 84906983279 scopus 로고    scopus 로고
    • Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response
    • Xu, C, He, X and Zheng, Z et al. Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response. J Virol 2014; 88: 11356-68.
    • (2014) J Virol , vol.88 , pp. 11356-11368
    • Xu, C.1    He, X.2    Zheng, Z.3
  • 137
    • 84861316194 scopus 로고    scopus 로고
    • A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71
    • Wang, X, Peng, W and Ren, J et al. A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71. Nat Struct Mol Biol 2012; 19: 424-9.
    • (2012) Nat Struct Mol Biol , vol.19 , pp. 424-429
    • Wang, X.1    Peng, W.2    Ren, J.3
  • 138
    • 84861975966 scopus 로고    scopus 로고
    • Crystal structure of human enterovirus 71
    • Plevka, P, Perera, R and Cardosa, J et al. Crystal structure of human enterovirus 71. Science 2012; 336: 1274.
    • (2012) Science , vol.336 , pp. 1274
    • Plevka, P.1    Perera, R.2    Cardosa, J.3
  • 139
    • 84875821776 scopus 로고    scopus 로고
    • Structure of human enterovirus 71 in complex with a capsid-binding inhibitor
    • Plevka, P, Perera, R and Yap, ML et al. Structure of human enterovirus 71 in complex with a capsid-binding inhibitor. Proc Natl Acad Sci USA 2013; 110: 5463-7.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 5463-5467
    • Plevka, P.1    Perera, R.2    Yap, M.L.3
  • 140
    • 84895890904 scopus 로고    scopus 로고
    • More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules
    • De Colibus, L, Wang, X and Spyrou, JA et al. More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules. Nat Struct Mol Biol 2014; 21: 282-8.
    • (2014) Nat Struct Mol Biol , vol.21 , pp. 282-288
    • De Colibus, L.1    Wang, X.2    Spyrou, J.A.3
  • 142
    • 0028925901 scopus 로고
    • Poliovirus protein 2C contains two regions involved in RNA binding activity
    • Rodriguez, PL and Carrasco, L. Poliovirus protein 2C contains two regions involved in RNA binding activity. J Biol Chem 1995; 270: 10105-12.
    • (1995) J Biol Chem , vol.270 , pp. 10105-10112
    • Rodriguez, P.L.1    Carrasco, L.2
  • 143
    • 0030831556 scopus 로고    scopus 로고
    • Poliovirus-encoded 2C polypeptide specifically binds to the 3'-terminal sequences of viral negative-strand RNA
    • Banerjee, R, Echeverri, A and Dasgupta, A. Poliovirus-encoded 2C polypeptide specifically binds to the 3'-terminal sequences of viral negative-strand RNA. J Virol 1997; 71: 9570-8.
    • (1997) J Virol , vol.71 , pp. 9570-9578
    • Banerjee, R.1    Echeverri, A.2    Dasgupta, A.3
  • 144
    • 0030765991 scopus 로고    scopus 로고
    • Poliovirus 2C region functions during encapsidation of viral RNA
    • Vance, LM, Moscufo, N and Chow, M et al. Poliovirus 2C region functions during encapsidation of viral RNA. J Virol 1997; 71: 8759-65.
    • (1997) J Virol , vol.71 , pp. 8759-8765
    • Vance, L.M.1    Moscufo, N.2    Chow, M.3
  • 145
    • 0032913223 scopus 로고    scopus 로고
    • Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: effects on gene expression
    • Novoa, I and Carrasco, L. Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: effects on gene expression.Mol Cell Biol 1999; 19: 2445-54.
    • (1999) Mol Cell Biol , vol.19 , pp. 2445-2454
    • Novoa, I.1    Carrasco, L.2
  • 146
    • 0242268125 scopus 로고    scopus 로고
    • Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved
    • Thompson, SR and Sarnow, P. Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved. Virology 2003; 315: 259-66.
    • (2003) Virology , vol.315 , pp. 259-266
    • Thompson, S.R.1    Sarnow, P.2
  • 147
    • 79953902499 scopus 로고    scopus 로고
    • Crystal structure of human enterovirus 71 3C protease
    • Cui, S, Wang, J and Fan, T et al. Crystal structure of human enterovirus 71 3C protease. J Mol Biol 2011; 408: 449-61.
    • (2011) J Mol Biol , vol.408 , pp. 449-461
    • Cui, S.1    Wang, J.2    Fan, T.3
  • 148
    • 84886727131 scopus 로고    scopus 로고
    • Crystal structure of 2A proteinase from hand, foot and mouth disease virus
    • Mu, Z, Wang, B and Zhang, X et al. Crystal structure of 2A proteinase from hand, foot and mouth disease virus. J Mol Biol 2013; 425: 4530-43.
    • (2013) J Mol Biol , vol.425 , pp. 4530-4543
    • Mu, Z.1    Wang, B.2    Zhang, X.3
  • 149
    • 80054000375 scopus 로고    scopus 로고
    • Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design
    • Lu, G, Qi, J and Chen, Z et al. Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design. J Virol 2011; 85: 10319-31.
    • (2011) J Virol , vol.85 , pp. 10319-10331
    • Lu, G.1    Qi, J.2    Chen, Z.3
  • 150
    • 80054007220 scopus 로고    scopus 로고
    • Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues
    • Wang, J, Fan, T and Yao, X et al. Crystal structures of enterovirus 71 3C protease complexed with rupintrivir reveal the roles of catalytically important residues. J Virol 2011; 85: 10021-30.
    • (2011) J Virol , vol.85 , pp. 10021-10030
    • Wang, J.1    Fan, T.2    Yao, X.3
  • 151
    • 84880367155 scopus 로고    scopus 로고
    • Conformational plasticity of the 2A proteinase from enterovirus 71
    • Cai, Q, Yameen, M and Liu, W et al. Conformational plasticity of the 2A proteinase from enterovirus 71. J Virol 2013; 87: 7348-56.
    • (2013) J Virol , vol.87 , pp. 7348-7356
    • Cai, Q.1    Yameen, M.2    Liu, W.3
  • 152
    • 84931259685 scopus 로고    scopus 로고
    • A peptidyl aldehyde NK-1.8k suppresses EV71 and EV68 infection by targeting at 3Cpro
    • Wang, Y, Yang, B and Zhai, Y et al. A peptidyl aldehyde NK-1.8k suppresses EV71 and EV68 infection by targeting at 3Cpro. Antimicrob Agents Chemother 2015; 59: 2636-46.
    • (2015) Antimicrob Agents Chemother , vol.59 , pp. 2636-2646
    • Wang, Y.1    Yang, B.2    Zhai, Y.3
  • 153
    • 79952537148 scopus 로고    scopus 로고
    • Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China
    • Wu, Y, Lou, Z and Miao, Y et al. Structures of EV71 RNA-dependent RNA polymerase in complex with substrate and analogue provide a drug target against the hand-foot-and-mouth disease pandemic in China. Protein Cell 2010; 1: 491-500.
    • (2010) Protein Cell , vol.1 , pp. 491-500
    • Wu, Y.1    Lou, Z.2    Miao, Y.3
  • 154
    • 84877616491 scopus 로고    scopus 로고
    • Crystal structure of enterovirus 71 RNAdependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation
    • Chen, C, Wang, Y and Shan, C et al. Crystal structure of enterovirus 71 RNAdependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation. J Virol 2013; 87: 5755-68.
    • (2013) J Virol , vol.87 , pp. 5755-5768
    • Chen, C.1    Wang, Y.2    Shan, C.3
  • 155
    • 84899079298 scopus 로고    scopus 로고
    • Attenuation of human enterovirus 71 high-replicationfidelity variants in AG129 mice
    • Meng, T and Kwang, J. Attenuation of human enterovirus 71 high-replicationfidelity variants in AG129 mice. J Virol 2014; 88: 5803-15.
    • (2014) J Virol , vol.88 , pp. 5803-5815
    • Meng, T.1    Kwang, J.2
  • 156
    • 67649997343 scopus 로고    scopus 로고
    • Novel antiviral agent DTriP-22 targets RNA-dependent RNA polymerase of enterovirus 71
    • Chen, TC, Chang, HY and Lin, PF et al. Novel antiviral agent DTriP-22 targets RNA-dependent RNA polymerase of enterovirus 71. Antimicrob Agents Chemother 2009; 53: 2740-7.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2740-2747
    • Chen, T.C.1    Chang, H.Y.2    Lin, P.F.3
  • 157
    • 17944363478 scopus 로고    scopus 로고
    • Neutralizing antiviral antibody responses
    • Zinkernagel, RM, LaMarre, A and Ciurea, A et al. Neutralizing antiviral antibody responses. Adv Immunol 2001; 79: 1-53.
    • (2001) Adv Immunol , vol.79 , pp. 1-53
    • Zinkernagel, R.M.1    LaMarre, A.2    Ciurea, A.3
  • 158
    • 84867900517 scopus 로고    scopus 로고
    • Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China
    • Ji, H, Li, L and Chen, XQ et al. Seroepidemiology of human enterovirus71 and coxsackievirusA16 in Jiangsu province, China. Virol J 2012; 9: 248.
    • (2012) Virol J , vol.9 , pp. 248
    • Ji, H.1    Li, L.2    Chen, X.Q.3
  • 159
    • 76049087808 scopus 로고    scopus 로고
    • Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany
    • Rabenau, HF, Richter, M and Doerr, HW et al. Hand, foot and mouth disease: seroprevalence of Coxsackie A16 and Enterovirus 71 in Germany. Med Microbiol Immunol 2010; 199: 45-50.
    • (2010) Med Microbiol Immunol , vol.199 , pp. 45-50
    • Rabenau, H.F.1    Richter, M.2    Doerr, H.W.3
  • 160
    • 84861466675 scopus 로고    scopus 로고
    • Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants
    • Zhu, FC, Liang, ZL and Meng, FY et al. Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants. PLoS One 2012; 7: e37206.
    • (2012) PLoS One , vol.7
    • Zhu, F.C.1    Liang, Z.L.2    Meng, F.Y.3
  • 161
    • 84878653325 scopus 로고    scopus 로고
    • Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial
    • Zhu, FC, Meng, FY and Li, JX et al. Efficacy, safety, and immunology of an inactivated alum-adjuvant enterovirus 71 vaccine in children in China: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet 2013; 381: 2024-32.
    • (2013) Lancet , vol.381 , pp. 2024-2032
    • Zhu, F.C.1    Meng, F.Y.2    Li, J.X.3
  • 162
    • 84896713013 scopus 로고    scopus 로고
    • An inactivated enterovirus 71 vaccine in healthy children
    • Li, R, Liu, L and Mo, Z et al. An inactivated enterovirus 71 vaccine in healthy children. N Engl J Med 2014; 370: 829-37.
    • (2014) N Engl J Med , vol.370 , pp. 829-837
    • Li, R.1    Liu, L.2    Mo, Z.3
  • 163
    • 84896701787 scopus 로고    scopus 로고
    • Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China
    • Zhu, F, Xu, W and Xia, J et al. Efficacy, safety, and immunogenicity of an enterovirus 71 vaccine in China. N Engl J Med 2014; 370: 818-28.
    • (2014) N Engl J Med , vol.370 , pp. 818-828
    • Zhu, F.1    Xu, W.2    Xia, J.3
  • 164
    • 84918582014 scopus 로고    scopus 로고
    • A booster dose of an inactivated enterovirus 71 vaccine in chinese young children: a randomized, double-blind, placebo-controlled clinical trial
    • Shen, YW, Jing, XL and Zheng, LL et al. A booster dose of an inactivated enterovirus 71 vaccine in chinese young children: a randomized, double-blind, placebo-controlled clinical trial. J Infect Dis 2014; 210: 1073-82.
    • (2014) J Infect Dis , vol.210 , pp. 1073-1082
    • Shen, Y.W.1    Jing, X.L.2    Zheng, L.L.3
  • 165
    • 84896690204 scopus 로고    scopus 로고
    • The cross-neutralizing activity of enterovirus 71 subgenotype C4 vaccines in healthy Chinese infants and children
    • Mao, Q, Cheng, T and Zhu, F et al. The cross-neutralizing activity of enterovirus 71 subgenotype C4 vaccines in healthy Chinese infants and children. Plos One 2013; 8: e79599.
    • (2013) Plos One , vol.8
    • Mao, Q.1    Cheng, T.2    Zhu, F.3
  • 166
    • 84983486003 scopus 로고    scopus 로고
    • The compatibility of inactivated-Enterovirus 71 vaccination with Coxsackievirus A16 and poliovirus immunizations in humans and animals
    • Mao, QY, Wang, YP and Liang, ZL et al. The compatibility of inactivated-Enterovirus 71 vaccination with Coxsackievirus A16 and poliovirus immunizations in humans and animals. Hum Vaccin Immunother 2015. doi:10.1080/21645515.2015.1011975.
    • (2015) Hum Vaccin Immunother
    • Mao, Q.Y.1    Wang, Y.P.2    Liang, Z.L.3
  • 167
    • 84898437031 scopus 로고    scopus 로고
    • A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses
    • Cai, Y, Ku, Z and Liu, Q et al. A combination vaccine comprising of inactivated enterovirus 71 and coxsackievirus A16 elicits balanced protective immunity against both viruses. Vaccine 2014; 32: 2406-12.
    • (2014) Vaccine , vol.32 , pp. 2406-2412
    • Cai, Y.1    Ku, Z.2    Liu, Q.3
  • 168
    • 84904389144 scopus 로고    scopus 로고
    • Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys
    • Wang, J, Qi, S and Zhang, X et al. Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys. Vaccine 2014; 32: 4436-42.
    • (2014) Vaccine , vol.32 , pp. 4436-4442
    • Wang, J.1    Qi, S.2    Zhang, X.3
  • 169
    • 84901395310 scopus 로고    scopus 로고
    • Comparative study of the immunogenicity in mice and monkeys of an inactivated CA16 vaccine made from a human diploid cell line
    • Yang, E, Cheng, C and Zhang, Y et al. Comparative study of the immunogenicity in mice and monkeys of an inactivated CA16 vaccine made from a human diploid cell line. Hum Vaccin Immunother 2014; 10: 1266-73.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 1266-1273
    • Yang, E.1    Cheng, C.2    Zhang, Y.3
  • 170
    • 84875844319 scopus 로고    scopus 로고
    • Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection
    • Cai, Y, Liu, Q and Huang, X et al. Active immunization with a Coxsackievirus A16 experimental inactivated vaccine induces neutralizing antibodies and protects mice against lethal infection. Vaccine 2013; 31: 2215-21.
    • (2013) Vaccine , vol.31 , pp. 2215-2221
    • Cai, Y.1    Liu, Q.2    Huang, X.3
  • 171
    • 84898436560 scopus 로고    scopus 로고
    • The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems
    • An, QW, Su, ZG and Pan, RW et al. The immunogenicity and protection effect of the BPL-inactivated CA16 vaccine in different animal systems. Hum Vaccin Immunother 2014; 10: 628-39.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 628-639
    • An, Q.W.1    Su, Z.G.2    Pan, R.W.3
  • 172
    • 84921383706 scopus 로고    scopus 로고
    • Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice
    • Sun, S, Jiang, L and Liang, Z et al. Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice. Hum Vaccin Immunother 2014; 10: 2885-95.
    • (2014) Hum Vaccin Immunother , vol.10 , pp. 2885-2895
    • Sun, S.1    Jiang, L.2    Liang, Z.3
  • 173
    • 84903819994 scopus 로고    scopus 로고
    • A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice
    • Ku, Z, Liu, Q and Ye, X et al. A virus-like particle based bivalent vaccine confers dual protection against enterovirus 71 and coxsackievirus A16 infections in mice. Vaccine 2014; 32: 4296-303.
    • (2014) Vaccine , vol.32 , pp. 4296-4303
    • Ku, Z.1    Liu, Q.2    Ye, X.3
  • 174
    • 33644913110 scopus 로고    scopus 로고
    • Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71
    • Chen, HF, Chang, MH and Chiang, BL et al. Oral immunization of mice using transgenic tomato fruit expressing VP1 protein from enterovirus 71. Vaccine 2006; 24: 2944-51.
    • (2006) Vaccine , vol.24 , pp. 2944-2951
    • Chen, H.F.1    Chang, M.H.2    Chiang, B.L.3
  • 175
    • 34648819319 scopus 로고    scopus 로고
    • Immunity to a virulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice
    • Wu, TC, Wang, YF and Lee, YP et al. Immunity to a virulent enterovirus 71 and coxsackie A16 virus protects against enterovirus 71 infection in mice. J Virol 2007; 81: 10310-5.
    • (2007) J Virol , vol.81 , pp. 10310-10315
    • Wu, T.C.1    Wang, Y.F.2    Lee, Y.P.3
  • 176
    • 43249110801 scopus 로고    scopus 로고
    • Expression of VP1 protein in the milk of transgenic mice: a potential oral vaccine protects against enterovirus 71 infection
    • Chen, HL, Huang, JY and Chu, TW et al. Expression of VP1 protein in the milk of transgenic mice: a potential oral vaccine protects against enterovirus 71 infection. Vaccine 2008; 26: 2882-9.
    • (2008) Vaccine , vol.26 , pp. 2882-2889
    • Chen, H.L.1    Huang, J.Y.2    Chu, T.W.3
  • 177
    • 84873503828 scopus 로고    scopus 로고
    • Recombinant baculovirus associated with bilosomes as an oral vaccine candidate against HEV71 infection in mice
    • Premanand, B, Prabakaran, M and Kiener, TK et al. Recombinant baculovirus associated with bilosomes as an oral vaccine candidate against HEV71 infection in mice. PLoS One 2013; 8: e55536.
    • (2013) PLoS One , vol.8
    • Premanand, B.1    Prabakaran, M.2    Kiener, T.K.3
  • 178
    • 84901002618 scopus 로고    scopus 로고
    • Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challenge
    • Zhang, F, Hao, C and Zhang, S et al. Oral immunization with recombinant enterovirus 71 VP1 formulated with chitosan protects mice against lethal challenge. Virol J 2014; 11: 80.
    • (2014) Virol J , vol.11 , pp. 80
    • Zhang, F.1    Hao, C.2    Zhang, S.3
  • 179
    • 23944501101 scopus 로고    scopus 로고
    • Cell surface display system for Lactococcus lactis: a novel development for oral vaccine
    • Raha, AR, Varma, NR and Yusoff, K et al. Cell surface display system for Lactococcus lactis: a novel development for oral vaccine. Appl Microbiol Biotechnol 2005; 68: 75-81.
    • (2005) Appl Microbiol Biotechnol , vol.68 , pp. 75-81
    • Raha, A.R.1    Varma, N.R.2    Yusoff, K.3
  • 180
    • 18144429034 scopus 로고    scopus 로고
    • Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys
    • Arita, M, Shimizu, H and Nagata, N et al. Temperature-sensitive mutants of enterovirus 71 show attenuation in cynomolgus monkeys. J Gen Virol 2005; 86: 1391-401.
    • (2005) J Gen Virol , vol.86 , pp. 1391-1401
    • Arita, M.1    Shimizu, H.2    Nagata, N.3
  • 181
    • 70649113050 scopus 로고    scopus 로고
    • Introduction of a strong temperaturesensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase
    • Kung, YH, Huang, SW and Kuo, PH et al. Introduction of a strong temperaturesensitive phenotype into enterovirus 71 by altering an amino acid of virus 3D polymerase. Virology 2010; 396: 1-9.
    • (2010) Virology , vol.396 , pp. 1-9
    • Kung, Y.H.1    Huang, S.W.2    Kuo, P.H.3
  • 182
    • 38849104931 scopus 로고    scopus 로고
    • Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model
    • Arita, M, Ami, Y and Wakita, T et al. Cooperative effect of the attenuation determinants derived from poliovirus sabin 1 strain is essential for attenuation of enterovirus 71 in the NOD/SCID mouse infection model. J Virol 2008; 82: 1787-97.
    • (2008) J Virol , vol.82 , pp. 1787-1797
    • Arita, M.1    Ami, Y.2    Wakita, T.3
  • 183
    • 70349648604 scopus 로고    scopus 로고
    • Monoclonal antibodies to VP1 recognize a broad range of enteroviruses
    • Miao, LY, Pierce, C and Gray-Johnson, J et al. Monoclonal antibodies to VP1 recognize a broad range of enteroviruses. J Clin Microbiol 2009; 47: 3108-13.
    • (2009) J Clin Microbiol , vol.47 , pp. 3108-3113
    • Miao, L.Y.1    Pierce, C.2    Gray-Johnson, J.3
  • 184
    • 79957836497 scopus 로고    scopus 로고
    • Identification and characterization of a cross-neutralization epitope of Enterovirus 71
    • Liu, CC, Chou, AH and Lien, SP et al. Identification and characterization of a cross-neutralization epitope of Enterovirus 71. Vaccine 2011; 29: 4362-72.
    • (2011) Vaccine , vol.29 , pp. 4362-4372
    • Liu, C.C.1    Chou, A.H.2    Lien, S.P.3
  • 185
    • 84869089930 scopus 로고    scopus 로고
    • Cross-reactive neutralizing antibody epitopes against Enterovirus 71 identified by an in silico approach
    • Kirk, K, Poh, CL and Fecondo, J et al. Cross-reactive neutralizing antibody epitopes against Enterovirus 71 identified by an in silico approach. Vaccine 2012; 30: 7105-10.
    • (2012) Vaccine , vol.30 , pp. 7105-7110
    • Kirk, K.1    Poh, C.L.2    Fecondo, J.3
  • 186
    • 84889873100 scopus 로고    scopus 로고
    • Immunization of N terminus of enterovirus 71 VP4 elicits cross-protective antibody responses
    • Zhao, M, Bai, Y and Liu, W et al. Immunization of N terminus of enterovirus 71 VP4 elicits cross-protective antibody responses. BMC Microbiol 2013; 13: 287.
    • (2013) BMC Microbiol , vol.13 , pp. 287
    • Zhao, M.1    Bai, Y.2    Liu, W.3
  • 187
    • 84901773077 scopus 로고    scopus 로고
    • A novel universal neutralizingmonoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein
    • Kiener, TK, Jia, Q and Meng, T et al. A novel universal neutralizingmonoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein. PLoS Negl Trop Dis 2014; 8: e2895.
    • (2014) PLoS Negl Trop Dis , vol.8
    • Kiener, T.K.1    Jia, Q.2    Meng, T.3
  • 188
    • 84902528771 scopus 로고    scopus 로고
    • Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly crossneutralizing epitope within the VP2 EF loop
    • Xu, L, He, D and Li, Z et al. Protection against lethal enterovirus 71 challenge in mice by a recombinant vaccine candidate containing a broadly crossneutralizing epitope within the VP2 EF loop. Theranostics 2014; 4: 498-513.
    • (2014) Theranostics , vol.4 , pp. 498-513
    • Xu, L.1    He, D.2    Li, Z.3
  • 189
    • 84890876293 scopus 로고    scopus 로고
    • Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms
    • Ye, X, Ku, Z and Liu, Q et al. Chimeric virus-like particle vaccines displaying conserved enterovirus 71 epitopes elicit protective neutralizing antibodies in mice through divergent mechanisms. J Virol 2014; 88: 72-81.
    • (2014) J Virol , vol.88 , pp. 72-81
    • Ye, X.1    Ku, Z.2    Liu, Q.3


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