Modification of the untranslated regions of human enterovirus 71 impairs growth in a cell-specific manner

Journal of Virology

Volumn 86, Issue 1, 2012, Pages 542-552

  Kok, Chee Choy ^a,b   Phuektes, Patchara ^a   Bek, Emily ^a   McMinn, Peter C ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; VIRUS RNA;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CHIMERA; CONTROLLED STUDY; DNA MODIFICATION; ENTEROVIRUS 71; ENTEROVIRUS INFECTION; GENE DELETION; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOLECULAR STABILITY; NEUROBLASTOMA CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHINOVIRUS; RNA SYNTHESIS; UNTRANSLATED REGION; VIRUS CELL INTERACTION; VIRUS MORPHOGENESIS; VIRUS PATHOGENESIS; VIRUS REPLICATION; VIRUS STRAIN; VIRUS VIRULENCE;

BASE SEQUENCE; CELL LINE; DNA, VIRAL; ENTEROVIRUS A, HUMAN; GENE EXPRESSION REGULATION, VIRAL; HAND, FOOT AND MOUTH DISEASE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BIOSYNTHESIS; SPECIES SPECIFICITY; UNTRANSLATED REGIONS; VIRAL PROTEINS; VIRUS CULTIVATION; VIRUS REPLICATION;

COXSACKIEVIRUS; ENTEROVIRUS; HUMAN ENTEROVIRUS 71; HUMAN ENTEROVIRUS A; HUMAN RHINOVIRUS 2;

EID: 84855932977     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00069-11     Document Type: Article

References (41)

1. Anderson EC, Hunt SL, Jackson RJ. 2007. Internal initiation of translation from the human rhinovirus-2 internal ribosome entry site requires the binding of Unr to two distinct sites on the 5' untranslated region. J. Gen. Virol. 88:3043-3052.
2. Barton DJ, Flanegan JB. 1997. Synchronous replication of poliovirus RNA: inhibition of negative-strandRNAsynthesis requires the guanidineinhibited activity of protein 2C. J. Virol. 71:8482- 8489.
3. Belsham GJ, Normann P. 2008. Dynamics of picornavirus RNA replication within infected cells. J. Gen. Virol. 89:485- 493.
4. Borman AM, Deliat FG, Kean KM. 1994. Sequences within the poliovirus internal ribosome entry site segment control viral RNA synthesis. EMBO J. 13:3149 -3157.
5. Brunner JE, et al. 2005. Functional interaction of heterogeneous nuclear ribonucleoprotein C with poliovirus RNA synthesis initiation complexes. J. Virol. 79:3254 -3266.
6. Campbell SA, Lin J, Dobrikova EY, Gromeier M. 2005. Genetic determinants of cell type-specific poliovirus propagation in HEK 293 cells. J. Virol. 79:6281- 6290.
7. Cardosa MJ, et al. 2003. Molecular epidemiology of human enterovirus 71 strains and recent outbreaks in the Asia-Pacific region: comparative analysis of the VP1 and VP4 genes. Emerg. Infect. Dis. 9:461- 468.
8. Chua BH, Phuektes P, Sanders SA, Nicholls PK, McMinn PC. 2008. The molecular basis of mouse adaptation by human enterovirus 71. J. Gen. Virol. 89:1622-1632.
9. De W, et al. 2011. A large outbreak of hand, foot and mouth disease caused by EV71 and CAV16 in Guangdong, China, 2009. Arch. Virol. 156:945-953.
10. De Jesus N, Franco D, Paul AV, Wimmer E, Cello J. 2005. Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence. J. Virol. 79: 14235-14243.
11. Dobrikova EY, Florez P, Bradrick S, Gromeier M. 2003. Activity of a type 1 picornavirus internal ribosomal entry site is determined by sequences within the 3' nontranslated region. Proc. Natl. Acad. Sci. U. S. A. 100: 15125-15130.
12. Dobrikova EY, Grisham RN, Kaizer C, Lin J, Gromeier M. 2006. Competitive translation efficiency and the picornavirus type I internal ribosome entry site facilitated by viral cis and trans factors. J. Virol. 80: 3310-3321.
13. Dunn JJ, Chapman NM, Tracy S, Romero JR. 2000. Genomic determinants of cardiovirulence in coxsackievirus B3 clinical isolates: localization to the 5' nontranslated region. J. Virol. 74:4787- 4794.
14. Evans DMA, Jr, et al. 1985. Increased neurovirulence associated with a single nucleotide change in a noncoding region of the Sabin type 3 polio vaccine genome. Nature 314:548 -550.
15. Fernandez-Miragall O, de Quinto SL, Martinez-Salas E. 2009. Relevance ofRNAstructure for the activity of picornavirus IRES elements. Virus Res. 139:172-182.
16. Gamarnik AV, Andino R. 1998. Switch from translation to RNA replication in a positive-stranded RNA-virus. Genes Dev. 12:2293-2304.
17. Gromeier M, Alexander L, Wimmer E. 1996. Internal ribosomal entry site substitution eliminates neurovirulence in intergeneric poliovirus recombinants. Proc. Natl. Acad. Sci. U. S. A. 93:2370 -2375.
18. Hellen CUT, Sarnow P. 2001. Internal ribosome entry sites in eukaryotic mRNA molecules. Genes Dev. 15:1593-1612.
19. Huez I, et al. 1998. Two independent internal ribosome entry sites are involved in translation of vascular endothelial growth factor mRNA. Mol. Cell. Biol. 18:6178-6190.
20. Hunziker IP, Cornell CT, Whitton JL. 2007. Deletions within the 5'UTR of coxsackievirus B3: consequences for virus translation and replication. Virology 360:120 -128.
21. Johansen LK, Morrow CD. 2000. The RNA encompassing the internal ribosome entry site in the poliovirus 5' nontranslated region enhances the encapsidation of genomic RNA. Virology 273:391-399.
22. Kauder S, Khan S, Racaniello VR. 2006. Age-dependent poliovirus replication in the mouse central nervous system is determined by internal ribosome entry site-mediated translation. J. Virol. 80:2589 -2595.
23. La Monica N, Racaniello VR. 1989. Differences in replication of attenuated and neurovirulent polioviruses in human neuroblastoma cell line SH-SY5Y. J. Virol. 63:2357-2360.
24. Lyons T, Murray KE, Roberts AW, Barton DJ. 2001. Poliovirus 5'-terminal cloverleaf RNA is required in cis for VPg uridylylation and the initiation of negative-strand RNA synthesis. J. Virol. 75:10696 -10708.
25. Mathews DH, Sabina J, Zuker M, Turner DH. 1999. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J. Mol. Biol. 288:911-940.
26. McMinn PC. 2002. An overview of the evolution of EV71 and its clinical and public health significance. FEMS Microbiol. Rev. 26:91-107.
27. Merkle I, et al. 2002. Biological significance of a human enterovirus B-specific RNA element in the 3' nontranslated region. J. Virol. 76: 9900-9909.
28. Merrill MK, Dobrikova EY, Gromeier M. 2006. Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNAbinding protein 76. J. Virol. 80:3147-3156.
29. Merrill MK, Gromeier M. 2006. The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site. J. Virol. 80:6936-6942.
30. Pilipenko EV, Maslova SV, Sinyakov AN, Agol VI. 1992. Towards identification of cis-acting elements involved in the replication of enterovirus and rhinovirus RNAs: a proposal for the existence of tRNA-like terminal structures. Nucleic Acids Res. 20:1739 -1745.
31. Reed LJ, Muench H. 1938. A simple method of estimating fifty percent endpoints. Am. J. Hyg. (London) 27:493- 497.
32. Shiroki K, et al. 1995. A new cis-acting element for RNA replication within the 5= noncoding region of poliovirus type 1 RNA. J. Virol. 69: 6825-6832.
33. Thompson JD, Higgins DG, Gibson TJ. 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673- 4680.
34. Thompson SR, Sarnow P. 2003. Enterovirus 71 contains a type I IRES element that functions when eukaryotic initiation factor eIF4G is cleaved. Virology 315:259 -266.
35. Todd S, Towner JS, Brown DM, Semler BL. 1997. Replicationcompetent picornaviruses with complete genomic RNA 3= noncoding region deletions. J. Virol. 71:8868-8874.
36. Toyoda H, Franco D, Fujita K, Paul AV, Wimmer E. 2007. Replication of poliovirus requires binding of poly(rC) binding protein to the cloverleaf as well as to the adjacent C-rich spacer sequence between the cloverleaf and the internal ribosome entry site. J. Virol. 81:10017-10028.
37. Tu PV, et al. 2007. Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005. Emerg. Infect. Dis. 13:1733-1741.
38. Xu J, et al. 2010. EV71: an emerging infectious disease vaccine target in the Far East? Vaccine 28:3516-4416.
39. Yang F, et al. 2009. Enterovirus 71 outbreak in the People's Republic of China in 2008. J. Clin. Microbiol. 47:2351-2352.
40. Zell R, et al. 1999. Functional features of the bovine enterovirus 5=-nontranslated region. J. Gen. Virol. 80:2299 -2309.
41. Zuker M. 2003. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31:3406 -3415.