EV71 induces COX-2 expression via c-Src/PDGFR/PI3K/Akt/p42/p44 MAPK/AP-1 and NF-κB in rat brain astrocytes

Journal of Cellular Physiology

Volumn 224, Issue 2, 2010, Pages 376-386

  Tung, Wei Hsuan ^a   Lee, I Ta ^a   Hsieh, Hsi Lung ^b   Yang, Chuen Mao ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 6,7 DIMETHOXY 2 PHENYLQUINOXALINE; CYCLOOXYGENASE 2; HELENALIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROSTAGLANDIN E2; PROTEIN C FOS; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN P42; PROTEIN P44; PROTEIN P85; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TANSHINONE; TRANSCRIPTION FACTOR AP 1; WORTMANNIN; MESSENGER RNA; PROTEIN TYROSINE KINASE; PTGS2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; BRAIN; CELL NUCLEUS; CELL STIMULATION; CYTOPLASM; EMBRYO; ENTEROVIRUS 71; ENZYME ACTIVATION; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE SRC; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; TRANSACTIVATION; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CYTOLOGY; ENTEROVIRUS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY; VIROLOGY;

HUMAN ENTEROVIRUS 71; RATTUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ASTROCYTES; BRAIN; CYCLOOXYGENASE 2; DINOPROSTONE; ENTEROVIRUS A, HUMAN; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RNA, MESSENGER; SRC-FAMILY KINASES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC;

EID: 77953644816     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22133     Document Type: Article

References (27)

1. Bianchi R, Giambanco I, Donato R. 2010. S100B/RAGE-dependent activation of microglia via NF-κB and AP-1 Co-regulation of COX-2 expression by S100B, IL-1β and TNF-α. Neurobiol Aging 31:665-677.
2. Carpentier PA, Getts MT, Miller SD. 2008. Pro-inflammatory functions of astrocytes correlate with viral clearance and strain-dependent protection from TMEV-induced demyelinating disease. Virology 375: 24-36.
3. Chen N, Reis CS. 2002. Distinct roles of eicosanoids in the immune response to viral encephalitis: Or why you should take NSAIDS. Viral Immunol 15:133-146. (Pubitemid 34273443)
4. Consilvio C, Vincent AM, Feldman EL. 2004. Neuroinflammation, COX-2, and ALS-a dual role? Exp Neurol 187:1-10.
5. Di Pasquale G, Davidson BL, Stein CS, Martins I, Scudiero D, Monks A, Chiorini JA. 2003. Identification of PDGFR as a receptor for AAV-5 transduction. Nat Med 9:1306-1312. (Pubitemid 37279855)
6. EvansDJ, Almond JW. 1998. Cell receptors for picornaviruses as determinants of cell tropism and pathogenesis. Trends Microbiol 6:198-202.
7. Fischer B, Marinov M, Arcaro A. 2007. Targeting receptor tyrosine kinase signalling in small cell lung cancer (SCLC): What have we learned so far? Cancer Treat Rev 33:391-406.
8. 2 release by suppressing the activity of NF-κB and JNK in LPS-treated microglia. J Neurochem 107:779-788.
9. Guan Z, Buckman SY, Miller BW, Springer LD, Morrison AR. 1998. Interleukin-1β-induced cyclooxygenase-2 expression requires activation of both c-Jun NH2-terminal kinase and p38 MAPK signal pathways in rat renal mesangial cells. J Biol Chem 273:28670-28676. (Pubitemid 28507552)
10. Hinson VK, Tyor WR. 2001. Update on viral encephalitis. Curr Opin Neurol 14:369-374.
11. Hiscott J, Kwon H, Genin P. 2001. Hostile takeovers: Viral appropriation of the NF-κB pathway. J Clin Invest 107:143-151.
12. Hsueh C, Jung SM, Shih SR, Kuo TT, Shieh WJ, Zaki S, Lin TY, Chang LY, Ning HC, Yen DC. 2000. Acute encephalomyelitis during an outbreak of enterovirus type 71 infection in Taiwan: Report of an autopsy case with pathologic, immunofluorescence, and molecular studies. Mod Pathol 13:1200-1205.
13. Iniguez MA, Martinez-Martinez S, Punzon C, Redondo JM, Fresno M. 2000. An essential role of the nuclear factor of activated T cells in the regulation of the expression of the cyclooxygenase-2 gene in human T lymphocytes. J Biol Chem 275:23627-23635. (Pubitemid 30624647)
14. Kwon D, Fuller AC, Palma JP, Choi IH, Kim BS. 2004. Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-κB. Glia 45:287-296. (Pubitemid 38222257)
15. Lin TY, Chang LY, Hsia SH, Huang YC, Chiu CH, Hsueh C, Shih SR, Liu CC, Wu MH. 2002. The 1998 enterovirus 71 outbreak in Taiwan: Pathogenesis and management. Clin Infect Dis 34:S52-S57. (Pubitemid 34442209)
16. Liu CC, Lian WC, Butler M, Wu SC. 2007. High immunogenic enterovirus 71 strain and its production using serum-free microcarrier Vero cell culture. Vaccine 25:19-24. (Pubitemid 44855252)
17. Ludwig S, Planz O, Pleschka S, Wolff T. 2003. Influenza-virus-induced signaling cascades: Targets for antiviral therapy? Trends Mol Med 9:46-52.
18. Luo H, Yanagawa B, Zhang J, Luo Z, Zhang M, Esfandiarei M, Carthy C, Wilson JE, Yang D, McManus BM. 2002. Coxsackievirus B3 replication is reduced by inhibition of the extracellular signal-regulated kinase (ERK) signaling pathway. J Virol 76:3365-3373.
19. Moolwaney AS, Igwe OJ. 2005. Regulation of the cyclooxygenase-2 system by interleukin-1β through mitogen-activated protein kinase signaling pathways: A comparative study of human neuroglioma and neuroblastoma cells. Brain Res Mol Brain Res 137:202-212.
20. O'Banion MK. 1999. Cyclooxygenase-2: Molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol 13:45-82.
21. Ohtsu H, Dempsey PJ, Eguchi S. 2006. ADAMs as mediators of EGF receptor transactivation by G protein-coupled receptors. Am J Physiol Cell Physiol 291:C1-C10.
22. Palacios G, Oberste MS. 2005. Enteroviruses as agents of emerging infectious diseases. J Neurovirol 11:424-433.
23. Rodemann HP, Dittmann K, Toulany M. 2007. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int J Radiat Biol 83:781-791.
24. Rohrenbeck AM, Bette M, Hooper DC, Nyberg F, Eiden LE, Dietzschold B, Weihe E. 1999. Upregulation of COX-2 and CGRP expression in resident cells of the Borna disease virus-infected brain is dependent upon inflammation. Neurobiol Dis 6:15-34.
25. Steer SA, Corbett JA. 2003. The role and regulation of COX-2 during viral infection. Viral Immunol 16:447-460.
26. Wetherington J, Serrano G, Dingledine R. 2008. Astrocytes in the epileptic brain. Neuron 58:168-178.
27. Wong WR, Chen YY, Yang SM, Chen YL, Horng JT. 2005. Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71. Life Sci 78:82-90.